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Start Over Author "Aimanianda, Vishukumar" Publisher elsevier bv
15 results on '"Aimanianda, Vishukumar"'

1. Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of Aspergillus fumigatus

Author

Wong, Sarah Sze Wah, primary, Dellière, Sarah, additional, Schiefermeier-Mach, Natalia, additional, Lechner, Lukas, additional, Perkhofer, Susanne, additional, Bomme, Perrine, additional, Fontaine, Thierry, additional, Schlosser, Anders G., additional, Sorensen, Grith L., additional, Madan, Taruna, additional, Kishore, Uday, additional, and Aimanianda, Vishukumar, additional

Published
2022
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2. Aspergillus fumigatus hydrophobin functional amyloids

Author

Rodriguez de Francisco, Borja, primary, Valsecchi, Isabel, additional, Pillé, Ariane, additional, Pham, Chi L., additional, Duprès, Vincent, additional, Lafont, Frank, additional, Bayry, Jagadesh, additional, Aimanianda, Vishukumar, additional, Sunde, Margaret, additional, and Guijarro, Inaki, additional

Published
2022
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4. Assembly and disassembly of Aspergillus fumigatus conidial rodlets

Author

UCL - SST/LIBST - Louvain Institute of Biomolecular Science and Technology, Valsecchi, Isabel, Lai, Jennifer I., Stephen-Victor, Emmanuel, Pillé, Ariane, Beaussart, Audrey, Lo, Victor, Pham, Chi L.L., Aimanianda, Vishukumar, Kwan, Ann H., Duchateau, Magalie, Gianetto, Quentin Giai, Matondo, Mariette, Lehoux, Melanie, Sheppard, Donald C., Dufrêne, Yves, Bayry, Jagadeesh, Guijarro, J. Iñaki, Sunde, Margaret, Latgé, Jean-Paul, UCL - SST/LIBST - Louvain Institute of Biomolecular Science and Technology, Valsecchi, Isabel, Lai, Jennifer I., Stephen-Victor, Emmanuel, Pillé, Ariane, Beaussart, Audrey, Lo, Victor, Pham, Chi L.L., Aimanianda, Vishukumar, Kwan, Ann H., Duchateau, Magalie, Gianetto, Quentin Giai, Matondo, Mariette, Lehoux, Melanie, Sheppard, Donald C., Dufrêne, Yves, Bayry, Jagadeesh, Guijarro, J. Iñaki, Sunde, Margaret, and Latgé, Jean-Paul

Abstract

The rodlet structure present on the Aspergillus fumigatus conidial surface hides conidia from immune recognition. In spite of the essential biological role of the rodlets, the molecular basis for their self-assembly and disaggregation is not known. Analysis of the soluble forms of conidia-extracted and recombinant RodA by NMR spectroscopy has indicated the importance of disulfide bonds and identified two dynamic regions as likely candidates for conformational change and intermolecular interactions during conversion of RodA into the amyloid rodlet structure. Point mutations introduced into the RODA sequence confirmed that (1) mutation of a single cysteine was sufficient to block rodlet formation on the conidial surface and (2) both presumed amyloidogenic regions were needed for proper rodlet assembly. Mutations in the two putative amyloidogenic regions retarded and disturbed, but did not completely inhibit, the formation of the rodlets in vitro and on the conidial surface. Even in a disturbed form, the presence of rodlets on the surface of the conidia was sufficient to immunosilence the conidium. However, in contrast to the parental conidia, long exposure of mutant conidia lacking disulfide bridges within RodA or expressing RodA carrying the double (I115S/I146G) mutation activated dendritic cells with the subsequent secretion of proinflammatory cytokines. The immune reactivity of the RodA mutant conidia was not due to a modification in the RodA structure, but to the exposure of different pathogenassociated molecular patterns on the surface as a result of the modification of the rodlet surface layer. The full degradation of the rodlet layer, which occurs during early germination, is due to a complex array of cell wall bound proteases. As reported earlier, this loss of the rodlet layer lead to a strong anti-fumigatus host immune response in mouse lungs.

Published
2019

5. Assembly and disassembly of Aspergillus fumigatus conidial rodlets

Author

Valsecchi, Isabel, primary, Lai, Jennifer I., additional, Stephen-Victor, Emmanuel, additional, Pillé, Ariane, additional, Beaussart, Audrey, additional, Lo, Victor, additional, Pham, Chi L.L., additional, Aimanianda, Vishukumar, additional, Kwan, Ann H., additional, Duchateau, Magalie, additional, Gianetto, Quentin Giai, additional, Matondo, Mariette, additional, Lehoux, Melanie, additional, Sheppard, Donald C., additional, Dufrene, Yves F., additional, Bayry, Jagadeesh, additional, Guijarro, J. Iñaki, additional, Sunde, Margaret, additional, and Latgé, Jean-Paul, additional

Published
2019
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6. Aspergillus fumigatus conidial metalloprotease Mep1p cleaves host complement proteins

Author

Shende, Rajashri, primary, Wong, Sarah Sze Wah, additional, Rapole, Srikanth, additional, Beau, Rémi, additional, Ibrahim-Granet, Oumaima, additional, Monod, Michel, additional, Gührs, Karl-Heinz, additional, Pal, Jayanta Kumar, additional, Latgé, Jean-Paul, additional, Madan, Taruna, additional, Aimanianda, Vishukumar, additional, and Sahu, Arvind, additional

Published
2018
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9. SUN Proteins Belong to a Novel Family of β-(1,3)-Glucan-modifying Enzymes Involved in Fungal Morphogenesis

Author

Gastebois, Amandine, primary, Aimanianda, Vishukumar, additional, Bachellier-Bassi, Sophie, additional, Nesseir, Audrey, additional, Firon, Arnaud, additional, Beauvais, Anne, additional, Schmitt, Christine, additional, England, Patrick, additional, Beau, Rémi, additional, Prévost, Marie-Christine, additional, d'Enfert, Christophe, additional, Latgé, Jean-Paul, additional, and Mouyna, Isabelle, additional

Published
2013
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13. The N-terminal Domain of Drosophila Gram-negative Binding Protein 3 (GNBP3) Defines a Novel Family of Fungal Pattern Recognition Receptors

Author

Mishima, Yumiko, primary, Quintin, Jessica, additional, Aimanianda, Vishukumar, additional, Kellenberger, Christine, additional, Coste, Franck, additional, Clavaud, Cecile, additional, Hetru, Charles, additional, Hoffmann, Jules A., additional, Latgé, Jean-Paul, additional, Ferrandon, Dominique, additional, and Roussel, Alain, additional

Published
2009
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