11 results on '"Álvaro Quintanal-Villalonga"'
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2. The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution
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Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer E. Rood, Orr Ashenberg, Ethan Cerami, Robert J. Coffey, Emek Demir, Li Ding, Edward D. Esplin, James M. Ford, Jeremy Goecks, Sharmistha Ghosh, Joe W. Gray, Justin Guinney, Sean E. Hanlon, Shannon K. Hughes, E. Shelley Hwang, Christine A. Iacobuzio-Donahue, Judit Jané-Valbuena, Bruce E. Johnson, Ken S. Lau, Tracy Lively, Sarah A. Mazzilli, Dana Pe’er, Sandro Santagata, Alex K. Shalek, Denis Schapiro, Michael P. Snyder, Peter K. Sorger, Avrum E. Spira, Sudhir Srivastava, Kai Tan, Robert B. West, Elizabeth H. Williams, Denise Aberle, Samuel I. Achilefu, Foluso O. Ademuyiwa, Andrew C. Adey, Rebecca L. Aft, Rachana Agarwal, Ruben A. Aguilar, Fatemeh Alikarami, Viola Allaj, Christopher Amos, Robert A. Anders, Michael R. Angelo, Kristen Anton, Jon C. Aster, Ozgun Babur, Amir Bahmani, Akshay Balsubramani, David Barrett, Jennifer Beane, Diane E. Bender, Kathrin Bernt, Lynne Berry, Courtney B. Betts, Julie Bletz, Katie Blise, Adrienne Boire, Genevieve Boland, Alexander Borowsky, Kristopher Bosse, Matthew Bott, Ed Boyden, James Brooks, Raphael Bueno, Erik A. Burlingame, Qiuyin Cai, Joshua Campbell, Wagma Caravan, Hassan Chaib, Joseph M. Chan, Young Hwan Chang, Deyali Chatterjee, Ojasvi Chaudhary, Alyce A. Chen, Bob Chen, Changya Chen, Chia-hui Chen, Feng Chen, Yu-An Chen, Milan G. Chheda, Koei Chin, Roxanne Chiu, Shih-Kai Chu, Rodrigo Chuaqui, Jaeyoung Chun, Luis Cisneros, Graham A. Colditz, Kristina Cole, Natalie Collins, Kevin Contrepois, Lisa M. Coussens, Allison L. Creason, Daniel Crichton, Christina Curtis, Tanja Davidsen, Sherri R. Davies, Ino de Bruijn, Laura Dellostritto, Angelo De Marzo, David G. DeNardo, Dinh Diep, Sharon Diskin, Xengie Doan, Julia Drewes, Stephen Dubinett, Michael Dyer, Jacklynn Egger, Jennifer Eng, Barbara Engelhardt, Graham Erwin, Laura Esserman, Alex Felmeister, Heidi S. Feiler, Ryan C. Fields, Stephen Fisher, Keith Flaherty, Jennifer Flournoy, Angelo Fortunato, Allison Frangieh, Jennifer L. Frye, Robert S. Fulton, Danielle Galipeau, Siting Gan, Jianjiong Gao, Long Gao, Peng Gao, Vianne R. Gao, Tim Geiger, Ajit George, Gad Getz, Marios Giannakis, David L. Gibbs, William E. Gillanders, Simon P. Goedegebuure, Alanna Gould, Kate Gowers, William Greenleaf, Jeremy Gresham, Jennifer L. Guerriero, Tuhin K. Guha, Alexander R. Guimaraes, David Gutman, Nir Hacohen, Sean Hanlon, Casey R. Hansen, Olivier Harismendy, Kathleen A. Harris, Aaron Hata, Akimasa Hayashi, Cody Heiser, Karla Helvie, John M. Herndon, Gilliam Hirst, Frank Hodi, Travis Hollmann, Aaron Horning, James J. Hsieh, Shannon Hughes, Won Jae Huh, Stephen Hunger, Shelley E. Hwang, Heba Ijaz, Benjamin Izar, Connor A. Jacobson, Samuel Janes, Reyka G. Jayasinghe, Lihua Jiang, Brett E. Johnson, Bruce Johnson, Tao Ju, Humam Kadara, Klaus Kaestner, Jacob Kagan, Lukas Kalinke, Robert Keith, Aziz Khan, Warren Kibbe, Albert H. Kim, Erika Kim, Junhyong Kim, Annette Kolodzie, Mateusz Kopytra, Eran Kotler, Robert Krueger, Kostyantyn Krysan, Anshul Kundaje, Uri Ladabaum, Blue B. Lake, Huy Lam, Rozelle Laquindanum, Ashley M. Laughney, Hayan Lee, Marc Lenburg, Carina Leonard, Ignaty Leshchiner, Rochelle Levy, Jerry Li, Christine G. Lian, Kian-Huat Lim, Jia-Ren Lin, Yiyun Lin, Qi Liu, Ruiyang Liu, William J.R. Longabaugh, Teri Longacre, Cynthia X. Ma, Mary Catherine Macedonia, Tyler Madison, Christopher A. Maher, Anirban Maitra, Netta Makinen, Danika Makowski, Carlo Maley, Zoltan Maliga, Diego Mallo, John Maris, Nick Markham, Jeffrey Marks, Daniel