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• Joint trajectory patterns did not vary by sarcopenia assessment, but did vary by social relationship assessment. • Persistent combination of social relationship and sarcopenia had greatest risk of adverse outcomes. • Social care and health care for older adults should be integrated. This study aimed to examine joint trajectories of loneliness, social isolation and sarcopenia and their associations with adverse outcomes. A total of 4701 participants aged ≥60 years who had a baseline and at least one follow-up assessment of loneliness, social isolation and sarcopenia across 2011, 2013 and 2015 waves in China Health and Retirement Longitudinal Study. Adverse outcomes were obtained in 2018 wave. Joint trajectories were fit using the parallel process latent class growth analysis, and their associations with adverse outcomes were evaluated using modified Poisson regression. Joint trajectory patterns for social relationship and sarcopenia did not vary by the assessment for sarcopenia, but did vary by the assessment for social relationship. Older adults exhibit distinct joint trajectories and those with persistent combination of loneliness or social isolation and sarcopenia experience greatest risk of adverse outcomes. These findings implicate integration of health care and social care for community-dwelling older adults. [ABSTRACT FROM AUTHOR]

High-temperature stable thermal storage materials are urgently needed to meet the demand for solar thermal power generation. Herein, Cu–20Si alloy-corundum ceramic composite thermal storage materials are prepared. The thermal storage performance of the composite, and the erosion resistance of ceramic matrix to alloy are investigated during high-temperature (1000 °C) service for 1000 h. The results show that the latent heat of Cu–20Si alloy is increased by 130.76 % to 201.2 kJ/kg compared with the original. Meanwhile, the alloy forms a dense transition layer on the ceramic matrix surface by melting and spreading. Furthermore, the ceramic matrix shows superior erosion resistance to the alloy, owing to the dense structure of ceramic and no chemical reactions between the alloy and ceramic matrix. Finally, test results of long-time service confirm the stability of the composite, which can be used stably for high temperature thermal storage. [ABSTRACT FROM AUTHOR]

• Social support interacted with intrinsic capacity to affect the downward trajectory of functional ability among older adults. • The interaction effects varied with the types of social support. • Functional ability significantly declined over 3 years among older adults. The ecological model of health and ageing has proposed that functional ability (FA) is determined by the interaction between intrinsic capacity (IC) and environmental characteristics. This study empirically examined how social support, as an important social environmental resource, interacts with IC to affect FA trajectories among older adults. This was a prospective three-wave cohort study with a sample of 775 community-dwelling older adults. Social support, IC and FA were assessed using the Social Support Rating Scale, the revised Integrated Care for Older People screening tool and the Lawton Instrumental Activities of Daily Living Scale, respectively. Latent growth curve models (LGCM) were implemented to test their relationships. FA significantly declined over 3 years, and the detrimental effect of impaired IC on the deterioration rate of FA was buffered by subjective support but was aggravated by support utilization and was not changed by objective support. FA decline among older adults with impaired IC was observed in those with low subjective support or with high support utilization but not in those with high subjective support or with low support utilization. Among older adults with intact IC, FA decline was observed in those with low support utilization but not in those with high support utilization or with low or high subjective support. Subjective support may prevent FA decline among older adults with impaired IC, while support utilization may benefit older adults with intact IC but may be detrimental for those with impaired IC. Social support interventions to optimize FA trajectories should improve older adults' perceptions of support and bridge the gap in support utilization among older adults with impaired IC. [ABSTRACT FROM AUTHOR]

