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2. A systematic review on the excess health risk of antibiotic-resistant bloodstream infections for six key pathogens in Europe

Author

Hassoun-Kheir, Nasreen, primary, Guedes, Mariana, additional, Ngo Nsoga, Marie-Therese, additional, Argante, Lorenzo, additional, Arieti, Fabiana, additional, Gladstone, Beryl P., additional, Kingston, Rhys, additional, Naylor, Nichola R., additional, Pezzani, Maria D., additional, Pouwels, Koen B., additional, Robotham, Julie V., additional, Rodríguez-Baño, Jesús, additional, Tacconelli, Evelina, additional, Vella, Venanzio, additional, Harbarth, Stephan, additional, de Kraker, Marlieke E.A., additional, Barana, Benedetta, additional, Cappelli, Eva, additional, De Rui, Maria Elena, additional, El-Abasiri, Radwa A., additional, Galia, Liliana, additional, Geurtsen, Jeroen, additional, Mejia, Jorly, additional, Palladino, Andrea, additional, Piljic, Alen, additional, Rajendran, Nithya Babu, additional, Reyna-Villasmil, Eduardo, additional, and Schmidt, Johannes E., additional

Published
2024
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6. Virion glycosylation influences mycobacteriophage immune recognition

Author

Freeman, Krista G., primary, Robotham, Anna C., additional, Parks, Olivia B., additional, Abad, Lawrence, additional, Jacobs-Sera, Deborah, additional, Lauer, Michael J., additional, Podgorski, Jennifer M., additional, Zhang, Yu, additional, Williams, John V., additional, White, Simon J., additional, Kelly, John F., additional, Hatfull, Graham F., additional, and Pope, Welkin H., additional

Published
2023
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8. Virtual Reality Therapy for the Negative Symptoms of Schizophrenia (V-NeST): A pilot randomised feasibility trial

Author

Matteo Cella, Paul Tomlin, Daniel Robotham, Patrick Green, Helena Griffiths, Daniel Stahl, and Lucia Valmaggia

Subjects
Psychiatry and Mental health, Research Design, Virtual Reality Exposure Therapy, Schizophrenia, Humans, Feasibility Studies, Pilot Projects, Biological Psychiatry
Abstract

BACKGROUND: Negative symptoms are typically observed in people with schizophrenia and indicate a loss or reduction of normal function (e.g. reduced motivation and affect display). Despite obstructing people's recovery, intervention development has received limited attention. This study tests the feasibility and acceptability of a novel Virtual Reality Supported Therapy for the Negative Symptoms of Schizophrenia (V-NeST).METHOD: A single (rater) blind randomised study with two conditions; V-NeST plus treatment as-usual (TAU) vs. TAU alone, recruiting people with schizophrenia experiencing debilitating negative symptoms. Assessment was at baseline and 3-month post-randomisation. The pre-specified primary outcome was participants' goal attainment, secondary outcomes were negative symptoms and functioning. The study assessed feasibility and acceptability parameters including recruitment, eligibility, treatment adherence and retention. Acceptability was also evaluated qualitatively using a post-therapy feedback interview. Explorative therapy effect on outcomes was estimated.RESULTS: The study recruited to its pre-specified target of 30 participants (15 randomised to V-Nest). Two participants in each trial arm disengaged and did not complete the study. Therapy engagement for those randomised to V-NeST was appropriate and research procedures were feasible. The experience with therapy and VR was described as positive and useful. Preliminary analysis suggested the therapy may have a large effect on participants goals and a possible effect on negative symptoms.CONCLUSION: V-NeST is a feasible and acceptable intervention. This therapy has the potential to support people with schizophrenia achieving their recovery goals and may reduce negative symptoms. The efficacy results need to be evaluated in an appropriately powered efficacy study.

Published
2022

13. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)

Author

Victoria Jane Hall, Sarah Foulkes, Andre Charlett, Ana Atti, Edward J M Monk, Ruth Simmons, Edgar Wellington, Michelle J Cole, Ayoub Saei, Blanche Oguti, Katie Munro, Sarah Wallace, Peter D Kirwan, Madhumita Shrotri, Amoolya Vusirikala, Sakib Rokadiya, Meaghan Kall, Maria Zambon, Mary Ramsay, Tim Brooks, Colin S Brown, Meera A Chand, Susan Hopkins, N Andrews, A Atti, H Aziz, T Brooks, CS Brown, D Camero, C Carr, MA Chand, A Charlett, H Crawford, M Cole, J Conneely, S D'Arcangelo, J Ellis, S Evans, S Foulkes, N Gillson, R Gopal, L Hall, VJ Hall, P Harrington, S Hopkins, J Hewson, K Hoschler, D Ironmonger, J Islam, M Kall, I Karagiannis, O Kay, J Khawam, E King, P Kirwan, R Kyffin, A Lackenby, M Lattimore, E Linley, J Lopez-Bernal, L Mabey, R McGregor, S Miah, EJM Monk, K Munro, Z Naheed, A Nissr, AM O'Connell, B Oguti, H Okafor, S Organ, J Osbourne, A Otter, M Patel, S Platt, D Pople, K Potts, M Ramsay, J Robotham, S Rokadiya, C Rowe, A Saei, G Sebbage, A Semper, M Shrotri, R Simmons, A Soriano, P Staves, S Taylor, A Taylor, A Tengbe, S Tonge, A Vusirikala, S Wallace, E Wellington, M Zambon, D Corrigan, M Sartaj, L Cromey, S Campbell, K Braithwaite, L Price, L Haahr, S Stewart, ED Lacey, L Partridge, G Stevens, Y Ellis, H Hodgson, C Norman, B Larru, S Mcwilliam, S Winchester, P Cieciwa, A Pai, C Loughrey, A Watt, F Adair, A Hawkins, A Grant, R Temple-Purcell, J Howard, N Slawson, C Subudhi, S Davies, A Bexley, R Penn, N Wong, G Boyd, A Rajgopal, A Arenas-Pinto, R Matthews, A Whileman, R Laugharne, J Ledger, T Barnes, C Jones, D Botes, N Chitalia, S Akhtar, G Harrison, S Horne, N Walker, K Agwuh, V Maxwell, J Graves, S Williams, A O'Kelly, P Ridley, A Cowley, H Johnstone, P Swift, J Democratis, M Meda, C Callens, S Beazer, S Hams, V Irvine, B Chandrasekaran, C Forsyth, J Radmore, C Thomas, K Brown, S Roberts, P Burns, K Gajee, TM Byrne, F Sanderson, S Knight, E Macnaughton, BJL Burton, H Smith, R Chaudhuri, K Hollinshead, RJ Shorten, A Swan, C Favager, J Murira, S Baillon, S Hamer, K Gantert, J Russell, D Brennan, A Dave, A Chawla, F Westell, D Adeboyeku, P Papineni, C Pegg, M Williams, S Ahmad, S Ingram, C Gabriel, K Pagget, G Maloney, J Ashcroft, I Del Rosario, R Crosby-Nwaobi, C Reeks, S Fowler, L Prentice, M Spears, G McKerron, K McLelland-Brooks, J Anderson, S Donaldson, K Templeton, L Coke, N Elumogo, J Elliott, D Padgett, M Mirfenderesky, A Cross, J Price, S Joyce, I Sinanovic, M Howard, T Lewis, P Cowling, D Potoczna, S Brand, L Sheridan, B Wadams, A Lloyd, J Mouland, J Giles, G Pottinger, H Coles, M Joseph, M Lee, S Orr, H Chenoweth, C Auckland, R Lear, T Mahungu, A Rodger, K Penny-Thomas, S Pai, J Zamikula, E Smith, S Stone, E Boldock, D Howcroft, C Thompson, M Aga, P Domingos, S Gormley, C Kerrison, L Marsh, S Tazzyman, L Allsop, S Ambalkar, M Beekes, S Jose, J Tomlinson, A Jones, C Price, J Pepperell, M Schultz, J Day, A Boulos, E Defever, D McCracken, K Gray, A Houston, T Planche, R Pritchard Jones, Diane Wycherley, S Bennett, J Marrs, K Nimako, B Stewart, N Kalakonda, S Khanduri, A Ashby, M Holden, N Mahabir, J Harwood, B Payne, K Court, N Staines, R Longfellow, ME Green, LE Hughes, M Halkes, P Mercer, A Roebuck, E Wilson-Davies, L Gallego, R Lazarus, N Aldridge, L Berry, F Game, T Reynolds, C Holmes, M Wiselka, A Higham, M Booth, C Duff, J Alderton, H Jory, E Virgilio, T Chin, MZ Qazzafi, AM Moody, R Tilley, T Donaghy, K Shipman, R Sierra, N Jones, G Mills, D Harvey, YWJ Huang, J Birch, L Robinson, S Board, A Broadley, C Laven, N Todd, DW Eyre, K Jeffery, S Dunachie, C Duncan, P Klenerman, L Turtle, T De Silva, H Baxendale, JL Heeney, Group, SIREN Study, Dunachie, SJ, Kirwan, Peter [0000-0001-6904-0500], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, medicine.medical_specialty, Health Personnel, 030204 cardiovascular system & hematology, Antibodies, Viral, Lower risk, Asymptomatic, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Pandemic, Health care, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Asymptomatic Infections, Pandemics, SARS-CoV-2, business.industry, Incidence (epidemiology), Public health, COVID-19, Articles, General Medicine, Middle Aged, England, COVID-19 Nucleic Acid Testing, Reinfection, Cohort, Female, medicine.symptom, business, Follow-Up Studies
Abstract

