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The aim of the study was to investigate the antioxidant effect of seleno-amino-oligosaccharide (Se-AOS) on intestinal porcine epithelial cells (IPEC-1). MTT assay showed that Se-AOS had no effect on the viability of IPEC-1 cells up to a concentration of 9200 μg/L and Se-AOS significantly increased the viability of IPEC-1 cells compared to cells exposed to H 2 O 2 alone. Se-AOS significantly increased the level of superoxide Dismutase (SOD) and decreased the levels of malonic dialdehyde (MDA) and lactate dehydrogenase (LDH) in IPEC-1 cells. The gene expression levels of different antioxidant enzymes dramatically increased by the pretreatment of Se-AOS compared to H 2 O 2 treatment. In addition, the results indicated that Se-AOS up-regulated the intracellular Nrf2 and down-regulated the level of Keap1 by western blot. Taken together, these findings suggested that Se-AOS can protect IPEC-1 cells from oxidative damage through activating the Keap1/Nrf2 signaling pathway. [ABSTRACT FROM AUTHOR]

Highlights • We analyzed the main issues involved in the satellite range scheduling system. • Established SRSP mathematical model and constraints, assumptions. • An improved genetic algorithm and local search method are proposed. • Verify the effectiveness of the proposed algorithm under different scenarios. Abstract Satellites play an important role in such areas as environmental monitoring and disaster prediction that are related to human survival and development. Satellite monitoring and control is the key to the satellite's management and control of the ground to ensure its smooth implementation. Because of the imbalance of demand and available resources, satellite range scheduling has become particularly important. This paper analyzes the satellite range scheduling problem and sets up mathematical models and constraints. Afterwards, this paper proposes an efficient algorithm that combines improved genetic algorithm and local search method. The improved genetic algorithm is used to rapidly improve the quality of the planning scheme, and the neighborhood search is used for the subsequent small-scale optimization. In order to improve the speed of search, our algorithm uses a reorganization operation and a mutation operation adjusted with the number of iterations. In order to test the effectiveness of the algorithm, we conducted experimental verifications of the calculations of various types of satellites at different mission scales and compared them with other algorithms. [ABSTRACT FROM AUTHOR]

Abstract: Polysaccharides extracted from papaya are a group of heteropolysaccharides, and their antioxidant activities and moisture-preserving activities were investigated employing various established in vitro systems. Available data obtained with in vitro models suggested that among the three samples, the second fraction (named after P2) showed significant inhibitory effects on superoxide, hydroxyl and DPPH radical; its reducing power was also the strongest. Data also reveal that P2 has strong in vitro moisture absorption and retention capacities as compared to hyaluronic acid and glycerol. These results clearly establish the possibility that polysaccharides extracted from papaya could be effectively employed as a type of natural moisturizer. However, comprehensive studies need to be conducted in experimental animal models. [Copyright &y& Elsevier]

Abstract: Porphyran (P) was extracted from red algae Porphyra by boiling water. A novel polysaccharide-iron complex (LPPC) was prepared under the alkaline condition by adding a ferric chloride solution to the low molecular weight porphyran (LP) solution. Physicochemical properties and inhibition effect on iron deficiency anemia of this complex were studied. The content of iron(III) in the complex is 21.57% determined with iodometry. The results indicate that LPPC was product required. The complex can increase red blood cell count (RBC), hemoglobin (Hb), Serum iron (SI), spleen index, spleen mass and mass of mice with iron deficiency anemia (IDA). Although the structure and deeper mechanisms on hemolytic anemia of LPPC should be further studied, LPPC is hoped to be developed as a late-model iron supplement which has a synergism on anemia. [Copyright &y& Elsevier]