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31 results on '"Voss, F."'

3. The n_TOF Total Absorption Calorimeter for neutron capture measurements at CERN

Author

Guerrero, C., Abbondanno, U., Aerts, G., Álvarez, H., Álvarez-Velarde, F., Andriamonje, S., Andrzejewski, J., Assimakopoulos, P., Audouin, L., Badurek, G., Baumann, P., Bečvář, F., Berthoumieux, E., Calviño, F., Calviani, M., Cano-Ott, D., Capote, R., Carrapiço, C., Cennini, P., Chepel, V., Chiaveri, E., Colonna, N., Cortes, G., Couture, A., Cox, J., Dahlfors, M., David, S., Dillmann, I., Domingo-Pardo, C., Dridi, W., Duran, I., Eleftheriadis, C., Ferrant, L., Ferrari, A., Ferreira-Marques, R., Fujii, K., Furman, W., Goncalves, I., González-Romero, E., Gramegna, F., Gunsing, F., Haas, B., Haight, R., Heil, M., Herrera-Martinez, A., Igashira, M., Jericha, E., Käppeler, F., Kadi, Y., Karadimos, D., Kerveno, M., Koehler, P., Kossionides, E., Krtička, M., Lampoudis, C., Leeb, H., Lindote, A., Lopes, I., Lozano, M., Lukic, S., Marganiec, J., Marrone, S., Martínez, T., Massimi, C., Mastinu, P., Mendoza, E., Mengoni, A., Milazzo, P.M., Moreau, C., Mosconi, M., Neves, F., Oberhummer, H., O’Brien, S., Pancin, J., Papachristodoulou, C., Papadopoulos, C., Paradela, C., Patronis, N., Pavlik, A., Pavlopoulos, P., Perrot, L., Pigni, M.T., Plag, R., Plompen, A., Plukis, A., Poch, A., Praena, J., Pretel, C., Quesada, J., Rauscher, T., Reifarth, R., Rubbia, C., Rudolf, G., Rullhusen, P., Salgado, J., Santos, C., Sarchiapone, L., Savvidis, I., Stephan, C., Tagliente, G., Tain, J.L., Tassan-Got, L., Tavora, L., Terlizzi, R., Vannini, G., Vaz, P., Ventura, A., Villamarin, D., Vicente, M.C., Vlachoudis, V., Vlastou, R., Voss, F., Walter, S., Wiescher, M., and Wisshak, K.

Published
2009
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5. Status and outlook of the neutron time-of-flight facility n_TOF at CERN

Author

Gunsing, F., Abbondanno, U., Aerts, G., Álvarez, H., Álvarez-Velarde, F., Andriamonje, S., Andrzejewski, J., Assimakopoulos, P., Audouin, L., Badurek, G., Baumann, P., Bečvář, F., Berthoumieux, E., Calviño, F., Cano-Ott, D., Capote, R., de Albornoz, A. Carrillo, Cennini, P., Chepel, V., Chiaveri, E., Colonna, N., Cortes, G., Couture, A., Cox, J., Dahlfors, M., David, S., Dillman, I., Dolfini, R., Domingo-Pardo, C., Dridi, W., Duran, I., Eleftheriadis, C., Ferrant, L., Ferrari, A., Ferreira-Marques, R., Frais-Koelbl, H., Fujii, K., Furman, W., Goncalves, I., González-Romero, E., Goverdovski, A., Gramegna, F., Griesmayer, E., Guerrero, C., Haas, B., Haight, R., Heil, M., Herrera-Martinez, A., Igashira, M., Isaev, S., Jericha, E., Käppeler, F., Kadi, Y., Karadimos, D., Karamanis, D., Kerveno, M., Ketlerov, V., Koehler, P., Konovalov, V., Kossionides, E., Krtička, M., Lampoudis, C., Leeb, H., Lindote, A., Lopes, I., Lozano, M., Lukic, S., Marganiec, J., Marques, L., Marrone, S., Martínez, T., Massimi, C., Mastinu, P., Mengoni, A., Milazzo, P.M., Moreau, C., Mosconi, M., Neves, F., Oberhummer, H., O’Brien, S., Oshima, M., Pancin, J., Papachristodoulou, C., Papadopoulos, C., Paradela, C., Patronis, N., Pavlik, A., Pavlopoulos, P., Perrot, L., Pigni, M.T., Plag, R., Plompen, A., Plukis, A., Poch, A., Pretel, C., Quesada, J., Rauscher, T., Reifarth, R., Rosetti, M., Rubbia, C., Rudolf, G., Rullhusen, P., Salgado, J., Sarchiapone, L., Savvidis, I., Stephan, C., Tagliente, G., Tain, J.L., Tassan-Got, L., Tavora, L., Terlizzi, R., Vannini, G., Vaz, P., Ventura, A., Villamarin, D., Vincente, M.C., Vlachoudis, V., Vlastou, R., Voss, F., Walter, S., Wendler, H., Wiescher, M., and Wisshak, K.

