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Your search keyword '"Xiao, Yong-Jun"' showing total 4 results
Start Over Author "Xiao, Yong-Jun" Publisher elsevier b.v.
4 results on '"Xiao, Yong-Jun"'

1. Nucleophilic substitution reaction at an sp2 carbon of vinyl halides with an intramolecular thiol moiety: synthesis of thio-heterocycles

Author

Lei, Mao-Yi, Xiao, Yong-Jun, Liu, Wei-Min, Fukamizu, Koji, Chiba, Shunsuke, Ando, Kaori, and Narasaka, Koichi

Subjects
*SUBSTITUTION reactions, *NUCLEOPHILIC reactions, *ORGANIC reaction mechanisms, *PHYSICAL & theoretical chemistry research, *CHEMISTRY experiments, *HETEROCYCLIC compounds, *THIOPHENES
Abstract

Abstract: This article presents a full account of intramolecular vinylic substitution reactions of bromoalkenes having an acetylthio moiety, which give sulfur-containing heterocycles such as dihydrothiophene, tetrahydrothiopyran, and 2-alkylidenethietane derivatives. The reaction pathways of the substitution reactions were investigated by theoretical and experimental studies. [Copyright &y& Elsevier]

Published
2009
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2. Identification of some novel AHAS inhibitors via molecular docking and virtual screening approach

Author

Wang, Jian-Guo, Xiao, Yong-Jun, Li, Yong-Hong, Ma, Yi, and Li, Zheng-Ming

Subjects
*HERBICIDES, *AMINO acids, *BIOLOGICAL assay, *ACETOLACTATE synthase
Abstract

Abstract: Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) catalyzes the first common step in branched-chain amino acid biosynthesis. This enzyme is an important target for the design of environmental-benign herbicides. Based on the crystal structure of AHAS/sulfonylurea complex, we have carried out computational screening of the ACD-3D database in order to look for novel non-sulfonylurea inhibitors of AHAS for the first time. Three novel compounds were found to inhibit plant AHAS in vitro among 14 procured compounds. One compound showed promising activity in vivo for rape root growth inhibition bioassay. This research provided useful clues for further design and discovery of AHAS inhibitors. [Copyright &y& Elsevier]

Published
2007
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4. Nucleophilic substitution at an sp2 carbon of vinyl halides with an intramolecular thiolate moiety: synthesis of 2-alkylidenethietanes

Author

Lei, Mao-Yi, Fukamizu, Koji, Xiao, Yong-Jun, Liu, Wei-Min, Twiddy, Scott, Chiba, Shunsuke, Ando, Kaori, and Narasaka, Koichi

Subjects
*CHEMICAL reactions, *CHEMICAL processes, *DENSITY functionals, *FUNCTIONAL analysis
Abstract

Abstract: Various 2-alkylidenethietanes were synthesized by intramolecular nucleophilic substitution reactions at an sp2 carbon of vinyl halides with thiolate moieties. The reaction pathway of the substitution reactions was confirmed as a very rare SNVπ mechanism by theoretical and experimental studies. [Copyright &y& Elsevier]

Published
2008
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