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Your search keyword '"Zhao, Qianqian"' showing total 169 results
Start Over Author "Zhao, Qianqian" Publisher elsevier b.v.
169 results on '"Zhao, Qianqian"'

49. KNbTeO6 transparent ceramics prepared by the combination of pressure-less sintering and pseudo hot isostatic pressing.

Author

Zhao, Qianqian, Wang, Hao, Tu, Bingtian, Xu, Pengyu, Jing, Zhengyang, Wang, Weimin, and Fu, Zhengyi

Subjects
*CERAMICS, *ISOSTATIC pressing, *TRANSPARENT ceramics, *HOT pressing, *SINTERING, *SPINEL
Abstract

KNbTeO 6 transparent ceramics were prepared by combining pressure-less sintering and pseudo-hot isostatic pressing (PHIP) of the synthesized submicron single-phase powder. The PHIP was conducted by wrapping coarse magnesium aluminate powders around the pre-sintered body in the spark plasma sintering (SPS) furnace. With an average grain size of 412 ± 23 nm, the in-line transmittance of transparent KNbTeO 6 ceramics reaches 80.25% at 2677 nm. By contrast, the density of the samples prepared by conventional SPS with the same sintering procedure is only 98.73%, and the highest in-line transmittance 64.25% occurs at 4976 nm. In particular, by investigating the sintering mechanism of PHIP, the improvement of microstructure and optical transmittance could be attributed to the plastic deformation caused by shear stress. The obtained ceramics exhibited excellent mechanical and dielectric properties, which was benefited from the novel sintering technology. • KNbTeO 6 transparent ceramics without significant grain growth were prepared by an innovative sintering route，and the optical, mechanical and dielectric properties of ceramics were synergistically improved. • Common SPS equipment was proved to be suitable for PHIP, and that transparent ceramics could be prepared with much higher transmittance compared to conventional SPS. • The plastic deformation of PHIP could effectively strengthen the densification process and optimize the microstructure. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Transferrin-targeted iridium nanoagglomerates with multi-enzyme activities for cerebral ischemia-reperfusion injury therapy.

Author

Du, Wenxian, Wang, Jienan, Zhou, Lingling, Zhou, Jia, Feng, Lishuai, Dou, Chaoran, Zhang, Qiang, Zhang, Xiaoxing, Zhao, Qianqian, Cai, Xiaojun, Wu, Jianrong, Zheng, Yuanyi, and Li, Yuehua

Subjects
REPERFUSION injury, TRANSFERRIN, GLUTATHIONE peroxidase, BLOOD-brain barrier, IRIDIUM, CATALASE, REACTIVE oxygen species, HYDROXYL group, BRAIN injuries
Abstract

Cerebral ischemia-reperfusion injury (CIRI) is a complex pathological condition with high mortality. In particular, reperfusion can stimulate overproduction of reactive oxygen species (ROS) and activation of inflammation, causing severe secondary injuries to the brain. Despite tremendous efforts, it remains urgent to rationally design antioxidative agents with straightforward and efficient ROS scavenging capability. Herein, a potent antioxidative agent was explored based on iridium oxide nano-agglomerates (Tf-IrO 2 NAs) via the facile transferrin (Tf)-templated biomineralization approach, and innovatively applied to treat CIRI. Containing some small-size IrO 2 aggregates, these NAs possess intrinsic hydroxyl radicals (•OH)-scavenging ability and multifarious enzyme activities, such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GP x). Moreover, they also showed improved blood-brain barrier (BBB) penetration and enhanced accumulation in the ischemic brain via Tf receptor-mediated transcytosis. Therefore, Tf-IrO 2 NAs achieved robust in vitro anti-inflammatory and cytoprotection effects against oxidative stress. Importantly, mice were effectively protected against CIRI by enhanced ROS scavenging activity in vivo , and the therapeutic mechanism was systematically verified. These findings broaden the idea of expanding Ir-based NAs as potent antioxidative agents to treat CIRI and other ROS-mediated diseases. (1) The ROS-scavenging activities of IrO 2 are demonstrated comprehensively, which enriched the family of nano-antioxidants. (2) The engineering Tf-IrO 2 nano-agglomerates present unique multifarious enzyme activities and simultaneous transferrin targeting and BBB crossing ability for cerebral ischemia-reperfusion injury therapy. (3) This work may open an avenue to enable the use of IrO 2 to alleviate ROS-mediated inflammatory and brain injury diseases. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
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