Background Increased understanding of whether individuals who have recovered from COVID-19 are protected from future SARS-CoV-2 infection is an urgent requirement. We aimed to investigate whether antibodies against SARS-CoV-2 were associated with a decreased risk of symptomatic and asymptomatic reinfection. Methods A large, multicentre, prospective cohort study was done, with participants recruited from publicly funded hospitals in all regions of England. All health-care workers, support staff, and administrative staff working at hospitals who could remain engaged in follow-up for 12 months were eligible to join The SARS-CoV-2 Immunity and Reinfection Evaluation study. Participants were excluded if they had no PCR tests after enrolment, enrolled after Dec 31, 2020, or had insufficient PCR and antibody data for cohort assignment. Participants attended regular SARS-CoV-2 PCR and antibody testing (every 2–4 weeks) and completed questionnaires every 2 weeks on symptoms and exposures. At enrolment, participants were assigned to either the positive cohort (antibody positive, or previous positive PCR or antibody test) or negative cohort (antibody negative, no previous positive PCR or antibody test). The primary outcome was a reinfection in the positive cohort or a primary infection in the negative cohort, determined by PCR tests. Potential reinfections were clinically reviewed and classified according to case definitions (confirmed, probable, or possible) and symptom-status, depending on the hierarchy of evidence. Primary infections in the negative cohort were defined as a first positive PCR test and seroconversions were excluded when not associated with a positive PCR test. A proportional hazards frailty model using a Poisson distribution was used to estimate incidence rate ratios (IRR) to compare infection rates in the two cohorts. Findings From June 18, 2020, to Dec 31, 2020, 30 625 participants were enrolled into the study. 51 participants withdrew from the study, 4913 were excluded, and 25 661 participants (with linked data on antibody and PCR testing) were included in the analysis. Data were extracted from all sources on Feb 5, 2021, and include data up to and including Jan 11, 2021. 155 infections were detected in the baseline positive cohort of 8278 participants, collectively contributing 2 047 113 person-days of follow-up. This compares with 1704 new PCR positive infections in the negative cohort of 17 383 participants, contributing 2 971 436 person-days of follow-up. The incidence density was 7·6 reinfections per 100 000 person-days in the positive cohort, compared with 57·3 primary infections per 100 000 person-days in the negative cohort, between June, 2020, and January, 2021. The adjusted IRR was 0·159 for all reinfections (95% CI 0·13–0·19) compared with PCR-confirmed primary infections. The median interval between primary infection and reinfection was more than 200 days. Interpretation A previous history of SARS-CoV-2 infection was associated with an 84% lower risk of infection, with median protective effect observed 7 months following primary infection. This time period is the minimum probable effect because seroconversions were not included. This study shows that previous infection with SARS-CoV-2 induces effective immunity to future infections in most individuals. Funding Department of Health and Social Care of the UK Government, Public Health England, The National Institute for Health Research, with contributions from the Scottish, Welsh and Northern Irish governments.

Published
2021

14. The Lancet Psychiatry Commission on intimate partner violence and mental health: advancing mental health services, research, and policy

Author

Oram, Sian, primary, Fisher, Helen L, additional, Minnis, Helen, additional, Seedat, Soraya, additional, Walby, Sylvia, additional, Hegarty, Kelsey, additional, Rouf, Khadj, additional, Angénieux, Caroline, additional, Callard, Felicity, additional, Chandra, Prabha S, additional, Fazel, Seena, additional, Garcia-Moreno, Claudia, additional, Henderson, Marion, additional, Howarth, Emma, additional, MacMillan, Harriet L, additional, Murray, Laura K, additional, Othman, Sajaratulnisah, additional, Robotham, Dan, additional, Rondon, Marta B, additional, Sweeney, Angela, additional, Taggart, Danny, additional, and Howard, Louise M, additional

Published
2022
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15. Effectiveness of infection prevention and control interventions, excluding personal protective equipment, to prevent nosocomial transmission of SARS-CoV-2: a systematic review and call for action

Author

Jafari, Yalda, Yin, Mo, Lim, Cherry, Pople, Diane, Evans, Stephanie, Stimson, James, Pham, Thi Mui, LSHTM CMMID COVID-19 working group, Read, Jonathan M, Robotham, Julie V, Cooper, Ben S, and Knight, Gwenan M

Abstract

Many infection prevention and control (IPC) interventions have been adopted by hospitals to limit nosocomial transmission of SARS-CoV-2. The aim of this systematic review is to identify evidence on the effectiveness of these interventions. We conducted a literature search of five databases (OVID MEDLINE, Embase, CENTRAL, COVID-19 Portfolio (pre-print), Web of Science). SWIFT ActiveScreener software was used to screen English titles and abstracts published between 1st January 2020 and 6th April 2021. Intervention studies, defined by Cochrane Effective Practice and Organisation of Care, that evaluated IPC interventions with an outcome of SARS-CoV-2 infection in either patients or healthcare workers were included. Personal protective equipment (PPE) was excluded as this intervention had been previously reviewed. Risks of bias were assessed using the Cochrane tool for randomised trials (RoB2) and non-randomized studies of interventions (ROBINS-I). From 23,156 screened articles, we identified seven articles that met the inclusion criteria, all of which evaluated interventions to prevent infections in healthcare workers and the majority of which were focused on effectiveness of prophylaxes. Due to heterogeneity in interventions, we did not conduct a meta-analysis. All agents used for prophylaxes have little to no evidence of effectiveness against SARS-CoV-2 infections. We did not find any studies evaluating the effectiveness of interventions including but not limited to screening, isolation and improved ventilation. There is limited evidence from interventional studies, excluding PPE, evaluating IPC measures for SARS-CoV-2. This review calls for urgent action to implement such studies to inform policies to protect our most vulnerable populations and healthcare workers.

Published
2022

16. Automated virtual reality therapy to treat agoraphobic avoidance and distress in patients with psychosis (gameChange): a multicentre, parallel-group, single-blind, randomised, controlled trial in England with mediation and moderation analyses

Author

Freeman, Daniel, primary, Lambe, Sinéad, additional, Kabir, Thomas, additional, Petit, Ariane, additional, Rosebrock, Laina, additional, Yu, Ly-Mee, additional, Dudley, Robert, additional, Chapman, Kate, additional, Morrison, Anthony, additional, O'Regan, Eileen, additional, Aynsworth, Charlotte, additional, Jones, Julia, additional, Murphy, Elizabeth, additional, Powling, Rosie, additional, Galal, Ushma, additional, Grabey, Jenna, additional, Rovira, Aitor, additional, Martin, Jennifer, additional, Hollis, Chris, additional, Clark, David M, additional, Waite, Felicity, additional, Altunkaya, James, additional, Andleeb, Humma, additional, Bergin, Aislinn, additional, Bold, Emily, additional, Bond, Jessica, additional, Bransby-Adams, Kate, additional, Brown, Susan, additional, Chan, Cindy, additional, Chauhan, Nisha, additional, Craven, Michael, additional, Freeman, Jason, additional, Geddes, John, additional, Goodsell, Andrew, additional, Jenner, Lucy, additional, Kenny, Alex, additional, Leal, José, additional, Mitchell, Joanna, additional, Peel, Heather, additional, Pervez, Maryam, additional, Prouten, Eloise, additional, Roberts, Eva, additional, Robotham, Dan, additional, Walker, Harry, additional, and West, Jonathan, additional

Published
2022
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17. Identification of a novel N-linked glycan on the archaellins and S-layer protein of the thermophilic methanogen, Methanothermococcus thermolithotrophicus

Author

John F. Kelly, Cezar M. Khursigara, Alison Berezuk, Susan M. Logan, Ken F. Jarrell, Anna Robotham, Evgeny Vinogradov, and Jacek Stupak

Subjects
0301 basic medicine, Glycan, nuclear magnetic resonance (NMR), archaellin, Biochemistry, Archaellum, 03 medical and health sciences, glycoproteinmass spectrometry (MS), Molecular Biology, archaeaglycobiology, chemistry.chemical_classification, glycan, thermophile, 030102 biochemistry & molecular biology, biology, Chemistry, Glycobiology, Thermophile, Methanococcus maripaludis, Cell Biology, biology.organism_classification, carbohydrates (lipids), 030104 developmental biology, post-translational modification, comic_books, biology.protein, Glycoprotein, S-layer protein, S-layer, comic_books.character, Archaea
Abstract

Motility in archaea is facilitated by a unique structure termed the archaellum. N-Glycosylation of the major structural proteins (archaellins) is important for their subsequent incorporation into the archaellum filament. The identity of some of these N-glycans has been determined, but archaea exhibit extensive variation in their glycans, meaning that further investigations can shed light not only on the specific details of archaellin structure and function, but also on archaeal glycobiology in general. Here we describe the structural characterization of the N-linked glycan modifications on the archaellins and S-layer protein of Methanothermococcus thermolithotrophicus, a methanogen that grows optimally at 65 °C. SDS-PAGE and MS analysis revealed that the sheared archaella are composed principally of two of the four predicted archaellins, FlaB1 and FlaB3, which are modified with a branched, heptameric glycan at all N-linked sequons except for the site closest to the N termini of both proteins. NMR analysis of the purified glycan determined the structure to be α-d-glycero-d-manno-Hep3OMe6OMe-(1–3)-[α-GalNAcA3OMe-(1–2)-]-β-Man-(1–4)-[β-GalA3OMe4OAc6CMe-(1–4)-α-GalA-(1–2)-]-α-GalAN-(1–3)-β-GalNAc-Asn. A detailed investigation by hydrophilic interaction liquid ion chromatography–MS discovered the presence of several, less abundant glycan variants, related to but distinct from the main heptameric glycan. In addition, we confirmed that the S-layer protein is modified with the same heptameric glycan, suggesting a common N-glycosylation pathway. The M. thermolithotrophicus archaellin N-linked glycan is larger and more complex than those previously identified on the archaellins of related mesophilic methanogens, Methanococcus voltae and Methanococcus maripaludis. This could indicate that the nature of the glycan modification may have a role to play in maintaining stability at elevated temperatures.