Martinez, Robert J. Mashl, Ignas Masilionais, Jennifer Mason, Joan Massagué, Pierre Massion, Marissa Mattar, Richard Mazurchuk, Linas Mazutis, Eliot T. McKinley, Joshua F. McMichael, Daniel Merrick, Matthew Meyerson, Julia R. Miessner, Gordon B. Mills, Meredith Mills, Suman B. Mondal, Motomi Mori, Yuriko Mori, Elizabeth Moses, Yael Mosse, Jeremy L. Muhlich, George F. Murphy, Nicholas E. Navin, Michel Nederlof, Reid Ness, Stephanie Nevins, Milen Nikolov, Ajit Johnson Nirmal, Garry Nolan, Edward Novikov, Brendan O’Connell, Michael Offin, Stephen T. Oh, Anastasiya Olson, Alex Ooms, Miguel Ossandon, Kouros Owzar, Swapnil Parmar, Tasleema Patel, Gary J. Patti, Itsik Pe'er, Tao Peng, Daniel Persson, Marvin Petty, Hanspeter Pfister, Kornelia Polyak, Kamyar Pourfarhangi, Sidharth V. Puram, Qi Qiu, Álvaro Quintanal-Villalonga, Arjun Raj, Marisol Ramirez-Solano, Rumana Rashid, Ashley N. Reeb, Mary Reid, Adam Resnick, Sheila M. Reynolds, Jessica L. Riesterer, Scott Rodig, Joseph T. Roland, Sonia Rosenfield, Asaf Rotem, Sudipta Roy, Charles M. Rudin, Marc D. Ryser, Maria Santi-Vicini, Kazuhito Sato, Deborah Schrag, Nikolaus Schultz, Cynthia L. Sears, Rosalie C. Sears, Subrata Sen, Triparna Sen, Alex Shalek, Jeff Sheng, Quanhu Sheng, Kooresh I. Shoghi, Martha J. Shrubsole, Yu Shyr, Alexander B. Sibley, Kiara Siex, Alan J. Simmons, Dinah S. Singer, Shamilene Sivagnanam, Michal Slyper, Artem Sokolov, Sheng-Kwei Song, Austin Southard-Smith, Avrum Spira, Janet Stein, Phillip Storm, Elizabeth Stover, Siri H. Strand, Timothy Su, Damir Sudar, Ryan Sullivan, Lea Surrey, Mario Suvà, Nadezhda V. Terekhanova, Luke Ternes, Lisa Thammavong, Guillaume Thibault, George V. Thomas, Vésteinn Thorsson, Ellen Todres, Linh Tran, Madison Tyler, Yasin Uzun, Anil Vachani, Eliezer Van Allen, Simon Vandekar, Deborah J. Veis, Sébastien Vigneau, Arastoo Vossough, Angela Waanders, Nikhil Wagle, Liang-Bo Wang, Michael C. Wendl, Robert West, Chi-yun Wu, Hao Wu, Hung-Yi Wu, Matthew A. Wyczalkowski, Yubin Xie, Xiaolu Yang, Clarence Yapp, Wenbao Yu, Yinyin Yuan, Dadong Zhang, Kun Zhang, Mianlei Zhang, Nancy Zhang, Yantian Zhang, Yanyan Zhao, Daniel Cui Zhou, Zilu Zhou, Houxiang Zhu, Qin Zhu, Xiangzhu Zhu, Yuankun Zhu, and Xiaowei Zhuang
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Cell ,Genomics ,Computational biology ,Tumor initiation ,Biology ,Article ,General Biochemistry, Genetics and Molecular Biology ,Metastasis ,03 medical and health sciences ,Atlases as Topic ,0302 clinical medicine ,Neoplasms ,Tumor Microenvironment ,medicine ,Humans ,Precision Medicine ,030304 developmental biology ,0303 health sciences ,Atlas (topology) ,Cancer ,medicine.disease ,3. Good health ,Human tumor ,Cell Transformation, Neoplastic ,medicine.anatomical_structure ,Single-Cell Analysis ,Single point ,030217 neurology & neurosurgery - Abstract
Crucial transitions in cancer-including tumor initiation, local expansion, metastasis, and therapeutic resistance-involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types. This effort complements both ongoing efforts to map healthy organs and previous large-scale cancer genomics approaches focused on bulk sequencing at a single point in time. Generating single-cell, multiparametric, longitudinal atlases and integrating them with clinical outcomes should help identify novel predictive biomarkers and features as well as therapeutically relevant cell types, cell states, and cellular interactions across transitions. The resulting tumor atlases should have a profound impact on our understanding of cancer biology and have the potential to improve cancer detection, prevention, and therapeutic discovery for better precision-medicine treatments of cancer patients and those at risk for cancer.
