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Your search keyword '"Zhang, Yuan-Yuan"' showing total 208 results
Start Over Author "Zhang, Yuan-Yuan" Publisher elsevier b.v.
208 results on '"Zhang, Yuan-Yuan"'

44. Epidemiological surveillance of acute respiratory infections based on targeted metagenomic next generation sequencing during the flu season after COVID-19 pandemic in Beijing.

Author

Han, Bing, Li, Xu-ming, Li, Ran, Ning, Wu, Zhang, Yuan-yuan, Tang, Yan-fen, Zhang, Ye, Hu, Long, Li, Jian-dong, Liu, Gang, Zhang, Dan, Gu, Li, Xia, Han, Wang, Xi, and Jiang, Rong-meng

Abstract

• During flu season, large-scale multicenter ARI surveillance conducted with tNGS. • tNGS achieved 80.80% positivity, with bacteria at 53.76% and RNA viruses at 76.24%. • Positivity rates for IAV and IBV: 22.16% and 25.28%, showing distinct trends. • Exactly 34.4% samples show mixed infections, primarily bacterial and viral (25.84%). [ABSTRACT FROM AUTHOR]

Published
2024
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49. Associations of Daytime Napping with Incident Cardiovascular Diseases and Hypertension in Chinese Adults: A Nationwide Cohort Study.

Author

WANG, Lu, WANG, Ke, LIU, Lin Jiong, ZHANG, Yuan Yuan, SHU, Hai Nan, WANG, Kai, ZHOU, Pei Xuan, and ZHANG, Yun Quan

Subjects
CARDIOVASCULAR diseases, COHORT analysis, PANEL analysis, ADULTS, HYPERTENSION
Abstract

This study aimed to examine the associations of daytime napping with incident risks of cardiovascular diseases (CVDs) and hypertension (HTN). Data for napping and CVD outcomes in 25 provinces were collected from baseline (2010) and three waves of follow-up (2012–2017) investigations of the China Family Panel Studies. Cox frailty models with random intercepts for the surveyed provinces were used to assess the longitudinal effects of daytime napping on CVD and HTN. Compared with non-nappers, 30+ min nappers had higher risks of CVD and HTN, while no significant associations were observed among < 30 min nappers. Incident risks among 30- to < 60-min nappers increased by 22% [hazard ratio (HR) 1.22, 95% confidence interval (CI) 1.08–1.39] for CVD and 21% (1.21, 1.04–1.41) for HTN, respectively, with corresponding HRs of CVD and HTN of 1.27 (1.09–1.47) and 1.38 (1.16–1.65) among ≥ 60 min nappers. Nap-associated CVD risks varied by subgroups, with stronger associations in participants with lower body mass index (< 24 kg/m2), physically inactive persons, smokers, and participants with longer nighttime sleep (≥ 7 h/night). Significant effects of daytime napping were observed on rural and northern residents only, highlighting great regional variations in CVD risks associated with napping habits. This cohort study revealed strong evidence that long daytime napping (≥ 30 min) is associated with an increased incidence of cardiovascular events. [ABSTRACT FROM AUTHOR]

Published
2022
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50. In vitro metabolism of the emerging contaminant 6PPD-quinone in human and rat liver microsomes: Kinetics, pathways, and mechanism.

Author

Zhang, Yuan-Yuan, Huang, Jun-Wei, Liu, Yue-Hong, Zhang, Jin-Na, Huang, Zheng, Liu, You-Sheng, Zhao, Jian-Liang, and Ying, Guang-Guo

Subjects
LIVER microsomes, EMERGING contaminants, METABOLISM, MOLECULAR docking, RATS, QUINONE, PHENYLENEDIAMINES, PHARMACOKINETICS
Abstract

N -(1,3-dimethylbutyl)- N ′-phenyl- p -phenylenediamine-quinone (6PPD-Q) is an ozonation product of the rubber antioxidant N -(1,3-dimethylbutyl)- N ′-phenyl- p -phenylenediamine (6PPD). 6PPD-Q has recently been detected in various environmental media, which may enter the human body via inhalation and skin contact pathways. However, the human metabolism of 6PPD-Q has remained unknown. This study investigated the in vitro Cytochrome P450-mediated metabolism of 6PPD-Q in human and rat liver microsomes (HLMs and RLMs). 6PPD-Q was significantly metabolized at lower concentrations but slowed at high concentrations. The intrinsic clearance (CL int) of 6PPD-Q was 21.10 and 18.58 μL min−1 mg−1 protein of HLMs and RLMs, respectively, suggesting low metabolic ability compared with other reported pollutants. Seven metabolites and one intermediate were identified, and metabolites were predicted immunotoxic or mutagenic toxicity. Mono- and di-oxygenation reactions were the main phase I in vitro metabolic pathways. Enzyme inhibition experiments and molecular docking techniques were further used to reveal the metabolic mechanism. CYP1A2, 3A4, and 2C19, especially CYP1A2, play critical roles in 6PPD-Q metabolism in HLMs, whereas 6PPD-Q is extensively metabolized in RLMs. Our study is the first to demonstrate the in vitro metabolic profile of 6PPD-Q in HLMs and RLMs. The results will significantly contribute to future human health management targeting the emerging pollutant 6PPD-Q. [Display omitted] • We firstly reported the in vitro metabolism of 6PPD-Q in HLMs and RLMs. • CL int of 6PPD-Q was at tens μ L·min−1 mg−1 protein, suggesting low metabolic ability. • Seven metabolites and one intermediate were identified. • Mono- and di-oxygenation reactions were the main phase I metabolic pathways. • Reaction phenotype analysis reveals the main CYP isoforms. [ABSTRACT FROM AUTHOR]

Published
2024
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