Published
2020

18. Extension of xMAP Food Allergen Detection Assay to Include Sesame

Author

Thomas Grace, Mansour Samadpour, Chung Y. Cho, Katherine O. Ivens, Kerry G. Oliver, William Nowatzke, Jason Robotham, and Eric A. E. Garber

Subjects
Analyte, Sesame Oils, food.ingredient, Population, 01 natural sciences, Microbiology, Antibodies, Sesamum, 0404 agricultural biotechnology, food, Humans, Food science, Food allergens, Canola, education, Immunoassay, Detection limit, education.field_of_study, Chemistry, 010401 analytical chemistry, 04 agricultural and veterinary sciences, Allergens, 040401 food science, 0104 chemical sciences, North american population, Sesame oil, Food Hypersensitivity, Food Science
Abstract

An estimated 0.1 to 0.2% of the North American population is allergic to sesame, and deaths due to anaphylactic shock have been reported. Detecting and quantifying sesame in various food samples is critical to safeguard the allergic population by ensuring accurate ingredient labeling. Because of the modular nature of the xMAP Food Allergen Detection Assay (FADA), it was possible through method extension to add sesame as a validated additional analyte. Because raw and toasted sesame are both commonly used and the two display significantly different antigenicity, three antibodies, one monoclonal and two polyclonal, were conjugated to bead sets to ensure reliable detection. The modified xMAP FADA successfully detected sesame incurred or spiked in baked muffins, spice mix, canola oil, and in both raw and toasted sesame oils with limit of quantitation values ≤ 1.3 ppm of sesame. Canola oil, sesame oil, toasted sesame oil, and olive oil inhibited sesame detection, as did the detection of sesame incurred in foods containing oil (e.g., hummus). Despite this inhibition, the xMAP FADA was still able to reliably detect sesame at levels throughout the dynamic range of the assay (22 to 750 ng of protein per mL) in all the foods examined. Further, the high signal-to-noise ratio of the lowest calibration standard and preliminary studies conjugating the antibodies at higher concentrations indicate an ability to increase the sensitivity of the assay should the need arise.

Published
2020

19. Community prevalence of SARS-CoV-2 in England from April to November, 2020: results from the ONS Coronavirus Infection Survey

Author

Koen B Pouwels, Thomas House, Emma Pritchard, Julie V Robotham, Paul J Birrell, Andrew Gelman, Karina-Doris Vihta, Nikola Bowers, Ian Boreham, Heledd Thomas, James Lewis, Iain Bell, John I Bell, John N Newton, Jeremy Farrar, Ian Diamond, Pete Benton, Ann Sarah Walker, Koen B. Pouwels, A. Sarah Walker, Derrick Crook, Philippa C. Matthews, Tim Peto, Nicole Stoesser, Alison Howarth, George Doherty, James Kavanagh, Kevin K. Chau, Stephanie B. Hatch, Daniel Ebner, Lucas Martins Ferreira, Thomas Christott, Brian D. Marsden, Wanwisa Dejnirattisai, Juthathip Mongkolsapaya, Sarah Hoosdally, Richard Cornall, David I. Stuart, Gavin Screaton, David Eyre, John Bell, Stuart Cox, Kevin Paddon, Tim James, John N. Newton, Julie V. Robotham, Paul Birrell, Helena Jordan, Tim Sheppard, Graham Athey, Dan Moody, Leigh Curry, Pamela Brereton, Jodie Hay, Harper Vansteenhouse, Alex Lambert, Emma Rourke, Stacey Hawkes, Sarah Henry, James Scruton, Peter Stokes, Tina Thomas, John Allen, Russell Black, Heather Bovill, David Braunholtz, Dominic Brown, Sarah Collyer, Megan Crees, Colin Daglish, Byron Davies, Hannah Donnarumma, Julia Douglas-Mann, Antonio Felton, Hannah Finselbach, Eleanor Fordham, Alberta Ipser, Joe Jenkins, Joel Jones, Katherine Kent, Geeta Kerai, Lina Lloyd, Victoria Masding, Ellie Osborn, Alpi Patel, Elizabeth Pereira, Tristan Pett, Melissa Randall, Donna Reeve, Palvi Shah, Ruth Snook, Ruth Studley, Esther Sutherland, Eliza Swinn, Anna Tudor, Joshua Weston, Shayla Leib, James Tierney, Gabor Farkas, Raf Cobb, Folkert Van Galen, Lewis Compton, James Irving, John Clarke, Rachel Mullis, Lorraine Ireland, Diana Airimitoaie, Charlotte Nash, Danielle Cox, Sarah Fisher, Zoe Moore, James McLean, and Matt Kerby

Subjects
Adult, Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Adolescent, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Population, 01 natural sciences, 03 medical and health sciences, Young Adult, 0302 clinical medicine, COVID-19 Testing, Residence Characteristics, Epidemiology, Pandemic, Credible interval, Prevalence, Medicine, Humans, Public Health Surveillance, 030212 general & internal medicine, Positive test, 0101 mathematics, Young adult, education, Child, Aged, education.field_of_study, business.industry, 010102 general mathematics, Public Health, Environmental and Occupational Health, COVID-19, Articles, Middle Aged, Health Surveys, England, Child, Preschool, Female, business, Demography
Abstract

Summary Background Decisions about the continued need for control measures to contain the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rely on accurate and up-to-date information about the number of people testing positive for SARS-CoV-2 and risk factors for testing positive. Existing surveillance systems are generally not based on population samples and are not longitudinal in design. Methods Samples were collected from individuals aged 2 years and older living in private households in England that were randomly selected from address lists and previous Office for National Statistics surveys in repeated cross-sectional household surveys with additional serial sampling and longitudinal follow-up. Participants completed a questionnaire and did nose and throat self-swabs. The percentage of individuals testing positive for SARS-CoV-2 RNA was estimated over time by use of dynamic multilevel regression and poststratification, to account for potential residual non-representativeness. Potential changes in risk factors for testing positive over time were also assessed. The study is registered with the ISRCTN Registry, ISRCTN21086382. Findings Between April 26 and Nov 1, 2020, results were available from 1 191 170 samples from 280 327 individuals; 5231 samples were positive overall, from 3923 individuals. The percentage of people testing positive for SARS-CoV-2 changed substantially over time, with an initial decrease between April 26 and June 28, 2020, from 0·40% (95% credible interval 0·29–0·54) to 0·06% (0·04–0·07), followed by low levels during July and August, 2020, before substantial increases at the end of August, 2020, with percentages testing positive above 1% from the end of October, 2020. Having a patient-facing role and working outside your home were important risk factors for testing positive for SARS-CoV-2 at the end of the first wave (April 26 to June 28, 2020), but not in the second wave (from the end of August to Nov 1, 2020). Age (young adults, particularly those aged 17–24 years) was an important initial driver of increased positivity rates in the second wave. For example, the estimated percentage of individuals testing positive was more than six times higher in those aged 17–24 years than in those aged 70 years or older at the end of September, 2020. A substantial proportion of infections were in individuals not reporting symptoms around their positive test (45–68%, dependent on calendar time. Interpretation Important risk factors for testing positive for SARS-CoV-2 varied substantially between the part of the first wave that was captured by the study (April to June, 2020) and the first part of the second wave of increased positivity rates (end of August to Nov 1, 2020), and a substantial proportion of infections were in individuals not reporting symptoms, indicating that continued monitoring for SARS-CoV-2 in the community will be important for managing the COVID-19 pandemic moving forwards. Funding Department of Health and Social Care.

