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Objective: The purpose of this study was to identify common and unique risk factors for intimate partner violence (IPV) among young adults in relationships. Guided by two models of IPV, the same set of risk factors was used to examine outcomes of unidirectional (perpetration or victimization) and bidirectional (reciprocal) IPV separately for males and females. Methods: The sample included 10,187 young adults, ages 18-27, from the National Longitudinal Study of Adolescent Health. The respondents were drawn from Wave 3 and stated they had a romantic relationship during the time of the study. The risk factors were primarily related to violent socialization (e.g., childhood maltreatment, youth violence) and personal adjustment (e.g., alcohol use, depression). Results: Approximately 47% of the respondents experienced some form of IPV in romantic relationships, and the majority of respondents reported bidirectional violence. For males, childhood sexual abuse was associated with perpetration and bidirectional IPV, and childhood neglect was associated with bidirectional IPV. For females, childhood neglect was associated with all three IPV outcomes, and childhood physical abuse was associated with bidirectional IPV. Youth violence perpetration during adolescence increased the odds for all IPV outcomes among females, while low self-esteem increased the odds for all IPV outcomes among males. A history of suicide attempts predicted bidirectional IPV across genders. Being married and living with a partner predicted all three IPV outcomes for males and females. Conclusions: The results revealed more common risk factors for bidirectional IPV than unidirectional IPV and few common risk factors across genders. The results indicate that IPV prevention and intervention strategies should be tailored to the unique risk experiences of males and females rather than focus on a common factors approach. However, child abuse, youth violence, and suicide prevention efforts may reduce incidents of later IPV for males and females, and these strategies should continue to be an emphasis in practice and research. [Copyright &y& Elsevier]

Abstract: The role of antibodies directed against the hyper variable envelope region V1 of human immunodeficiency virus type 1 (HIV-1), has not been thoroughly studied. We show that a vaccine able to elicit strain-specific non-neutralizing antibodies to this region of gp120 is associated with control of highly pathogenic chimeric SHIV89.6P replication in rhesus macaques. The vaccinated animal that had the highest titers of antibodies to the amino terminus portion of V1, prior to challenge, had secondary antibody responses that mediated cell killing by antibody-dependent cellular cytotoxicity (ADCC), as early as 2 weeks after infection and inhibited viral replication by antibody-dependent cell-mediated virus inhibition (ADCVI), by 4 weeks after infection. There was a significant inverse correlation between virus level and binding antibody titers to the envelope protein, (R =−0.83, p =0.015), and ADCVI (R =−0.84 p =0.044). Genotyping of plasma virus demonstrated in vivo selection of three SHIV89.6P variants with changes in potential N-linked glycosylation sites in V1. We found a significant inverse correlation between virus levels and titers of antibodies that mediated ADCVI against all the identified V1 virus variants. A significant inverse correlation was also found between neutralizing antibody titers to SHIV89.6 and virus levels (R =−0.72 p =0.0050). However, passive inoculation of purified immunoglobulin from animal M316, the macaque that best controlled virus, to a naïve macaque, resulted in a low serum neutralizing antibodies and low ADCVI activity that failed to protect from SHIV89.6P challenge. Collectively, while our data suggest that anti-envelope antibodies with neutralizing and non-neutralizing Fc(R-dependent activities may be important in the control of SHIV replication, they also demonstrate that low levels of these antibodies alone are not sufficient to protect from infection. [Copyright &y& Elsevier]

Abstract: Suicidal behavior among children and adolescents is a national problem and schools can be an effective context for suicide prevention and intervention efforts. School-wide screening programs are viewed as most effective from a public health standpoint, although they garner the least support from school administrators. The purpose of this article is to examine administrators'' perceptions of three school-based suicide prevention models while also capturing opinions on barriers and benefits to implementation. Data were gathered through interviews with seven principals from one Midwestern state. Findings reveal agreement among principals that schools play a key role in suicide prevention, but they differ on which type of prevention approach is most appropriate. School principals believed the school-wide screening program included more barriers to implementation than either the in-service or the curriculum-based program, largely due to the likelihood of parental disapproval. Limitations of the study and implications for improving suicide prevention efforts are discussed. [Copyright &y& Elsevier]

