Search

Your search keyword '"Zieliński, Zbigniew"' showing total 8 results
Start Over Author "Zieliński, Zbigniew" Publisher elsevier b.v.
8 results on '"Zieliński, Zbigniew"'

2. Properties of phosphorylated thymidylate synthase

Author

Frączyk, Tomasz, Ruman, Tomasz, Wilk, Piotr, Palmowski, Paweł, Rogowska-Wrzesinska, Adelina, Cieśla, Joanna, Zieliński, Zbigniew, Nizioł, Joanna, Jarmuła, Adam, Maj, Piotr, Gołos, Barbara, Wińska, Patrycja, Ostafil, Sylwia, Wałajtys-Rode, Elżbieta, Shugar, David, and Rode, Wojciech

Published
2015
Full Text
View/download PDF

5. Synthesis, reactivity and biological activity of N(4)-boronated derivatives of 2'-deoxycytidine.

Author

Nizioł, Joanna, Zieliński, Zbigniew, Leś, Andrzej, DČbrowska, Magdalena, Rode, Wojciech, and Ruman, Tomasz

Subjects
*DRUG synthesis, *REACTIVITY (Chemistry), *BORON, *ANALYTICAL chemistry, *DEOXYCYTIDINE, *DRUG delivery systems, *NUCLEOSIDES
Abstract

By seeking new stable boron-containing nucleoside derivatives, potential BNCT boron delivery agents, a novel synthetic approach was tested, aimed at a boron attachment via a single bond to an aliphatic carbon of sp3 hybridization. The latter allowed successful modification of deoxycytidine in the reaction with 2-(iodomethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane of the deoxynucleoside amino group. For new compounds, detailed NMR, LDI HRMS (Laser Desorption/Ionization High-Resolution Mass Spectrometry) analyses along with in vivo phosphorylation studies, toxicity assays and DFT modelling are presented. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results