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Abstract: The concepts underlying the connectivity of neurons and the dynamics of interaction required to explain information processing have undergone significant change over the past century. A re-examination of the evolution of the modern view in historical context reveals that rules for connectivity have changed in a manner that might be expected from critical analysis enabled by technical advance. A retrospective examination of some germane issues that moved Camillo Golgi to question the widely held dogma of his era reveals network principles that could not have been recognized a century ago. The currently evolving rules of cellular discontinuity and interaction have proven sufficiently complex to justify the arguments of critical skepticism that sustain scientific progress. [ABSTRACT FROM AUTHOR]

Abstract: In 1906 the Nobel Prize in Physiology or Medicine was shared between Camillo Golgi and Ramón y Cajal in recognition of their work on the structure of the nervous system. Golgi''s most impressive contribution was his method, described in 1873. This was applied in studies of the cerebellum, the olfactory bulb, hippocampus and the spinal cord. These studies together with his earlier work were included in his Opera Omnia, published in 1903. His method was highly praised by Cajal. His adherence to the reticular theory was opposed by Cajal, however, who had spelled out the neuron theory already in the late 1800s. Cajal''s extraordinary contributions to the structure of the nervous system, based largely on the Golgi method and Ehrlich''s methylene blue stain, were published in his Textura del Sistema Nerviosa de Hombre y de los Vertebrados, three volumes published from 1897 to 1904. Documents from the Nobel Archives reveal that Kölliker, Retzius and Fürst were the ones who proposed Golgi and Cajal for a shared prize. Golgi was nominated by Hertwig, as well. Cajal was proposed by Ziehen and Holmgren, and also by Retzius, as an alternative to a shared prize. Holmgren, who was commissioned to write the report to the Nobel Committee, found Cajal far superior to Golgi. Sundberg, asked for another evaluation, was more positive to Golgi''s contributions than Holmgren. Gadelius supported Holmgren''s views. The final vote gave a majority for a shared prize. The prize ceremony and the lectures were described in detail in Cajal''s autobiography. [Copyright &y& Elsevier]

Abstract: While Golgi''s concept of the sensory neuron provided sound reasons for his rejection of the polarity principles underlying the ‘neuron doctrine’, it is now apparent that his concern about recovery of function after injury and the vast modern findings of ephemerality of connexin-clustered connections in the cerebral cortex and elsewhere in the central nervous system, and credibly termed ‘reticularist’, has somewhat eclipsed the polarized neuron doctrine of reflex physiology with the “fixed and immutable” connections championed by Cajal. Although Golgi''s view was not the result of incisive reasoning based on subsequently confirmed observation, both principles espoused by these combatant Nobel laureate partners have proven robustly operative in different spheres and time frames of neural activity that have vastly enhanced contemporary understanding of neural connectivity. [Copyright &y& Elsevier]

Abstract: The 100th anniversary of the shared first Nobel prize in neuroscience by Camillo Golgi and Ramon y Cajal invites reappraisal of the merits of the arguments adduced by these two combative scientists in the light of contemporary knowledge. Guided by cogent reasons for reluctance in accepting the inviolable polarity principle of the neuron doctrine and concern for explaining cerebral recovery of function, Golgi joined the ‘reticularists’ of his generation. Modern observations of axo-axonic and dendro-dendritic synapses, gap-junction interconnections, rules for the direction and mode of analog or impulse conduction, the myriad diversity of ion channels and gating principles and the complexities of synaptic plasticity have eclipsed the polarized neuron doctrine explanations of reflex physiology and the ‘fixed and immutable’ connections successfully championed by Cajal. Without violating the cell theory, expanded modes of neuronal and glial communication have encompassed reticularist notions and provided insight into the long-term changes underlying synaptic and extra-synaptic neural patterns. Both laureates espoused operative principles that have survived in different modes and distinctive temporal domains. Together, they reflect the roots of our contemporary understanding of neural interaction. [Copyright &y& Elsevier]