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1,099 results on '"A. Poisson"'

4. Features of cryptococcosis among 652 HIV-seronegative individuals in France: a cross-sectional observational study (2005-2020)

Author

Paccoud, Olivier, primary, Desnos-Ollivier, Marie, additional, Persat, Florence, additional, Demar, Magalie, additional, Boukris-Sitbon, Karine, additional, Bellanger, Anne-Pauline, additional, Bonhomme, Julie, additional, Bonnal, Christine, additional, Botterel, Françoise, additional, Bougnoux, Marie-Elisabeth, additional, Brun, Sophie, additional, Cassaing, Sophie, additional, Cateau, Estelle, additional, Chouaki, Taieb, additional, Cornet, Muriel, additional, Dannaoui, Eric, additional, Desbois-Nogard, Nicole, additional, Durieux, Marie-Fleur, additional, Favennec, Loïc, additional, Fekkar, Arnaud, additional, Gabriel, Frederic, additional, Gangneux, Jean-Pierre, additional, Guitard, Juliette, additional, Hasseine, Lilia, additional, Huguenin, Antoine, additional, Le Gal, Solène, additional, Letscher-Bru, Valérie, additional, Mahinc, Caroline, additional, Morio, Florent, additional, Nicolas, Muriel, additional, Poirier, Philippe, additional, Ranque, Stéphane, additional, Roosen, Gabrielle, additional, Rouges, Célia, additional, Roux, Anne-Laure, additional, Sasso, Milène, additional, Alanio, Alexandre, additional, Lortholary, Olivier, additional, Lanternier, Fanny, additional, Brieu, N., additional, Durand, C., additional, Bertei, D., additional, Bouchara, J.P., additional, Pihet, M., additional, Bland, S., additional, Bru (Annecy), J.P., additional, Pulik, M., additional, Le Turdu, F., additional, Lefrand, C, H., additional, Ferrand, M., additional, Larrouy, M., additional, Millon, L., additional, Delhaes, L., additional, Imbert, S., additional, Accoceberry, I., additional, Bachelier, M.N., additional, Nevez, G., additional, Quinio, D., additional, Le Coustumier, A., additional, Carmagnol, F., additional, Rivière, B., additional, Boex, P., additional, Podac, B., additional, Moniot, M., additional, Nourrisson, C., additional, Augereau, O., additional, Emond, J.P., additional, Belkacem-Belkaki, G., additional, Bacri, J.L., additional, Berthelot, G., additional, Dalle, F., additional, Vallee, E., additional, Bizet, J., additional, Noussair, L., additional, Herrmann, J.L., additional, Maubon, D., additional, Brocard, C., additional, Guiffault, P., additional, Layet, A., additional, Morel, A., additional, Angoulvant, A., additional, Penn, P., additional, Gigandon, A., additional, Sendid, B., additional, Cornu, M., additional, Darde, M.L., additional, Jaccard, A., additional, Bouteille, B., additional, Azjenberg, D., additional, Prades, N., additional, Bienvenu, A.L., additional, Benoit-Cattin, T., additional, Fiacre, A., additional, Levy, S., additional, Pitsch, A., additional, Kiefer, M.H., additional, Debourgogne, A., additional, Moquet, O., additional, Colot, J., additional, Courtellemont, L., additional, Poisson, D., additional, Laurens, V., additional, Kauffmann-Lacroix, C., additional, Martres, P., additional, Gargala, G., additional, Godineau, N., additional, Picot, S., additional, Chassagne, C., additional, Djibo, N., additional, Devallière, R., additional, Sabou, M., additional, Camin-Ravenne, A.M., additional, Bissuel, F., additional, Janvier, F., additional, Aubert, X., additional, Chadapaud, S., additional, Delbeck, X., additional, Lafeuillade, A., additional, Raoult, X., additional, Baclet, V., additional, Coignard, C., additional, Mouton, Y., additional, Ravaux, I., additional, Eloy, C., additional, Fur, A., additional, Rezzouk, L., additional, Mazards, E., additional, Eloy, O., additional, Chachaty, E., additional, Mihaila, L., additional, Dellion, S., additional, Patey, O., additional, Thouvenot, A., additional, Limousin, L., additional, Paugam, A., additional, Desplaces, N., additional, Raguin, G., additional, Sitterlé, E., additional, Blaize, M., additional, Gits-Muselli, M., additional, Hennequin, C., additional, Poirot, J.L., additional, Bretagne, S., additional, Lacroix, Claire, additional, and Hamane, Samia, additional

Published
2024
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8. Vaccination of squirrel monkeys (Saimiri spp.) with nanoparticle-based Toxoplasma gondii antigens: new hope for captive susceptible species

Author

Céline Ducournau, Pauline Cantin, Vanessa Alerte, Benoît Quintard, Florine Popelin-Wedlarski, Rudy Wedlarski, Florence Ollivet-Courtois, Johanne Ferri-Pisani Maltot, Clément Herkt, François Fasquelle, Mylène Sannier, Mélanie Berthet, Vanessa Fretay, Dominique Aubert, Isabelle Villena, Didier Betbeder, Nathalie Moiré, and Isabelle Dimier-Poisson

