7 results on '"dos Santos, Antonio C."'
Search Results
2. 3D DEWS digital parametric modeling and manufacturing for obtaining the post-cracking parameters of SFRC.
- Author
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Buttignol, Thomaz E.T., dos Santos, Antonio C., and Bitencourt, Luís A.G.
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PARAMETRIC modeling , *FIBER-reinforced concrete , *DISTRIBUTION (Probability theory) , *DATA acquisition systems , *DEW - Abstract
A pullout analytical model is introduced to simulate the Double Edge Wedge Splitting (DEWS) test to obtain the tensile post-peak response of steel fiber reinforced concretes. One of the main barriers to the widespread utilization of FRC as a structural system is the anisotropy of the material. This augments the uncertainty of the material behavior (fibers random distribution and orientation in the bulk concrete), increases the dispersion of the test results, and requires the performance of characterization tests to check the residual tensile stresses at specific crack opening intervals. The characterization tests proposed in the literature (e.g., Barcelona, Montevideo, Wedge Splitting Test, EN 14651) are time-consuming and relatively complex, demanding careful preparation and hydraulic presses with data acquisition systems. This paper aims to contribute to the discussion of alternatives for FRC characterization procedures by the introduction of a pullout analytical model to predict FRC constitutive law based on DEWS tests. The pullout analytical model is calibrated with pullout tests considering straight and hooked-end steel fibers with different strengths, embedment lengths, inclinations, and diameters. A 3D digital model reproducing the experimental DEWS samples is developed, considering the fibers' randomness distribution, orientation, and wall effect. The analyses are compared with four different experimental tests. The results define a linear post-peak tensile constitutive law, considering the mean residual stress values at different COD values. The model was able to reproduce the specimens' production procedures and the fibers' distribution and orientation correctly. The results demonstrated a good agreement with the experimental data. [Display omitted] • Pullout analytical model for straight and hooked-end steel fibers. • 3D parametric digital model considering fibers random distribution and wall effect. • Prediction of DEWS tests considering the manufacturing process. • Determination of FRC linear tensile post-peak constitutive model. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice
- Author
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Casagrande, Rúbia, Georgetti, Sandra R., Verri, Waldiceu A., Jr., Dorta, Daniel J., dos Santos, Antônio C., and Fonseca, Maria J.V.
- Published
- 2006
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4. Effect of pelleting on the enzymatic digestibility of corn stover.
- Author
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Chen, Xueli, Freitas dos Santos, Antonio C., Ramirez Gutierrez, Diana M., Song, Peiyuan, Aston, John E., Thompson, David N., Dooley, James H., Ladisch, Michael R., and Mosier, Nathan S.
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CORN stover , *PELLETIZING , *SIZE reduction of materials , *LIGNOCELLULOSE - Abstract
[Display omitted] • Pelleting improved the bulk density and enzymatic digestibility of corn stover. • Stover composition was not significantly altered by high moisture pelleting. • Pelleting decreased substrate surface area but increased protein accessibility. • Hydrolysis of cross-linking structures may occur during the pelleting process. Pelleting of lignocellulosic biomass to improve its transportation, storage and handling impacts subsequent processing and conversion. This work reports the role of high moisture pelleting in the enzymatic digestibility of corn stover prior to pretreatment, together with associated substrate characteristics. Pelleting increases the digestibility of unpretreated corn stover, from 8.2 to 15.5% glucan conversion, at 5% solid loading using 1 FPU Cellic® CTec2 per g solids. Compositional analysis indicates that loose and pelleted corn stover have similar non-dissolvable compositions, although their extractives are different. Enzymatic hydrolysis of corn stover after size reduction to normalize particle sizes and removal of extractives confirms that pelleting improves corn stover digestibility. Such differences may be explained by the decreased particle size, improved substrate accessibility, and hydrolysis of cross-linking structures induced by pelleting. These findings are useful for the development of processing schemes for sustainable and efficient use of lignocellulose. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
- View/download PDF
5. New strategy for liquefying corn stover pellets.
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dos Santos, Antonio C. Freitas, Overton, Jonathan C., Szeto, Ryan, Patel, Maulik H., Gutierrez, Diana M.R., Eby, Clark, Martínez Moreno, Ana M., Erk, Kendra A., Aston, John E., Thompson, David N., Dooley, James H., Sharma, Pankaj, Mosier, Nathan S., Ximenes, Eduardo, and Ladisch, Michael R.