Published
2007
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7. Measurement of the 151Sm(n, γ) 152Sm cross section at n_TOF

Author

Marrone, S., Abbondanno, U., Aerts, G., Alvarez-Velarde, F., Álvarez-Pol, H., Andriamonje, S., Andrzejewski, J., Badurek, G., Baumann, P., Bečvář, F., Benlliure, J., Berthoumieux, E., Calviño, F., Cano-Ott, D., Capote, R., Cennini, P., Chepel, V., Chiaveri, E., Colonna, N., Cortes, G., Cortina, D., Couture, A., Cox, J., Dababneh, S., Dahlfors, M., David, S., Dolfini, R., Domingo-Pardo, C., Duran, I., Embid-Segura, M., Ferrant, L., Ferrari, A., Ferreira-Marques, R., Frais-Koelbl, H., Furman, W., Goncalves, I., Gallino, R., Gonzalez-Romero, E., Goverdovski, A., Gramegna, F., Griesmayer, E., Gunsing, F., Haas, B., Haight, R., Heil, M., Herrera-Martinez, A., Isaev, S., Jericha, E., Käppeler, F., Kadi, Y., Karadimos, D., Kerveno, M., Ketlerov, V., Koehler, P., Konovalov, V., Krtička, M., Lamboudis, C., Leeb, H., Lindote, A., Lopes, I., Lozano, M., Lukic, S., Marganiec, J., Martinez-Val, J., Mastinu, P., Mengoni, A., Milazzo, P.M., Molina-Coballes, A., Moreau, C., Mosconi, M., Neves, F., Oberhummer, H., O'Brien, S., Pancin, J., Papaevangelou, T., Paradela, C., Pavlik, A., Pavlopoulos, P., Perlado, J.M., Perrot, L., Pignatari, M., Flag, R., Plompen, A., Plukis, A., Poch, A., Policarpo, A., Pretel, C., Quesada, J., Raman, S., Rapp, W., Rauscher, T., Reifarth, R., Rosetti, M., Rubbia, C., Rudolf, G., Rullhusen, P., Salgado, J., Scares, J.C., Stephan, C., Tagliente, G., Tain, J.L., Tassan-Got, L., Tavora, L., Terlizzi, R., Vannini, G., Vaz, P., Ventura, A., Villamarin, D., Vincente, M.C., Vlachoudis, V., Voss, F., Wendler, H., Wiescher, M., and Wisshak, K.

Published
2005
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8. Neutron capture cross section measurements for nuclear astrophysics at CERN n_TOF

Author

Abbondanno, U., Aerts, G., Alvarez-Velarde, F., Álvarez-Pol, H., Andriamonje, S., Andrzejewski, J., Badurek, G., Baumann, P., Bečvář, F., Benlliure, J., Berthoumieux, E., Calviño, F., Cano-Ott, D., Capote, R., Cennini, P., Chepel, V., Chiaveri, E., Colonna, N., Cortes, G., Cortina, D., Couture, A., Cox, J., Dababneh, S., Dahlfors, M., David, S., Dolfini, R., Domingo-Pardo, C., Duran, I., Embid-Segura, M., Ferrant, L., Ferrari, A., Ferreira-Marques, R., Frais-Kölbl, H., Furman, W., Goncalves, I., Gallino, R., Gonzalez-Romero, E., Goverdovski, A., Gramegna, F., Griesmayer, E., Gunsing, F., Haas, B., Haight, R., Heil, M., Herrera-Martinez, A., Isaev, S., Jericha, E., Käppeler, F., Kadi, Y., Karadimos, D., Kerveno, M., Ketlerov, V., Koehler, P., Konovalov, V., Krtička, M., Lamboudis, C., Leeb, H., Lindote, A., Lopes, I., Lorusso, G., Lozano, M., Lukic, S., Marganiec, J., Marrone, S., Martinez-Val, J., Mastinu, P., Mengoni, A., Milazzo, P.M., Molina-Coballes, A., Moreau, C., Mosconi, M., Neves, F., Oberhummer, H., O'Brien, S., Pancin, J., Papaevangelou, T., Paradela, C., Pavlik, A., Pavlopoulos, P., Perlado, J.M., Perrot, L., Pignatari, M., Plag, R., Plompen, A., Plukis, A., Poch, A., Policarpo, A., Pretel, C., Quesada, J., Rapp, W., Rauscher, T., Reifarth, R., Rosetti, M., Rubbia, C., Rudolf, G., Rullhusen, P., Salgado, J., Soares, J.C., Stephan, C., Tagliente, G., Tain, J.L., Tassan-Got, L., Tavora, L., Terlizzi, R., Vannini, G., Vaz, P., Ventura, A., Villamarin, D., Vincente, M.C., Vlachoudis, V., Voss, F., Wendler, H., Wiescher, M., and Wisshak, K.

