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Your search keyword '"Vernooij, M."' showing total 5 results
Start Over Author "Vernooij, M." Publisher elsevier b.v.
5 results on '"Vernooij, M."'

5. Three-dimensional digital reconstruction of human placental villus architecture in normal and complicated pregnancies.

Author

McCarthy, R., Orsi, N.M., Treanor, D., Moran, O., Vernooij, M., Magee, D.R., Roberts, N., Stahlschmidt, J., and Simpson, N.A.B.

Subjects
*PLACENTA diseases, *VILLI (Anatomy), *IMAGE reconstruction, *PREGNANCY complications, *EOSIN, *CESAREAN section, *CHORIONIC villi, *GESTATIONAL diabetes, *FETAL growth retardation, *PLACENTA, *PREECLAMPSIA, *THREE-dimensional imaging, *PILOT projects, *CASE-control method
Abstract

Objective: This study aimed to examine the use of digital technology in the three-dimensional reconstruction of human placentas.Study Design: Placentas obtained at term elective caesarean section were sampled, formalin-fixed and embedded in paraffin. Two hundred 5 μm consecutive sections were cut from each specimen and the resultant slides stained with haematoxylin and eosin. Slides were then scanned and the digitised images reconstructed using customised software.Results: Three-dimensional reconstructions were successfully achieved in placentas from normal pregnancies and those complicated by pre-eclampsia, growth restriction, and gestational diabetes. Marked morphological differences were readily identifiable, most clearly in the stem villus architecture.Conclusion: This method is an emerging research tool for examining placental histoarchitecture at high resolution and gaining clinically relevant insight into the placental pathology allied to pregnancy complications such as PET, IUGR and GD. [ABSTRACT FROM AUTHOR]

Published
2016
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