Published
2021
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20. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Author

Murray, Christopher J L, primary, Ikuta, Kevin Shunji, additional, Sharara, Fablina, additional, Swetschinski, Lucien, additional, Robles Aguilar, Gisela, additional, Gray, Authia, additional, Han, Chieh, additional, Bisignano, Catherine, additional, Rao, Puja, additional, Wool, Eve, additional, Johnson, Sarah C, additional, Browne, Annie J, additional, Chipeta, Michael Give, additional, Fell, Frederick, additional, Hackett, Sean, additional, Haines-Woodhouse, Georgina, additional, Kashef Hamadani, Bahar H, additional, Kumaran, Emmanuelle A P, additional, McManigal, Barney, additional, Achalapong, Sureeruk, additional, Agarwal, Ramesh, additional, Akech, Samuel, additional, Albertson, Samuel, additional, Amuasi, John, additional, Andrews, Jason, additional, Aravkin, Aleskandr, additional, Ashley, Elizabeth, additional, Babin, François-Xavier, additional, Bailey, Freddie, additional, Baker, Stephen, additional, Basnyat, Buddha, additional, Bekker, Adrie, additional, Bender, Rose, additional, Berkley, James A, additional, Bethou, Adhisivam, additional, Bielicki, Julia, additional, Boonkasidecha, Suppawat, additional, Bukosia, James, additional, Carvalheiro, Cristina, additional, Castañeda-Orjuela, Carlos, additional, Chansamouth, Vilada, additional, Chaurasia, Suman, additional, Chiurchiù, Sara, additional, Chowdhury, Fazle, additional, Clotaire Donatien, Rafai, additional, Cook, Aislinn J, additional, Cooper, Ben, additional, Cressey, Tim R, additional, Criollo-Mora, Elia, additional, Cunningham, Matthew, additional, Darboe, Saffiatou, additional, Day, Nicholas P J, additional, De Luca, Maia, additional, Dokova, Klara, additional, Dramowski, Angela, additional, Dunachie, Susanna J, additional, Duong Bich, Thuy, additional, Eckmanns, Tim, additional, Eibach, Daniel, additional, Emami, Amir, additional, Feasey, Nicholas, additional, Fisher-Pearson, Natasha, additional, Forrest, Karen, additional, Garcia, Coralith, additional, Garrett, Denise, additional, Gastmeier, Petra, additional, Giref, Ababi Zergaw, additional, Greer, Rachel Claire, additional, Gupta, Vikas, additional, Haller, Sebastian, additional, Haselbeck, Andrea, additional, Hay, Simon I, additional, Holm, Marianne, additional, Hopkins, Susan, additional, Hsia, Yingfen, additional, Iregbu, Kenneth C, additional, Jacobs, Jan, additional, Jarovsky, Daniel, additional, Javanmardi, Fatemeh, additional, Jenney, Adam W J, additional, Khorana, Meera, additional, Khusuwan, Suwimon, additional, Kissoon, Niranjan, additional, Kobeissi, Elsa, additional, Kostyanev, Tomislav, additional, Krapp, Fiorella, additional, Krumkamp, Ralf, additional, Kumar, Ajay, additional, Kyu, Hmwe Hmwe, additional, Lim, Cherry, additional, Lim, Kruy, additional, Limmathurotsakul, Direk, additional, Loftus, Michael James, additional, Lunn, Miles, additional, Ma, Jianing, additional, Manoharan, Anand, additional, Marks, Florian, additional, May, Jürgen, additional, Mayxay, Mayfong, additional, Mturi, Neema, additional, Munera-Huertas, Tatiana, additional, Musicha, Patrick, additional, Musila, Lilian A, additional, Mussi-Pinhata, Marisa Marcia, additional, Naidu, Ravi Narayan, additional, Nakamura, Tomoka, additional, Nanavati, Ruchi, additional, Nangia, Sushma, additional, Newton, Paul, additional, Ngoun, Chanpheaktra, additional, Novotney, Amanda, additional, Nwakanma, Davis, additional, Obiero, Christina W, additional, Ochoa, Theresa J, additional, Olivas-Martinez, Antonio, additional, Olliaro, Piero, additional, Ooko, Ednah, additional, Ortiz-Brizuela, Edgar, additional, Ounchanum, Pradthana, additional, Pak, Gideok D, additional, Paredes, Jose Luis, additional, Peleg, Anton Yariv, additional, Perrone, Carlo, additional, Phe, Thong, additional, Phommasone, Koukeo, additional, Plakkal, Nishad, additional, Ponce-de-Leon, Alfredo, additional, Raad, Mathieu, additional, Ramdin, Tanusha, additional, Rattanavong, Sayaphet, additional, Riddell, Amy, additional, Roberts, Tamalee, additional, Robotham, Julie Victoria, additional, Roca, Anna, additional, Rosenthal, Victor Daniel, additional, Rudd, Kristina E, additional, Russell, Neal, additional, Sader, Helio S, additional, Saengchan, Weerawut, additional, Schnall, Jesse, additional, Scott, John Anthony Gerard, additional, Seekaew, Samroeng, additional, Sharland, Mike, additional, Shivamallappa, Madhusudhan, additional, Sifuentes-Osornio, Jose, additional, Simpson, Andrew J, additional, Steenkeste, Nicolas, additional, Stewardson, Andrew James, additional, Stoeva, Temenuga, additional, Tasak, Nidanuch, additional, Thaiprakong, Areerat, additional, Thwaites, Guy, additional, Tigoi, Caroline, additional, Turner, Claudia, additional, Turner, Paul, additional, van Doorn, H Rogier, additional, Velaphi, Sithembiso, additional, Vongpradith, Avina, additional, Vongsouvath, Manivanh, additional, Vu, Huong, additional, Walsh, Timothy, additional, Walson, Judd L, additional, Waner, Seymour, additional, Wangrangsimakul, Tri, additional, Wannapinij, Prapass, additional, Wozniak, Teresa, additional, Young Sharma, Tracey E M W, additional, Yu, Kalvin C, additional, Zheng, Peng, additional, Sartorius, Benn, additional, Lopez, Alan D, additional, Stergachis, Andy, additional, Moore, Catrin, additional, Dolecek, Christiane, additional, and Naghavi, Mohsen, additional

Published
2022
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22. Community prevalence of SARS-CoV-2 in England from April to November, 2020: results from the ONS Coronavirus Infection Survey

Author

Pouwels, Koen B, primary, House, Thomas, additional, Pritchard, Emma, additional, Robotham, Julie V, additional, Birrell, Paul J, additional, Gelman, Andrew, additional, Vihta, Karina-Doris, additional, Bowers, Nikola, additional, Boreham, Ian, additional, Thomas, Heledd, additional, Lewis, James, additional, Bell, Iain, additional, Bell, John I, additional, Newton, John N, additional, Farrar, Jeremy, additional, Diamond, Ian, additional, Benton, Pete, additional, Walker, Ann Sarah, additional, Pouwels, Koen B., additional, Walker, A. Sarah, additional, Crook, Derrick, additional, Matthews, Philippa C., additional, Peto, Tim, additional, Stoesser, Nicole, additional, Howarth, Alison, additional, Doherty, George, additional, Kavanagh, James, additional, Chau, Kevin K., additional, Hatch, Stephanie B., additional, Ebner, Daniel, additional, Martins Ferreira, Lucas, additional, Christott, Thomas, additional, Marsden, Brian D., additional, Dejnirattisai, Wanwisa, additional, Mongkolsapaya, Juthathip, additional, Hoosdally, Sarah, additional, Cornall, Richard, additional, Stuart, David I., additional, Screaton, Gavin, additional, Eyre, David, additional, Bell, John, additional, Cox, Stuart, additional, Paddon, Kevin, additional, James, Tim, additional, Newton, John N., additional, Robotham, Julie V., additional, Birrell, Paul, additional, Jordan, Helena, additional, Sheppard, Tim, additional, Athey, Graham, additional, Moody, Dan, additional, Curry, Leigh, additional, Brereton, Pamela, additional, Hay, Jodie, additional, Vansteenhouse, Harper, additional, Lambert, Alex, additional, Rourke, Emma, additional, Hawkes, Stacey, additional, Henry, Sarah, additional, Scruton, James, additional, Stokes, Peter, additional, Thomas, Tina, additional, Allen, John, additional, Black, Russell, additional, Bovill, Heather, additional, Braunholtz, David, additional, Brown, Dominic, additional, Collyer, Sarah, additional, Crees, Megan, additional, Daglish, Colin, additional, Davies, Byron, additional, Donnarumma, Hannah, additional, Douglas-Mann, Julia, additional, Felton, Antonio, additional, Finselbach, Hannah, additional, Fordham, Eleanor, additional, Ipser, Alberta, additional, Jenkins, Joe, additional, Jones, Joel, additional, Kent, Katherine, additional, Kerai, Geeta, additional, Lloyd, Lina, additional, Masding, Victoria, additional, Osborn, Ellie, additional, Patel, Alpi, additional, Pereira, Elizabeth, additional, Pett, Tristan, additional, Randall, Melissa, additional, Reeve, Donna, additional, Shah, Palvi, additional, Snook, Ruth, additional, Studley, Ruth, additional, Sutherland, Esther, additional, Swinn, Eliza, additional, Tudor, Anna, additional, Weston, Joshua, additional, Leib, Shayla, additional, Tierney, James, additional, Farkas, Gabor, additional, Cobb, Raf, additional, Van Galen, Folkert, additional, Compton, Lewis, additional, Irving, James, additional, Clarke, John, additional, Mullis, Rachel, additional, Ireland, Lorraine, additional, Airimitoaie, Diana, additional, Nash, Charlotte, additional, Cox, Danielle, additional, Fisher, Sarah, additional, Moore, Zoe, additional, McLean, James, additional, and Kerby, Matt, additional

Published
2021
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25. Histopathological assessment of the health status of Mytilus chilensis (Hupé 1854) in southern Chile

Author

John P. Bignell, Florencia Navarrete, Hugo Robotham, Eduardo Bustos, Karin B. Lohrmann, and Rosanna Rojas

Subjects
Mytilus chilensis, animal structures, biology, business.industry, fungi, Zoology, Aquatic animal, Mussel, Aquatic Science, biology.organism_classification, Monitoring program, Aquaculture, Helminths, business, Copepod, Shellfish
Abstract

Mussel (Mytilus chilensis) farming is an important economic and social activity in the south of Chile. With a landing of 302,642 tons in year 2016, Chile is the second mytilid producer after China, and the first exporter worldwide. To be better prepared to protect this industry, the health status of a total number of 478 mussels (M. chilensis) from the Los Lagos Region, in the south of Chile, was assessed. Baseline information on symbionts, parasites and pathological conditions of both cultivated and natural mussels was collected using histology. Organisms detected included: intracellular microcolonies of bacteria (IMC), located in the epithelium of the gill and of digestive gland tubules; a microsporidian resembling Steinhausia mytilovum hosted by oocytes; two gill ciliates; a copepod; and a digenean trematode. Pathological conditions included neoplasia, hemocyte aggregates within digestive epithelia, lipofuscin-like pigments in various tissues, and gill epithelium desquamation. The prevalence of each finding was assessed and compared statistically between sites and between cultured and natural populations. The infection intensity of them was low, and no OIE listed parasite was detected. Of all the findings of this study, those that could be of concern are the IMC, neoplasia, and the Steinhausia mytilovum-like microsporidian. This study provided baseline data necessary for the design of a larger, seasonal sampling, which will allow to assess the feasibility of a permanent monitoring program to protect the huge mussel cultivating industry of the Los Lagos Region in Chile.

