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Start Over Descriptor "a desintegrin and metalloprotease (ADAM)" Publisher elsevier b.v.
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1. Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes.

Author

Silva, Tiago, Reis, Joana, Teixeira, José, and Borges, Fernanda

Subjects
*ALZHEIMER'S disease, *PROTOTYPES, *DRUG design, *ACETYLCHOLINESTERASE inhibitors, *EFFECT of drugs on enzymes, *GLYCOGEN synthase kinase, *NATURAL products
Abstract

Highlights: [•] Alzheimer's disease: the state of the drug discovery art. [•] Acetylcholinesterase inhibitors in therapy. [•] New enzymatic targets and inhibitors/enhancers. [•] Secretases, sirtuins, caspases, glycogen synthase kinase-3. [•] Autophagy and synaptogenesis inhibitors/enhancers. [ABSTRACT FROM AUTHOR]

Published
2014
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