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Your search keyword '"Vidriales, María B."' showing total 2 results
Start Over Author "Vidriales, María B." Publisher elsevier b.v.
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2. High FOXO3a expression is associated with a poorer prognosis in AML with normal cytogenetics

Author

Santamaría, Carlos M., Chillón, Maria C., García-Sanz, Ramón, Pérez, Cristina, Caballero, María D., Ramos, Fernando, de Coca, Alfonso García, Alonso, José M., Giraldo, Pilar, Bernal, Teresa, Queizán, José A., Rodriguez, Juan N., Fernández-Abellán, Pascual, Bárez, Abelardo, Peñarrubia, María J., Vidriales, María B., Balanzategui, Ana, Sarasquete, María E., Alcoceba, Miguel, and Díaz-Mediavilla, Joaquín

Subjects
*TUMOR proteins, *GENE expression, *ACUTE myeloid leukemia, *CYTOGENETICS, *GENETIC regulation, *CELLULAR signal transduction, *MEDICAL protocols, *MULTIVARIATE analysis, *PROGNOSIS
Abstract

Abstract: The PI3/AKT pathway is up-regulated in acute myeloid leukemia (AML), but its prognostic relevance in cytogenetically normal AML (CN-AML) is unclear. We evaluated RNA levels of AKT and two downstream substrates (FOXO3a-p27) in 110 de novo CN-AML, included in the Spanish PETHEMA therapeutic protocols. Patients with high FOXO3a gene expression displayed shorter OS (p =0.015) and RFS (p =0.048) than low FOXO3a expressers. Features selected in the multivariate analysis as having an independent prognostic value for a shorter survival were WBC>50×109/L, age >65 years and high FOXO3a expression. We concluded that FOXO3a assessment could contribute to improve the molecular-based risk stratification in CN-AML. [Copyright &y& Elsevier]

Published
2009
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