1. Associated factors to serious infections in a large cohort of juvenile-onset systemic lupus erythematosus from Lupus Registry (RELESSER)
- Author
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Torrente-Segarra, Vicenç, Salman-Monte, Tarek C, Rúa-Figueroa, Íñigo, Del Campo, Víctor, López-Longo, Francisco Javier, Galindo-Izquierdo, María, Calvo-Alén, Jaime, Olivé-Marqués, Alejandro, Mouriño-Rodríguez, Coral, Horcada, Loreto, Bohórquez, Cristina, Montilla, Carlos, Salgado, Eva, Díez-Álvarez, Elvira, Blanco, Ricardo, Andreu, José Luis, Fernández-Berrizbeitia, Olaia, Expósito, Lorena, Gantes, Marian, Hernández-Cruz, Blanca, Pecondón-Español, Ángela, Lozano-Rivas, Nuria, Bonilla, Gema, Lois Iglesias, Ana, Rubio-Muñoz, Paula, Ovalles, Juan, Tomero, Eva, Boteanu, Alina, Narvaez, Javier, Freire, Mercedes, Vela, Paloma, Quevedo-Vila, Víctor, Juan Mas, Antonio, Muñoz-Fernández, Santiago, Raya, Enrique, Moreno, Mireia, Velloso-Feijoo, M L, Soler, Gregorio, Vázquez-Rodríguez, Tomás Ramón, Pego-Reigosa, José M, and RELESSER Study Group of the Spanish Society of Rheumatology (SER) and the Study Group of Systemic Autoimmune Diseases of the SER (EAS-SER)
- Subjects
Adult ,Male ,RELESSER ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Splenectomy ,Serious infection ,Infections ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Adrenal Cortex Hormones ,Internal medicine ,medicine ,Humans ,Lupus Erythematosus, Systemic ,Registries ,030212 general & internal medicine ,Serious Infections ,Child ,skin and connective tissue diseases ,Retrospective Studies ,030203 arthritis & rheumatology ,Juvenile-onset Systemic Lupus Erythematosus ,Systemic lupus erythematosus ,business.industry ,Incidence ,Incidence (epidemiology) ,Retrospective cohort study ,medicine.disease ,3. Good health ,Large cohort ,Cross-Sectional Studies ,Anesthesiology and Pain Medicine ,Juvenile onset ,Female ,business ,Immunosuppressive Agents ,Follow-Up Studies - Abstract
Objective: To assess the incidence of serious infection (SI) and associated factors in a large juvenile-onset systemic lupus erythematosus (jSLE) retrospective cohort. Methods: All patients in the Spanish Rheumatology Society Lupus Registry (RELESSER) who meet >= 4 ACR-97 SLE criteria and disease onset = 6, 5.8%). Incidence rate was 3.7 (95%CI: 3.2-4.2) SI per 100 patient years. Respiratory location and bacterial infections were the most frequent. Higher number of SLE classification criteria, SLICC/ACR DI score and immunosuppressants use were associated to the presence of SI. Associated factors to shorter time to first infection were higher number of SLE criteria, splenectomy and immunosuppressants use. Conclusions: The risk of SI in jSLE patients is significant and higher than aSLE. It is associated to higher number of SLE criteria, damage accrual, some immunosuppressants and splenectomy. (C) 2020 Elsevier Inc. All rights reserved.
- Published
- 2020
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