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2. Efficacité et tolérance en vie réelle du sotorasib en comparaison au docétaxel dans le traitement des carcinomes bronchiques non à petites cellules métastatiques avec mutation KRASG12C

Author

Muchembled, M., primary, Gauvain, C., additional, Escande, F., additional, Tavernier, J.-Y., additional, Saelens, T., additional, Ampère, A., additional, Henni, A., additional, Chuffart, C., additional, Thirard, L., additional, Dansin, E., additional, Wasielewski, E., additional, Leroy, V., additional, and Cortot, A., additional

Published
2024
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4. Oncogene-Induced Senescence Mitochondrial Oxidative Metabolism: Further Characterization and Comparison with Hydrogen Peroxide and Doxorubicin Induced Senescence

Author

Marmisolle, Inés, primary, Chacon, Eliana, additional, Mansilla, Santiago, additional, Bresque, Mariana, additional, Martínez, Jennyfer, additional, Martínez-Zamudio, Ricardo Iván, additional, Herbig, Utz, additional, Liu, Jie, additional, Finkel, Toren, additional, Escande, Carlos, additional, Castro, Laura, additional, and Quijano, Celia, additional

Published
2024
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10. Cancer broncho-pulmonaire : Quel bilan moléculaire ?

Author

Mascaux, C., primary, Leroy, K., additional, Escande, F., additional, Levallet, G., additional, Gounant, V., additional, Descarpentries, C., additional, Blons, H., additional, Pabst, L., additional, Pencreach, E., additional, and Beau-Faller, M., additional

Published
2023
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11. Respective Roles of Surgery, Chemotherapy, and Radiation Therapy for Recurrent Pediatric and Adolescent Ependymoma: A National Multicentric Study

Author

Desrousseaux, Jacques, primary, Claude, Line, additional, Chaltiel, Leonor, additional, Tensaouti, Fatima, additional, Padovani, Laetitia, additional, Bolle, Stephanie, additional, Escande, Alexandre, additional, Alapetite, Claire, additional, Supiot, Stéphane, additional, Bernier-Chastagner, Valérie, additional, Huchet, Aymeri, additional, Leseur, Julie, additional, Truc, Gilles, additional, Leblond, Pierre, additional, Bertozzi, Anne-Isabelle, additional, Ducassou, Anne, additional, and Laprie, Anne, additional

Published
2023
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12. Enjeux éthiques de l’information en oncologie radiothérapie : penser le risque et construire l’alliance thérapeutique

Author

Haaser, T., primary, Lahmi, L., additional, Osman, D., additional, Gesbert, C., additional, Cheval, V., additional, Constantinides, Y., additional, de Crevoisier, R., additional, Dejean, C., additional, Escande, A., additional, Ghannam, Y., additional, Lorchel, F., additional, Thureau, S., additional, Lagrange, J.L., additional, Durdux, C., additional, and Huguet, F., additional

Published
2023
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13. Artificial intelligence algorithms aimed at characterizing or detecting prostate cancer on MRI: How accurate are they when tested on independent cohorts? – A systematic review

Author

Olivier Rouvière, Tristan Jaouen, Pierre Baseilhac, Mohammed Lamine Benomar, Raphael Escande, Sébastien Crouzet, and Rémi Souchon

Subjects
Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and imaging, General Medicine
Abstract

The purpose of this study was to perform a systematic review of the literature on the diagnostic performance, in independent test cohorts, of artificial intelligence (AI)-based algorithms aimed at characterizing/detecting prostate cancer on magnetic resonance imaging (MRI).Medline, Embase and Web of Science were searched for studies published between January 2018 and September 2022, using a histological reference standard, and assessing prostate cancer characterization/detection by AI-based MRI algorithms in test cohorts composed of more than 40 patients and with at least one of the following independency criteria as compared to the training cohort: different institution, different population type, different MRI vendor, different magnetic field strength or strict temporal splitting.Thirty-five studies were selected. The overall risk of bias was low. However, 23 studies did not use predefined diagnostic thresholds, which may have optimistically biased the results. Test cohorts fulfilled one to three of the five independency criteria. The diagnostic performance of the algorithms used as standalones was good, challenging that of human reading. In the 12 studies with predefined diagnostic thresholds, radiomics-based computer-aided diagnosis systems (assessing regions-of-interest drawn by the radiologist) tended to provide more robust results than deep learning-based computer-aided detection systems (providing probability maps). Two of the six studies comparing unassisted and assisted reading showed significant improvement due to the algorithm, mostly by reducing false positive findings.Prostate MRI AI-based algorithms showed promising results, especially for the relatively simple task of characterizing predefined lesions. The best management of discrepancies between human reading and algorithm findings still needs to be defined.

Published
2023

18. Réunions nationales de cas complexes en radiothérapie pédiatrique : retour sur six années d’expérience

Author

Ronan Tanguy, Claire Alapetite, Anne Laprie, Céline Vigneron, Stéphanie Bolle, Julien Wellmant, Aymeri Huchet, Dinu Stefan, Hélène Potet, Valérie Bernier, Emmanuel Jouglar, Alexandre Escande, Xavier Murraciole, Julie Leseur, Gilles Truc, Sophie Chapet, Caroline Pasteris, Pierre-Yves Bondiau, and Line Claude

Subjects
Cancer Research, Oncology, Radiology, Nuclear Medicine and imaging, Hematology, General Medicine
Published
2022

19. Reirradiation: A complex situation

Author

C, Chargari, A, Escande, P, Dupuis, and J, Thariat

Subjects
Oncology, Humans, Neoplasms, Second Primary, Radiotherapy Dosage, Radiology, Nuclear Medicine and imaging, Neoplasm Recurrence, Local, Re-Irradiation
Abstract

Reirradiation of a tumor recurrence or second cancer in a previously irradiated area is challenging due to lack of high-quality physical, radiobiological, clinical data and inherent substantial risks of toxicity with cumulative dose and uncertain tissue recovery. Yet, major advances have been made in radiotherapy techniques, that have the potential to achieve cure while limiting severe toxicity rates, but still much research is necessary to better appraise the therapeutic index in such a complex situation.

