1. The significance of bone marrow cell morphology and its correlation with cytogenetic features in the diagnosis of MDS-RA patients
- Author
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Liu, Dandan, Chen, Zixing, Xue, Yongquan, Lu, Dingwei, Zhou, Youning, Gong, Jingxia, Wu, Weilin, Liang, Jianying, Ma, Qinfen, Pan, Jinlan, Wu, Yafang, Wang, Yong, Zhang, Jun, and Shen, Juan
- Subjects
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MYELODYSPLASTIC syndromes , *BONE marrow cells , *CELL morphology , *DYSPLASIA , *KARYOTYPES , *ANEMIA , *CHROMOSOME abnormalities , *DIAGNOSIS - Abstract
Abstract: Besides cytopenia, dysplasia is crucial characteristic of MDS-RA. To summarize the morphological features that contribute to the diagnosis of MDS-RA, 48 RA patients with abnormal karyotype were analyzed for the features of morphological and cytogenetical abnormalities and the relationships between them. 46 MDS-RA patients with normal karyotype and 207 patients with non-MDS anemia were enrolled into control groups. More conspicuous and diverse dysplasia can be found in abnormal karyotype MDS-RA than those in control groups (P <0.05). Apparent dysplasia in granulocyte and megakaryocytoid lineages may provide valuable evidence for the diagnosis. Dysplasia occurred more frequently in patients with severe chromosome abnormalities. [Copyright &y& Elsevier]
- Published
- 2009
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