Abstract: Purpose: The study investigated protective factors (school commitment/importance, parent/peer disapproval of antisocial behavior, positive future orientation, and religion) hypothesized to lower risk for antisocial behavior among adolescents who, as children, had been physically abused. Protective factors also were investigated for comparison, nonabused children, and for children at risk on abuse and other factors: low socioeconomic status and early antisocial behavior. Methods: Analyses used a two-step hierarchical regression approach. In step 1, age, gender, and early antisocial behavior were entered as controls. In step 2, each protective factor was entered separately as a predictor. A final regression model in each case examined the additive (combined) effect of all protective factors on a given outcome. Tests of predictor-by-group interactions were used to examine group differences. Results: Among abused and nonabused children, having a strong commitment to school, having parents and peers who disapprove of antisocial behavior, and being involved in a religious community lowered rates of lifetime violence, delinquency, and status offenses. Having a positive future orientation appeared less powerful as a protective influence. Exposure to an increasing number of protective factors was for each outcome associated with a diminution in risk for antisocial behavior. Conclusions: Protective factors represent targets for preventive intervention that are viable for children as they enter adolescence. The fact that protective factors were predictive of lower antisocial behavior in both the abuse and comparison groups suggests that protective effects are more universal than they are unique to a given group of children. [Copyright &y& Elsevier]

Human immunodeficiency virus type 1 (HIV-1) isolates from India mainly belong to clade C and are quite distinct from clade C isolates from Africa in terms of their phylogenetic makeup, serotype, and sensitivity to known human broadly neutralizing monoclonal antibodies. Because many of these properties are associated with the envelope proteins of HIV-1, it is of interest to study the envelope proteins of Indian clade C isolates as part of the ongoing efforts to develop a vaccine against HIV-1. To this end, we purified trimeric uncleaved gp145 of a CCR5 tropic Indian clade C HIV-1 (93IN101) from the conditioned medium of 293 cells. The purified protein was shown to be properly folded with stable structure by circular dichroism. Conformational integrity was further demonstrated by its high affinity binding to soluble CD4, CD4 binding site antibodies such as b12 and VRC01, quaternary epitope-specific antibody PG9, and CD4-induced epitope-specific antibody 17b. Sera from rabbits immunized with gp145 elicited high titer antibodies to various domains of gp120 and neutralized a broad spectrum of clade B and clade C HIV-1 isolates. Similar to other clade B and clade C envelope immunogens, most of the Tier 1 neutralizing activity could be absorbed with the V3-specific peptide. Subsequent boosting of these rabbits with a clade B HIV-1 Bal gp145 resulted in an expanded breadth of neutralization of HIV-1 isolates. The present study strongly supports the inclusion of envelopes from Indian isolates in a future mixture of HIV-1 vaccines. [ABSTRACT FROM AUTHOR]

Purpose: Although researchers have concluded that child maltreatment has a negative effect on children's learning and academic achievement, not all children are negatively affected by maltreatment, and some children seem to succeed academically despite being maltreated. Drawing on risk and resilience theory, we examined a broad range of potential risk, promotive, and protective factors within children and their environments along with characteristics of the maltreatment to account for variability in test scores. Methods: A national longitudinal probability sample of 702 maltreated school-aged children, ages 6–10, and their caregivers was used to predict reading and math scores among maltreated children over three years. Results: We found that chronic maltreatment, poorer daily living skills, and lower intelligence explained a substantial proportion of the variance in maltreated children's math scores (39%), whereas type of maltreatment, poorer daily living skills and lower intelligence explained a substantial proportion of the variance in reading scores (54%) over time. Contrary to our prediction, having a behavior problem seemed to protect chronically maltreated children from poorer performance in math over time. Conclusions: To increase academic achievement among maltreated children, it is imperative that we prevent chronic maltreatment and help children increase their competency on daily living skills. [Copyright &y& Elsevier]

Abstract: A toxicity and immunogenicity study, evaluating the safety of a polyvalent DNA prime/protein boost HIV-1 vaccine (DP6-001), was examined in rabbits. Animals were primed with a cocktail of six different DNA plasmids expressing five HIV-1 env genes and one gag gene followed by boosting with five gp120 proteins homologous to the DNA vaccines. The vaccine was shown to be immunogenic as evident from the induction of high-titered anti-Env and anti-Gag antibodies. There was an absence of detectable adverse effects on key toxicology parameters. Although plasmids persisted in the injection sites following single administration for 64 days, no evidence of integration into the host genomic DNA was observed. These studies demonstrate that a novel polyvalent DNA prime/protein boost vaccine lacks signs of toxicity and DNA integration in a rabbit model, and immunogenicity and toxicology data support clinical testing of the vaccine in humans. [Copyright &y& Elsevier]