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- 2020
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3. Protocol to dissociate, process, and analyze the human lung tissue using single-cell RNA-seq
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Álvaro Quintanal-Villalonga, Joseph M. Chan, Ignas Masilionis, Vianne Ran Gao, Yubin Xie, Viola Allaj, Andrew Chow, John T. Poirier, Dana Pe’er, Charles M. Rudin, and Linas Mazutis
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cancer ,cell isolation ,flow cytometry/mass cytometry ,molecular biology ,RNAseq ,sequence analysis ,sequencing ,single cell ,General Immunology and Microbiology ,Sequence Analysis, RNA ,Gene Expression Profiling ,General Neuroscience ,Biopsy, Fine-Needle ,Humans ,RNA-Seq ,Lung ,General Biochemistry, Genetics and Molecular Biology - Abstract
We report a protocol for obtaining high-quality single-cell transcriptomics data from human lung biospecimens acquired from core needle biopsies, fine-needle aspirates, surgical resection, and pleural effusions. The protocol relies upon the brief mechanical and enzymatic disruption of tissue, enrichment of live cells by fluorescence-activated cell sorting (FACS), and droplet-based single-cell RNA sequencing (scRNA-seq). The protocol also details a procedure for analyzing the scRNA-seq data. For complete details on the use and execution of this protocol, please refer to Chan et al. (2021).
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- 2022
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4. OA07.01 Signatures of Plasticity and Immunosuppression in a Single-Cell Atlas of Human Small Cell Lung Cancer
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Vianne R. Gao, Linas Mazutis, Travis J. Hollmann, Yubin Xie, Joseph M. Chan, Dana Pe'er, Metamia Ciampricotti, Tal Nawy, V. Lai, Ignas Masilionis, David R. Jones, Matthew J. Bott, Ojasvi Chaudhary, Thomas Walle, Michael Offin, Triparna Sen, Andrew Chow, Álvaro Quintanal-Villalonga, Jacklynn V. Egger, Charles M. Rudin, and Viola Allaj
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Pulmonary and Respiratory Medicine ,medicine.anatomical_structure ,Oncology ,Atlas (topology) ,business.industry ,medicine.medical_treatment ,Cell ,Cancer research ,medicine ,Immunosuppression ,Non small cell ,business - Published
- 2021
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5. MA16.03 CRISPR Screen Reveals XPO1 as a Therapeutic Target Strongly Sensitizing to First and Second Line Therapy in Small Cell Lung Cancer
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Yingqian Zhan, Joseph M. Chan, E. De Stanchina, Fathema Uddin, Andrew Chow, Jacklynn V. Egger, U. Bhanot, Viola Allaj, Álvaro Quintanal-Villalonga, Triparna Sen, John T. Poirier, Michael Offin, Yuan Hao, Hirokazu Taniguchi, P. Manoj, Shweta S. Chavan, Charles M. Rudin, J. Qiu, and Nisargbhai S. Shah
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Pulmonary and Respiratory Medicine ,Second-line therapy ,XPO1 ,Oncology ,business.industry ,Cancer research ,Medicine ,CRISPR ,Non small cell ,business - Published
- 2021
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6. 1MO Multi-omic characterization of lung tumors identify AKT and EZH2 as potential therapeutic targets in adenocarcinoma-to-squamous transdifferentiation
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Yingqian Zhan, Nisargbhai S. Shah, J. Qiu, P. Manoj, Natasha Rekhtman, Hiroya Taniguchi, Viola Allaj, Metamia Ciampricotti, U. Bhanot, Charles M. Rudin, Brian Houck-Loomis, Maysun Hasan, Jacklynn V. Egger, Álvaro Quintanal-Villalonga, E. De Stanchina, Fathema Uddin, Richard Koche, Shweta S Chavan, Helena Alexandra Yu, and Triparna Sen
