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Abstract: Regional and University Hospitals of Lille holds many of analysis laboratories with a great diversity of biology specialities. To date, a great biology center is building to accommodate there all these laboratories at the beginning of 2007. In this biology center, a room of metrology is foreseen where will be carried out the update of the metrological checks on the equipment concerned and the metrological traceability. The analysis laboratories of medical biology must have a perfect control of their equipment within the framework of the analytical process in order to ensure the quality of their results. This first work is a reflection on the failures of the metrology function within the laboratories from the biomedical point of view. Finally, the objective will be to provide to the laboratories of a coherent and homogeneous metrology tool to all the specialities of the biology of the CHRU of Lille to the service of their quality assurance. [Copyright &y& Elsevier]

Résumé: Dans un espace de Baire une propriété est générique ( « quasi-sûre ») si elle a lieu sur une intersection dénombrable d''ouverts denses. Dans un espace de Fréchet (qui est de Baire) une propriété est prévalente ( « presque sûre ») si elle est presque sûre pour une probabilité et toutes ses translatées. On sait qu''une conjonction dénombrable de propriétés prévalentes est prévalente (Christensen 1972 ; Hunt, Sauer et Yorke 1992) et des exemples de propriétés prévalentes sont connus (Hunt 1994 ; Jaffard 2004 ; Fraysse 2005) ; dans beaucoup de cas, ce sont également des propriétés génériques. L''article concerne les fonctions continues ou hölderiennes sur la droite, à valeurs dans , et met en évidence des propriétés prévalentes très différentes des propriétés génériques. Un appendice donne une version rapide de la théorie de la prévalence dans les espaces de Fréchet. [Copyright 2006 Elsevier]

Based on the hypothesis that rhythmical, tremor-like movements produced by normal subjects might be influenced by similar central oscillatory neuronal networks believed to determine the features of the pathologic tremors of Parkinson’s disease (PD) or Essential Tremor (ET) patients, we examined the neurophysiological characteristics of a tremor mimicked by normal volunteers and compare this data with those from PD or ET tremors. Voluntarily simulated tremor (VST) was studied in 47 neurologically intact subjects, resting tremor in 10 patients with PD and postural tremor in 10 patients with ET. Using a tremor analysis system based on a solid state gyroscopic sensor sensitive to angular rate, the following parameters were determined : frequency, amplitude (angular displacement) and regularity (Q coefficient of constancy). We also performed an inertial loading test and a test-retest analysis. Nearly all normal subjects were able to simulate a tremor that was indistinguishable, in frequency and regularity, from that of PD or ET, although the amplitude was significantly higher in normal subjects. As in pathological tremors, the VST frequency was significantly influenced by age, but not by gender, handedness or previous knowledge of tremor. Inertial load did not modify the tremor frequency, suggesting that mechanical factors were minor. We also found a logarithmic inverse relationship between frequency and amplitude of the VST. We concluded that VST shares many similarities with pathological tremors. It is therefore possible that all tremors are somehow influenced by the same central oscillators which may become disinhibited and clinically apparent in pathological conditions such as PD or ET. [ABSTRACT FROM AUTHOR]