Subjects
Infectious Diseases, Parasitology
Published
2023
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13. Intermittent fasting induced ketogenesis inhibits mouse epithelial ovarian cancer by promoting antitumor T cell response

Author

Udumula, Mary Priyanka, primary, Singh, Harshit, additional, Rashid, Faraz, additional, Poisson, Laila, additional, Tiwari, Nivedita, additional, Dimitrova, Irina, additional, Hijaz, Miriana, additional, Gogoi, Radhika, additional, Swenor, Margaret, additional, Munkarah, Adnan, additional, Giri, Shailendra, additional, and Rattan, Ramandeep, additional

Published
2023
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15. Changes in fecal elastase-1 following initiation of CFTR modulator therapy in pediatric patients with cystic fibrosis

Author

Stephenson, Kimberly G., primary, Lingle, Abby J., additional, Baumberger, Kelly A., additional, Dellon, Elisabeth P., additional, Esther, Charles R., additional, Meier, Ellen M., additional, Oermann, Christopher M., additional, Shenoy, Vivek K., additional, Smith, Natalie R., additional, Wimmer, Nicole S., additional, Duehlmeyer, Stephanie R., additional, Kam, Charissa W., additional, McKinzie, Cameron J., additional, Poisson, Margaret O., additional, and Elson, E. Claire, additional

Published
2023
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19. Authors’ Response

Author

Vincent M. Timpone, Margaret Reid, Alexandria Jensen, Sharon N. Poisson, Luke Patten, Bernardo Costa, and Premal S. Trivedi

Subjects
Radiology, Nuclear Medicine and imaging
Published
2023
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20. The global evolution of mental health problems during the COVID-19 pandemic: A systematic review and meta-analysis of longitudinal studies

Author

Jude Mary Cénat, Seyed Mohammad Mahdi Moshirian Farahi, Rose Darly Dalexis, Wina Paul Darius, Farid Mansoub Bekarkhanechi, Hannah Poisson, Cathy Broussard, Gloria Ukwu, Emmanuelle Auguste, Duy Dat Nguyen, Ghizlène Sehabi, Sarah Elizabeth Furyk, Andi Phaelle Gedeon, Olivia Onesi, Aya Mesbahi El Aouame, Samiyah Noor Khodabocus, Muhammad S. Shah, and Patrick R. Labelle

Subjects
Psychiatry and Mental health, Clinical Psychology, Mental Health, Depression, Prevalence, COVID-19, Humans, Anxiety, Anxiety Disorders, Pandemics
Abstract

The COVID-19 pandemic impacted mental health, but the global evolution of mental health problems during the pandemic is unknown. We conducted a systematic review and meta-analysis of longitudinal studies to evaluate the global evolution of mental health problems during the pandemic.To conduct this systematic review, we searched for published articles from APA PsycInfo (Ovid), CINAHL (EBSCOhost), Embase (Ovid), MEDLINE (Ovid), and Web of Science. Longitudinal (at least 2 waves during the COVID-19 pandemic) and peer-reviewed articles on mental health problems conducted as from 2020 and after were included in the current study. Of 394 eligible full texts, 64 articles were included in the analysis. We computed random effects, standardized mean differences, and log odds ratio (LOR) with 95 % CIs. The meta-analysis protocol was registered with PROSPERO (CRD42021273624).Results showed that anxiety (LOR = -0.33; 95 % CI, -0.54, -0.12) and depression symptoms (LOR = -0.12; 95 % CI, -0.21, -0.04) decreased from baseline to follow up. However, other mental health problems showed no change. Higher prevalence rates (40.9 %; 95 % CI, 16.1 %-65.8 %) of psychological distress were found in months after July 2020, respectively, while there were no significant month differences for the prevalence of other mental health problems. Higher means of anxiety (d = 3.63, 95 % CI, 1.66, 5.61), depression (d = 3.93; 95 % CI, 1.68, 6.17), and loneliness (d = 5.96; 95 % CI, 3.22, 8.70) were observed in May 2020. Higher prevalence of anxiety, depression, and PTSD and higher means of anxiety, depression and loneliness were observed in North America. The prevalence of psychological distress and insomnia was higher in Latin America and Europe, respectively.There is a lack of longitudinal studies in some parts of the world, such as Africa, the Caribbean, India, the Middle East, in Latin America, and Asia.Results indicated that anxiety and depression symptoms decreased during the COVID-19 pandemic while other mental health problems showed no statistical change. The findings reveal that mental health problems peaked in April and May 2020. Prevalence of mental health problems remains high during the pandemic and mental health prevention, promotion and intervention programs should be implemented to mitigate the consequences of the COVID-19 pandemic on the global population.

