10 results on '"Zhang, Shimeng"'
Search Results
2. Microenvironment-regulated dual-hydrophilic coatings for glaucoma valve surface engineering.
- Author
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Zhang, Shimeng, Liu, Yejia, Li, Linhua, Wang, Binjian, Zhang, Zezhen, Chen, Shiyan, Zhang, Guanghong, Huang, Qiongjian, Chen, Xiao, Chen, Jiang, and Qu, Chao
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GLAUCOMA ,ADDITION polymerization ,SILICONE rubber ,ARTIFICIAL implants ,VALVES ,ENGINEERING design ,BIOCOMPATIBILITY ,ANTIFOULING paint ,SURFACE coatings - Abstract
Glaucoma valves (GVs) play an essential role in treating glaucoma. However, fibrosis after implantation has limited their long-term success in clinical applications. In this study, we aimed to develop a comprehensive surface-engineering strategy to improve the biocompatibility of GVs by constructing a microenvironment-regulated and dual-hydrophilic antifouling coating on a GV material (silicone rubber, SR). The coating was based on a superhydrophilic polydopamine (SPD) coating with good short-range superhydrophilicity and antifouling abilities. In addition, SPD coatings contain many phenolic hydroxyl groups that can effectively resist oxidative stress and the inflammatory microenvironment. Furthermore, based on its in situ photocatalytic free-radical polymerization properties, the SPD coating polymerized poly 2-methylacryloxyethylphosphocholine, providing an additional long-range hydrophilic and antifouling effect. The in vitro test results showed that the microenvironment-regulated and dual-hydrophilic coatings had anti-protein contamination, anti-oxidation, anti-inflammation, and anti-fiber proliferation capabilities. The in vivo test results indicated that this coating substantially reduced the fiber encapsulation formation of the SR material by inhibiting inflammation and fibrosis. This design strategy for dual hydrophilic coatings with microenvironmental regulation can provide a valuable reference for the surface engineering design of novel medical implantable devices. Superhydrophilic polydopamine (SPD) coatings were prepared on silicone rubber (SR) by a two-electron oxidation method. Introduction of pMPC to SPD surface using photocatalytic radical polymerization to obtain a dual-hydrophilic coating. The dual-hydrophilic coating effectively modulates the oxidative and inflammatory microenvironment. This coating significantly reduced protein contamination and adhesion of inflammatory cells and fibroblasts in vitro. The coating-modified SR inhibits inflammatory and fibrosis responses in vivo , promising to serve the glaucoma valves. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2024
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3. Is it high time to leave the chronic disease care of rural older people to village doctors in China: Insights from a population-based atrial fibrillation screening study.
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Li, Mingfang, Chu, Ming, Zhang, Shimeng, Shen, Youmei, Sun, Xingxing, Gong, Jinlong, Yang, Gang, Shi, Jiaojiao, Ding, Xiangwei, Gu, Zhoushan, Li, Chengzong, Zhang, Chaoqun, Xia, Yaodongqin, Wang, Zhirong, Lip, Gregory Y.H., and Chen, Minglong
- Abstract
No study has systematically investigated the quality of long-term care delivered to the rural older people with chronic diseases, such as atrial fibrillation (AF) in China. This study aims to provide contemporary data on the prevalence and awareness of AF among the older population in rural China and to evaluate healthcare knowledge and delivery by village doctors. A cross-sectional study. Rural villages in Daqiao and Xiaoji towns of Jiangsu Province, China. Rural population aged ≥65 years. AF was identified using 12-lead electrocardiography in the first-step (government-led health examination) and single-lead electrocardiography in the second-step (in-house AF screening). Questionnaire surveys were designed for the AF patients and their village doctors. Among 31,342 permanent residents, 12,630 (40.3 %) declined, 7,956 (25.3 %) participated in the first-step and 10,756 (34.3 %) in the second-step. The overall AF detection