Anorthite solar thermal energy storage ceramics were fabricated from magnesium slag solid waste by pressureless sintering. The effects of CaO/SiO 2 ratio and sintering temperature on the physical, chemical, and thermophysical properties of ceramics were explored. X-ray diffraction results demonstrated that thermal shock process contributed to the formation of anorthite, and increasing CaO/SiO 2 ratio promoted the transformation of anorthite (CAS 2) into melilite (C 2 AS). Some micro-cracks were found according to SEM analysis, forming by the mismatch of thermal expansion coefficients among phases. The combined effects of the low thermal expansion coefficient of anorthite and micro-crack toughing endowed the ceramic with good thermal shock resistance. Optimum comprehensive performances were observed in the sample with a CaO/SiO 2 ratio of 0.58 sintered at 1160°C, of which the specific thermal storage capacity was 0.63 J·g-1·°C-1(room temperature). The bending strength increased by 0.22% after 30 thermal shock times (room temperature-800°C, wind cooling). Therefore, the anorthite ceramics exhibited great potential for solar thermal energy storage. [ABSTRACT FROM AUTHOR]

• The supersonic premixed cavity-stabilized combustion was realized in a gaseous ethylene-fueled scramjet with a transverse injection scheme. • The combustion stabilization mechanism of the cavity-stabilized supersonic premixed flame was analyzed through OH-LIF and CH* photography. • The transient flame morphology of the cavity-stabilized supersonic premixed flame was investigated from the aspect of flame spreading angle and flame front position abstracting from high-speed photography results. With the overwhelming trend of fast and economic aviation, it is becoming increasingly difficult for fuel to burn stably and efficiently in a constrained space and time period in the combustor of a hypersonic air-breathing vehicle. Conventional supersonic diffusion flame runs the risk of blowing out in the incoming flow at such high velocity. Upstream fuel injection of the flame holder is gaining popularity due to its prominent advantage in improving mixing efficiency, and this fuel injection method contributes to the organization of supersonic premixed combustion. In order to study the combustion characteristics of the supersonic premixed flame, corresponding experiments are carried out on a direct-connected scramjet platform with the inflow total temperature of 1700 K and the inflow Mach Number of 2.0. Gaseous ethylene with an equivalence ratio of 0.15 was injected transversely 670 mm upstream of a cavity. Optical measurements including laser-induced fluorescence on the hydroxyl radical (OH-LIF), CH*chemiluminescence photography, and high-speed photography were performed to investigate the steady-state and transient combustion characteristics of the cavity-stabilized supersonic premixed flame. From steady-state OH-LIF and CH* results, the flame could be divided into reactant zone, preheating zone, intense reacting zone, and product zone. It could be inferred that the preheating zone induced by the hot product in the cavity acts as a radical source and heat source for combustion stabilization in the cavity. In addition, the transient flame morphology analysis was carried out from the high-speed photography results. The flame base position and flame spreading angle were abstracted from the binarized image. The results showed that there existed a subtle flame flashback phenomenon for the flame base, whereas the flame spreading angle maintained a relatively constant value with a small deviation. The frequency-domain analysis revealed that both the flame base position and flame spreading angle reached the peak amplitude in the direct current component (0 Hz), exhibiting no explicit high-amplitude resonance component within 1500 Hz compared to those in the diffusion combustion mode. In all, the supersonic premixed flame presented a stabilized flame morphology. [ABSTRACT FROM AUTHOR]

• Three patterns of intrinsic capacity were identified by the latent class analysis. • Specific patterns had high risks of disability and poor physical quality of life. • 12.8% of older adults had high decline rates in sensory domain. • 79.4% of older adults had low decline ratios in all intrinsic capacity domains. • 7.8% of participants had sharp declines in locomotion, psychology cognition and vitality domains. To identify patterns of intrinsic capacity (IC) and determine the association between these patterns with incident one-year outcomes. A total of 756 older adults aged ≥ 60 years were followed up after 1 year. IC was assessed using the revised integrated care for older people screening tool, and its patterns were examined by the latent class analysis. Logistic regression models were conducted to compare the risk of adverse outcomes. Three IC patterns were identified. Both "sharp declines in sensory domain" (Class 2) and "sharp declines in locomotion, psychological, cognition and vitality domains" (Class 3) were at greater risk of disabilities and poor physical quality of life than "relatively healthy" (Class 1). The Class 3 was twice as likely to be hospitalized as Class 1. Assessment of IC could provide valuable information on stratifying older adults into heterogeneous groups, promoting targeted interventions to delay the adverse outcomes. [ABSTRACT FROM AUTHOR]