Published
2005
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9. Measurements of the 90,91,92,94,96Zr( n, γ) cross-sections at n_TOF

Author

Tagliente, G., Abbondanno, U., Aerts, G., Alvarez-Velarde, F., Álvarez-Pol, H., Andriamonje, S., Andrzejewski, J., Badurek, G., Baumann, P., Bečvář, F., Benlliure, J., Berthoumieux, E., Calviño, F., Cano-Ott, D., Capote, R., Cennini, P., Chepel, V., Chiaveri, E., Colonna, N., Cortes, G., Cortina, D., Couture, A., Cox, J., Dababneh, S., Dahlfors, M., David, S., Dolfini, R., Domingo-Pardo, C., Duran, I., Embid-Segura, M., Ferrant, L., Ferrari, A., Ferreira-Marques, R., Frais-Köelbl, H., Furman, W., Goncalves, I., Gallino, R., Gonzalez-Romero, E., Goverdovski, A., Gramegna, F., Griesmayer, E., Gunsing, F., Haas, B., Haight, R., Heil, M., Herrera-Martinez, A., Isaev, S., Jericha, E., Käppeler, F., Kadi, Y., Karadimos, D., Kerveno, M., Ketlerov, V., Koehler, P., Konovalov, V., Krtička, M., Lamboudis, C., Leeb, H., Lindote, A., Lopes, I., Lorusso, G., Lozano, M., Lukic, S., Marganiec, J., Marrone, S., Martinez-Val, J., Mastinu, P., Mengoni, A., Milazzo, P.M., Molina-Coballes, A., Moreau, C., Mosconi, M., Neves, F., Oberhummer, H., O'Brien, S., Pancin, J., Papaevangelou, T., Paradela, C., Pavlik, A., Pavlopoulos, P., Perlado, J.M., Perrot, L., Pignatari, M., Plag, R., Plompen, A., Plukis, A., Poch, A., Policarpo, A., Pretel, C., Quesada, J., Rapp, W., Rauscher, T., Reifarth, R., Rosetti, M., Rubbia, C., Rudolf, G., Rullhusen, P., Salgado, J., Soares, J.C., Stephan, C., Tain, J.L., Tassan-Got, L., Tavora, L., Terlizzi, R., Vannini, G., Vaz, P., Ventura, A., Villamarin, D., Vincente, M.C., Vlachoudis, V., Voss, F., Wendler, H., Wiescher, M., and Wisshak, K.

Published
2005
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10. The data acquisition system of the neutron time-of-flight facility n_TOF at CERN

Author

Abbondanno, U., Aerts, G., Álvarez, F., Álvarez, H., Andriamonje, S., Andrzejewski, J., Badurek, G., Baumann, P., Bečvář, F., Benlliure, J., Berthomieux, E., Betev, B., Calviño, F., Cano-Ott, D., Capote, R., Cennini, P., Chepel, V., Chiaveri, E., Colonna, N., Cortes, G., Cortina, D., Couture, A., Cox, J., Dababneh, S., David, S., Dolfini, R., Domingo-Pardo, C., Duran, I., Embid-Segura, M., Ferrant, L., Ferrari, A., Ferreira-Marques, R., Frais-Koelbl, H., Furman, W., Goncalves, I., Gonzalez-Romero, E., Goverdovski, A., Gramegna, F., Griesmayer, E., Gunsing, F., Haas, B., Haight, R., Heil, M., Herrera-Martinez, A., Isaev, S., Jericha, E., Kadi, Y., Käppeler, F., Kerveno, M., Ketlerov, V., Koehler, P.E., Konovalov, V., Krtička, M., Leeb, H., Lindote, A., Lopes, M.I., Lozano, M., Lukic, S., Marganiec, J., Marrone, S., Martinez-Val, J., Mastinu, P., Mengoni, A., Milazzo, P.M., Molina-Coballes, A., Moreau, C., Mosconi, M., Neves, F., Oberhummer, H., O'Brien, S., Pancin, J., Papaevangelou, T., Paradela, C., Pavlik, A., Pavlopoulos, P., Perlado, J.M., Perrot, L., Peskov, V., Plag, R., Plompen, A., Plukis, A., Poch, A., Policarpo, A., Pretel, C., Quesada, J.M., Rapp, W., Rauscher, T., Reifarth, R., Rosetti, M., Rubbia, C., Rudolf, G., Rullhusen, P., Salgado, J., Schäfer, E., Soares, J.C., Stephan, C., Tagliente, G., Tain, J.L., Tassan-Got, L., Tavora, L.M.N., Terlizzi, R., Vannini, G., Vaz, P., Ventura, A., Villamarin-Fernandez, D., Vincente-Vincente, M., Vlachoudis, V., Voss, F., Wendler, H., Wiescher, M., and Wisshak, K.

