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Start Over Author "Voigt, Sabine" Publisher elsevier b.v.
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3. TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation in to the endoplasmic reticulum

Author

Hedge, Ramanujan S., Voigt, Sabine, Rapoport, Tom A., and Lingappa, Vishwanath R.

Subjects
Proteins -- Research, Cytosol -- Research, Endoplasmic reticulum -- Research, Biological sciences
Abstract

Research was conducted to characterize the regulatory components of the translocon that affect translocational pausing in the endoplasmic reticulum. Constructs were truncated at Stu1 before transcription to produce mRNA utilized in translocation intermediates while reconstitutions from crude detergent extracts were determined by modifying previous study procedures. Results identified a prerequisite for the membrane glycoprotein translocating chain-associated membrane protein to regulate the translocational pausing of a secretory protein.

Published
1998

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