Published
2022
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22. Obesity in adult patients with inflammatory bowel disease: Clinical features and impact on disability. A cross-sectional survey from the GETAID

Author

Bacha, Rose Al, primary, Bouhnik, Yoram, additional, Serrero, Melanie, additional, Filippi, Jerome, additional, Roblin, Xavier, additional, Bourrier, Anne, additional, Bouguen, Guillaume, additional, Franchimont, Denis, additional, Savoye, Guillaume, additional, Buisson, Anthony, additional, Louis, Edouard, additional, Nancey, Stephane, additional, Abitbol, Vered, additional, Reimund, Jean-Marie, additional, DeWit, Olivier, additional, Vuitton, Lucine, additional, Mathieu, Nicolas, additional, Peyrin-Biroulet, Laurent, additional, Gilletta, Cyrielle, additional, Allez, Matthieu, additional, Viennot, Stephanie, additional, Berre, Catherine Le, additional, Laharie, David, additional, Nachury, Maria, additional, Amiot, Aurelien, additional, Tadbiri, Sara, additional, Gagniere, Charlotte, additional, Tannoury, Jenny, additional, Pariente, Benjamin, additional, Wils, Pauline, additional, Stefanescu, Carmen, additional, Treton, Xavier, additional, Martins, Carole, additional, Uzzan, Mathieu, additional, Hébuterne, Xavier, additional, Arab, Nadia, additional, Cluzeau, Virginie, additional, Tedesco, Emilie Del, additional, Beaugerie, Laurent, additional, Seksik, Philippe, additional, Landmann, Cecilia, additional, Kirchgesner, Julien, additional, Sokol, Harry, additional, Siproudhis, Laurent, additional, DeWitte, Marie, additional, Reenaers, Catherine, additional, Boschetti, Gilles, additional, Gay, Claire, additional, Danion, Pauline, additional, Flourié, Bernard, additional, Malamut, Georgia, additional, Caron, Benedicte, additional, DeWitt, Olivier, additional, Pestour, Sandie, additional, Chateau, Thomas, additional, Zallot, Camille, additional, Gornet, Jean-Marc, additional, Baudry, Clotilde, additional, Bourreille, Arnaud, additional, Trang-Poisson, Caroline, additional, Dib, Nina, additional, Brixi, Hedi, additional, Cadiot, Guillaume, additional, Boualit, Medina, additional, Painchart, Claire, additional, Plastaras, Laurianne, additional, Altwegg, Romain, additional, Boivineau, Lucile, additional, Fumery, Mathurin, additional, Caillo, Ludovic, additional, Riviere, Pauline, additional, Poullenot, Florian, additional, Coffin, Benoit, additional, Duboc, Henri, additional, Nahon, Stephane, additional, Tavernier, Noemie, additional, Simon, Marion, additional, Coulibaly, Baya, additional, Amil, Morgane, additional, Nicolas, Duveau, additional, Khater, Sherine, additional, Kaassis, Mehdi, additional, Goutorbe, Felix, additional, Moussata, Driffa, additional, and Picon, Laurence, additional

Published
2023
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23. Obesity in adult patients with inflammatory bowel disease: Clinical features and impact on disability. A cross-sectional survey from the GETAID

Author

Rose Al Bacha, Yoram Bouhnik, Melanie Serrero, Jerome Filippi, Xavier Roblin, Anne Bourrier, Guillaume Bouguen, Denis Franchimont, Guillaume Savoye, Anthony Buisson, Edouard Louis, Stephane Nancey, Vered Abitbol, Jean-Marie Reimund, Olivier DeWit, Lucine Vuitton, Nicolas Mathieu, Laurent Peyrin-Biroulet, Cyrielle Gilletta, Matthieu Allez, Stephanie Viennot, Catherine Le Berre, David Laharie, Maria Nachury, Aurelien Amiot, Sara Tadbiri, Charlotte Gagniere, Jenny Tannoury, Benjamin Pariente, Pauline Wils, Carmen Stefanescu, Xavier Treton, Carole Martins, Mathieu Uzzan, Xavier Hébuterne, Nadia Arab, Virginie Cluzeau, Emilie Del Tedesco, Laurent Beaugerie, Philippe Seksik, Cecilia Landmann, Julien Kirchgesner, Harry Sokol, Laurent Siproudhis, Marie DeWitte, Catherine Reenaers, Gilles Boschetti, Claire Gay, Pauline Danion, Bernard Flourié, Georgia Malamut, Benedicte Caron, Olivier DeWitt, Sandie Pestour, Thomas Chateau, Camille Zallot, Jean-Marc Gornet, Clotilde Baudry, Arnaud Bourreille, Caroline Trang-Poisson, Nina Dib, Hedi Brixi, Guillaume Cadiot, Medina Boualit, Claire Painchart, Laurianne Plastaras, Romain Altwegg, Lucile Boivineau, Mathurin Fumery, Ludovic Caillo, Pauline Riviere, Florian Poullenot, Benoit Coffin, Henri Duboc, Stephane Nahon, Noemie Tavernier, Marion Simon, Baya Coulibaly, Morgane Amil, Duveau Nicolas, Sherine Khater, Mehdi Kaassis, Felix Goutorbe, Driffa Moussata, Laurence Picon, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Nord [CHU - APHM], Immunité muqueuse et vaccination, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pontchaillou [Rennes], Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), CHU Rouen, Normandie Université (NU), CHU Clermont-Ferrand, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Liège (CHU-Liège), Hospices Civils de Lyon (HCL), Hôpital Cochin [AP-HP], Voies de Signalisation du Développement et du Stress Cellulaire dans les Cancers Digestifs et Urologiques, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Service de Gastro-Entérologie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), CHU Grenoble, Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hopital Saint-Louis [AP-HP] (AP-HP), CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Groupe d’Étude Thérapeutique des Affections Inflammatoires du Tube Digestif (GETAID), and This study was supported by Abbvie.