Published
2022

20. PO-02-070 COMBINED LOCAL IMPEDANCE AND CONTACT FORCE FOR SUCCESSFUL RADIOFREQUENCY ABLATION OF ATRIAL FIBRILLATION

Author

Stabile, Giuseppe, primary, Lepillier, Antoine, additional, Anselmino, Matteo, additional, Maggio, Ruggero, additional, DeSanctis, Valerio, additional, ZAKINE, Cyril, additional, RIGOT, Laure CHAMP, additional, Dell'Era, Gabriele, additional, Garnier, Fabien, additional, Mascia, Giuseppe, additional, Segreti, Luca, additional, Escande, William, additional, Cosaro, Giuseppe, additional, Malacrida, Maurizio, additional, Maglia, Giampiero, additional, and Solimene, Francesco, additional

Published
2023
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22. Faisabilité et sécurité du portage de nouveau-né bénéficiant d’une hypothermie thérapeutique contrôlée dans le cadre d’une encéphalopathie anoxo-ischémique néonatale

Author

Gançarski, Lucas, primary, Langlet-Muteau, Claire, additional, Fourié, Gwenaelle, additional, Mertes, Cmara, additional, Rondel, Jennifer, additional, Escande, Benoît, additional, Dillenseger, Laurence, additional, Zores, Claire, additional, and Kuhn, Pierre, additional

Published
2023
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23. Vascular hyperintensities on baseline FLAIR images are associated with functional outcome in stroke patients with successful recanalization after mechanical thrombectomy

Author

Bani-Sadr, Alexandre, primary, Escande, Raphaël, additional, Mechtouff, Laura, additional, Pavie, Dylan, additional, Hermier, Marc, additional, Derex, Laurent, additional, Choc, Tae-Hee, additional, Eker, Omer F., additional, Nighoghossian, Norbert, additional, and Berthezène, Yves, additional

Published
2023
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25. Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design

Author

Fizazi, Karim, Foulon, Stéphanie, Carles, Joan, Roubaud, Guilhem, McDermott, Ray, Fléchon, Aude, Tombal, Bertrand, Supiot, Stéphane, Berthold, Dominik, Ronchin, Philippe, Kacso, Gabriel, Gravis, Gwenaëlle, Calabro, Fabio, Berdah, Jean-François, Hasbini, Ali, Silva, Marlon, Thiery-Vuillemin, Antoine, Latorzeff, Igor, Mourey, Loïc, Laguerre, Brigitte, Abadie-Lacourtoisie, Sophie, Martin, Etienne, El Kouri, Claude, Escande, Anne, Rosello, Alvar, Magne, Nicolas, Schlurmann, Friederike, Priou, Frank, Chand-Fouche, Marie-Eve, Freixa, Salvador Villà, Jamaluddin, Muhammad, Rieger, Isabelle, Bossi, Alberto, PEACE-1 investigators, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, and UCL - (SLuc) Service d'urologie

Subjects
Male, Antineoplastic Combined Chemotherapy Protocols, Hypertension, Androgens, Humans, Prednisone, Prostatic Neoplasms, Androgen Antagonists, Androstenes, Female, Castration, Docetaxel, General Medicine
Abstract

Current standard of care for metastatic castration-sensitive prostate cancer supplements androgen deprivation therapy with either docetaxel, second-generation hormonal therapy, or radiotherapy. We aimed to evaluate the efficacy and safety of abiraterone plus prednisone, with or without radiotherapy, in addition to standard of care. We conducted an open-label, randomised, phase 3 study with a 2 × 2 factorial design (PEACE-1) at 77 hospitals across Belgium, France, Ireland, Italy, Romania, Spain, and Switzerland. Eligible patients were male, aged 18 years or older, with histologically confirmed or cytologically confirmed de novo metastatic prostate adenocarcinoma, and an Eastern Cooperative Oncology Group performance status of 0-1 (or 2 due to bone pain). Participants were randomly assigned (1:1:1:1) to standard of care (androgen deprivation therapy alone or with intravenous docetaxel 75 mg/m once every 3 weeks), standard of care plus radiotherapy, standard of care plus abiraterone (oral 1000 mg abiraterone once daily plus oral 5 mg prednisone twice daily), or standard of care plus radiotherapy plus abiraterone. Neither the investigators nor the patients were masked to treatment allocation. The coprimary endpoints were radiographic progression-free survival and overall survival. Abiraterone efficacy was first assessed in the overall population and then in the population who received androgen deprivation therapy with docetaxel as standard of care (population of interest). This study is ongoing and is registered with ClinicalTrials.gov, NCT01957436. Between Nov 27, 2013, and Dec 20, 2018, 1173 patients were enrolled (one patient subsequently withdrew consent for analysis of his data) and assigned to receive standard of care (n=296), standard of care plus radiotherapy (n=293), standard of care plus abiraterone (n=292), or standard of care plus radiotherapy plus abiraterone (n=291). Median follow-up was 3·5 years (IQR 2·8-4·6) for radiographic progression-free survival and 4·4 years (3·5-5·4) for overall survival. Adjusted Cox regression modelling revealed no interaction between abiraterone and radiotherapy, enabling the pooled analysis of abiraterone efficacy. In the overall population, patients assigned to receive abiraterone (n=583) had longer radiographic progression-free survival (hazard ratio [HR] 0·54, 99·9% CI 0·41-0·71; p

Published
2022

27. Impacts of microplastics and the associated plastisphere on physiological, biochemical, genetic expression and gut microbiota of the filter-feeder amphioxus