rate was 4.3 % (810/18,712). Of the 810 AF patients (mean age 76.1±5.9 years; 51.4 % female), 51.5 % were illiterate, only 2.6 % could use smartphone applications, and 8.1 % lived with their children. Common risk factors were older age, men, hypertension, diabetes, prior stroke, vascular disease, and congestive heart failure. Among the 402 patients with known AF, 367 were at high risk of stroke and 10.9 % (40/367) were anticoagulated. Only 17.6 % patients with known hypertension had blood pressure level <140/90 mmHg, and 6.0 % with known diabetes had a fasting blood glucose level ≤6.1 mmol/L. Only 7.3 % (9/122) village doctors reported having the knowledge of integrated care AF management. This study identified AF in 4.3 %, but AF management was suboptimal in rural China. The current village doctor-dominant rural healthcare system is far from delivering standardized AF management for older patients in rural China. There is an urgent need to empower the village doctors in optimising the care of AF patients. [ABSTRACT FROM AUTHOR]
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- 2024
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4. PO-04-031 A NOVEL MODEL OF INTEGRATED CARE OF OLDER PATIENTS WITH ATRIAL FIBRILLATION IN RURAL CHINA: A CLUSTER RANDOMIZED CONTROLLED TRIAL.
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Li, Mingfang, Chu, Ming, Zhang, Shimeng, Yang, Shu, Shen, Youmei, Wu, Dan, Sun, Xingxing, Gong, Jinlong, Yang, Gang, Lip, Gregory, and Chen, Minglong
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- 2024
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5. Control over the morphology of TiO2 hierarchically structured microspheres in solvothermal synthesis
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Zhao, Wei, Wang, Hongxing, Feng, Xiangning, Zhang, Yubo, and Zhang, Shimeng
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- 2015
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6. Phylogenetic relationships among Scirtothrips species and related genera (Thysanoptera, Thripidae) based on morphology.
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Zhang, Shimeng, Mound, Laurence A., and Feng, Jinian
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AVOCADO ,THRIPS ,MOLECULAR phylogeny ,HOST plants ,AGRICULTURAL pests ,MORPHOLOGY ,SPECIES - Abstract
Scirtothrips , one of the largest genera of Thripinae, includes several species that are important pests for agricultural and horticultural plants. Scirtothrips genus-group comprises 11 genera, but phylogenetic relationships among these are unclear, as are the interspecific relationships within Scirtothrips. We used 61 morphological characters to study the morphological variation and phylogenetic relationships among the members of this genus-group. Phylogenetic analysis supported the inclusion of eight genera in Scirtothrips genus-group but excluded Ajothrips and Scirtidothrips , although the monophyly of Scirtothrips was not well-supported. Our analysis strongly supported two different species-groups both comprising species associated with Acacia in Australia, suggesting the occurrence of at least two separate radiations onto this plant genus. The monophyly of Scirtothrips perseae species-group was not supported; members of this group are involved in damage to avocado in the New World. The Scirtothrips aurantii species-group was recognised as comprising S. aurantii , Scirtothrips dodonaeae and Scirtothrips mugambii , based on one synapomorphic character, male hind femora with a comb of setae. We demonstrated that the conspicuous drepanae that occur in males of some Scirtothrips species evolved separately in New and Old World species. We discussed the relationships among Scirtothrips species together with data on geographic distributions and host plants, and noted inconsistencies that presumably result from homoplasy. [ABSTRACT FROM AUTHOR]
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- 2019
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7. A building-block strategy for dynamic anti-counterfeiting by using (Ba,Sr)Ga2O4:Sm3+ new red persistent luminescent phosphor as an important component.
