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Le syndrome de Wells secondaire à une piqûre d'abeille est peu fréquent. Nous en rapportons un cas, survenu chez un nourrisson de 18 mois ayant présenté un œdème de la main gauche surmonté de lésions bulleuses après une piqûre d'abeille. Le patient a été traité initialement par des antibiotiques, mais sans amélioration. Un traitement par corticothérapie systémique a été instauré avec une bonne évolution. Le diagnostic de la cellulite de Wells a été retenu devant l'aspect clinique, les données biologiques et histopathologiques. Wells' syndrome caused by a honeybee sting is not common. We report the case of a 18-month-old infant who was stung by a honeybee, and whose left hand showed swelling with bullous lesions. The lesions showed no response to antibiotic treatment, but the lesion gradually resolved with subsequent systemic corticosteroid treatment. The diagnosis of Wells' syndrome was made according to clinical features, biological and histopathological findings. [ABSTRACT FROM AUTHOR]

Mosquito bites are skin irritating reactions, which usually resolve spontaneously without intensive medical care. However, in certain situations, mosquito bites may form a more vicious reaction, sometimes accompanying fever and systemic symptoms. In such cases, the presence of rare hematological disorders, abnormalities in eosinophils and/or association with Epstein-Barr virus (EBV) may underlie. Importantly, hypersensitivity to mosquito bites (HMB), which is characterized by necrotic skin reactions to mosquito bites with various systemic symptoms, is often observed in association with EBV infection and natural killer (NK) cell lymphoproliferative disorder. Exaggerated skin reaction to mosquito bites is also seen in Wells’ syndrome. While strong Th2-skewing immune dysregulation is apparent in the patients, they also show robust CD4 + T cell proliferation in response to mosquito salivary gland extracts, indicating close association between Wells’ syndrome and mosquito bites. Similar skin reaction to mosquito bites is also noticed in certain types of B cell neoplasm, although the role of B cells in this peculiar reaction to mosquito bites is yet to be elucidated. In this review, we will discuss the current knowledge of exaggerated reaction toward mosquito bites seen in conjunction with these unique hematological disorders, and examine the scientific studies and observations reported in previous literatures to organize our current understanding of the pathogenesis of this distinct disorder. [ABSTRACT FROM AUTHOR]

Abstract: Perivascular epithelioid tumors (PEComa) are uncommon mesenchymal neoplasms demonstrating positivity for muscular and melanocytic immuno-markers. Included in this category are angiomyolipoma, lymphangioleiomyomatosis, and clear cell sugar tumors. Lesions which do not fit into these categories are classified as “not otherwise specified”. We present a case of an incidentally discovered PEComa within inguinal hernia sac contents in a 70-year-old woman. It consisted of spindled and epithelioid cells with bland oval nuclei, small nucleoli and clear to light eosinophilic cytoplasm. There was no atypia or mitoses. The lesion was strongly positive for HMB45 and smooth muscle actin. Pelvic soft tissue and peritoneal PEComas are rarely reported in literature and very little is known about their prognosis. We discuss the immunohistochemistry, differential diagnosis, and pathogenesis of PEComas. [Copyright &y& Elsevier]

Stings by honeybees are not uncommon and most cases cause pain but no significant medical problems. Some patients, however, have lethal complications such as acute anaphylactic shock. Cellulitis caused by honeybee sting is very rare and can be a late complication in some patients. We report a 45-year-old female patient who was stung by a honeybee, and whose right forearm showed progressive swelling with bullous formation after the sting. She was sent to our emergency department with the diagnosis of right hand cellulitis. After treatment with antibiotics for 5 days, the lesions showed no response. Then, systemic steroid was used and the lesion gradually resolved. Diagnosis of Wells'' syndrome was made according to clinical appearance, course and characteristic histopathological findings. [Copyright &y& Elsevier]