Published
2005
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11. Time–energy relation of the n_TOF neutron beam: energy standards revisited

Author

Lorusso, G., Colonna, N., Marrone, S., Tagliente, G., Heil, M., Cano-Ott, D., Mosconi, M., Moreau, C., Mengoni, A., Abbondanno, U., Aerts, G., Alvarez-Pol, H., Alvarez-Velarde, F., Andriamonje, S., Andrzejewski, J., Angelopoulos, A., Assimakopoulos, P., Badurek, G., Baumann, P., Bečvář, F., Benlliure, J., Berthomieux, E., Bisceglie, E., Calviño, P., Capote, R., Cennini, P., Chepel, V., Chiaveri, E., Coceva, C., Cortes, G., Cortina, D., Couture, A., Cox, J., Dababneh, S., Dahlfors, M., David, S., Dolfini, R., Domingo-Pardo, C., Duran, I., Eleftheriadis, C., Embid-Segura, M., Ferrant, L., Ferrari, A., Ferreira-Marques, R., Frais-Koelbl, H., Furman, W.I., Goncalves, I.F., Gonzalez-Romero, E., Goverdovski, A., Gramegna, F., Griesmayer, E., Gunsing, F., Haas, B., Haight, R., Herrera-Martinez, A., Ioannides, K.G., Isaev, S., Jericha, E., Käppeler, F., Kadi, Y., Karamanis, D., Ketlerov, V., Kitis, G., Koehler, P.E., Konovalov, V., Kossionides, E., Krticka, M., Leeb, H., Lindote, A., Lopes, M.I., Lozano, M., Lukic, S., Marganiec, J., Mastinu, P.F., Milazzo, P.M., Molina-Coballes, A., Neves, F., Oberhummer, H., O’Brien, S., Pancin, J., Paradela, C., Pavlik, A., Pavlopoulos, P., Perrot, L., Peskov, V., Plag, R., Plompen, A., Plukis, A., Poch, A., Policarpo, A., Pretel, C., Quesada, J.M., Rapp, W., Rauscher, T., Reifarth, R., Rosetti, M., Rubbia, C., Rudolf, G., Rullhusen, P., Salgado, J., Savvidis, E., Soares, J.C., Stephan, C., Tain, J.L., Tassan-Got, L., Tavora, L.M.N., Terlizzi, R., Tsangas, N., Vannini, G., Vaz, P., Ventura, A., Villamarin, D., Vincente, M.C., Vlachoudis, V., Vlastou, R., Voss, F., Wendler, H., Wiescher, M., and Wisshak, K.

Published
2004
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12. Measurement of the n_TOF beam profile with a micromegas detector

Author

Pancin, J., Abbondanno, U., Aerts, G., Alvarez, H., Andriamonje, S., Angelopoulos, A., Assimakopoulos, P., Bacri, C., Badurek, G., Baumann, P., Bečvář, F., Beer, H., Benlliure, J., Berthier, B., Berthoumieux, E., Boffi, S., Borcea, C., Boscolo-Marchi, E., Bustreo, N., Calvino, F., Cano-ott, D., Capote, R., Carlson, P., Cennini, P., Chepel, V., Chiaveri, E., Colonna, N., Cortes, G., Cortina, D., Couture, A., Cox, J., Dababneh, S., Dahlfors, M., David, S., Delbart, A., Derre, J., Dolfini, R., Domingo, C., Duran-Escribano, I., Eleftheriadis, C., Embid-Segura, M., Ferrant, L., Ferrari, A., Ferreira-Lourenco, L., Ferreiramarques, R., Frais-Koelbl, H., Furman, W., Giomataris, Y., Goncalves, I., Gonzalez-Romero, E., Goverdovski, A., Gramegna, F., Griesmayer, E., Gunsing, F., Haight, R., Heil, M., Herrera-Martinez, A., Ioannides, K., Janeva, N., Jeanneau, F., Jericha, E., Käppeler, F., Kadi, Y., Karamanis, D., Kelic, A., Ketlerov, V., Kitis, G., Koehler, P., Konovalov, V., Kossionides, E., Lacoste, V., Leeb, H., Lindote, A., Lopes, I., Lozano, M., Lukic, S., Markov, S., Marrone, S., Martinez-Val, J., Mastinu, P., Mengoni, A., Milazzo, P., Minguez, E., Molina-Coballes, A., Moreau, C., Neves, F., Oberhummer, H., O'brien, S., Papadopoulos, I., Papavengelou, T., Paradela, C., Pavlik, A., Pavlopoulos, P., Perez-Parra, A., Perlado, J., Peskov, V., Perrot, L., Plag, R., Plompen, A., Plukis, A., Poch, A., Policarpo, A., Pretel, C., Quesada, J., Radici, M., Raman, S., Rapp, W., Reifarth, R., Rejmund, F., Rosetti, M., Rubbia, C., Rudolf, G., Rullhusen, P., Salgado, J., Savvidis, E., Stephan, C., Tagliente, G., Tain, J., Tapia, C., Tassan-Got, L., Tavora, L., Terlizzi, R., Terrani, M., Tsangas, N., Vannini, G., Vaz, P., Ventura, A., Villamarin-Fernandez, D., Vincente-Vincente, M., Vlachoudis, V., Vlastou, R., Voss, F., Wendler, H., Wiescher, M., Wisshak, K., and Zanini, L.

