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Start Over Descriptor "4-benzoquinones" Publisher elsevier bv
1 results on '"4-benzoquinones"'

1. Convenient oxidation of alkylated phenols and methoxytoluenes to antifungal 1,4-benzoquinones with hydrogen peroxide (H2O2)/methyltrioxorhenium (CH3ReO3) catalytic system in neutral ionic liquid

Author

Sabrina Tempesta, Maurizio Barontini, Marcella Pasqualetti, Roberta Bernini, Enrico Mincione, and Giancarlo Fabrizi

Subjects
Antifungal, 4-benzoquinones, 1-butyl-3-methylimidazolium tetrafluoroborate [bmim]bf4, antifungal activity, catalytic oxidations, hydrogen peroxide/methyltrioxorhenium, Tetrafluoroborate, medicine.drug_class, Organic Chemistry, Alkylation, Biochemistry, Catalysis, chemistry.chemical_compound, chemistry, Drug Discovery, Ionic liquid, medicine, Organic chemistry, Phenol, Phenols, Hydrogen peroxide
Abstract

Alkylated phenol and methoxytoluene derivatives were catalytically and selectively oxidized to the corresponding 1,4-benzoquinones in good conversions and yields. Reactions were performed with hydrogen peroxide (H2O2)/methyltrioxorhenium (CH3ReO3) in 1-butyl-3-methylimidazolium tetrafluoroborate [bmim]BF4, a neutral ionic liquid. Compounds were tested in vitro for their antifungal activity against the growth of several widespread soil fungi. Some of them were proved to be potent inhibitors of Fusarium sp. than ketoconazole, a commercially available and expensive antifungal agent.

Published
2006
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