1. Effectiveness of topical caraway essential oil loaded into nanostructured lipid carrier as a promising platform for the treatment of infected wounds.
- Author
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Tazehjani, Del Aram Jafari, Farahpour, Mohammad Reza, and Hamishehkar, Hamed
- Subjects
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ESSENTIAL oils , *LIPIDS , *GRANULATION tissue , *STAPHYLOCOCCUS epidermidis , *SCANNING electron microscopy - Abstract
The present study was conducted to evaluate the in vitro antibacterial activity and wound healing effects of caraway essential oil (CEO) loaded into nanostructured lipid carriers (CEO-NLCs). Zeta size (ZS), zeta potential (ZP) and scanning electron microscopy (SEM) techniques were employed in order to investigate the size and morphology of CEO-NLCs. According to the obtained results, the particle size was 40 nm-250 nm with narrow PDI∼0.23. The ZP value of all the CEO-NLCs was -11.7. The findings of SEM analysis showed a smooth-surfaced, spherical and uniform distribution of the particles. The results of In vitro studies indicated the antibacterial activity of the CEO-NLCs groups against Escherichia coli , Staphylococcus aureus , Staphylococcus epidermidis and Pseudomonas aeruginosa compared to blank and DMSO. Topical administration of the CEO-NLCs decreased the inflammatory phase whereas it increased granulation tissue formation. Seemingly, the CEO-NLCs can be used for the treatment of the infected excision wounds in the clinical condition. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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