Subjects
Crohn's disease, Disability, Ulcerative colitis, Hepatology, Gastroenterology, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Fatigue, Inflammatory bowel disease, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Background: In recent years, an increasing prevalence of obesity in inflammatory bowel disease (IBD) has been observed. However, only a few studies have focused on the impact of overweight and obesity on IBD-related disability.Aims: To identify the factors associated with obese and overweight patients with IBD, including IBD-related disability.Patients and methods: In this cross-sectional study, we included 1704 consecutive patients with IBD in 42 centres affiliated with the Groupe d'Etude Therapeutique des Affections Inflammatoires du tube Digestif (GETAID) using a 4-page questionnaire. Factors associated with obesity and overweight were assessed using univariate and multivariate analyses (odds ratios (ORs) are provided with 95% confidence intervals).Results: The prevalence rates of overweight and obesity were 24.1% and 12.2%, respectively. Multivariable analyses were stratified by age, sex, type of IBD, clinical remission and age at diagnosis of IBD. Overweight was significantly associated with male sex (OR = 0.52, 95% CI [0.39-0.68], p < 0.001), age (OR = 1.02, 95% CI [1.01-1.03], p < 0.001) and body image subscore (OR = 1.15, 95% CI [1.10-1.20], p < 0.001) (Table 2). Obesity was significantly associated with age (OR = 1.03, 95% CI [1.02-1.04], p < 0.001), joint pain subscore (OR = 1.08, 95% CI [1.02-1.14], p < 0.001) and body image subscore (OR = 1.25, 95% CI [1.19-1.32], p < 0.001) (Table 3).Conclusion: The increasing prevalence of overweight and obesity in patients with IBD is associated with age and poorer body image. A holistic approach to IBD patient care should be encouraged to improve IBD-related disability and to prevent rheumatological and cardiovascular complications.

Published
2023
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25. Development of New Donor Specific and Human Leukocyte Antigen Antibodies after Transfusion in Adult Lung Transplantation

Author

Stoker, Alexander, primary, Hicks, Anne, additional, Wright, Mary Cooter, additional, Ali, Azfar, additional, Klapper, Jacob, additional, Poisson, Jessica, additional, Zaffiri, Lorenzo, additional, Chen, Dongfeng, additional, Hartwig, Matthew, additional, Ghadimi, Kamrouz, additional, Welsby, Ian, additional, and Bottiger, Brandi, additional

Published
2023
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26. Impact of variants of SARS-CoV-2 on obstetrical and neonatal outcomes

Author

Poisson, M., primary, Sibiude, J., additional, Mosnino, E., additional, Koual, M., additional, Landraud, L., additional, Fidouh, N., additional, Mandelbrot, L., additional, Vauloup-Fellous, C., additional, Luton, D., additional, Benachi, A., additional, Vivanti, A.J., additional, and Picone, O., additional

Published
2023
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27. Mise en place d’une stratégie multimodale d’information et de recueil des directives anticipées dans un Centre de lutte contre le cancer (CLCC)

Author

Blot, François, primary, Fasse, Léonor, additional, Mateus, Christine, additional, Renard, Perrine, additional, Verotte, Nelly, additional, de Jesus, Anne, additional, Dumont, Sarah N., additional, Dagorne, Patrick, additional, de la Roque, France, additional, Faveur, Anne, additional, Hollemaert, Catherine, additional, Garnier, Lydia, additional, Manighetti, Joëlle, additional, Roux, Raimonda, additional, Servant, Claire, additional, Fournier-Bidoz, Nathalie, additional, Le Pechoux, Cécile, additional, Rieutord, André, additional, Rouby, Pascal, additional, Rullier (Comité éthique et Commission des usagers), François, additional, Blot, François, additional, Poisson, Caroline, additional, and Sampetrean, Anda, additional

Published
2023
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28. Vaccination of squirrel monkeys (Saimiri spp.) with nanoparticle-based Toxoplasma gondii antigens: new hope for captive susceptible species

Author

Ducournau, Céline, primary, Cantin, Pauline, additional, Alerte, Vanessa, additional, Quintard, Benoît, additional, Popelin-Wedlarski, Florine, additional, Wedlarski, Rudy, additional, Ollivet-Courtois, Florence, additional, Ferri-Pisani Maltot, Johanne, additional, Herkt, Clément, additional, Fasquelle, François, additional, Sannier, Mylène, additional, Berthet, Mélanie, additional, Fretay, Vanessa, additional, Aubert, Dominique, additional, Villena, Isabelle, additional, Betbeder, Didier, additional, Moiré, Nathalie, additional, and Dimier-Poisson, Isabelle, additional

Published
2023
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32. Lethal Pediatric Cerebral Vasculitis Triggered by Severe Acute Respiratory Syndrome Coronavirus 2

Author

David B. Haslam, Barbara Hallinan, Marissa Vawter-Lee, Charles B. Stevenson, Tracy V. Ting, Gwendolyn M. Clay, Kelsey E. Poisson, Monica M. McNeal, Blaise V. Jones, Shannon M. Standridge, Alexander Zygmunt, Melissa E. Day, Kristen Wesselkamper, Daniel Leino, Mary Allen Staat, and Christine Fuller