Published
2004
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13. New experimental validation of the pulse height weighting technique for capture cross-section measurements

Author

Abbondanno, U, Aerts, G, Alvarez, H, Andriamonje, S, Angelopoulos, A, Assimakopoulos, P, Bacri, C.O, Badurek, G, Baumann, P, Bečvář, F, Beer, H, Benlliure, J, Berthier, B, Berthomieux, E, Boffi, S, Borcea, C, Boscolo-Marchi, E, Bustreo, N, Calviño, P, Cano-Ott, D, Capote, R, Carlson, P, Cennini, P, Chepel, V, Chiaveri, E, Coceva, C, Colonna, N, Cortes, G, Cortina, D, Couture, A, Cox, J, Dababneh, S, Dahlfors, M, David, S, Dolfini, R, Domingo-Pardo, C, Duran, I, Eleftheriadis, C, Embid-Segura, M, Ferrant, L, Ferrari, A, Ferreira-Lourenco, L, Ferreira-Marques, R, Frais-Koelbl, H, Furman, W.I, Giomataris, Y, Goncalves, I.F, Gonzalez-Romero, E, Goverdovski, A, Gramegna, F, Griesmayer, E, Gunsing, F, Haight, R, Heil, M, Herrera-Martinez, A, Ioannides, K.G, Janeva, N, Jericha, E, Käppeler, F, Kadi, Y, Karamanis, D, Kelic, A, Ketlerov, V, Kitis, G, Koehler, P.E, Konovalov, V, Kossionides, E, Lacoste, V, Leeb, H, Lindote, A, Lopes, M.I, Lozano, M, Lukic, S, Markov, S, Marrone, S, Martinez-Val, J, Mastinu, P, Mengoni, A, Milazzo, P.M, Minguez, E, Molina-Coballes, A, Moreau, C, Neves, F, Oberhummer, H, O'Brien, S, Pancin, J, Papaevangelou, T, Paradela, C, Pavlik, A, Pavlopoulos, P, Perez-Parra, A, Perlado, J.M, Perrot, L, Peskov, V, Plag, R, Plompen, A, Plukis, A, Poch, A, Policarpo, A, Pretel, C, Quesada, J.M, Radici, M, Raman, S, Rapp, W, Rauscher, T, Reifarth, R, Rejmund, F, Rosetti, M, Rubbia, C, Rudolf, G, Rullhusen, P, Salgado, J, Savvidis, E, Soares, J.C, Stephan, C, Tagliente, G, Tain, J.L, Tapia, C, Tassan-Got, L, Tavora, L.M.N, Terlizzi, R, Terrani, M, Tsangas, N, Vannini, G, Vaz, P, Ventura, A, Villamarin-Fernandez, D, Vincente-Vincente, M, Vlachoudis, V, Vlastou, R, Voss, F, Wendler, H, Wiescher, M, Wisshak, K, and Zanini, L

Published
2004
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16. Subclinical Myocardial Leukocyte Infiltration after Covid-19-Vaccination in Heart-Transplant Recipients.

Author

Voss, F., Oehler, D., Scheiber, D., Schultheiss, H., Kelm, M., Lichtenberg, A., Boeken, U., and Westenfeld, R.

Subjects
*HEART transplant recipients, *LEUCOCYTES, *COVID-19, *COVID-19 vaccines, *LYMPHOCYTE count
Abstract