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Guo, Ao, Zhu, Qi, Zhang, Shimeng, Sun, Xudong, and Li, Ji-Guang
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LIGHT sources , *ELECTRON traps , *PHOSPHORS , *LUMINESCENCE , *SAMARIUM , *PHOTON upconversion , *THERMAL stability , *TERBIUM - Abstract
Long persistent luminescence materials developed to commercial standards are primarily concentrated in the blue and green regions, with only a few in the red region. Red, as one of the three basic colors, can be mixed in various proportions with blue and green to yield various colors. The development of red persistent phosphors has a broader application potential but remains a challenge. A solid-state reaction method was used to synthesize new red persistent luminescent materials of Ba 1- x Sr x Ga 2 O 4 :Sm3+ (x = 0–0.09). In BaGa 2 O 4 , both Sr2+ and Sm3+ preferentially occupy the Ba2+ site rather than the Ga3+ site. When exposed to UV light at 254 nm, the phosphors emit the characteristic red emission of Sm3+ at wavelengths ranging from 500 nm to 750 nm. After removing the UV light source, an intense red afterglow that lasted more than 1400 s was observed. The red afterglow signal reappears after a heating process. Doping Sr2+ reduces the trap depth and improves the red persistent luminescence significantly. Because the escaped electrons from traps compensate for the emission loss of Sm3+ during the heating process, the red phosphors have unimaginably luminescent thermal stability. Thus, the emission intensity at 200 °C is 1.6 times that at room temperature. The prepared red persistent phosphors show multimode luminescence, with the output signal being time and temperature sensitive, indicating that they are potential luminescent materials for anti-counterfeiting applications. Finally, a building-block strategy for advanced anti-counterfeiting applications of dynamic display information is proposed, with red persistent phosphors serving as an important component combined with upconversion phosphors of NaYF 4 :Yb3+, Tm3+, and green persistent phosphors of SrAl 2 O 4 :Eu2+, Dy3+. [ABSTRACT FROM AUTHOR]
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- 2023
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8. The role of Beclin 1 in IR-induced crosstalk between autophagy and G2/M cell cycle arrest.
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Liang, Nan, Liu, Xiaodong, Zhang, Shimeng, and Sun, Hui
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CELL cycle , *CELL cycle regulation , *CROSSTALK , *AUTOPHAGY , *IONIZING radiation - Abstract
Beclin 1 is a well-established core mammalian autophagy protein. Autophagy has been demonstrated to play roles in cellular responses to DNA damage, such as cell cycle regulation and apoptosis. In the present study, we investigated the exact mechanism by which Beclin 1 acts as a bridge between autophagy and cell cycle, when cells are exposed to ionizing radiation (IR). Western blotting and coimmunoprecipitation were performed to investigate protein expression levels and interactions. Immunofluorescence was used to monitor the localization and distribution of the indicated proteins. The levels of apoptosis and cell cycle changes were evaluated by flow cytometry. Double thymidine deoxyribonucleoside (TdR) blocking was conducted to differentiate G2 from mitotic delay. In vitro kinase assays using ATM kinase were performed to elucidate the specific phosphorylation site in Beclin 1. In this study, we show that Beclin 1 knockdown reduces IR-induced autophagy. IR enhanced Beclin 1/PIK3CIII complex activity as demonstrated by the results of coimmunoprecipitation and immunofluorescence assays. An investigation to assess the possible relationship between autophagy and G2/M arrest showed that, similar to the autophagy inhibitor 3MA, Beclin 1 knockdown delayed IR-induced G2/M arrest. Furthermore, the interactions between Beclin 1 and several G2/M checkpoint-related proteins, namely, PLK1 and CDC25C, were observed to increase. In addition, we observed that both 3MA and Beclin 1 inhibition decreased IR-induced apoptosis. Regarding the potential mechanism associated with this phenomenon, we showed that IR induced the interaction between Beclin 1 and Tip60 as well as their redistribution. Furthermore, we demonstrated that Beclin 1 T57 may be a targeted phosphorylation site for ATM. In the present study, we demonstrate the crucial and intricate roles of Beclin 1 in IR-induced autophagy, G2/M cell cycle arrest, and apoptosis. Additionally, Tip60 and ATM were identified as important molecular regulators of Beclin 1. Our findings show the precise mechanism of crosstalk between IR-induced autophagy and G2/M cell cycle arrest. • The roles of Beclin 1 in IR-induced autophagy, G2/M cell cycle arrest, and apoptosis. • Tip60 and ATM were identified as important molecular regulators of Beclin 1. • Beclin 1 mediated the crosstalk between IR-induced autophagy and G2/M cell cycle. [ABSTRACT FROM AUTHOR]
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- 2019
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9. A facile in-situ hydrothermal synthesis of SrTiO3/TiO2 microsphere composite.
