Search

Your search keyword '"Zou, Lina"' showing total 126 results
Start Over Author "Zou, Lina" Publisher elsevier b.v.
126 results on '"Zou, Lina"'

21. Survivin as a potential biomarker in the diagnosis of bladder cancer: A systematic review and meta-analysis.

Author

Zhou, Zhiren, Zou, Lina, Guan, Yue, Jiang, Lizhe, Liu, Yanan, Zhang, Xueqing, Huang, Xiaojing, Ren, Huanyu, Li, Zheng, Niu, Huiru, Liao, Hao, Zhang, Xiaojing, Pan, Hongzhi, Rong, Shengzhong, and Ma, Hongkun

Subjects
*BLADDER cancer, *SURVIVIN (Protein), *CANCER diagnosis, *BIOMARKERS, *TUMOR markers, *ODDS ratio
Abstract

• Survivin as an effective diagnostic marker of bladder cancer was confirmed. • Sensitivity of survivin mRNA was higher than that of survivin protein. • Immunohistochemical detection of survivin is more effective for diagnosis. Early detection, diagnosis, and treatment take on critical significance in preventing and treating bladder cancer. As indicated by numerous studies, survivin can serve as a biomarker of bladder cancer, whereas the results of a wide variety of studies have been controversial. This paper is to assess the accuracy of survivin in the diagnosis of bladder cancer by a meta-analysis. The studies regarding the diagnosis of bladder cancer using survivin were systematically retrieved from the CNKI, WanFang, CBM, VIP, Web of science, cochrane library and pubmed were extracted, and the literature quality was assessed. Meta-analysis was conducted using STATA 16.0 MP. 2,082 relevant studies were searched, and 40 studies were finally covered for meta-analysis. The pooled specificity and pooled sensitivity of survivin mRNA was 0.95 (95% CI : 0.91, 0.97) and 0.94 (95% CI : 0.88, 0.97). The pooled specificity and pooled sensitivity of survivin protein reached 0.95 (95% CI : 0.90, 0.97) and 0.87 (95% CI : 0.78, 0.92). The pooled positive likelihood ratio, pooled negative likelihood ratio, the area under the curve, and diagnostic odds ratio for survivin mRNA reached 17.7 (95% CI : 10.3, 30.6), 0.07 (95% CI : 0.04, 0.12), 0.98 (95% CI : 0.97, 0.99) and 266 (95% CI : 114, 621), respectively. For survivin protein was 16.4 (95% CI : 7.9, 33.9), 0.14 (95% CI : 0.08, 0.24), 0.97 (95% CI : 0.95, 0.98) and 117 (95% CI : 38, 357), respectively. Survivin takes on great significance in diagnosing bladder cancer. However, due to some limitations in the number and quality of covered studies, this conclusion should be validated through additional higher quality clinical studies. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results