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CORN stover , *MALEIC acid , *HYDROLASES , *YIELD stress , *SLURRY , *MAGNITUDE (Mathematics) - Abstract
• Corn stover pellets (300 g/L) were successfully liquefied without pretreatment. • Combination of enzyme and maleic acid liquefactions reduced yield stress 40 times. • Efficient mixing improved liquefaction by an order of magnitude. • Mimetic maleic acid cooking of biomass lowered subsequent inhibition of enzymes. The movement of solid material into and between unit operations within a biorefinery is a bottleneck in reaching design capacity, with formation of biomass slurries needed to introduce feedstock. Corn stover slurries have been achieved from dilute acid, pretreated materials resulting in slurry concentrations of up to about 150 g/L, above which flowability is compromised. We report a new strategy to liquefy corn stover at higher solids concentration (300 g/L) by initially cooking it with the enzyme mimetic maleic acid at 40 mM and 150 °C. This is followed by 6 h of enzymatic modification at 1 FPU (2.2 mg protein)/g solids, resulting in a yield stress of 171 Pa after 6 h and 58 Pa in 48 h compared to 6806 Pa for untreated stover. Mimetic treatment of corn stover pellets minimizes the inhibitory effect of xylo -oligomers on hydrolytic enzymes. This strategy allows for the delivery of solid lignocellulosic slurry into a pretreatment reactor by pumping, improving operability of a biorefinery. [ABSTRACT FROM AUTHOR]
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- 2021
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- View/download PDF
6. Mechanisms for consideration for intervention in the development of organophosphorus-induced delayed neuropathy
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Emerick, Guilherme L., DeOliveira, Georgino H., dos Santos, Antonio C., and Ehrich, Marion
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NEUROPATHY , *ORGANOPHOSPHORUS compounds , *NEURODEGENERATION , *ATAXIA , *PARALYSIS , *CARBAMATES , *SKELETAL muscle , *HOMEOSTASIS - Abstract
Abstract: Organophosphorus-induced delayed neuropathy (OPIDN) is a neurodegenerative disorder characterised by ataxia progressing to paralysis with concomitant central and peripheral distal axonopathy. Symptoms of OPIDN in people include tingling of the hands and feet. This tingling is followed by sensory loss, progressive muscle weakness and flaccidity of the distal skeletal muscles of the lower and upper extremities and ataxia, which appear about 8–14days after exposure. Some organophosphorus compounds (OPs) that are still used in worldwide agriculture have potential to induce OPIDN, including methamidophos, trichlorfon, dichlorvos and chorpyrifos. This review summarizes experimental attempts to prevent and/or treat OPIDN and the different mechanisms involved in each approach. The initial mechanism associated with development of OPIDN is phosphorylation and inhibition of neuropathy target esterase (NTE). The phosphorylated enzyme undergoes a second reaction known as “aging” that results in the loss of one of the “R” groups bound to the phosphorus of the OP. A second mechanism involved in OPIDN is an imbalance in calcium homeostasis. This can lead to the activation of calcium-activated neutral protease and increases in calcium/calmodulin-dependent protein kinases. These events contribute to aberrant phosphorylation of cytoskeletal proteins and protein digestion in the terminal axon that can proceed similarly to Wallerian-type degeneration. Several experimental studies demonstrated alleviation of the signs and symptoms of OPIDN by restoring calcium balance. Other studies have used preadministration of NTE inhibitors, such as carbamates, thiocarbamates, sulfonyl fluorides and phosphinate to prevent OPIDN. Progress is being made, but there is yet no single specific treatment available for use in clinical practice to prevent or alleviate the severe effects of OPIDN. [Copyright &y& Elsevier]
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- 2012
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7. Dehydromonocrotaline inhibits mitochondrial complex I. A potential mechanism accounting for hepatotoxicity of monocrotaline
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Mingatto, Fábio E., Dorta, Daniel J., dos Santos, Aline B., Carvalho, Ivone, da Silva, Carlos H.T.P., da Silva, Vinícius B., Uyemura, Sérgio A., dos Santos, Antonio C., and Curti, Carlos
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MONOCROTALINE , *ORGANELLES , *CELL membranes , *SCIENTIFIC method - Abstract
Abstract: Monocrotaline is a pyrrolizidine alkaloid present in plants of the Crotalaria species, which causes cytotoxicity and genotoxicity, including hepatotoxicity in animals and humans. It is metabolized by cytochrome P-450 in the liver to the alkylating agent dehydromonocrotaline. We evaluated the effects of monocrotaline and its metabolite on respiration, membrane potential and ATP levels in isolated rat liver mitochondria, and on respiratory chain complex I NADH oxidase activity in submitochondrial particles. Dehydromonocrotaline, but not the parent compound, showed a concentration-dependent inhibition of glutamate/malate-supported state 3 respiration (respiratory chain complex I), but did not affect succinate-supported respiration (complex II). Only dehydromonocrotaline dissipated mitochondrial membrane potential, depleted ATP, and inhibited complex I NADH oxidase activity (IC50=62.06μM) through a non-competitive type of inhibition (K I=8.1μM). Therefore, dehydromonocrotaline is an inhibitor of the activity of respiratory chain complex I NADH oxidase, an action potentially accounting for the well-documented monocrotaline''s hepatotoxicity to animals and humans. The mechanism probably involves change of the complex I conformation resulting from modification of cysteine thiol groups by the metabolite. [Copyright &y& Elsevier]
- Published
- 2007
- Full Text
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