Subjects
Weakness, Pathology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Autopsy, medicine.disease, Lesion, Cerebrospinal fluid, Developmental Neuroscience, Neurology, Pediatrics, Perinatology and Child Health, medicine, Etiology, Neurology (clinical), medicine.symptom, Vasculitis, business, Cerebral vasculitis
Abstract

Objectives We report the clinical, radiological, laboratory, and neuropathological findings in support of the first diagnosis of lethal, small-vessel cerebral vasculitis triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a pediatric patient. Patient description A previously healthy, 8-year-old Hispanic female presented with subacute onset left-sided weakness two weeks after a mild febrile illness. SARS-CoV-2 nasopharyngeal swab was positive. Magnetic resonance imaging (MRI) revealed an enhancing right frontal lobe lesion with significant vasogenic edema. Two brain biopsies of the lesion showed perivascular and intraluminal lymphohistiocytic inflammatory infiltrate consistent with vasculitis. Despite extensive treatment with immunomodulatory therapies targeting primary angiitis of the central nervous system, she experienced neurologic decline and died 93 days after presentation. SARS-CoV-2 testing revealed positive serum IgG and positive cerebrospinal fluid IgM. Comprehensive infectious, rheumatologic, hematologic/oncologic, and genetic evaluation did not identify an alternative etiology. Post-mortem brain autopsy remained consistent with vasculitis. Discussion This is the first pediatric presentation to suggest SARS-CoV-2 can lead to a fatal, post-infectious, inflammatory small-vessel cerebral vasculitis. Our case is unique in including supportive cerebrospinal fluid and post-mortem tissue analysis. While most children recover well from neurologic complications of SARS-CoV-2, we emphasize the potential mortality in a child with no risk factors for severe disease.

Published
2022
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34. Mise en place d’une stratégie multimodale d’information et de recueil des directives anticipées dans un Centre de lutte contre le cancer (CLCC)

Author

François Blot, Léonor Fasse, Christine Mateus, Perrine Renard, Nelly Verotte, Anne de Jesus, Sarah N. Dumont, Patrick Dagorne, France de la Roque, Anne Faveur, Catherine Hollemaert, Lydia Garnier, Joëlle Manighetti, Raimonda Roux, Claire Servant, Nathalie Fournier-Bidoz, Cécile Le Pechoux, André Rieutord, Pascal Rouby, François Rullier (Comité éthique et Commission des usagers), Caroline Poisson, and Anda Sampetrean

Subjects
Cancer Research, Oncology, Radiology, Nuclear Medicine and imaging, Hematology, General Medicine
Published
2023
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37. Authors’ Response

Author

Timpone, Vincent M., primary, Reid, Margaret, additional, Jensen, Alexandria, additional, Poisson, Sharon N., additional, Patten, Luke, additional, Costa, Bernardo, additional, and Trivedi, Premal S., additional

Published
2022
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38. Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial

Author

Thierry Conroy, Jean-François Bosset, Pierre-Luc Etienne, Emmanuel Rio, Éric François, Nathalie Mesgouez-Nebout, Véronique Vendrely, Xavier Artignan, Olivier Bouché, Dany Gargot, Valérie Boige, Nathalie Bonichon-Lamichhane, Christophe Louvet, Clotilde Morand, Christelle de la Fouchardière, Najib Lamfichekh, Béata Juzyna, Claire Jouffroy-Zeller, Eric Rullier, Frédéric Marchal, Sophie Gourgou, Florence Castan, Christophe Borg, Philippe Ronchin, Jean-François Seitz, Stéphane Corbinais, Emmanuel Maillard, Monique Noirclerc, Farid El Hajbi, Anne-Laure Villing, Yves Bécouarn, Lam Foong Fat Lam Kam Sang, Pascal Artru, Jean-Baptiste Bachet, Fayçal Hocine, Catherine Ligeza-Poisson, Claire Vautravers, Meher Ben Abdelghani, Thomas Aparicio, Elise Desot, and Isabelle Marquis

Subjects
Adult, Male, medicine.medical_specialty, FOLFIRINOX, medicine.medical_treatment, Population, Leucovorin, Irinotecan, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Adjuvant therapy, Humans, 030212 general & internal medicine, education, Neoadjuvant therapy, Aged, education.field_of_study, Performance status, Rectal Neoplasms, business.industry, Chemoradiotherapy, Middle Aged, Total mesorectal excision, Neoadjuvant Therapy, Oxaliplatin, Oncology, 030220 oncology & carcinogenesis, Quality of Life, Female, Fluorouracil, business, medicine.drug
Abstract