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Lung ,business.industry ,EZH2 ,Transdifferentiation ,Hematology ,medicine.disease ,Omics ,medicine.anatomical_structure ,Oncology ,Cancer research ,Medicine ,Adenocarcinoma ,business ,Protein kinase B - Published
- 2021
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7. MA11.06 Multi-Omic Characterization of Lung Tumors Implicates AKT and MYC Signaling in Adenocarcinoma to Squamous Cell Transdifferentiation
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Charles M. Rudin, Helena Alexandra Yu, Jason C. Chang, Joseph M. Chan, Maysun Hasan, Brian Houck-Loomis, Andrew Chow, Álvaro Quintanal-Villalonga, Richard Koche, Triparna Sen, Jacklynn V. Egger, Yingqian Zhan, J. Qiu, M. Offin, P. Manoj, U. Bhanot, E. De Stanchina, Fathema Uddin, Viola Allaj, Nisargbhai S. Shah, Shweta S Chavan, Natasha Rekhtman, and Hiroya Taniguchi
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Pulmonary and Respiratory Medicine ,Lung ,medicine.anatomical_structure ,Oncology ,business.industry ,Cell Transdifferentiation ,medicine ,Cancer research ,Adenocarcinoma ,medicine.disease ,business ,Protein kinase B - Published
- 2021
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8. 2MO XPO1 inhibition strongly sensitizes to first-line and second-line therapy in small cell lung cancer
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Travis J. Hollmann, E. De Stanchina, Fathema Uddin, Metamia Ciampricotti, Triparna Sen, Y. Hao, Jacklynn V. Egger, J. Qiu, Yingqian Zhan, John T. Poirier, Hirokazu Taniguchi, Richard Koche, Andrew Chow, Álvaro Quintanal-Villalonga, Viola Allaj, Joseph M. Chan, Michael Offin, Nisargbhai S. Shah, Charles M. Rudin, and P. Manoj
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XPO1 ,Second-line therapy ,Oncology ,business.industry ,First line ,Cancer research ,Medicine ,Hematology ,Non small cell ,business - Published
- 2021
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9. 1800O Multi-omic characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation
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Metamia Ciampricotti, Triparna Sen, Maysun Hasan, Jacklynn V. Egger, P. Manoj, Viola Allaj, Yingqian Zhan, Helena Alexandra Yu, E. De Stanchina, J. Qiu, Fathema Uddin, Joseph M. Chan, Nisargbhai S. Shah, Charles M. Rudin, Natasha Rekhtman, Shweta S. Chavan, U. Bhanot, Andrew Chow, Álvaro Quintanal-Villalonga, and Hirokazu Taniguchi
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Lung ,medicine.anatomical_structure ,Oncology ,business.industry ,Cell Transdifferentiation ,medicine ,Cancer research ,Adenocarcinoma ,Hematology ,medicine.disease ,business ,Protein kinase B - Published
- 2021
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10. Prognostic Role of the FGFR4-388Arg Variant in Lung Squamous-Cell Carcinoma Patients With Lymph Node Involvement
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Sonia Molina-Pinelo, Luis Paz-Ares, Álvaro Quintanal-Villalonga, Andrés Carranza-Carranza, Ricardo Melendez, Irene Ferrer, Instituto de Salud Carlos III, Fundación Mutua Madrileña, Asociación Española Contra el Cáncer, and Regional Government of Andalusia (España)
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Male ,0301 basic medicine ,Pulmonary and Respiratory Medicine ,Cancer Research ,medicine.medical_specialty ,Pathology ,Lung Neoplasms ,Genotype ,MAP Kinase Signaling System ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Carcinoma, Non-Small-Cell Lung ,Lung squamous cell carcinoma ,Biomarkers, Tumor ,Humans ,Medicine ,media_common.cataloged_instance ,Receptor, Fibroblast Growth Factor, Type 4 ,European union ,rs351855 ,Aged ,media_common ,Aged, 80 and over ,Gynecology ,business.industry ,Biomarker ,Middle Aged ,Prognosis ,MAPK ,Immunohistochemistry ,Survival Rate ,030104 developmental biology ,Oncology ,Chemotherapy, Adjuvant ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Multivariate Analysis ,Carcinoma, Squamous Cell ,Female ,business ,Proto-Oncogene Proteins c-akt - Abstract