It was reported that mRNA-based Covid-19 vaccines rarely cause myocarditis. Although endomyocardial biopsy (EMB) is considered the gold standard for diagnosing myocarditis, no standardized study has been performed after Covid-19 vaccination in humans. Because routine EMB is frequently performed in heart transplant recipients (HTX), we aimed here to investigate effects of Covid-19 vaccination by analyzing myocardial inflammation with state-of-the-art quantitative immunohistochemistry. Consecutive patients after HTX who underwent routine EMB at a median of 167 days before and 136 days after the first Covid 19 vaccination with an mRNA vaccine were included and divided into groups with and without postvaccination inflammatory response, defined as increased CD3+ lymphocyte count >14/ mm2. Patients with evidence of rejection (ISHLT grade >1) or >14 CD3+ lymphocytes/mm2 at baseline were excluded. The final analysis included 46 patients with a mean age of 63 years and a time after HTX of 2.4 years. Thirty-six (78%) patients remained below the threshold of 14 CD3+ lymphocytes/mm2. However, in 10 (22%) recipients, we detected significant leukocyte infiltration by quantitative analysis of EMB after vaccination (4 vs. 33.7 leukocytes/ mm2, p=0.001). The groups did not differ with respect to age (63 vs. 57 years, p=0.21), body mass index (25 vs. 24 kg/m2, p=0.24), NYHA class (≥2 at 19 vs. 10%, p=0.4), NT-ProBNP levels (592 vs. 514 ng/l, p=0.55) or myocardial CD3+ cell count (4.9 vs. 2.6 cells/mm2, p=0.07) before vaccination. Patients with leukocyte infiltration remained clinically inapparent with stable NYHA class (≥2 in 10 vs. 20%, p=0.99) and did not have increased NT-ProBNP levels (514 vs. 478 ng/l, p=0.03). No hospitalizations for suspected myocarditis were reported. For the first time, we report subclinical myocardial leukocyte infiltration after Covid-19 mRNA vaccination in one in five patients without clinical sequelae during the short observation period. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Genetic suppression of atrial fibrillation using a dominant-negative ether-a-go-go-related gene mutant.

Author

Soucek R, Thomas D, Kelemen K, Bikou O, Seyler C, Voss F, Becker R, Koenen M, Katus HA, Bauer A, Soucek, Radim, Thomas, Dierk, Kelemen, Kamilla, Bikou, Olympia, Seyler, Claudia, Voss, Frederik, Becker, Rüdiger, Koenen, Michael, Katus, Hugo A, and Bauer, Alexander

Abstract

Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Gene therapy-dependent modulation of atrial electrophysiology may provide a more specific alternative to pharmacological and ablative treatment strategies.Objective: We hypothesized that genetic inactivation of atrial repolarizing ether-a-go-go-related gene (ERG) K(+) currents using a dominant-negative mutant would provide rhythm control in AF.Methods: Ten domestic swine underwent pacemaker implantation and were subjected to atrial burst pacing to induce persistent AF. Animals were then randomized to receive either AdCERG-G627S to suppress ERG/I(Kr) currents or green fluorescent protein (AdGFP) as control. Adenoviruses were applied using a novel hybrid technique combining atrial virus injection and epicardial electroporation to increase transgene expression.Results: In pigs treated with AdCERG-G627S, the onset of persistent AF was prevented (n = 2) or significantly delayed compared with AdGFP controls (12 ± 2.1 vs. 6.2 ± 1.3 days; P < .001) during 14-day follow-up. Effective refractory periods were prolonged in the AdCERG-G627S group compared with AdGFP animals (221.5 ± 4.7 ms vs. 197.0 ± 4.7 ms; P < .006). Impairment of left ventricular ejection fraction (LVEF) during AF was prevented by AdCERG-G627S application (LVEF(CERG-G627S) = 62.1% ± 4.0% vs. LVEF(GFP) = 30.3% ± 9.1%; P < .001).Conclusion: Inhibition of ERG function using atrial AdCERG-G627S gene transfer suppresses or delays the onset of persistent AF by prolongation of atrial refractoriness in a porcine model. Targeted gene therapy represents an alternative to pharmacological or ablative treatment of AF. [ABSTRACT FROM AUTHOR]

Published
2012
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18. Modelling the impact of Global Change on the hydrological system of the Aral Sea basin

Author

Aus der Beek, T., Voß, F., and Flörke, M.

Subjects
*HYDROLOGY, *GLOBAL environmental change, *ENVIRONMENTAL impact analysis, *EFFECT of human beings on weather, *CLIMATE change, *HAZARD mitigation, *WATERSHEDS
Abstract

Abstract: During the last decades the Aral Sea basin has suffered an enormous depletion of water resources within its lakes and rivers with consequences for society, economy, and nature. Within this model study, Global Change impacts on the Amu Darya and Syr Darya rivers, as well as on the Aral Sea itself, are being analysed for the period 1958–2002. In a first step, a multi-annual data base on crop specific irrigated areas has been set-up, which has then been integrated in the hydrology and water use model WaterGAP3. As a second step, anthropogenic water abstractions have been calculated, which were then assimilated in the simulation of river runoff of the Amu Darya and Syr Darya. The last step includes the simulation of the water balance of the Aral Sea, by taking into account modelled river inflow. Within WaterGAP3, the water use module has been switched on and off to separate the impacts of Climate and Global Change (i.e. water abstractions). Irrigation water abstractions are very well represented by WaterGAP3 and lie within the range of reported values. Modelled river discharge also shows a good fit to observed data, whereas phases are in sync but volumes are slightly overestimated. Simulated volumes of the Aral Sea itself are well reflected by the model, though results for the period 1990–2002 are too high. In this study, the Climate Change impacts are much smaller (14%) than the water use impacts (86%) on the shrinkage of the Aral Sea. Finally, an outlook on potential scenario model studies is given, which could analyse the different strategies of mitigation and adaptation of Global Change in the Aral Sea basin. [Copyright &y& Elsevier]