Summary Background Treatment of locally advanced rectal cancer with chemoradiotherapy, surgery, and adjuvant chemotherapy controls local disease, but distant metastases remain common. We aimed to assess whether administering neoadjuvant chemotherapy before preoperative chemoradiotherapy could reduce the risk of distant recurrences. Methods We did a phase 3, open-label, multicentre, randomised trial at 35 hospitals in France. Eligible patients were adults aged 18–75 years and had newly diagnosed, biopsy-proven, rectal adenocarcinoma staged cT3 or cT4 M0, with a WHO performance status of 0–1. Patients were randomly assigned (1:1) to either the neoadjuvant chemotherapy group or standard-of-care group, using an independent web-based system by minimisation method stratified by centre, extramural extension of the tumour into perirectal fat according to MRI, tumour location, and stage. Investigators and participants were not masked to treatment allocation. The neoadjuvant chemotherapy group received neoadjuvant chemotherapy with FOLFIRINOX (oxaliplatin 85 mg/m2, irinotecan 180 mg/m2, leucovorin 400 mg/m2, and fluorouracil 2400 mg/m2 intravenously every 14 days for 6 cycles), chemoradiotherapy (50 Gy during 5 weeks and 800 mg/m2 concurrent oral capecitabine twice daily for 5 days per week), total mesorectal excision, and adjuvant chemotherapy (3 months of modified FOLFOX6 [intravenous oxaliplatin 85 mg/m2 and leucovorin 400 mg/m2, followed by intravenous 400 mg/m2 fluorouracil bolus and then continuous infusion at a dose of 2400 mg/m2 over 46 h every 14 days for six cycles] or capecitabine [1250 mg/m2 orally twice daily on days 1–14 every 21 days]). The standard-of-care group received chemoradiotherapy, total mesorectal excision, and adjuvant chemotherapy (for 6 months). The primary endpoint was disease-free survival assessed in the intention-to-treat population at 3 years. Safety analyses were done on treated patients. This trial was registered with EudraCT (2011-004406-25) and ClinicalTrials.gov ( NCT01804790 ) and is now complete. Findings Between June 5, 2012, and June 26, 2017, 461 patients were randomly assigned to either the neoadjuvant chemotherapy group (n=231) or the standard-of-care group (n=230). At a median follow-up of 46·5 months (IQR 35·4–61·6), 3-year disease-free survival rates were 76% (95% CI 69–81) in the neoadjuvant chemotherapy group and 69% (62–74) in the standard-of-care group (stratified hazard ratio 0·69, 95% CI 0·49–0·97; p=0·034). During neoadjuvant chemotherapy, the most common grade 3–4 adverse events were neutropenia (38 [17%] of 225 patients) and diarrhoea (25 [11%] of 226). During chemoradiotherapy, the most common grade 3–4 adverse event was lymphopenia (59 [28%] of 212 in the neoadjuvant chemotherapy group vs 67 [30%] of 226 patients in the standard-of-care group). During adjuvant chemotherapy, the most common grade 3–4 adverse events were lymphopenia (18 [11%] of 161 in the neoadjuvant chemotherapy group vs 42 [27%] of 155 in the standard-of-care group), neutropenia (nine [6%] of 161 vs 28 [18%] of 155), and peripheral sensory neuropathy (19 [12%] of 162 vs 32 [21%] of 155). Serious adverse events occurred in 63 (27%) of 231 participants in the neoadjuvant chemotherapy group and 50 (22%) of 230 patients in the standard-of-care group (p=0·167), during the whole treatment period. During adjuvant therapy, serious adverse events occurred in 18 (11%) of 163 participants in the neoadjuvant chemotherapy group and 36 (23%) of 158 patients in the standard-of-care group (p=0·0049). Treatment-related deaths occurred in one ( Interpretation Intensification of chemotherapy using FOLFIRINOX before preoperative chemoradiotherapy significantly improved outcomes compared with preoperative chemoradiotherapy in patients with cT3 or cT4 M0 rectal cancer. The significantly improved disease-free survival in the neoadjuvant chemotherapy group and the decreased neurotoxicity indicates that the perioperative approach is more efficient and better tolerated than adjuvant chemotherapy. Therefore, the PRODIGE 23 results might change clinical practice. Funding Institut National du Cancer, Ligue Nationale Contre le Cancer, and R&D Unicancer.

Published
2021
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39. CLINICAL UTILITY OF SYSTEMATIC CGH-ARRAY GENETIC TESTING IN REAL WORLD SCHIZOPHRENIA

Author

Rey, Romain, primary, Poisson, Alice, additional, Lio, Guillaume, additional, Franck, Nicolas, additional, Chatron, Nicolas, additional, Till, Marianne, additional, Bralet, Marie-Cécile, additional, Babinet, Marie-Noëlle, additional, Bardel-Danjean, Claire, additional, Sanlaville, Damien, additional, Lesca, Gaëtan, additional, and Demily, Caroline, additional

Published
2022
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40. Prevalence of anti-TNF contraindications in Crohn's disease: A cross-sectional survey from the GETAID

