Search

Efficient 2D-inorganic spinel perovskites nanostructure materials are used as potential candidates for highly sensitive detection of harmful substances present in the environment. In this regard, a facile one-pot hydrothermal synthesis was employed to fabricate nanocomposite material containing iron manganese oxide (FeMn 2 O 4) decorated with reduced graphene oxide (rGO) which is used as an electrochemical detection of metronidazole (MTZ). The crystalline nature and structural insights of the as-synthesized FeMn 2 O 4 -rGO nanocomposite were established using various spectroscopic and electrochemical techniques. Distinctively FeMn 2 O 4 -rGO nanocomposite fashioned glassy carbon electrode (GCE) showed excellent linear range (0.01–512.2 μM), sensitivity (71.4 μA mM−1 cm−2), limit of detection (0.0129 μM), reproducibility, stability and resist-interference capability towards metronidazole (MTZ) antibiotic drug. In addition, the fabricated FeMn 2 O 4 -rGO/GCE electrochemical sensor exhibited a remarkable MTZ detection in spiked water as well as urine samples with better recovery percentages supporting its facile and feasible nature for environmental applications. The present work established the fabrication of FeMn 2 O 4 -rGO/GCE nanocomposite for effective determination of antibiotic drugs in real sample analysis. [ABSTRACT FROM AUTHOR]

Nitroimidazole compounds are widely used antibiotics to encounter anaerobic bacterial and parasitic infections. The wide usage of antibiotic drugs became an ecological contaminant which in turn into potential monitoring. In this regards, we have designed and developed a new electrochemical sensing probe to monitor an antiprotozoal drug, ornidazole (ODZ), with the aid of a glassy carbon electrode (GCE) integrated with manganese molybdate nanorods (MnMoO 4) decorated graphene nanosheets (GNS) hybrid materials that prepared by feasible probe sonochemical method (parameters: 2–4 W, 5 mV amp, 20 kHz). The electrochemical investigations of the developed probe were performed by using rapid scan electrochemical workstations namely cyclic voltammetry (CV) and amperometric (i-t) techniques. The as-prepared MnMoO 4 /GNS nanocomposite was characterized and its purity of nanocomposite formation was confirmed by various analytical techniques like X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and Raman spectroscopy. In addition to that, the textural morphology of the MnMoO 4 /GNS nanocomposite was examined with the aid of field emission scanning electron microscopy (FE-SEM) and high-resolution transmission electron microscopy (HR-TEM). The MnMoO 4 /GNS nanocomposite rotating disk glassy carbon electrode (RDGCE) plays a crucial role in electrochemical detection of ODZ, which results in excellent anti-interference ability, a lower detection limit of 845 pM, massive linear ranges from 10 to 770 nM, and good sensitivity of about 104.62 μA μM−1 cm−2. From the acquired electrochemical studies, we have developed a disposable electrochemical sensor probe using a low-cost screen-printed carbon electrode (SPCE) with MnMoO 4 /GNS nanocomposite. The MnMoO 4 /GNS/SPCE are capably employed in real-time sensing of ODZ in water and urine samples. These electrochemical studies revealed the integral new vision on the electrocatalytic performance of the modified SPCE and also shown excellent amplification results in ultra-trace levels. [Display omitted] • A robust electrochemical sensor probe for ornidazole (ODZ) detection has been reported. • The MnMoO 4 decorated graphene nanosheets (GNS) hybrid catalyst prepared by probe sonication method. • The MnMoO 4 /GNS electrocatalyst showed trace-level detection limit around 845 pM. • The developed sensor was employed for real-time sensing of ODZ in water and urine samples. [ABSTRACT FROM AUTHOR]

Flutamide is a non-steroidal antiandrogen drug and widely used in the treatment of prostatic carcinoma. Nevertheless, the excessive intake and improper disposal could affect the living organisms. In this work, we have synthesized a new nanocomposite based on ZnMn 2 O 4 nanoparticles and porous reduced graphene oxide nanosheets (ZnMn 2 O 4 -PGO) for the electrocatalytic detection of flutamide (FLU) drug. The crystallinity and morphological properties of ZnMn 2 O 4 -PGO composite examined by different characterization techniques such as X-ray diffraction, Raman spectroscopy and so on. The fabricated ZnMn 2 O 4 -PGO nanocomposite modified electrode exhibited superior electrocatalytic performance to FLU drug in an optimized pH electrolyte. Fascinatingly, the electrode received a wide linear range (0.05–3.5 µM) with limit of detection of 8 nM. Besides, the developed ZnMn 2 O 4 -PGO nanocomposite electrode showed good sensitivity 1.05 µAµM−1 cm−2 and excellent selectivity for FLU detection in presence of various interfering species. A developed disposable electrode was scrutinized to determine FLU level in human urine samples by spiking method and the results achieved good recoveries in real sample analysis. ga1 Nanomolar detection of flutamide with ZnMn 2 O 4 -PGO modified SPCE • Development of scalable and cost efficient synthesis strategy. • ZnMn 2 O 4 wrapped porous reduced graphene oxide nanosheets electrode is an efficient catalyst for flutamide detection. • Disposable sensor displays lower detection limit and better recoveries for flutamide in human urine samples. [ABSTRACT FROM AUTHOR]