Published
2019

27. COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

Author

Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Saei, Ayoub, additional, Andrews, Nick, additional, Oguti, Blanche, additional, Charlett, Andre, additional, Wellington, Edgar, additional, Stowe, Julia, additional, Gillson, Natalie, additional, Atti, Ana, additional, Islam, Jasmin, additional, Karagiannis, Ioannis, additional, Munro, Katie, additional, Khawam, Jameel, additional, Chand, Meera A, additional, Brown, Colin S, additional, Ramsay, Mary, additional, Lopez-Bernal, Jamie, additional, Hopkins, Susan, additional, Andrews, N, additional, Atti, A, additional, Aziz, H, additional, Brooks, T, additional, Brown, CS, additional, Camero, D, additional, Carr, C, additional, Chand, MA, additional, Charlett, A, additional, Crawford, H, additional, Cole, M, additional, Conneely, J, additional, D'Arcangelo, S, additional, Ellis, J, additional, Evans, S, additional, Foulkes, S, additional, Gillson, N, additional, Gopal, R, additional, Hall, L, additional, Hall, VJ, additional, Harrington, P, additional, Hopkins, S, additional, Hewson, J, additional, Hoschler, K, additional, Ironmonger, D, additional, Islam, J, additional, Kall, M, additional, Karagiannis, I, additional, Kay, O, additional, Khawam, J, additional, King, E, additional, Kirwan, P, additional, Kyffin, R, additional, Lackenby, A, additional, Lattimore, M, additional, Linley, E, additional, Lopez-Bernal, J, additional, Mabey, L, additional, McGregor, R, additional, Miah, S, additional, Monk, EJM, additional, Munro, K, additional, Naheed, Z, additional, Nissr, A, additional, O'Connell, AM, additional, Oguti, B, additional, Okafor, H, additional, Organ, S, additional, Osbourne, J, additional, Otter, A, additional, Patel, M, additional, Platt, S, additional, Pople, D, additional, Potts, K, additional, Ramsay, M, additional, Robotham, J, additional, Rokadiya, S, additional, Rowe, C, additional, Saei, A, additional, Sebbage, G, additional, Semper, A, additional, Shrotri, M, additional, Simmons, R, additional, Soriano, A, additional, Staves, P, additional, Taylor, S, additional, Taylor, A, additional, Tengbe, A, additional, Tonge, S, additional, Vusirikala, A, additional, Wallace, S, additional, Wellington, E, additional, Zambon, M, additional, Corrigan, D, additional, Sartaj, M, additional, Cromey, L, additional, Campbell, S, additional, Braithwaite, K, additional, Price, L, additional, Haahr, L, additional, Stewart, S, additional, Lacey, ED, additional, Partridge, L, additional, Stevens, G, additional, Ellis, Y, additional, Hodgson, H, additional, Norman, C, additional, Larru, B, additional, Mcwilliam, S, additional, Roynon, A, additional, Northfield, J, additional, Winchester, S, additional, Cieciwa, P, additional, Pai, A, additional, Bakker, P, additional, Loughrey, C, additional, Watt, A, additional, Adair, F, additional, Hawkins, A, additional, Grant, A, additional, Temple-Purcell, R, additional, Howard, J, additional, Slawson, N, additional, Subudhi, C, additional, Davies, S, additional, Bexley, A, additional, Penn, R, additional, Wong, N, additional, Boyd, G, additional, Rajgopal, A, additional, Arenas-Pinto, A, additional, Matthews, R, additional, Whileman, A, additional, Laugharne, R, additional, Ledger, J, additional, Barnes,, T, additional, Jones, C, additional, Osuji, N, additional, Chitalia, N, additional, Bailey, T, additional, Akhtar, S, additional, Harrison, G, additional, Horne, S, additional, Walker, N, additional, Agwuh, K, additional, Maxwell, V, additional, Graves, J, additional, Williams, S, additional, O'Kelly, A, additional, Ridley, P, additional, Cowley, A, additional, Johnstone, H, additional, Swift, P, additional, Democratis, J, additional, Meda, M, additional, Brake, S, additional, Gunn, J, additional, Selassi, A, additional, Hams, S, additional, Irvine, V, additional, Chandrasekaran, B, additional, Forsyth, C, additional, Radmore, J, additional, Thomas, C, additional, Brown, K, additional, Roberts, S, additional, Burns, P, additional, Gajee, K, additional, Lewis, T, additional, Byrne, TM, additional, Sanderson, F, additional, Knight, S, additional, Macnaughton, E, additional, Burton, BJL, additional, Smith, H, additional, Chaudhuri, R, additional, Aeron-Thomas, J, additional, Hollinshead, K, additional, Shorten, RJ, additional, Swan, A, additional, Favager, C, additional, Murira, J, additional, Baillon, S, additional, Hamer, S, additional, Shah, A, additional, Russell, J, additional, Brennan, D, additional, Dave, A, additional, Chawla, A, additional, Westwell, F, additional, Adeboyeku, D, additional, Papineni, P, additional, Pegg, C, additional, Williams, M, additional, Ahmad, S, additional, Horsley, A, additional, Gabriel, C, additional, Pagget, K, additional, Maloney, G, additional, Ashcroft, J, additional, Del Rosario, I, additional, Crosby-Nwaobi, R, additional, Flanagan, D, additional, Dhasmana, D, additional, Fowler, S, additional, Cameron, E, additional, Prentice, L, additional, Sinclair, C, additional, Bateman, V, additional, McLelland-Brooks, K, additional, Ho, A, additional, Murphy, M, additional, Cochrane, A, additional, Gibson, A, additional, Black, K, additional, Tempeton, K, additional, Donaldson, S, additional, Coke, L, additional, Elumogo, N, additional, Elliott, J, additional, Padgett, D, additional, Cross, A, additional, Mirfenderesky, M, additional, Joyce, S, additional, Sinanovic, I, additional, Howard, M, additional, Cowling, P, additional, Brazil, M, additional, Hanna, E, additional, Abdelrazik, A, additional, Brand, S, additional, Sheridan, EA, additional, Wadams, B, additional, Lloyd, A, additional, Mouland, J, additional, Giles, J, additional, Pottinger, G, additional, Coles, H, additional, Joseph, M, additional, Lee, M, additional, Orr, S, additional, Chenoweth, H, additional, Browne, D, additional, Auckland, C, additional, Lear, R, additional, Mahungu, T, additional, Rodger, A, additional, Warren, S, additional, Brooking, D, additional, Pai, S, additional, Druyeh, R, additional, Smith, E, additional, Stone, S, additional, Meisner, S, additional, Delgado, D, additional, Underhill, E, additional, Keen, L, additional, Aga, M, additional, Domingos, P, additional, Gormley, S, additional, Kerrison, C, additional, Birch, S, additional, DeSilva, T, additional, Allsop, L, additional, Ambalkar, S, additional, Beekes, M, additional, Jose, S, additional, Tomlinson, J, additional, Painter, Sharen, additional, Price, C, additional, Pepperell, J, additional, James, K, additional, Trinick, T, additional, Moore, L, additional, Day, J, additional, Boulos, A, additional, Knox, I, additional, Defever, E, additional, McCracken, D, additional, Gray, K, additional, Houston, A, additional, Planche, T, additional, Pritchard Jones, R, additional, Wycherley, Diane, additional, Bennett, S, additional, Marrs, J, additional, Nimako, K, additional, Stewart, B, additional, Bain, SC, additional, Kalakonda, N, additional, Khanduri, S, additional, Ashby, A, additional, Holden, M, additional, Mahabir, N, additional, Harwood, J, additional, Payne, B, additional, Court, K, additional, White, N, additional, Longfellow, R, additional, Hughes, LE, additional, Green, ME, additional, Halkes, M, additional, Mercer, P, additional, Roebuck, A, additional, Wilson-Davies, E, additional, Gallego, L, additional, Lazarus, R, additional, Aldridge, N, additional, Berry, L, additional, Game, F, additional, Reynolds, T, additional, Holmes, C, additional, Wiselka, M, additional, Higham, A, additional, Booth, M, additional, Duff, C, additional, Alderton, J, additional, Hilton, D, additional, Powell, J, additional, Jackson, A, additional, Plant, AJ, additional, Ahmed, N, additional, Chin, T, additional, Qazzafi, MZ, additional, Moody, AM, additional, Tilley, RE, additional, Donaghy, T, additional, O'Kane, M, additional, Shipman, K, additional, Sierra, R, additional, Parmar, C, additional, Mills, G, additional, Harvey, D, additional, Huang, YWJ, additional, Birch, J, additional, Robinson, L, additional, Board, S, additional, Broadley, A, additional, Laven, C, additional, Todd, N, additional, Eyre, DW, additional, Jeffery, K, additional, Dunachie, S, additional, Duncan, C, additional, Klenerman, P, additional, Turtle, L, additional, Baxendale, H, additional, and Heeney, JL, additional