Author

Cheng, Jingguang, primary, Meistertzheim, Anne-Leila, additional, Leistenschneider, David, additional, Philip, Lena, additional, Jacquin, Justine, additional, Escande, Marie-Line, additional, Barbe, Valérie, additional, ter Halle, Alexandra, additional, Chapron, Leila, additional, Lartaud, Franck, additional, Bertrand, Stéphanie, additional, Escriva, Hector, additional, and Ghiglione, Jean-François, additional

Published
2023
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28. 36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE

Author

Turpie, Alexander G.G., primary, Farjat, Alfredo E., additional, Haas, Sylvia, additional, Ageno, Walter, additional, Weitz, Jeffrey I., additional, Goldhaber, Samuel Z., additional, Goto, Shinya, additional, Angchaisuksiri, Pantep, additional, Kayani, Gloria, additional, Lopes, Renato D., additional, Chiang, Chern-En, additional, Gibbs, Harry, additional, Tse, Eric, additional, Verhamme, Peter, additional, ten Cate, Hugo, additional, Muntaner, Juan, additional, Schellong, Sebastian, additional, Bounameaux, Henri, additional, Prandoni, Paolo, additional, Maheshwari, Uma, additional, Kakkar, Ajay K., additional, Loualidi, Ab, additional, Colak, Abdurrahim, additional, Bezuidenhout, Abraham, additional, Abdool-Carrim, Abu, additional, Azeddine, Addala, additional, Beyers, Adriaan, additional, Dees, Adriaan, additional, Mohamed, Ahmed, additional, Aksoy, Ahmet, additional, Abiko, Akihiko, additional, Watanabe, Akinori, additional, Krichell, Alan, additional, Fernandez, Alberto Alfredo, additional, Tosetto, Alberto, additional, Khotuntsov, Alexey, additional, Oropallo, Alisha, additional, Slocombe, Alison, additional, Kelly, Allan, additional, Clark, Amanda, additional, Gad, Amr, additional, Arouni, Amy, additional, Schmidt, Andor, additional, Berni, Andrea, additional, Kleiban, Andres Javier, additional, Machowski, Andrew, additional, Kazakov, Andrey, additional, Galvez, Angel, additional, Lockman, Ann, additional, Falanga, Anna, additional, Chauhan, Anoop, additional, Riera-Mestre, Antoni, additional, Mazzone, Antonino, additional, D'Angelo, Armando, additional, Herdy, Artur, additional, Kato, Atsushi, additional, Salem, Ayman Abd Elhamid Ebrahim Mahmoud, additional, Husin, Azlan, additional, Erdelyi, Barbara, additional, Jacobson, Barry, additional, Amann-Vesti, Beatrice, additional, Battaloglu, Bektas, additional, Wilson, Benedicte, additional, Cosmi, Benilde, additional, Francois, Bergmann Jean, additional, Toufek, Berremeli, additional, Hunt, Beverley, additional, Natha, Bhavesh, additional, Mustafa, Bisher, additional, Kho, Bonnie Chi Shan, additional, Carine, Boulon, additional, Zidel, Brian, additional, Dominique, Brisot, additional, Christophe, Brousse, additional, Trimarco, Bruno, additional, Luo, Canhua, additional, Cuneo, Carlos Alberto, additional, Diaz, Carlos Jerjes Sanchez, additional, Schwencke, Carsten, additional, Cader, Cas, additional, Yavuz, Celal, additional, Zaidman, Cesar Javier, additional, Lunn, Charles, additional, Wu, Chau-Chung, additional, Toh, Cheng Hock, additional, Elisa, Chevrier, additional, Hsia, Chien-Hsun, additional, Huang, Chien-Lung, additional, Kwok, Chi-Hang Kevin, additional, Wu, Chih-Cheng, additional, Huang, Chi-Hung, additional, Ward, Chris, additional, Opitz, Christian, additional, Jeanneret-Gris, Christina, additional, Ha, Chung Yin, additional, Huang, Chun-Yao, additional, Bidi, Claude Luyeye, additional, Smith, Clifford, additional, Brauer, Cornelia, additional, Lodigiani, Corrado, additional, Francis, Couturaud, additional, Wu, Cynthia, additional, Staub, Daniel, additional, Theodoro, Daniel, additional, Poli, Daniela, additional, Acevedo, David - Riesco, additional, Adler, David, additional, Jimenez, David, additional, Keeling, David, additional, Scott, David, additional, Imberti, Davide, additional, Creagh, Desmond, additional, Helene, Desmurs-Clavel, additional, Hagemann, Dirk, additional, Le Roux, Dirk, additional, Skowasch, Dirk, additional, Belenky, Dmitry, additional, Dorokhov, Dmitry, additional, Petrov, Dmitry, additional, Zateyshchikov, Dmitry, additional, Prisco, Domenico, additional, Møller, Dorthe, additional, Kucera, Dusan, additional, Esheiba, Ehab M., additional, Panchenko, Elizaveta, additional, Dominique, Elkouri, additional, Dogan, Emre, additional, Kubat, Emre, additional, Diaz, Enrique Diaz, additional, Tse, Eric Wai Choi, additional, Yeo, Erik, additional, Hashas, Erman, additional, Grochenig, Ernst, additional, Tiraferri, Eros, additional, Blessing, Erwin, additional, Michèle, Escande