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Wang, Hongxing, Zhao, Wei, Zhang, Yubo, Zhang, Shimeng, Wang, Zihao, and Zhao, Dan
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STRONTIUM titanate , *METALLIC composites , *METAL microstructure , *EFFECT of temperature on metals , *PHOTOCATALYSIS - Abstract
TiO 2 was successfully used as sacrificed template to synthesise SrTiO 3 /TiO 2 microsphere composite via an in-situ hydrothermal process. The diameter of SrTiO 3 /TiO 2 microsphere was about 700 nm with the same size of the template, and all of the microspheres were in good dispersity. The optimized reaction parameters for the phase and morphology of the as-synthesized samples were investigated. The results showed the SrTiO 3 /TiO 2 microsphere can be synthesized at 170 °C when the concentration of sodium hydroxide was 0.1 M. Lower hydrothermal temperature hampered the formation of the SrTiO 3 /TiO 2 composite, the higher alkali concentration, however, will destroy the morphology of products. The formation mechanism of SrTiO 3 /TiO 2 microsphere composite was proposed and the photocatalytic properties of the samples were characterized using methylene blue solution as the pollutant under the UV light irradiation. The results indicated the proper OH − concentration will provide a channel for Sr 2+ to react with Ti 4+ located in the template and form the SrTiO 3 /TiO 2 composite, and those with micro-scaled spherical morphology exhibited good photocatalytic activities. [ABSTRACT FROM AUTHOR]
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- 2016
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10. S-Phase Cells Are More Sensitive to High-Linear Energy Transfer Radiation
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Wang, Hongyan, Liu, Shuang, Zhang, Piyan, Zhang, Shimeng, Naidu, Mamta, Wang, Huichen, and Wang, Ya
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CELL cycle , *LINEAR energy transfer , *IONIZING radiation , *DNA repair , *GENETIC recombination - Abstract
Purpose: S-phase cells are more resistant to low-linear energy transfer (LET) ionizing radiation (IR) than nonsynchronized and G1-phase cells, because both nonhomologous end-joining (NHEJ) and homologous recombination repair can repair DNA double-strand breaks (DSBs) in the S phase. Although it was reported 3 decades ago that S-phase cells did not show more resistance to high-LET IR than cells in other phases, the mechanism remains unclear. We therefore attempted to study the phenotypes and elucidate the mechanism involved. Methods and Materials: Wild-type and NHEJ-deficient cell lines were synchronized using the double-thymidine approach. A clonogenic assay was used to detect the sensitivity of nonsynchronized, synchronized S-phase, and G2-phase cells to high- and low-LET IR. The amounts of Ku bound to DSBs in the high- and low-LET–irradiated cells were also examined. Results: S-phase wild-type cells (but not NHEJ-deficient cells) were more sensitive to high-LET IR than nonsynchronized and G2-phase cells. In addition, S-phase wild-type cells showed less efficient Ku protein binding to DSBs than nonsynchronized and G2-phase cells in response to high-LET IR, although all cells at all phases showed similarly efficient levels of Ku protein binding to DSBs in response to low-LET IR. Conclusions: S-phase cells are more sensitive to high-LET IR than nonsynchronized and G2-phase cells, because of the following mechanism: it is more difficult for Ku protein to bind to high-LET IR-induced DNA DSBs in S-phase cells than in cells at other phases, which results in less efficient NHEJ. [Copyright &y& Elsevier]
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- 2009
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