Author

Amiot, Aurelien, primary, Seksik, Philippe, additional, Reimund, Jean-Marie, additional, Nachury, Maria, additional, Altwegg, Romain, additional, Bourreille, Arnaud, additional, Viennot, Stephanie, additional, Fumery, Mathurin, additional, Roblin, Xavier, additional, Serrero, Melanie, additional, Allez, Matthieu, additional, Painchart, Claire, additional, Chanteloup, Elise, additional, Vuitton, Lucine, additional, Fotsing, Ginette, additional, Buisson, Anthony, additional, Coulibaly, Baya, additional, Nancey, Stephane, additional, Gilletta, Cyrielle, additional, Plastaras, Laurianne, additional, Abitbol, Vered, additional, Guillo, Lucas, additional, Simon, Marion, additional, Nahon, Stephane, additional, Laharie, David, additional, Peyrin-Biroulet, Laurent, additional, Bouguen, Guillaume, additional, Amiot, Aurelien, additional, Gagniere, Charlotte, additional, Wils, Pauline, additional, Bouhnik, Yoram, additional, Stefanescu, Carmen, additional, Treton, Xavier, additional, Martins, Carole, additional, Uzzan, Mathieu, additional, Tedesco, Emilie Del, additional, Beaugerie, Laurent, additional, Bourrier, Anne, additional, Landmann, Cecilia, additional, Kirchgesner, Julien, additional, Sokol, Harry, additional, Boschetti, Gilles, additional, Gay, Claire, additional, Danion, Pauline, additional, Flourié, Bernard, additional, Malamut, Georgia, additional, Caron, Benedicte, additional, Zallot, Camille, additional, Gornet, Jean-Marc, additional, Baudry, Clotilde, additional, Trang-Poisson, Caroline, additional, Boualit, Medina, additional, Boivineau, Lucile, additional, Riviere, Pauline, additional, Poullenot, Florian, additional, Coffin, Benoit, additional, and Duboc, Henri, additional

Published
2022
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41. The global evolution of mental health problems during the COVID-19 pandemic: A systematic review and meta-analysis of longitudinal studies

Author

Cénat, Jude Mary, primary, Farahi, Seyed Mohammad Mahdi Moshirian, additional, Dalexis, Rose Darly, additional, Darius, Wina Paul, additional, Bekarkhanechi, Farid Mansoub, additional, Poisson, Hannah, additional, Broussard, Cathy, additional, Ukwu, Gloria, additional, Auguste, Emmanuelle, additional, Nguyen, Duy Dat, additional, Sehabi, Ghizlène, additional, Furyk, Sarah Elizabeth, additional, Gedeon, Andi Phaelle, additional, Onesi, Olivia, additional, El Aouame, Aya Mesbahi, additional, Khodabocus, Samiyah Noor, additional, Shah, Muhammad S., additional, and Labelle, Patrick R., additional

Published
2022
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44. Biomarker-guided clustering of Alzheimer's disease clinical syndromes

Author

Toschi, Nicola, Lista, Simone, Lamari, Foudil, Genthon, Remy, Habert, Marie-Odile, Dubois, Bruno, Floris, Roberto, Garaci, Francesco, Vergallo, Andrea, Hampel, Harald, group, INSIGHT-preAD study, Initiative, Alzheimer Precision Medicine, Baldacci, Filippo, Bakardjian, Hovagim, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Boukerrou, Nadia, Cavedo, Enrica, Chiesa, Patrizia, Colliot, Olivier, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Houot, Marion, Kas, Aurélie, Levy, Marcel, Zetterberg, Henrik, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Potier, Marie-Claude, Revillon, Marie, Santos, Antonio, Andrade, Katia Santos, Sole, Marine, Blennow, Kaj, Surtee, Mohmed, Thiebaut de Schotten, Michel, Younsi, Nadjia, Kilimann, Ingo, Teipel, Stefan J, Melo Dos Santos, Antonio, Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 AMP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CCSD, Accord Elsevier, Università degli Studi di Roma Tor Vergata [Roma], Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 APM), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] (IM2A), University of Pisa - Università di Pisa, University of Gothenburg (GU), University of Rostock, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre pour l'Acquisition et le Traitement des Images (CATI), Eisai, and Hovagim Bakardjian, Habib Benali, Hugo Bertin, Joel Bonheur, Laurie Boukadida, Nadia Boukerrou, Enrica Cavedo, Patrizia Chiesa, Olivier Colliot, Bruno Dubois, Marion Dubois, Stéphane Epelbaum, Geoffroy Gagliardi, Remy Genthon, Marie-Odile Habert, Harald Hampel, Marion Houot, Aurélie Kas, Foudil Lamari, Marcel Levy, Simone Lista, Christiane Metzinger, Fanny Mochel, Francis Nyasse, Catherine Poisson, Marie-Claude Potier, Marie Revillon, Antonio Santos, Katia Santos Andrade, Marine Sole, Mohmed Surtee, Michel Thiebaut de Schotten, Andrea Vergallo, Nadjia Younsi

Subjects
Male, 0301 basic medicine, Oncology, Aging, [SDV]Life Sciences [q-bio], cerebrospinal fluid [Amyloid beta-Peptides], Disease, 0302 clinical medicine, Risk Factors, General Neuroscience, Precision medicine, diagnosis [Alzheimer Disease], Alzheimer's disease, Middle Aged, Pathophysiology, 3. Good health, [SDV] Life Sciences [q-bio], cerebrospinal fluid [Alzheimer Disease], cerebrospinal fluid [Cognitive Dysfunction], cerebrospinal fluid [Biomarkers], Biomarker (medicine), Female, Biomarker-guided categorization, Clustering, medicine.medical_specialty, tau Proteins, Neuropathology, 03 medical and health sciences, Settore MED/36 - Diagnostica per Immagini e Radioterapia, Alzheimer Disease, Internal medicine, medicine, Humans, Dementia, Cognitive Dysfunction, ddc:610, cerebrospinal fluid [Peptide Fragments], Cluster analysis, Aged, Amyloid beta-Peptides, business.industry, medicine.disease, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), Peptide Fragments, 030104 developmental biology, diagnosis [Cognitive Dysfunction], cerebrospinal fluid [tau Proteins], Spatial clustering, Neurology (clinical), Geriatrics and Gerontology, business, Biomarkers, 030217 neurology & neurosurgery, Developmental Biology
Abstract