Orthlieb, additional, Usandizaga, Esther, additional, Porreca, Ettore, additional, Ferroni, Fabian, additional, Nicolas, Falvo, additional, Ayala-Paredes, Félix, additional, Koura, Firas, additional, Henry, Fitjerald, additional, Cosmi, Franco, additional, Erdkamp, Frans, additional, Kamalov, Gadel, additional, Dalmau, Garcia-Bragado, additional, Damien, Garrigues, additional, Klein, Garry, additional, Shah, Gaurand, additional, Hollanders, Geert, additional, Merli, Geno, additional, Plassmann, Georg, additional, Platt, George, additional, Poirier, Germain, additional, Sokurenko, German, additional, Haddad, Ghassan, additional, Ali, Gholam, additional, Agnelli, Giancarlo, additional, Gan, Gin Gin, additional, Kaye-Eddie, Grace, additional, Le Gal, Gregoire, additional, Allen, Gregory, additional, Esperón, Guillermo Antonio Llamas, additional, Jean-Paul, Guillot, additional, Gerofke, Hagen, additional, Elali, Hallah, additional, Burianova, Hana, additional, Ohler, Hans-Juergen, additional, Wang, Haofu, additional, Darius, Harald, additional, Gogia, Harinder S., additional, Striekwold, Harry, additional, Hasanoglu, Hatice, additional, Turker, Hatice, additional, Franow, Hendrik, additional, De Raedt, Herbert, additional, Schroe, Herman, additional, ElDin, Hesham Salah, additional, Zidan, Hesham, additional, Nakamura, Hiroaki, additional, Kim, Ho Young, additional, Lawall, Holger, additional, Zhu, Hong, additional, Tian, Hongyan, additional, Yhim, Ho-Young, additional, Hwang, Hun Gyu, additional, Shim, Hyeok, additional, Kim, Igor, additional, Libov, Igor, additional, Sonkin, Igor, additional, Suchkov, Igor, additional, Song, Ik-Chan, additional, Kiris, Ilker, additional, Staroverov, Ilya, additional, Looi, Irene, additional, De La Azuela Tenorio, Isabel M., additional, Savas, Ismail, additional, Gordeev, Ivan, additional, Podpera, Ivo, additional, Lee, Jae Hoon, additional, Sathar, Jameela, additional, Welker, James, additional, Beyer-Westendorf, Jan, additional, Kvasnicka, Jan, additional, Vanwelden, Jan, additional, Kim, JangYong, additional, Svobodova, Jaromira, additional, Gujral, Jaspal, additional, Marino, Javier, additional, Galvar, Javier Tristan, additional, Kassis, Jeannine, additional, Kuo, Jen-Yuan, additional, Shih, Jhih-Yuan, additional, Kwon, JiHyun, additional, Joh, Jin Hyun, additional, Park, Jin Hyun, additional, Kim, Jin Seok, additional, Yang, Jinghua, additional, Krupicka, Jiri, additional, Lastuvka, Jiri, additional, Pumprla, Jiri, additional, Vesely, Jiri, additional, Souto, Joan Carlos, additional, Correa, João Antônio, additional, Duchateau, Johan, additional, Fletcher, John Perry, additional, del Toro, Jorge, additional, Paez, Jorge Guillermo Chavez, additional, Nielsen, Jørn, additional, Filho, Jose Dalmo Araujo, additional, Saraiva, Jose, additional, Peromingo, Jose Antonio Diaz, additional, Lara, Jose Gomez, additional, Fedele, Jose Luis, additional, Surinach, Jose Maria, additional, Chacko, Joseph, additional, Muntaner, Juan Antonio, additional, Benitez, Juan Carlos Álvarez, additional, Abril, Juan Moreno Hoyos, additional, Humphrey, Julian, additional, Bono, Julio, additional, Kanda, Junji, additional, Boondumrongsagoon, Juree, additional, Yiu, Kai Hang, additional, Chansung, Kanchana, additional, Boomars, Karin, additional, Burbury, Kate, additional, Kondo, Katsuhiro, additional, Karaarslan, Kemal, additional, Takeuchi, Kensuke, additional, Kroeger, Knut, additional, Zrazhevskiy, Konstantin, additional, Svatopluk, Koscál, additional, Shyu, Kou-Gi, additional, Vandenbosch, Kristel, additional, Chang, Kuan-Cheng, additional, Chiu, Kuan-Ming, additional, Jean-Manuel, Kubina, additional, Wern, Kwan Jing, additional, Ueng, Kwo-Chang, additional, Norasetthada, Lalita, additional, Binet, Laure, additional, Chew, Lee Ping, additional, Zhang, Lei, additional, Cristina, Leone Maria, additional, Tick, Lidwine, additional, Schiavi, Lilia Beatriz, additional, Wong, Lily Lee Lee, additional, Borges, Lohana, additional, Botha, Louis, additional, Capiau, Luc, additional, Timmermans, Luc, additional, López, Luciano Eduardo, additional, Ria, Luigi, additional, Blasco, Luis Manuel Hernandez, additional, Guzman, Luis Alberto, additional, Cervera, Luis Flota, additional, Isabelle, Mahe, additional, Bosch, Manuel Monreal, additional, de los Rios Ibarra, Manuel, additional, Fernandez, Manuel Núñez, additional, Carrier, Marc, additional, Barrionuevo, Marcelo Raul, additional, Gamba, Marco Antonio Alcocer, additional, Cattaneo, Marco, additional, Moia, Marco, additional, Bowers, Margaret, additional, Chetanachan, Mariam, additional, Berli, Mario Alberto, additional, Fixley, Mark, additional, Faghih, Markus, additional, Stuecker, Markus, additional, Schul, Marlin, additional, Banyai, Martin, additional, Koretzky, Martin, additional, Myriam, Martin, additional, Gaffney, Mary Elizabeth, additional, Hirano, Masao, additional, Kanemoto, Masashi, additional, Nakamura, Mashio, additional, Tahar, Mersel, additional, Emmanuel, Messas, additional, Kovacs, Michael, additional, Leahy, Michael, additional, Levy, Michael, additional, Munch, Michael, additional, Olsen, Michael, additional, De