• Two frailty trajectory classes were identified. • Subjective support delays frailty progression through preventing depression. • Objective support delays frailty progression through promoting physical activity. • Support utilization delays frailty progression through promoting physical activity. • Social support should be considered in the management of frailty. To investigate whether and how social support influenced frailty progression through depressive symptoms and physical activity. Of 1235 community-dwelling older adults enrolled at baseline, 778 (63.0%) undergoing at least one yearly follow-up were included in the final analysis. Data were collected on frailty, social support, depressive symptoms, physical activity and covariates. Two frailty trajectory classes were identified and labeled as alleviated frailty and deteriorated frailty. Subjective support prevented the deterioration of frailty through decreased depressive symptoms, while objective support and support utilization prevented the deterioration of frailty through increased physical activity. The pathways through which social support ameliorates frailty vary by support types. Subjective support interventions should be included in the multifactorial interdisciplinary management of frailty to address social and psychological vulnerabilities, along with objective support and support utilization interventions addressing physical inactivity. [ABSTRACT FROM AUTHOR]

Effective crosslinking among food constituents has the potential to enhance their overall quality. Distarch phosphate (DSP), a common food additive employed as a thickening agent, bears a pre-crosslinked oligosaccharide (PCO) moiety within its molecular structure. Once this moiety is released, its double reducing end has the potential to undergo crosslinking with amino-rich macromolecules through Maillard reaction. In this study, hydrolyzed distarch phosphate (HDSP) was synthesized, and spectroscopic analysis verified the presence of PCO within HDSP. Preliminary validation experiment showed that HDSP could crosslink chitosan to form a hydrogel and significant browning was also observed during the process. Furthermore, rehydrated sea cucumber (RSC) crosslinked with HDSP exhibited a more intact appearance, higher mechanical strength, better color profile, and increased water-holding capacity. This series of results have confirmed that HDSP is capable to crosslink amino-rich macromolecules and form more stable three-dimensional network. [Display omitted] • Distarch phosphate, a thickener, was converted to a crosslinker by simple hydrolysis. • Hydrolyzed distarch phosphate crosslinks amino-rich substrates via Maillard reaction. • The treated chitosan and sea cucumber both show better hydrogel strength. • The crosslinking method is practical and has commercialization potential. • This strategy can potentially convert other pre-crosslinked starch to crosslinkers. [ABSTRACT FROM AUTHOR]

• The predictive value of intrinsic capacity on adverse outcomes varies in domains. • Cognitive decline, limited mobility, visual impairment and depressive symptoms predicted one-year incident disability. • Visual impairment predicted recurrent falls during one-year follow-up. • Cognitive decline and limited mobility predicted emergency department visits during one-year follow-up. • Limited mobility predicted incident poor quality of life. To examine the predictive value of intrinsic capacity on one-year incident adverse outcomes among community-dwelling older adults. A total of 756 community-dwelling older adults aged ≥ 60 years were followed up after 1 year. Intrinsic capacity was assessed using the revised integrated care for older people screening tool. Adverse outcomes included incident disability, recurrent falls, hospitalization, emergency department visits, and poor quality of life. Multivariate logistic regression models were performed to evaluate the predictive value of intrinsic capacity domains on adverse outcomes. Cognitive decline, limited mobility, visual impairment and depressive symptoms predicted incident disability. Visual impairment predicted recurrent falls. Cognitive decline and limited mobility predicted emergency department visits. Limited mobility predicted poor quality of life. Intrinsic capacity could predict incident adverse outcomes among community-dwelling older adults. Assessing intrinsic capacity would facilitate early identification of older adults at high risk of adverse outcomes and prompt targeted interventions. [ABSTRACT FROM AUTHOR]

