1. Proportion of published primary health care protocols with published results in subsequent papers was decreasing
- Author
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Eleni Ntalaouti, Christina Antoniadou, Athina Tatsioni, Chrysoula Doxani, Elias Zintzaras, and Ioannis Staikos
- Subjects
PubMed ,medicine.medical_specialty ,Epidemiology ,Trial protocol ,Primary health care ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Primary outcome ,Clinical Protocols ,Randomized controlled trial ,law ,medicine ,Humans ,030212 general & internal medicine ,Randomized Controlled Trials as Topic ,Protocol (science) ,Primary Health Care ,Absolute number ,business.industry ,Publication bias ,Clinical trial ,Emergency medicine ,Journal Impact Factor ,Periodicals as Topic ,business ,030217 neurology & neurosurgery - Abstract
Objectives We assessed the proportion of primary health care (PHC) randomized controlled trial (RCT) protocols published in peer-reviewed journals that published results in subsequent papers in peer-reviewed journals; and whether this proportion changed over time. Study Design and Setting We searched (last update June 2019) for RCTs published in peer-reviewed journals reporting primary outcome results for 620 protocols that were published up to 2014 and were retrieved in PubMed. We recorded the absolute number and the proportion of protocols with published results per year; and estimated whether the proportion changed over time. Results Of the 620 published protocols, 525 (85%) disseminated their results through a published RCT by June 2019. The number of published protocols was increasing over time especially after 2001. However, the proportion of protocols per year with published results in subsequent papers was decreasing over time after 2002. Specifically, the proportion ranged from 86% to 96% for protocols published until 2010 while for those published from 2011 onward ranged from 76% to 86%. Mean time from protocol to results publication was 39 months (95% CI 37, 41). Conclusion Almost one-sixth of PHC trial protocols published in peer-reviewed journals did not publish their results in subsequent papers.
- Published
- 2020