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Your search keyword '"Ved, Prakash"' showing total 146 results
Start Over Author "Ved, Prakash" Publisher elsevier b.v.
146 results on '"Ved, Prakash"'

37. Clinicoradiologic Risk Stratification and Outcome Assessment in Symptomatic Intracranial Arachnoid Cyst Managed Over Fifteen Years.

Author

Singh, Guramritpal, Maurya, Ved Prakash, Ahamed TP, Waseem, Rai, Shreyash, Srivastava, Arun Kumar, Bhaisora, Kamlesh Singh, Verma, Pawan Kumar, Das, Kuntal Kanti, Mehrotra, Anant, Jaiswal, Awadhesh Kumar, Mishra, Prabhaker, Behari, Sanjay, and Kumar, Raj

Subjects
*ARACHNOID cysts, *CEREBROSPINAL fluid shunts, *SYMPTOMS, *BRAIN damage, *CLINICAL prediction rules, *TEMPORAL lobectomy, *AGE groups
Abstract

Arachnoid cysts (ACs) are developmental anomalies formed by splitting the arachnoid membrane's layers. ACs contribute around 2% of all intracranial space–occupying lesions. ACs are more prevalent in children. Because of varied clinical presentation, there has been a constant need for clinicoradiologic risk stratification with a possible role in outcome prediction. The present study describes the management strategies and outcomes in symptomatic intracranial ACs. All biopsy-proven symptomatic patients who underwent surgical management over last 15 years were included in this study (January 2008–December 2022), while those with non-conclusive biopsies were excluded. Patients presenting with acute deterioration were managed in the emergency department with or without cerebrospinal fluid diversion and decompression of the AC. The microsurgical or endoscopic approach was the preferred surgical modality. Postoperative clinicoradiologic improvement was evaluated at 3 months follow-up visit. A total of 108 patients were analyzed in this retrospective observational study. The median age of the patients was 27.5 years (range, 1 to 76 years). Headache was the most typical clinical presentation. Supratentorial ACs (n = 59, 54.6%) were higher than the infratentorial ACs (n = 49, 45.4%). Forty-seven patients belonged to the pediatric age group (<18 years), and seizure was their presenting complaint. In this observational study, there was no statistical difference in operative duration between microsurgical technique versus endoscopic decompression (P = 0.23). ACs are uncommon brain lesions having a broad spectrum of symptoms. The location and clinical presentation of ACs decide the preferred surgical approach. Individuals in high-risk groups must be treated on priority to achieve long-term relief of symptoms. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Bergenin potentiates BCG efficacy by enriching mycobacteria-specific adaptive memory responses via the Akt-Foxo-Stat4 axis.

Author

Mukhopadhyay, Suparba, Pahuja, Isha, Okieh, Ahmed Abdallah, Pandey, Darshana, Yadav, Vinod, Bhaskar, Ashima, and Dwivedi, Ved Prakash

Abstract

The extensive inability of the BCG vaccine to produce long-term immune protection has not only accelerated the disease burden but also progressed towards the onset of drug resistance. In our previous study, we have reported the promising effects of Bergenin (Berg) in imparting significant protection as an adjunct immunomodulator against tuberculosis (TB). In congruence with our investigations, we delineated the impact of Berg on T cells, wherein it enhanced adaptive memory responses by modulating key transcription factors, STAT4 and Akt. We translated this finding into the vaccine model of TB and observed a notable reduction in the burden of Mycobacterium tuberculosis (M.tb) in BCG-Berg co-immunized mice as compared to BCG vaccination. Moreover, Berg, along with BCG, also aided in a heightened proinflammatory response milieu that corroborates the host protective immune response against TB. Furthermore, this response aligns with the escalated central and resident memory responses by modulating the Akt-Foxo-Stat4 axis, which plays a crucial role in enhancing the vaccine efficacy of BCG. These findings showcase the utilization of immunomodulator Berg as an immunoprophylactic agent to upgrade immunological memory, making it a more effective defender against TB. [ABSTRACT FROM AUTHOR]

Published
2024
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