Pauw, Michel, additional, Gustin, Michel, additional, Van Betsbrugge, Michiel, additional, Boyarkin, Mikhail, additional, Homza, Miroslav, additional, Koto, Modise, additional, Abdool-Gaffar, Mohamed, additional, Nagib, Mohamed Ayman Fakhry, additional, El-Dessoki, Mohamed, additional, Khan, Mohamed, additional, Mohamed, Monniaty, additional, Kim, Moo Hyun, additional, Lee, Moon-Hee, additional, Soliman, Mosaad, additional, Ahmed, Mostafa Shawky, additional, el Bary, Mostafa Soliman Abd, additional, Moustafa, Moustafa A., additional, Hameed, Muhammad, additional, Kanko, Muhip, additional, Majumder, Mujibur, additional, Zubareva, Nadezhda, additional, Mumoli, Nicola, additional, Abdullah, Nik Azim Nik, additional, Makruasi, Nisa, additional, Paruk, Nishen, additional, Kanitsap, Nonglak, additional, Duda, Norberto, additional, Nordin, Nordiana, additional, Nyvad, Ole, additional, Barbarash, Olga, additional, Gurbuz, Orcun, additional, Vilamajo, Oscar Gomez, additional, Flores, Oscar Nandayapa, additional, Gur, Ozcan, additional, Oto, Oztekin, additional, Marchena, Pablo Javier, additional, Carroll, Patrick, additional, Lang, Pavel, additional, MacCallum, Peter, additional, von Bilderling, Peter Baron, additional, Blombery, Peter, additional, Jansky, Petr, additional, Bernadette, Peuch, additional, De Vleeschauwer, Philippe, additional, Hainaut, Philippe, additional, Ferrini, Piera Maria, additional, Iamsai, Piriyaporn, additional, Christian, Ponchaux, additional, Viboonjuntra, Pongtep, additional, Rojnuckarin, Ponlapat, additional, Ho, Prahlad, additional, Mutirangura, Pramook, additional, Wells, Rachel, additional, Martinez, Rafael, additional, Miranda, Raimundo Tirado, additional, Kroening, Ralf, additional, Ratsela, Rapule, additional, Reyes, Raquel Lopez, additional, de Leon, Raul Franco Diaz, additional, Wong, Raymond Siu Ming, additional, Alikhan, Raz, additional, Jerwan-Keim, Reinhold, additional, Otero, Remedios, additional, Murena-Schmidt, Renate, additional, Canevascini, Reto, additional, Ferkl, Richard, additional, White, Richard, additional, Van Herreweghe, Rika, additional, Santoro, Rita, additional, Klamroth, Robert, additional, Mendes, Robert, additional, Prosecky, Robert, additional, Cappelli, Roberto, additional, Spacek, Rudolf, additional, Singh, Rupesh, additional, Griffin, Sam, additional, Na, Sang Hoon, additional, Chunilal, Sanjeev, additional, Middeldorp, Saskia, additional, Nakazawa, Satoshi, additional, Toh, See Guan, additional, Christophe, Seinturier, additional, Isbir, Selim, additional, Raymundo, Selma, additional, Ting, Seng Kiat, additional, Motte, Serge, additional, Aktogu, Serir Ozkan, additional, Donders, Servaas, additional, Cha, Seung Ick, additional, Nam, Seung-Hyun, additional, Marie-Antoinette, Sevestre-Pietri, additional, Maasdorp, Shaun, additional, Sun, Shenghua, additional, Wang, Shenming, additional, Essameldin, Sherif Mohamed, additional, Sholkamy, Sherif Mohamed, additional, Kuki, Shintaro, additional, Yoshida, Shuichi, additional, Matsuoka, Shunzo, additional, McRae, Simon, additional, Watt, Simon, additional, Patanasing, Siriwimon, additional, Jean-Léopold, Siwe-Nana, additional, Wongkhantee, Somchai, additional, Bang, Soo-Mee, additional, Testa, Sophie, additional, Zemek, Stanislav, additional, Behrens, Steffen, additional, Dominique, Stephan, additional, Mellor, Stuart, additional, Singh, Suaran Singh Gurcharan, additional, Datta, Sudip, additional, Chayangsu, Sunee, additional, Solymoss, Susan, additional, Everington, Tamara, additional, Abdel-Azim, Tarek Ahmed Adel, additional, Suwanban, Tawatchai, additional, Adademir, Taylan, additional, Hart, Terence, additional, Béatrice, Terriat, additional, Luvhengo, Thifhelimbilu, additional, Horacek, Thomas, additional, Zeller, Thomas, additional, Boussy, Tim, additional, Reynolds, Tim, additional, Biss, Tina, additional, Chao, Ting-Hsing, additional, Casabella, Tomas Smith, additional, Onodera, Tomoya, additional, Numbenjapon, Tontanai, additional, Gerdes, Victor, additional, Cech, Vladimir, additional, Krasavin, Vladimir, additional, Tolstikhin, Vladimir, additional, Bax, W.A., additional, Malek, Wagih Fawzy Abdel, additional, Ho, Wai Khoon, additional, Pharr, Walter, additional, Jiang, Weihong, additional, Lin, Wei-Hsiang, additional, Zhang, Weihua, additional, Tseng, Wei-Kung, additional, Lai, Wen-Ter, additional, De Backer, Wilfried, additional, Haverkamp, Wilhelm, additional, Yoshida, Winston, additional, Korte, Wolfgang, additional, Choi, Won Il, additional, Kim, Yang-Ki, additional, Tanabe, Yasuhiro, additional, Ohnuma, Yasushi, additional, Mun, Yeung-Chul, additional, Balthazar, Yohan, additional, Park, Yong, additional, Shibata, Yoshisato, additional, Burov, Yuriy, additional, Subbotin, Yuriy, additional, Coufal, Zdenek, additional, Yang, Zhenwen, additional, Jing, Zhicheng, additional, and Yang, Zhongqi, additional