[Display omitted] • Synthesized and characterized Dialdo-galactose (DAG) – a hetero-sugar bearing two aldehyde groups. • The monocyclic structure of DAG in aqueous solution was proved. • DAG has a great cross-linking ability under typical food processing conditions. • DAG is a potential candidate for future food cross-linking additives. Cross-linking is a popular strategy to tailor the mechanical profile of foods and materials. Dialdo-galactose (DAG) is a hetero-sugar bearing two aldehyde groups that could potentially cross-link amino-group rich systems. In this study, we proved even in undesirable Maillard reaction condition, DAG is a very reactive Maillard substrate that could effectively cross-link all the tested foods, enhance their mechanical strength, and generate brown pigments during cross-linking. In particular, DAG treated sea cucumber exhibited good stability against heat-induced deterioration. In addition, DAG treated collagen sausage casing was more elastic and flexible then glutaraldehyde (GA) treated ones. DAG also outperformed GA in generating stronger chitosan hydrogels with higher G', and the DAG cross-linked chitosan film was more robust against acid-catalyzed decompositions. These results have not only confirmed DAG's cross-linking ability in food processing condition, but also provided useful information for the development of new food cross-linking agents based on oxidized saccharides. [ABSTRACT FROM AUTHOR]

[Display omitted] Whether IgE affects eosinophil migration in chronic rhinosinusitis with nasal polyps (CRSwNP) remains largely unclear. Moreover, our understanding of local IgE, eosinophils, and omalizumab efficacy in CRSwNP remains limited. We investigated whether IgE acts directly on eosinophils and determined its role in omalizumab therapy. Eosinophils and their surface receptors were detected by hematoxylin and eosin staining and flow cytometry. IgE and its receptors, eosinophil peroxidase (EPX), eosinophilic cationic protein, and CCR3 were detected by immunohistochemistry and immunofluorescence. Functional analyses were performed on blood eosinophils and polyp tissues. Logistic regression was performed to screen for risk factors. Receiver operating characteristic curve was generated to evaluate the accuracy. Both FcεRI and CD23 were expressed on eosinophils. The expression of FcεRI and CD23 on eosinophil in nasal polyp tissue was higher than in peripheral blood (both P <.001). IgE and EPX colocalized in CRSwNP. IgE directly promoted eosinophil migration by upregulating CCR3 in CRSwNP but not in healthy controls. Omalizumab and lumiliximab were found to be effective in restraining this migration, indicating CD23 was involved in IgE-induced eosinophil migration. Both IgE+ and EPX+ cells were significantly reduced after omalizumab treatment in those who experienced response (IgE+ cells, P =.001; EPX+ cells, P =.016) but not in those with no response (IgE+ cells, P =.060; EPX+ cells, P =.151). Baseline IgE+ cell levels were higher in those with response compared to those without response (P =.024). The baseline local IgE+ cell count predicted omalizumab efficacy with an accuracy of 0.811. IgE directly promotes eosinophil migration, and baseline local IgE+ cell counts are predictive of omalizumab efficacy in CRSwNP. [ABSTRACT FROM AUTHOR]

The preparation of powder adsorbent into microsphere adsorbent is one of the effective methods for the industrialization of uranium extraction from seawater. Herein, a MOF-derived Co-Ni layered double hydroxides/polyethyleneimine modified chitosan micro-nanoreactor (DNPM) was prepared by a simple method in this work. The microstructure and chemical structure of DNPM were comprehensively characterized. The pH value, adsorption time, initial solution concentration, temperature, competitive ions, regeneration performance, and bed column heights were investigated for the adsorption performance of DNPM by batch adsorption and fixed-bed column continuous adsorption experiments. When the contact time was 8 h, the initial concentration was 150 mg/L, and the pH value was 6, the adsorption capacity of DNPM was 334.67 mg/g. The uranium adsorption by DNPM fits with the pseudo-second-order kinetic and Langmuir models, which was a spontaneous and endothermic process. In addition, DNPM has good adsorption selectivity and reusability. The fixed-bed column continuous adsorption experiment shows that the adsorption capacity increased with the increase of bed column height. The adsorption mechanism can be attributed to coordination chelation and electrostatic interaction. In general, this work provides an effective strategy for developing environmentally friendly uranium adsorbent that can be industrially used. [Display omitted] [ABSTRACT FROM AUTHOR]