Published
2021
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28. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)

Author

Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Charlett, Andre, additional, Atti, Ana, additional, Monk, Edward J M, additional, Simmons, Ruth, additional, Wellington, Edgar, additional, Cole, Michelle J, additional, Saei, Ayoub, additional, Oguti, Blanche, additional, Munro, Katie, additional, Wallace, Sarah, additional, Kirwan, Peter D, additional, Shrotri, Madhumita, additional, Vusirikala, Amoolya, additional, Rokadiya, Sakib, additional, Kall, Meaghan, additional, Zambon, Maria, additional, Ramsay, Mary, additional, Brooks, Tim, additional, Brown, Colin S, additional, Chand, Meera A, additional, Hopkins, Susan, additional, Andrews, N, additional, Atti, A, additional, Aziz, H, additional, Brooks, T, additional, Brown, CS, additional, Camero, D, additional, Carr, C, additional, Chand, MA, additional, Charlett, A, additional, Crawford, H, additional, Cole, M, additional, Conneely, J, additional, D'Arcangelo, S, additional, Ellis, J, additional, Evans, S, additional, Foulkes, S, additional, Gillson, N, additional, Gopal, R, additional, Hall, L, additional, Hall, VJ, additional, Harrington, P, additional, Hopkins, S, additional, Hewson, J, additional, Hoschler, K, additional, Ironmonger, D, additional, Islam, J, additional, Kall, M, additional, Karagiannis, I, additional, Kay, O, additional, Khawam, J, additional, King, E, additional, Kirwan, P, additional, Kyffin, R, additional, Lackenby, A, additional, Lattimore, M, additional, Linley, E, additional, Lopez-Bernal, J, additional, Mabey, L, additional, McGregor, R, additional, Miah, S, additional, Monk, EJM, additional, Munro, K, additional, Naheed, Z, additional, Nissr, A, additional, O'Connell, AM, additional, Oguti, B, additional, Okafor, H, additional, Organ, S, additional, Osbourne, J, additional, Otter, A, additional, Patel, M, additional, Platt, S, additional, Pople, D, additional, Potts, K, additional, Ramsay, M, additional, Robotham, J, additional, Rokadiya, S, additional, Rowe, C, additional, Saei, A, additional, Sebbage, G, additional, Semper, A, additional, Shrotri, M, additional, Simmons, R, additional, Soriano, A, additional, Staves, P, additional, Taylor, S, additional, Taylor, A, additional, Tengbe, A, additional, Tonge, S, additional, Vusirikala, A, additional, Wallace, S, additional, Wellington, E, additional, Zambon, M, additional, Corrigan, D, additional, Sartaj, M, additional, Cromey, L, additional, Campbell, S, additional, Braithwaite, K, additional, Price, L, additional, Haahr, L, additional, Stewart, S, additional, Lacey, ED, additional, Partridge, L, additional, Stevens, G, additional, Ellis, Y, additional, Hodgson, H, additional, Norman, C, additional, Larru, B, additional, Mcwilliam, S, additional, Winchester, S, additional, Cieciwa, P, additional, Pai, A, additional, Loughrey, C, additional, Watt, A, additional, Adair, F, additional, Hawkins, A, additional, Grant, A, additional, Temple-Purcell, R, additional, Howard, J, additional, Slawson, N, additional, Subudhi, C, additional, Davies, S, additional, Bexley, A, additional, Penn, R, additional, Wong, N, additional, Boyd, G, additional, Rajgopal, A, additional, Arenas-Pinto, A, additional, Matthews, R, additional, Whileman, A, additional, Laugharne, R, additional, Ledger, J, additional, Barnes, T, additional, Jones, C, additional, Botes, D, additional, Chitalia, N, additional, Akhtar, S, additional, Harrison, G, additional, Horne, S, additional, Walker, N, additional, Agwuh, K, additional, Maxwell, V, additional, Graves, J, additional, Williams, S, additional, O'Kelly, A, additional, Ridley, P, additional, Cowley, A, additional, Johnstone, H, additional, Swift, P, additional, Democratis, J, additional, Meda, M, additional, Callens, C, additional, Beazer, S, additional, Hams, S, additional, Irvine, V, additional, Chandrasekaran, B, additional, Forsyth, C, additional, Radmore, J, additional, Thomas, C, additional, Brown, K, additional, Roberts, S, additional, Burns, P, additional, Gajee, K, additional, Byrne, TM, additional, Sanderson, F, additional, Knight, S, additional, Macnaughton, E, additional, Burton, BJL, additional, Smith, H, additional, Chaudhuri, R, additional, Hollinshead, K, additional, Shorten, RJ, additional, Swan, A, additional, Favager, C, additional, Murira, J, additional, Baillon, S, additional, Hamer, S, additional, Gantert, K, additional, Russell, J, additional, Brennan, D, additional, Dave, A, additional, Chawla, A, additional, Westell, F, additional, Adeboyeku, D, additional, Papineni, P, additional, Pegg, C, additional, Williams, M, additional, Ahmad, S, additional, Ingram, S, additional, Gabriel, C, additional, Pagget, K, additional, Maloney, G, additional, Ashcroft, J, additional, Del Rosario, I, additional, Crosby-Nwaobi, R, additional, Reeks, C, additional, Fowler, S, additional, Prentice, L, additional, Spears, M, additional, McKerron, G, additional, McLelland-Brooks, K, additional, Anderson, J, additional, Donaldson, S, additional, Templeton, K, additional, Coke, L, additional, Elumogo, N, additional, Elliott, J, additional, Padgett, D, additional, Mirfenderesky, M, additional, Cross, A, additional, Price, J, additional, Joyce, S, additional, Sinanovic, I, additional, Howard, M, additional, Lewis, T, additional, Cowling, P, additional, Potoczna, D, additional, Brand, S, additional, Sheridan, L, additional, Wadams, B, additional, Lloyd, A, additional, Mouland, J, additional, Giles, J, additional, Pottinger, G, additional, Coles, H, additional, Joseph, M, additional, Lee, M, additional, Orr, S, additional, Chenoweth, H, additional, Auckland, C, additional, Lear, R, additional, Mahungu, T, additional, Rodger, A, additional, Penny-Thomas, K, additional, Pai, S, additional, Zamikula, J, additional, Smith, E, additional, Stone, S, additional, Boldock, E, additional, Howcroft, D, additional, Thompson, C, additional, Aga, M, additional, Domingos, P, additional, Gormley, S, additional, Kerrison, C, additional, Marsh, L, additional, Tazzyman, S, additional, Allsop, L, additional, Ambalkar, S, additional, Beekes, M, additional, Jose, S, additional, Tomlinson, J, additional, Jones, A, additional, Price, C, additional, Pepperell, J, additional, Schultz, M, additional, Day, J, additional, Boulos, A, additional, Defever, E, additional, McCracken, D, additional, Gray, K, additional, Houston, A, additional, Planche, T, additional, Pritchard Jones, R, additional, Wycherley, Diane, additional, Bennett, S, additional, Marrs, J, additional, Nimako, K, additional, Stewart, B, additional, Kalakonda, N, additional, Khanduri, S, additional, Ashby, A, additional, Holden, M, additional, Mahabir, N, additional, Harwood, J, additional, Payne, B, additional, Court, K, additional, Staines, N, additional, Longfellow, R, additional, Green, ME, additional, Hughes, LE, additional, Halkes, M, additional, Mercer, P, additional, Roebuck, A, additional, Wilson-Davies, E, additional, Gallego, L, additional, Lazarus, R, additional, Aldridge, N, additional, Berry, L, additional, Game, F, additional, Reynolds, T, additional, Holmes, C, additional, Wiselka, M, additional, Higham, A, additional, Booth, M, additional, Duff, C, additional, Alderton, J, additional, Jory, H, additional, Virgilio, E, additional, Chin, T, additional, Qazzafi, MZ, additional, Moody, AM, additional, Tilley, R, additional, Donaghy, T, additional, Shipman, K, additional, Sierra, R, additional, Jones, N, additional, Mills, G, additional, Harvey, D, additional, Huang, YWJ, additional, Birch, J, additional, Robinson, L, additional, Board, S, additional, Broadley, A, additional, Laven, C, additional, Todd, N, additional, Eyre, DW, additional, Jeffery, K, additional, Dunachie, S, additional, Duncan, C, additional, Klenerman, P, additional, Turtle, L, additional, De Silva, T, additional, Baxendale, H, additional, and Heeney, JL, additional

Published
2021
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30. To be, or not to be…Black: The effects of racial codeswitching on perceived professionalism in the workplace

Author

Richard E. Smith, Myles I. Durkee, Kathrina Robotham, Courtney L. McCluney, and Serenity Sai-Lai Lee