BACKGROUND: The identification of prognostic biomarkers for lung squamous-cell carcinoma (SCC) pathology is crucial because of its poor prognosis. A variant of the FGFR4 (fibroblast growth factor receptor 4) gene, FGFR4-388Arg, has been associated with prognosis and is linked to oncogenesis in vitro in several types of cancer. We analyzed the association of this variant with prognosis and downstream signaling alteration in lung SCC patients. METHODS: The presence of the FGFR4-388Arg variant was determined in 114 formalin-fixed, paraffin-embedded lung SCC tissue samples by DNA genotyping and was correlated with clinicopathologic data. The activation of the protein kinase B (AKT) and mitogen-activated protein kinase (MAPK) pathways was determined by immunohistochemistry, and its association with the presence of FGFR4-388Arg was analyzed. RESULTS: We found that tumor differentiation status and adjuvant chemotherapy administration could be independent prognostic factors for overall survival (OS) in lymph node-affected patients, as expected. The progression-free survival and OS of patients with lymph node involvement (n = 41) and the FGFR4-388Arg genotype were significantly lower than those of patients lacking this variant (P = .035 and P = .042, respectively). Importantly, multivariate analysis supported the independent prognostic role of the FGFR4-388Arg genotype in OS (P = .025). Regarding downstream signaling, the FGFR4-388Arg genotype was not correlated with altered AKT signaling but was associated with increased MAPK activation in the SCC tumor samples (P = .017). CONCLUSION: The FGFR4-388Arg variant may represent a promising prognostic biomarker in SCC patients with lymph node involvement. For these patients, FGFR4 may be a potential therapeutic target. L.P.A. was funded by Instituto de Salud Carlos III (PI14/01964, PIE15/00076, C316/12/00442, and R12/0036/0028) and cofun- ded by European Union (ERDF/ESF, “ Investing in Your Future ” ). S.M.P. is funded by Consejería de Salud y Bienestar Social (PI-0046-2012) and Fundación Mutua Madrileña (2014). I.F. is funded by AECC (AIO2015) and Consejería de Igualdad, Salud y Políticas Sociales de la Junta de Andalucía (PI-0029-2013), andInstituto de Salud Carlos III (PI16/01311) and cofunded byEuropean Union (ERDF/ESF,“Investing in Your Future”). A.Q. isfunded by Instituto de Salud Carlos III (FI12/00429) and cofundedby European Union (ERDF/ESF,“Investing in Your Future”). The authors thank the donors and the HUVR-IBiS Biobank (Andalusian Public Health System Biobank and ISCIII-Red de Biobancos PT13/ 0010/0056) for the human specimens used in this study Sí
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- 2017
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11. FGFR4 exerts differential roles in tumorigenesis through a mechanism of cooperation
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Laura Ojeda-Márquez, Amancio Carnero, R. Suarez, L. García-Redondo, Álvaro Quintanal-Villalonga, Irene Ferrer, Jon Zugazagoitia, Sonia Molina-Pinelo, Ángela Marrugal, and Luis Paz-Ares
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Oncology ,Mechanism (biology) ,business.industry ,Medicine ,Hematology ,Fibroblast growth factor receptor 4 ,business ,Carcinogenesis ,medicine.disease_cause ,Differential (mathematics) ,Cell biology - Published
- 2016
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