An angiotensin-converting enzyme inhibitory (ACEI) peptide with a median inhibitory concentration (IC 50) of 1.26 mg/mL was purified from whey proteins resulting from a fermentation using Lactobacillus plantarum QS670. The peptide was subsequently derived from an α S1 -casein, κ-casein, β-lactoglobulin, or serum albumin fraction. Analysis via liquid chromatography tandem mass spectrometry indicated that it had an amino acid sequence of Gly-Ala (GA). The GA dipeptide was also synthesized using an Fmoc solid-phase method. The GA dipeptide exhibited an IC 50 of 1.22 mg/mL and was shown to be stable across both temperature (20 to 60°C) and pH (2 to 12). Digestive enzymes including pepsin, trypsin, and chymotrypsin had negligible effects on activity. The whey exerted hypotensive effects when fed to spontaneously hypertensive rats (SHR), which exhibited a blood pressure drop of 2.33 kPa. A 4-wk gavage treatment resulted in greater decreases of 7.46 kPa. Results of this study indicate that milk fermented using Lb. plantarum QS306 has potential to be used as a functional food to help prevent or reduce hypertension-associated diseases. [ABSTRACT FROM AUTHOR]

Abstract Transmembrane protein P-gp's overexpression at the drug-resistant cell membrane is the most important characteristic of multidrug resistance (MDR). Quercetin (QUE) can effectively suppress the function of P-gp to reverse MDR. This study uses QUE as the P-gp inhibitor andfilm-ultrasound technique with ammonium sulfate transmembrane gradient method to prepare long-circulating liposomes simultaneously encapsulating QUE and Adriamycin (doxorubicin) (AMD/DOX). The optimal conditions for the preparation of AMD_QUE_long-circulating liposomes (SLs) are as follows: hydrogenated soybean phospholipids (HSPC):cholesterol:DSPE-PEG 2000 = 73.07:24.36:2.57 mol/mol, QUE:HSPC = 1:20 mol/mol, AMD:HSPC = 1:7.9 w/w (NH 4)2 SO 4 0.15 mol/L, drug loaded (AMD) at 55°C for 25 min). The average encapsulation efficiency of AMD and QUE was 97.49% and 95.50%, respectively. The average particle size is 85 nm (n = 3), and the average zeta potential is −14.9 mV. First, the pharmacokinetic study proved that codelivery liposomes enveloping QUE and AMD (AMD_QUE_SL) can obviously increase the blood concentration of AMD (C max : 140.50 ± 32.37 μg/mL) and extend the half-life period of AMD in plasma (t 1/2 :14.02 ± 1.54 h). Second, AMD_QUE_SL can obviously enhance the cell toxicity to AMD-resistant cell strains (HL-6/ADR and MCF-7/ADR), and the reverse effects on the resistance of HL-6/ADR and MCF-7/ADR is increased to 4.81-fold and 3.21-fold, respectively. Third, according to the in vivo pharmacodynamic study, the relative tumor volume and relative tumor growth of the AMD_QUE_SL group were the lowest. The inhibition rate of tumor growth of this group was the highest. It can be concluded that AMD_QUE_SL can effectively reverse MDR, lower cardiac toxicity of AMD in clinical treatment, and improve the clinical treatment effect of AMD. [ABSTRACT FROM AUTHOR]