International audience; Alzheimer's disease (AD) neuropathology is extremely heterogeneous, and the evolution from preclinical to mild cognitive impairment until dementia is driven by interacting genetic/biological mechanisms not fully captured by current clinical/research criteria. We characterized the heterogeneous "construct" of AD through a cerebrospinal fluid biomarker-guided stratification approach. We analyzed 5 validated pathophysiological cerebrospinal fluid biomarkers (Aβ1-42, t-tau, p-tau181, NFL, YKL-40) in 113 participants (healthy controls [N = 20], subjective memory complainers [N = 36], mild cognitive impairment [N = 20], and AD dementia [N = 37], age: 66.7 ± 10.4, 70.4 ± 7.7, 71.7 ± 8.4, 76.2 ± 3.5 years [mean ± SD], respectively) using Density-Based Spatial Clustering of Applications with Noise, which does not require a priori determination of the number of clusters. We found 5 distinct clusters (sizes: N = 38, 16, 24, 14, and 21) whose composition was independent of phenotypical groups. Two clusters showed biomarker profiles linked to neurodegenerative processes not associated with classical AD-related pathophysiology. One cluster was characterized by the neuroinflammation biomarker YKL-40. Combining nonlinear data aggregation with informative biomarkers can generate novel patient strata which are representative of cellular/molecular pathophysiology and may aid in predicting disease evolution and mechanistic drug response.

Published
2019
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49. Glioma progression is shaped by genetic evolution and microenvironment interactions

Author

Varn, Frederick S., primary, Johnson, Kevin C., additional, Martinek, Jan, additional, Huse, Jason T., additional, Nasrallah, MacLean P., additional, Wesseling, Pieter, additional, Cooper, Lee A.D., additional, Malta, Tathiane M., additional, Wade, Taylor E., additional, Sabedot, Thais S., additional, Brat, Daniel, additional, Gould, Peter V., additional, Wöehrer, Adelheid, additional, Aldape, Kenneth, additional, Ismail, Azzam, additional, Sivajothi, Santhosh K., additional, Barthel, Floris P., additional, Kim, Hoon, additional, Kocakavuk, Emre, additional, Ahmed, Nazia, additional, White, Kieron, additional, Datta, Indrani, additional, Moon, Hyo-Eun, additional, Pollock, Steven, additional, Goldfarb, Christine, additional, Lee, Ga-Hyun, additional, Garofano, Luciano, additional, Anderson, Kevin J., additional, Nehar-Belaid, Djamel, additional, Barnholtz-Sloan, Jill S., additional, Bakas, Spyridon, additional, Byrne, Annette T., additional, D’Angelo, Fulvio, additional, Gan, Hui K., additional, Khasraw, Mustafa, additional, Migliozzi, Simona, additional, Ormond, D. Ryan, additional, Paek, Sun Ha, additional, Van Meir, Erwin G., additional, Walenkamp, Annemiek M.E., additional, Watts, Colin, additional, Weiss, Tobias, additional, Weller, Michael, additional, Palucka, Karolina, additional, Stead, Lucy F., additional, Poisson, Laila M., additional, Noushmehr, Houtan, additional, Iavarone, Antonio, additional, Verhaak, Roel G.W., additional, Varn, Frederick S., additional, Ryan Ormond, D., additional, Ha Paek, Sun, additional, Alfaro, Kristin D., additional, Amin, Samirkumar B., additional, Ashley, David M., additional, Bock, Christoph, additional, Brodbelt, Andrew, additional, Bulsara, Ketan R., additional, Castro, Ana Valeria, additional, Connelly, Jennifer M., additional, Costello, Joseph F., additional, de Groot, John F., additional, Finocchiaro, Gaetano, additional, French, Pim J., additional, Golebiewska, Anna, additional, Hau, Ann C., additional, Hong, Chibo, additional, Horbinski, Craig, additional, Kannan, Kasthuri S., additional, Kouwenhoven, Mathilde CM., additional, Lasorella, Anna, additional, LaViolette, Peter S., additional, Ligon, Keith L., additional, Lowman, Allison K., additional, Mehta, Shwetal, additional, Miletic, Hrvoje, additional, Molinaro, Annette M., additional, Ng, Ho Keung, additional, Niclou, Simone P., additional, Niers, Johanna M., additional, Phillips, Joanna J., additional, Rabadan, Raul, additional, Rao, Ganesh, additional, Reifenberger, Guido, additional, Sanai, Nader, additional, Short, Susan C., additional, Sillevis Smitt, Peter, additional, Sloan, Andrew E., additional, Smits, Marion, additional, Snyder, James M., additional, Suzuki, Hiromichi, additional, Tabatabai, Ghazaleh, additional, Tanner, Georgette, additional, Tomaszewski, William H., additional, Wells, Michael, additional, Westerman, Bart A., additional, Wheeler, Helen, additional, Xie, Jichun, additional, Alfred Yung, W.K., additional, Zadeh, Gelareh, additional, Zhao, Junfei, additional, and Verhaak, Roel GW., additional

Published
2022
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