Subjects
White (horse), Sociology and Political Science, Social Psychology, media_common.quotation_subject, Impression formation, Variety (linguistics), Style (sociolinguistics), Impression management, Perception, Natural (music), Psychology, Social psychology, Mirroring, media_common
Abstract

Black people engage in a variety of behaviors to avoid stereotyping and promote a professional image in the workplace. Racial codeswitching is one impression management strategy where Black people adjust their self-presentation to receive desirable outcomes (e.g., perceived professionalism) through mirroring the norms, behaviors, and attributes of the dominant group (i.e., White people) in specific contexts. In this study, we examine whether racial codeswitching enhances perceived professionalism for Black employees. We investigate Black and White participants' perceptions of racial codeswitching and subsequent evaluations of professionalism through manipulating three behaviors (e.g., adjusting style of speech, name selection, hairstyle) of a fictitious Black coworker in two, between-subjects experimental studies using audio and written stimuli. Results indicate that employees who engage in racial codeswitching are consistently perceived as more professional by both Black and White participants compared to employees who do not codeswitch (Studies 1 & 2). We also found that Black participants perceive the non-codeswitching employee as more professional than White participants (Studies 2a & 2b). Black and White participants' evaluation of specific codeswitching behaviors varied with both groups supporting adjustment of speech, opposing adjusting one's name, and diverging on wearing natural hairstyles (Studies 1 & 2). Although racial codeswitching is presented as an impression management strategy, it may reinforce White professional standards and generate social and psychological costs for Black employees. Implications of our work for impression management and impression formation are further discussed.

Published
2021

38. Counting the cost of an outbreak of carbapenemase-producing Enterobacteriaceae : an economic evaluation from a hospital perspective

Author

Eimear T Brannigan, Jonathan A. Otter, Mark Gilchrist, Frances Davies, J Singleton, Julie V. Robotham, Siddharth Mookerjee, P Burgess, D Parsons, and Alison Holmes

Subjects
0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Opportunity cost, Cost estimate, 030106 microbiology, Carbapenem-resistant enterobacteriaceae, 030501 epidemiology, beta-Lactamases, Disease Outbreaks, 03 medical and health sciences, Bacterial Proteins, London, Humans, Medicine, Revenue, Hospital Costs, Intensive care medicine, health care economics and organizations, Cross Infection, business.industry, Outbreak, General Medicine, medicine.disease, Hospitals, Klebsiella Infections, Klebsiella pneumoniae, Infectious Diseases, Economic evaluation, Observational study, Medical emergency, 0305 other medical science, business, Elective Surgical Procedure
Abstract

Objective To perform an economic evaluation on the cost associated with an outbreak of carbapenemase-producing Enterobacteriaceae (CPE). Methods We performed an observational economic evaluation of an outbreak of CPE (NDM-producing Klebsiella pneumoniae ) affecting 40 patients in a group of five hospitals across three sites in West London. Costs were split into actual expenditure (including anti-infective costs, enhanced CPE screening, contact precautions, temporary ward-based monitors of hand and environmental practice, and environmental decontamination), and ‘opportunity cost' (staff time, bed closures and elective surgical missed revenue). Costs are estimated from the hospital perspective over the 10-month duration of the outbreak. Results The outbreak cost €1.1m over 10 months (range €0.9–1.4m), comprising €312 000 actual expenditure, and €822 000 (range €631 000–€1.1m) in opportunity cost. An additional €153 000 was spent on Estates renovations prompted by the outbreak. Actual expenditure comprised: €54 000 on anti-infectives for 18 patients treated, €94 000 on laboratory costs for screening, €73 000 on contact precautions for 1831 contact precautions patient-days, €42 000 for hydrogen peroxide vapour decontamination of 24 single rooms, €43 000 on 2592 hours of ward-based monitors, and €6000 of expenditure related to ward and bay closures. Opportunity costs comprised: €244 000 related to 1206 lost bed-days (range 366–2562 bed-days, €77 000–€512 000), €349 000 in missed revenue from 72 elective surgical procedures, and €228 000 in staff time (range €205 000–€251 000). Reduced capacity to perform elective surgical procedures related to bed closures (€349 000) represented the greatest cost. Conclusions The cost estimates that we present suggest that CPE outbreaks are highly costly.

Published
2017

39. Altering the central carbon metabolism of HEK293 cells: Impact on recombinant glycoprotein quality

Author

John F. Kelly, Gregory De Crescenzo, Olivier Henry, Anna Robotham, Yves Durocher, and Eric Karengera

Subjects
protein quality, 0106 biological sciences, 0301 basic medicine, Glycosylation, Glutamine, Bioengineering, PYC2-overexpression, Interferon alpha-2, Biology, 01 natural sciences, Applied Microbiology and Biotechnology, law.invention, Metabolic engineering, 03 medical and health sciences, chemistry.chemical_compound, Bioreactors, Ammonia, law, Yeasts, HEK293 cells, 010608 biotechnology, Humans, Lactic Acid, Cloning, Molecular, Glycoproteins, Pyruvate Carboxylase, O-Glycosylation, chemistry.chemical_classification, Cell growth, HEK 293 cells, Interferon-alpha, General Medicine, Metabolism, Carbon, Recombinant Proteins, Glucose, 030104 developmental biology, Metabolic Engineering, Biochemistry, chemistry, Recombinant DNA, Electrophoresis, Polyacrylamide Gel, Glycoprotein, Protein quality, Biotechnology
Abstract

The accumulation of metabolic by-products remains a critical challenge in the development of mammalian cells culture processes as it impacts cellular growth, productivity and product quality. Although the overexpression of the PYC2 gene was shown to significantly improve the nutrient metabolism efficiency of mammalian cells, its impact on recombinant protein quality has not been investigated yet. In this study, we assess the effect of this metabolic engineering strategy on the quality of a recombinant therapeutic glycoprotein, the human interferon α2b (IFNα2b). As inferred from densitometry analysis of SDS-PAGE gels, PYC2-overexpressing cells sustained a higher percentage of intact glycosylated IFNα2b at the late stage of batch cultures, which was correlated with prolonged viability and reduced accumulation of waste metabolites. Contrarily to the IFNα2b produced by the PYC2 cells, LC–MS analysis confirmed the presence of less glycosylated IFNα2b as well as the occurrence of proteolytic cleavage in the IFNα2b produced in the parental cells. Taken together, these results indicate that PYC2-overexpression in mammalian cells leads to extended favorable conditions for glycosylation and offer an attractive approach to mass-produce high-quality recombinant proteins.

Published
2017

40. Reducing Expectations for Antibiotics in Primary Care: A Randomised Experiment to Test the Response to Fear-Based Messages About Antimicrobial Resistance

Author

Susan Hopkins, Michele Peters, Sarah Wordsworth, Derrick W. Crook, A. Sarah Walker, Natalie Herd, Christopher C Butler, S Tonkin-Crine, Susan Michie, Laurence Roope, Anna Sallis, Enrique Castro-Sánchez, Koen B. Pouwels, Tim E. A. Peto, and Julie V. Robotham

Subjects
medicine.medical_specialty, Research ethics, Informed consent, Public health, Family medicine, Declaration, medicine, Survey data collection, Subject (documents), Associate professor, Test (assessment)
Abstract

Background: Public health campaigns often provide fear-based information about antibiotic-use and antimicrobial-resistance (AMR). This study aimed to test the likely impact of fear-based messages on patient consultations/antibiotic-requests for influenza-like-illnesses. Methods: We hypothesised that fear-based messages containing empowering information about self-management without antibiotics would be more effective, particularly in a pre-specified subgroup with low AMR awareness. Respondents from an online research panel, representative of United Kingdom adults, were randomised to receive three different messages about antibiotic-use and AMR, designed to induce fear about AMR to varying degrees. Two messages (one 'strong-fear', one 'mild-fear') also contained empowering information regarding influenza-like-symptoms being easily self-managed without antibiotics. The main outcome measures were self-reported effect of information on likelihood of visiting a doctor, and requesting antibiotics, for influenza-like-illness; analysed separately according to whether the AMR information was "very/somewhat new" to respondents, pre-specified based on a previous non-randomised survey. Findings: The 'fear-only' message was "very/somewhat new" to 285/1,000(28·5%) respondents; 'mild-fear-plus-empowerment' to 336/1,500(22·4%); and 'strong-fear-plus-empowerment' to 388/1,500(25·9%) (p=0·002). Of those for whom the respective information was "very/somewhat new", only those given the 'strong-fear-plus-empowerment' message said they would be less likely to request antibiotics if they visited a doctor for an influenza-like-illness (p

Published
2019

41. PSU3 A Framework for Evaluating the Health and Cost Implications of Antimicrobial Resistance in the Context of Surgical Procedures

Author

Marta Soares, A. Belloni, J. Robotham, J. Russell, Bethan Sarah Woods, Mark Sculpher, H. Davies, Stuart Mealing, H. Holmes, R. Puig-Peiro, A. Varghese, and S. Evans

Subjects
Antibiotic resistance, Risk analysis (engineering), business.industry, Health Policy, Public Health, Environmental and Occupational Health, Medicine, Context (language use), Surgical procedures, business, Cost implications
Published
2020

42. New barrier encapsulation and lifetime assessment of printed organic photovoltaic modules

Author

Doojin Vak, Christopher J. Fell, David J. Jones, Andrew D. Scully, Benjamin Robotham, and Hasitha Weerasinghe

Subjects
Fabrication, Atmospheric oxygen, Organic solar cell, Renewable Energy, Sustainability and the Environment, business.industry, Photovoltaic system, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Durability, Polymer solar cell, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Encapsulation (networking), Optoelectronics, 0210 nano-technology, business, Device degradation
Abstract

Organic photovoltaic (OPV) modules printed on plastic substrates are attracting worldwide attention due to advantages such as flexibility, large-scale printability, lightweight, and potential utility for new products. However, exposure to atmospheric oxygen and water vapour is known to cause rapid device degradation and OPV devices thus require encapsulation using materials having ultra-low permeability to these atmospheric constituents to achieve the required operational lifetimes for commercial applications. In this work, various encapsulation architectures using flexible barrier films and adhesives available from commercial suppliers are developed and the lifetime of encapsulated large-area (active area ~50 cm2) fully-printed OPV modules are assessed under ambient laboratory and outdoor conditions. New encapsulation architectures significantly enhance the durability of printed OPV modules, with results showing modules exhibiting a shelf-life of more than 5 years, and no evidence of degradation after 13 months׳ exposure under outdoor conditions.