Published
2011
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24. (510) - Effect of Cytomegalovirus Prophylaxis with Immunoglobulins or Antiviral Drugs on Lymphoproliferative Disease After Heart Transplantation: Single-Center Experience in 300 Patients.

Author

Boeken, U., Hettlich, V., Jenkins, F., Sigetti, D., Böttger, C., Scheiber, D., Polzin, A., Voss, F., Dalyanoglu, H., Ramadani, B., Aubin, H., and Lichtenberg, A.

Subjects
*HEART transplantation, *LYMPHOPROLIFERATIVE disorders, *ANTIVIRAL agents, *IMMUNOGLOBULINS, *PATIENTS' attitudes
Published
2024
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25. Assessment of Risk Factors for Cytomegalovirus DNAemia after Termination of Regular Prophylaxes after Heart Transplantation.

Author

Immohr, M., Oehler, D., Jenkins, F.S., Kalampokas, N., Voß, F., Dalyanoglu, H., Aubin, H., Akhyari, P., Lichtenberg, A., and Boeken, U.

Subjects
*HEART transplantation, *RISK assessment, *CYTOMEGALOVIRUSES, *SURGICAL complications, *ANTIVIRAL agents, *KIDNEY transplantation
Abstract

Cytomegalovirus (CMV) infections after heart transplantation (HTx) can cause development of cardiac allograft vasculopathy (CAV). Consequently, frequent monitoring and prophylaxes for CMV-DNAemia within the first weeks after HTx is regularly performed. However, CMV-DNAemia after termination of the perioperative prophylaxes is commonly observed. All adult patients undergoing HTx between September of 2010 and 2021 surviving the first 90 days (n=196) were retrospectively reviewed in September 2022. Patients were divided regarding the prevalence of CMV-DNAemia during the first postoperative year after termination of the institutional 90-day CMV prophylaxis. A total of n=35 (20.1%) developed CMV-DNAemia (CMV group) and were compared to patients without CMV-DNAemia (Controls, n=139). The remaining patients (n=22) were excluded due to incomplete data. CMV prophylaxis consisted of val-/ganciclovir as well as intravenous CMV immunoglobulin for high-risk D+/R- CMV IgG match. D+/R- and D-/R+ serology was significantly increased and D-/R- decreased in the CMV group (p<.01). In addition, mean age was 57.7±8.7 years but only 53.6±10.0 years for Controls (p=.03). Furthermore, ICU (p=.02) and total hospital stay (p=.03) after HTx was about 50% longer compared to the controls. Interestingly, incidence of CMV-DNAemia during the regular prophylaxis was only numerically increased in the CMV group (5.7% respectively.7%, p=.10), the same effect was also overserved for postoperative infective complications. Multivariate analyses could confirm that increased recipient age and D+/R- and D-/R+ CMV IgG match of donors and recipients were independent risk factors for post-prophylaxis CMV-DNAemia within the first year after heart transplantation. Our data should raise awareness for CMV-DNAemia after termination of regular prophylaxis schemes, as this affects one of five HTx patients and can contribute to the development of CAV. Especially old recipients as well as D+/R- and D-/R+ serology share an elevated risk for late CMV-DNAemia. For these patients, prolongation or repetition of CMV prophylaxis including antiviral drugs and CMV immunoglobulins may be considered. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Impact of SARS-CoV-2 Infection on Reactivation of Herpesviridae after Heart and Heart and Kidney Transplantation.

Author

Immohr, M.B., Oehler, D., Ballázs, C., Hettlich, V.H., Voß, F., Dalyanoglu, H., Aubin, H., Akhyari, P., Lichtenberg, A., and Boeken, U.