Published
2023
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29. Radiotherapy for penile cancers

Author

A, Escande, D, Peiffert, C, Dejean, J-M, Hannoun-Lévi, A, Cordoba, P, Pommier, C, Haie-Méder, and C, Chargari

Subjects
Male, Lymphatic Irradiation, Brachytherapy, Palliative Care, Inguinal Canal, Chemoradiotherapy, Oncology, Radiation Oncology, Humans, Radiotherapy, Adjuvant, Radiology, Nuclear Medicine and imaging, Dose Fractionation, Radiation, France, Lymph Nodes, Organ Sparing Treatments, Penile Neoplasms, Neoplasm Staging
Abstract

Penile cancers are uncommon and should be treated in expert center. Radiotherapy indications are mainly limited to exclusive brachytherapy for early stage penile glans cancer. Brachytherapy yields to excellent outcome for disease control and organ and function preservation. Only scarce data are available for external beam radiation therapy. It could be considered as palliative setting for irradiation of the primary tumor. For lymph node irradiation, external beam radiation therapy (with or without chemotherapy) could be discussed either as neoadjuvant approach prior to surgery for massive inguinal lymph node invasion or as adjuvant approach in case of high-risk of relapse. However, these cases should be discussed on an individual basis, as the level of evidence is poor. We present the recommendations of the French Society of Oncological Radiotherapy on the indications and techniques for external beam radiotherapy and brachytherapy for penile glans cancer.

Published
2022

30. Role of radiotherapy in the treatment of primary vaginal cancer: Recommendations of the French society for radiation oncology

Author

C, Chargari, K, Peignaux, A, Escande, C, Lafond, D, Peiffert, A, Petit, J-M, Hannoun-Lévi, C, Durdux, and C, Haie-Méder

Subjects
Rare Diseases, Vaginal Neoplasms, Oncology, Brachytherapy, Carcinoma, Squamous Cell, Radiation Oncology, Humans, Female, Radiology, Nuclear Medicine and imaging, France, Retrospective Studies
Abstract

Primary vaginal cancers are rare tumours, for which external beam radiotherapy and brachytherapy are major treatment tools. Given the complexity of brachytherapy techniques, the treatment should be performed in specialised centres. We present the recommendations of the French society for radiation oncology on the indications and techniques for external beam radiotherapy and brachytherapy for primary vaginal cancer.

Published
2022

33. Hypofractionated stereotactic body radiation therapy (SBRT) in pediatric patients: results of a national prospective multicenter study

Author

Claude, L., primary, Bolle, S., additional, Morelle, M., additional, Huchet, A., additional, Vigneron, C., additional, Escande, A., additional, Chapet, S., additional, Leseur, J., additional, Bernier, V., additional, Carrie, C., additional, Barry, A., additional, Vizoso, S., additional, Blanc, E., additional, Laprie, A., additional, and Supiot, S., additional

Published
2022
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34. Brachytherapy training survey among radiation oncology residents in Europe

Author

Sturdza, Alina Emiliana, primary, Stephanides, Marianne, additional, Jurgenliemk-Schulz, Ina, additional, Eriksen, Jesper Grau, additional, Benstead, Kim, additional, Hoskin, Peter, additional, Vlad, Stefanel, additional, Escande, Alexandre, additional, Corradini, Stefanie, additional, Knoth, Johannes, additional, Westerveld, Henrike, additional, Tagliaferri, Luca, additional, Najari-Jamali, Dina, additional, Konat-Bąska, Katarzyna, additional, Plesinac, Vesna, additional, Tan, Li Tee, additional, Nout, Remi, additional, Strnad, Vratislav, additional, Niehoff, Peter, additional, Pieters, Bradley R., additional, Tanderup, Kari, additional, and Kamrava, Mitchell, additional

Published
2022
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35. Radiothérapie du carcinome épidermoïde du larynx de stade précoce, étage glottique : intérêt de l’hypofractionnement ?

Author

F. Crop, David Pasquier, Xavier Mirabel, M. Tonneau, Thomas Lacornerie, R. Matta, A. Escande, S. Lals, and Xavier Liem

Subjects
Hypofractionated Radiotherapy, Larynx, medicine.medical_specialty, business.industry, medicine.medical_treatment, Rate control, Glottic Squamous Cell Carcinoma, Radiation therapy, 03 medical and health sciences, Regimen, 0302 clinical medicine, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Toxicity, medicine, Radiology, Nuclear Medicine and imaging, Radiology, Stage (cooking), business
Abstract

Hypofractionated radiotherapy of early-stage squamous cell carcinoma of the glottic larynx is a promising treatment option. This can be divided into radiotherapy with moderate hypofractionation (up to 2.5Gy per fraction), more intense hypofractionation (between 2.5 and 4.5Gy per fraction) and stereotactic radiotherapy (above 4.5Gy per fraction). Most studies evaluating moderate hypofractionation show a local control rate between 85 and 95%. Acute laryngeal toxicity is superior to conventional treatment, but only for grades 1 and 2, with no significant difference reported for severe toxicity. Stereotactic radiotherapy in this pathology is also an emerging entity, but some authors have reported significant toxicity. There are currently no standardized guidelines for treatment and management regimen. We conducted a systemic review of published prospective and retrospective trials to evaluate efficacy, toxicity, and discuss future directions.

Published
2021

36. Nitro-fatty acids as activators of hSIRT6 deacetylase activity

Author

Carreño Sastre, Mara, Bresque, Mariana, Machado, Matías, Santos Costa, Leonardo, Durán, Rosario, Vitturi, D.A., Escande, Carlos, Denicola, Ana, Banerjee, R., Carreño Sastre Mara, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica., Bresque Mariana, Instituto Pasteur (Montevideo)., Machado Matías, Instituto Pasteur (Montevideo)., Santos Costa Leonardo, Instituto Pasteur (Montevideo)., Durán Rosario, Instituto Pasteur (Montevideo)., Vitturi D.A., Escande Castro Carlos José, Instituto Pasteur (Montevideo)., and Denicola Ana, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.