Published
2016

43. Contribution to the study of sustainability of small-scale artisanal fisheries in Chile

Author

Carlos Hidalgo, Hugo Robotham, Francisco Ther-Rios, Eduardo Bustos, Marcela Ávila, Matias Robotham, and Jorge Muñoz

Subjects
0106 biological sciences, Sustainable development, Economics and Econometrics, business.industry, 010604 marine biology & hydrobiology, Environmental resource management, Fishing, Pillar, 04 agricultural and veterinary sciences, Artisanal fishing, Management, Monitoring, Policy and Law, Aquatic Science, 01 natural sciences, Structural equation modeling, Proxy (climate), Environmental Sustainability Index, Geography, Sustainability, 040102 fisheries, 0401 agriculture, forestry, and fisheries, business, Law, General Environmental Science
Abstract

The present work aims to advance the study of sustainability in the small-scale fishing sector by exploring the relationships between the four pillars (economic, social, environmental and institutional) of sustainable development, based on a set of proxy indicators for each one. Faced with a lack of calibrated indicators for the artisanal fishing sector in Chile, the first stage was to identify a set of sustainability indicators that could be used to this end. Subsequently, using partial least squares structural equation modelling (PLS-SEM), the relationships of causality between the pillars were explored, and finally, from the scores obtained for each pillar through structural equation modelling, a sustainability index was determined for each fishing community. This index will provide an indicator with which to measure and compare the relative sustainability of the fishing communities found within three different zones. The results obtained show important differences between the sustainability indices of the three zones, with fishing communities in the northern zone having a lower sustainability index, while those in the central and southern zones have a higher sustainability index. Several causal relationships between the pillars were detected.

Published
2019

44. Gambling with antibiotics: a novel approach for exploring antibiotic consumption decision-making

Author

Nichola R. Naylor, Anuja Chatterjee, Julie V. Robotham, and Ijeoma Uchegbu

Subjects
Consumption (economics), medicine.medical_specialty, medicine.drug_class, business.industry, Public health, Antibiotics, Public Health, Environmental and Occupational Health, 030208 emergency & critical care medicine, General Medicine, 03 medical and health sciences, 0302 clinical medicine, 1117 Public Health And Health Services, Environmental health, medicine, Public Health, 030212 general & internal medicine, business
Abstract

Highlights • Standard gamble approach is used to explore the propensity for wanting antibiotics. • The public seem more reluctant to want antibiotics when effectiveness is reduced. • Mention of negative community impact did appear to alter public decision-making. • Future work should utilise representative samples and hypothesis testing techniques.

Published
2017

45. Ex-vessel price monitoring design in small-scale fisheries: An application in Chilean fisheries

Author

Elizabeth Palta, Hugo Robotham, Camilo Torres, and Zaida Young

Subjects
0106 biological sciences, geography, geography.geographical_feature_category, 010604 marine biology & hydrobiology, 04 agricultural and veterinary sciences, Variance (accounting), Aquatic Science, 01 natural sciences, Fishery, Order (exchange), Sample size determination, Sampling design, 040102 fisheries, Range (statistics), 0401 agriculture, forestry, and fisheries, Environmental science, Fisheries management, Cove, Sampling frame
Abstract

Small-scale fishery monitoring programs can provide valuable information about ex-vessel prices, which are essential for economic analyses and fisheries management. Ex-vessel prices obtained without adequate statistical support can generate inconsistent data and imprecise estimates that do not comply with quality standards that guarantee their usefulness in decision-making. We propose methodological approach for monitoring of ex-vessel prices across a wide range species and coves. In this study, an ex-vessel prices monitoring design was applied to small-scale fisheries in Chile. Our proposal includes: i) development of a sample frame, ii) adoption of a sampling design and estimators for the mean ex-vessel prices and their variance; and iii) determination of sample sizes. A sample frame of 40 species and 54 coves were selected to be monitored, representing close to 94 % of the small-scale landings. We proposed a stratified two-stage sampling design. Sample sizes of 2–5 days/month per species in each cove are suggested, with minimum limits between 3 and 10 transactions/day, in accordance with price variability. In coves where catch is transferred directly from fisher to consumer (shortened trade chains), higher and more variable prices were verified. In contrast, coves that destined their catch only to processing plants, ex-vessel prices remained relatively constant. The precision in mean ex-vessel price estimate depend largely on the number of days sampled. Data collection system used should be updated periodically, in order to capture the dynamics of the seafood trade at the landing sites and ensure precise and accurate estimates of mean ex-vessel prices. The methodological approach for price monitoring developed in this study can be used to implement or improve other ex-vessel price monitoring designs in small-scale fisheries.

Published
2020

46. Morphological and reproductive studies on the green filamentous pest Rhizoclonium-like affecting Agarophyton chilensis commercial farms in southern Chile

Author

M.E. Ramírez, G.E. Aroca, Marcela Ávila, and H. Robotham

Subjects
0106 biological sciences, biology, Vegetative reproduction, 010604 marine biology & hydrobiology, Plant Science, Aquatic Science, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Thallus, Spore, Salinity, Horticulture, Algae, Germination, PEST analysis, Rhizoclonium
Abstract

Cultivation of Agarophyton chilensis, common name “pelillo”, in Chile began 40 years ago. Technology adopted has been based on culture by vegetative propagation and culture from spores. Mass seaweed culture is associated with increased instances of pests and/or disease, as has been observed in the agricultural sector. The aim of this work is to study the pest alga Rhizoclonium sp, and its development under different controlled environmental conditions, given that this alga has affected “pelillo” production in southern Chile since 2015. Fresh thalli of the pest alga collected from culture centers located in Maullin river were described morphologically in order to confirm the identity of the species. Filaments were cultured under different temperature (10, 16 and 20 °C), photoperiod (8:16; 12:12 and 16:8 L:D), salinity (5; 10; 20; 27 and 30 psu) and nutrient (0.14 and 0.28 mmol/L nitrate) conditions to evaluate growth and reproduction. Nevertheless, given the taxonomic status situation of the polyphyletic genus Rhizoclonium, the pest is named Rhizoclonium-like. It formed lateral branches under culture conditions tested and showed a wide range of tolerance to temperature, salinity, photoperiod and nitrate concentration. Growth increases with temperature, reaching a daily growth rate of between 5.5 and 5.9%/day at 16 and 20 °C respectively. Rhizoclonium-like reproduction is described for the first time under culture conditions in Chile. Formation of reproductive structures occurs in the vegetative cells generating reproductive structures (zoosporangia) that mature under 16 °C, salinity >20 psu and nitrate concentration >0,14 mmol/L, observing release and germination of spores. After reproduction filaments do not decay and grow again.

Published
2020

47. Recommendations for detection and rapid management of carbapenemase-producing Enterobacterales outbreaks

Author

Richard Puleston, Colin S Brown, S. Singleton, Rachel Freeman, C. Fry, Julie V. Robotham, and B. Patel

Subjects
Process management, Clinical Audits/Service Improvements, Blueprint, business.industry, Enterobacterales, Action plan, Health care, Psychological intervention, Infection control, Outbreak, business, Risk assessment
Abstract

Summary There is large heterogeneity in approaches to tackling nosocomial outbreaks caused by carbapenemase-producing Enterobacterales (CPE), however there is limited guidance on how to approach their management. Rapid and robust infection prevention and control interventions can be effective in preventing and reducing the impact of outbreaks in healthcare environments. We present a stepwise approach to aspects of CPE outbreak management, including the development of an action plan, engagement and communication with key stakeholders, developing a dynamic risk assessment, and staff education. These can provide a blueprint for organisations to create templates and checklists to inform their own outbreak response.

Published
2020

48. Pedagogical principles and methods underpinning education of health and social care practitioners on experiences and needs of older LGBT+ people: Findings from a systematic review

Author

Higgins, Agnes, primary, Downes, Carmel, additional, Sheaf, Greg, additional, Bus, Elisa, additional, Connell, Sandra, additional, Hafford-Letchfield, Trish, additional, Jurček, Anže, additional, Pezzella, Alfonso, additional, Rabelink, Irma, additional, Robotham, George, additional, Urek, Mojca, additional, van der Vaart, Nina, additional, and Keogh, Brian, additional

Published
2019
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