Subjects
*HERPESVIRUS diseases, *HEART transplantation, *KIDNEY transplantation, *SARS-CoV-2, *HERPES simplex virus
Abstract

Immunosuppression after Heart transplantation (HTx) carries a life-long risk for infection and reactivation of herpesviridae. Especially changes in the immunosuppressive therapy regime can promote viral reactivation. Infections with SARS-CoV-2 can also alter the immune response. However, potential effects on herpesviridae reactivation still needs to be examined in this context. Since emerge of the COVID-19 pandemic in the early 2020, n=61 of our HTx or heart and kidney transplant (HKTx) patients had positive polymerase chain reaction (PCR) for SARS-CoV-2. Relevant patient data including results for potential concomitant herpes simplex virus (HSV-1, HSV-2), cytomegalovirus (CMV), Epstein-Barr-virus (EBV), varicella zoster virus (CZV) and human herpesvirus-8 (HHV-8) DNAemia were retrospectively reviewed in September 2022 to evaluate its clinical impact. Most patients have received at least one and up to six doses of COVID-19 vaccine before contracting SARS-CoV-2. In general, HTx and HKTx patients developed symptomatic but mild COVID-19, which was most likely caused by any kind of omicron subvariant. SARS-CoV-2 positive HTx and HKTx patients were pharmacologically treated for COVID-19. DNAemia of herpesviridae was examined in about one third of the patients (n=20). HSV-1 DNAemia was confirmed in 6.25% of tested patients with a maximum viral load of 1,130,000 HSV-1-DNA copies/µg-DNA. In not a single patient HSV-2, VZV and HHV-8 DNA was found. In contrast, CMV was observed in 20% of tested patients with a maximum of 195 CMV-DNA copies/µg-DNA and EBV in 23.5% (maximum 1230 EBV-DNA copies/µg-DNA). In one patient simultaneous CMV- and EBV-DNAemia and in another patient EBV- and HSV-1-DNAemia were found. Nevertheless, none of these patients developed clinically relevant infection or reactivation of herpesviridae and therefore no targeted treatment was initiated. Recently, SARS-CoV-2 infections are commonly observed in patients after HTx and HKTx. Fortunately, patients rarely suffer from severe COVID-19-related symptoms. Meanwhile, concomitant infections or reactivation of herpesviridae, especially CMV and EBV, are regularly observed. Although we did not overserved CMV or EBV disease, regularly testing for herpesviridae seems reasonable in these patients. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Preparation of a 60Fe target for nuclear astrophysics experiments

Author

Schumann, D., Neuhausen, J., Dillmann, I., Domingo Pardo, C., Käppeler, F., Marganiec, J., Voss, F., Walter, S., Heil, M., Reifarth, R., Goerres, J., Uberseder, E., Wiescher, M., and Pignatari, M.

Subjects
*NUCLEAR astrophysics, *NEUTRON capture, *NUCLEAR cross sections, *IRON isotopes, *NUCLEAR energy, *PARTICLE accelerators
Abstract

Abstract: An 60Fe target for studying the 60Fe(n, γ)61Fe cross-section at stellar energies was prepared using radio-chemical separation techniques. In total, 7.8×1015 60Fe atoms (777ng) were separated from a copper beam dump for the 590MeV proton beam of the high intensity accelerator at PSI. The final target was prepared by evaporating the iron-containing aqueous solution onto a graphite backing. With this sample the keV neutron capture cross-section of 60Fe has been measured at FZ Karlsruhe. The work is part of the ERAWAST-initiative (Exotic Radionuclides from Accelerator WAste for Science and Technology) which is aimed at extracting rare valuable radionuclides from accelerator waste by chemical means. [Copyright &y& Elsevier]

Published
2010
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28. P1122 COMPARISONS OF POPULATIONS IN FALDAPREVIR PHASE III STUDIES BASED ON PEGYLATED INTERFERON a-2a AND RIBAVIRIN-PREDICTED RESPONSIVENESS AND IMPACT ON ACHIEVING SVR12.

Author

Ferenci, P., Jensen, D.M., Dieterich, D., Jacobson, I.M., Romero-Gómez, M., Foster, G.R., Asselah, T., Cooper, C., Tural, C., Streinu-Cercel, A., Ryder, S., Puoti, M., Tam, E., Calleja, J.L., Núñez, M., Quinson, A.-M., Böcher, W., Voss, F., and Scherer, J.

Subjects
*THERAPEUTIC use of interferons, *RIBAVIRIN, *POPULATION health, *HEPATITIS C, *HEPATITIS C treatment, *GENOTYPES, *PATIENTS
Published
2014
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29. P725 IMPACT OF THE rs8099917 SNP ON SVR12 IN PATIENTS WITH HCV GT-1 INFECTION TREATED WITH FALDAPREVIR, DELEOBUVIR AND RIBAVIRIN.

Author

Asselah, T., Zeuzem, S., Soriano, V., Bronowicki, J.-P., Lohse, A.W., Müllhaupt, B., Schuchmann, M., Bourlière, M., Buti, M., Roberts, S., Gane, E., Voss, F., Gallivan, J.-P., Herichova, I., Baum, P., and Mensa, F.

Subjects
*SINGLE nucleotide polymorphisms, *HEPATITIS C virus, *HEPATITIS C treatment, *THIAZOLES, *RIBAVIRIN, *THERAPEUTICS
Published
2014
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