Subjects
cysteine covalent modification, 0301 basic medicine, Protein Conformation, Linoleic acid, fatty acids, Biochemistry, activator, 03 medical and health sciences, chemistry.chemical_compound, Enzyme activator, nitro-fatty acid, Michael addition, enzyme kinetics, SIRT6, Humans, Sirtuins, histone deacetylation, enzyme mechanism, Molecular Biology, nitro-fatty acids, chemistry.chemical_classification, 030102 biochemistry & molecular biology, biology, histone deacetylase (HDAC), cysteine covalent-modification, Fatty acid, Active site, Acetylation, enzyme activation, Cell Biology, Nitro Compounds, Enzyme structure, enzyme structure, Oxidative Stress, sirtuin, Oleic acid, 030104 developmental biology, chemistry, docking, Sirtuin, Enzymology, biology.protein, fatty acid, enzyme activator, Deacetylase activity
Abstract

Sirtuin 6, SIRT6, is critical for both glucose and lipid homeostasis and is involved in maintaining genomic stability under conditions of oxidative DNA damage such as those observed in age-related diseases. There is an intense search for modulators of SIRT6 activity, however, not many specific activators have been reported. Long acyl-chain fatty acids have been shown to increase the weak in vitro deacetylase activity of SIRT6 but this effect is modest at best. Herein we report that electrophilic nitro-fatty acids (nitro-oleic acid and nitro-conjugated linoleic acid) potently activate SIRT6. Binding of the nitro-fatty acid to the hydrophobic crevice of the SIRT6 active site exerted a moderate activation (2-fold at 20 μm), similar to that previously reported for non-nitrated fatty acids. However, covalent Michael adduct formation with Cys-18, a residue present at the N terminus of SIRT6 but absent from other isoforms, induced a conformational change that resulted in a much stronger activation (40-fold at 20 μm). Molecular modeling of the resulting Michael adduct suggested stabilization of the co-substrate and acyl-binding loops as a possible additional mechanism of SIRT6 activation by the nitro-fatty acid. Importantly, treatment of cells with nitro-oleic acid promoted H3K9 deacetylation, whereas oleic acid had no effect. Altogether, our results show that nitrated fatty acids can be considered a valuable tool for specific SIRT6 activation, and that SIRT6 should be considered as a molecular target for in vivo actions of these anti-inflammatory nitro-lipids.

Published
2020

37. Enjeux éthiques de la pratique des soins à visée palliative en oncologie radiothérapique

Author

A. Escande, F. Lorchel, Jean-Léon Lagrange, R. de Crevoisier, I. Lecouillard, Y Ghannam, P. Le Tallec, Y. Constantinidès, T. Haaser, Florence Huguet, L Lahmi, Catherine Dejean, and S. Thureau

Subjects
Palliative care, medicine.medical_treatment, Commission, Variety (cybernetics), Task (project management), Radiation therapy, Oncology, Nursing, Palliative radiotherapy, Multidisciplinary approach, Radiation oncology, medicine, Radiology, Nuclear Medicine and imaging, Psychology
Abstract

In 2021, the Ethics Commission of the SFRO has chosen the issue of the practice of palliative care in radiotherapy oncology. Radiation oncology plays a central role in the care of patients with cancer in palliative phase. But behind the broad name of palliative radiotherapy, we actually find a large variety of situations involving diverse ethical issues. Radiation oncologists have the delicate task to take into account multiple factors throughout a complex decision-making process. While the question of the therapeutic indication and the technical choice allowing it to be implemented remains central, reflection cannot be limited to these decision-making and technical aspects alone. It is also a question of being able to create the conditions for a singularity focused care and to build an authentic care relationship, beyond technicity. It is through this daily ethical work, in close collaboration with patients, and under essential conditions of multidisciplinarity and multiprofessionalism, that our fundamental role as caregiver can be deployed.

Published
2021

40. Réunions nationales de cas complexes en radiothérapie pédiatrique : retour sur six années d’expérience

Author

Tanguy, Ronan, primary, Alapetite, Claire, additional, Laprie, Anne, additional, Vigneron, Céline, additional, Bolle, Stéphanie, additional, Wellmant, Julien, additional, Huchet, Aymeri, additional, Stefan, Dinu, additional, Potet, Hélène, additional, Bernier, Valérie, additional, Jouglar, Emmanuel, additional, Escande, Alexandre, additional, Murraciole, Xavier, additional, Leseur, Julie, additional, Truc, Gilles, additional, Chapet, Sophie, additional, Pasteris, Caroline, additional, Bondiau, Pierre-Yves, additional, and Claude, Line, additional

Published
2022
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41. Switch to fulvestrant and palbociclib versus no switch in advanced breast cancer with rising ESR1 mutation during aromatase inhibitor and palbociclib therapy (PADA-1): a randomised, open-label, multicentre, phase 3 trial

Author

Bidard, François-Clément, primary, Hardy-Bessard, Anne-Claire, additional, Dalenc, Florence, additional, Bachelot, Thomas, additional, Pierga, Jean-Yves, additional, de la Motte Rouge, Thibault, additional, Sabatier, Renaud, additional, Dubot, Coraline, additional, Frenel, Jean-Sébastien, additional, Ferrero, Jean Marc, additional, Ladoire, Sylvain, additional, Levy, Christelle, additional, Mouret-Reynier, Marie-Ange, additional, Lortholary, Alain, additional, Grenier, Julien, additional, Chakiba, Camille, additional, Stefani, Laetitia, additional, Plaza, Jérôme Edouard, additional, Clatot, Florian, additional, Teixeira, Luis, additional, D'Hondt, Véronique, additional, Vegas, Hélène, additional, Derbel, Olfa, additional, Garnier-Tixidre, Claire, additional, Canon, Jean-Luc, additional, Pistilli, Barbara, additional, André, Fabrice, additional, Arnould, Laurent, additional, Pradines, Anne, additional, Bièche, Ivan, additional, Callens, Céline, additional, Lemonnier, Jérôme, additional, Berger, Frédérique, additional, Delaloge, Suzette, additional, BIDARD, Francois-Clement, additional, PISTILLI, Barbara, additional, DALENC, Florence, additional, BACHELOT, Thomas, additional, DE LA MOTTE ROUGE, Thibault, additional, SABATIER, Renaud, additional, DUBOT, Coraline, additional, FRENEL, Jean-Sébastien, additional, FERRERO, Jean-Marc, additional, LADOIRE, Sylvain, additional, LEVY, Christelle, additional, MOURET-REYNIER, Marie-Ange, additional, HARDY-BESSARD, Anne-Claire, additional, LORTHOLARY, Alain, additional, GRENIER, Julien, additional, CHAKIBA, Camille, additional, STEFANI, Laetitia, additional, SOULIE, Patrick, additional, JACQUIN, Jean-Philippe, additional, PLAZA, Jérôme Edouard, additional, CLATOT, Florian, additional, TEIXEIRA, Luis, additional, D'HONDT, Véronique, additional, VEGAS, Hélène, additional, DERBEL, Olfa, additional, GARNIER TIXIDRE, Claire, additional, DELBALDO, Catherine, additional, MOREAU, Lionel, additional, CHENEAU, Caroline, additional, PAITEL, Jean-François, additional, BERNARD-MARTY, Chantal, additional, SPAETH, Dominique, additional, GENET, Dominique, additional, MOULLET, Isabelle, additional, BONICHON-LAMICHHANE, Nathalie, additional, DEIANA, Laura, additional, GREILSAMER, Charlotte, additional, VENAT-BOUVET, Laurence, additional, DELECROIX, Valérie, additional, MELIS, Adrien, additional, ORFEUVRE, Hubert, additional, NGUYEN, Suzanne, additional, LEGOUFFE, Eric, additional, ZANNETTI, Alain, additional, LE SCODAN, Romuald, additional, DOHOLLOU, Nadine, additional, DALIVOUST, Philippe, additional, ARSENE, Olivier, additional, MARQUES, Nathalie, additional, PETIT, Thierry, additional, MOLLON, Delphine, additional, DAUBA, Jérôme, additional, BONNIN, Nathalie, additional, MORVAN, François, additional, GARDNER, Miriam, additional, MARTI, Adina, additional, LEVACHE, Charles-Briac, additional, LACHAIER, Emma, additional, ACHILLE, Mihaela, additional, VALMAR, Christophe, additional, BOUAITA, Ryan, additional, MEDIONI, Jacques, additional, FOA, Cyril, additional, DEL PIANO, Francesco, additional, GOZY, Michel, additional, ESCANDE, Anne, additional, LEDUC, Nicolas, additional, LUCAS, Brigitte, additional, MILLE, Dominique, additional, AMMARGUELLAT, Hanifa, additional, NAJEM, Abeer, additional, TROUBOUL, Fanny, additional, BARTHELEMY, Philippe, additional, DESCLOS, Hervé, additional, MAYEUR, Didier, additional, LORCHEL, Fabrice, additional, GUINET, François, additional, LAURENTY, Anne-Pascale, additional, BOUDRANT, Axelle, additional, GISSEROT, Olivier, additional, ALLEAUME, Corinne, additional, and DE GRAMONT, Aimery, additional

Published
2022
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44. Malignant Purkinje ectopy induced by sodium channel blockers

Author

Escande, William, primary, Gourraud, Jean-Baptiste, additional, Haissaguerre, Michel, additional, Gandjbakhch, Estelle, additional, Lavergne, Thomas, additional, Martins, Raphael, additional, Cheniti, Ghassen, additional, Krisai, Philipp, additional, Hermida, Jean Sylvain, additional, Maury, Philippe, additional, Merino, Jose-Louis, additional, Pasquié, Jean-Luc, additional, Combes, Nicolas, additional, Surget, Elodie, additional, Duchateau, Josselin, additional, Pambrun, Thomas, additional, Derval, Nicolas, additional, Hocini, Mélèze, additional, Jaïs, Pierre, additional, Postema, Pieter G., additional, Nademanee, Koonlawee, additional, Vigmond, Ed, additional, Bernus, Olivier, additional, Sacher, Frederic, additional, and Probst, Vincent, additional

Published
2022
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45. Situations de crise : réflexion éthique sur la priorisation de l’accès aux soins en oncologie radiothérapie

Author

Haaser, T., primary, Constantinides, Y., additional, Lahmi, L., additional, Huguet, F., additional, de Crevoisier, R., additional, Dejean, C., additional, Escande, A., additional, Ghannam, Y., additional, Le Tallec, P., additional, Lorchel, F., additional, Mourman, V., additional, Thureau, S., additional, and Lagrange, J.L., additional

Published
2022
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48. Monoallelic and biallelic variants in LEF1 are associated with a new syndrome combining ectodermal dysplasia and limb malformations caused by altered WNT signaling

Author

Dufour, William, primary, Alawbathani, Salem, additional, Jourdain, Anne-Sophie, additional, Asif, Maria, additional, Baujat, Geneviève, additional, Becker, Christian, additional, Budde, Birgit, additional, Gallacher, Lyndon, additional, Georgomanolis, Theodoros, additional, Ghoumid, Jamal, additional, Höhne, Wolfgang, additional, Lyonnet, Stanislas, additional, Ba-Saddik, Iman Ali, additional, Manouvrier-Hanu, Sylvie, additional, Motameny, Susanne, additional, Noegel, Angelika A., additional, Pais, Lynn, additional, Vanlerberghe, Clémence, additional, Wagle, Prerana, additional, White, Susan M., additional, Willems, Marjolaine, additional, Nürnberg, Peter, additional, Escande, Fabienne, additional, Petit, Florence, additional, and Hussain, Muhammad Sajid, additional

Published
2022
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