1. The Benefit of Complete Response to Treatment in Patients With Chronic Spontaneous Urticaria—CURE Results
- Author
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Pavel Kolkhir, Pedro A. Laires, Pascale Salameh, Riccardo Asero, Mojca Bizjak, Mitja Košnik, Joachim Dissemond, Martijn van Doorn, Tomasz Hawro, Alicja Kasperska-Zajac, Magdalena Zajac, Emek Kocatürk, Jonny Peter, Claudio A.S. Parisi, Carla A. Ritchie, Kanokvalai Kulthanan, Papapit Tuchinda, Daria Fomina, Elena Kovalkova, Maryam Khoshkhui, Samaneh Kouzegaran, Niki Papapostolou, Aurélie Du-Thanh, Akiko Kamegashira, Raisa Meshkova, Alexander Vitchuk, Andrea Bauer, Clive Grattan, Petra Staubach, Laurence Bouillet, Ana M. Giménez-Arnau, Marcus Maurer, Karsten Weller, and Dermatology
- Subjects
Quality of life ,Patient-reported outcomes ,CURE registry ,Medizin ,Immunology and Allergy ,Complete control/complete response to treatment ,Chronic spontaneous urticaria - Abstract
Background and Objective: Chronic spontaneous urticaria (CSU) is a distressing disease. We report real-world data from the global Chronic Urticaria Registry (CURE) about associations between various CSU states and sleep impairment, plus important health-related quality-of-life (HRQoL) outcomes and compared different methods to assess CSU states. Methods: CURE data were collected at baseline and 6-monthly follow-ups (FU). Assessments included CSU states using the Urticaria Control Test (UCT), weekly Urticaria Activity Score (UAS7), and Physician Global Assessment (PhyGA) of treatment response. Complete response to treatment (CR, UAS7 = 0), complete control of disease (CC, UCT = 16), and PhyGA = CR were assessed, plus the Dermatology Life Quality Index and the Chronic Urticaria Quality-of-Life Questionnaire (CU-Q2oL) sleep domain. Results: Overall, 2078 patients were included. At baseline, 9.8%, 17.9%, and 42.3% of patients had UCT = 16, UAS7 = 0, or PhyGA = CR, respectively, which increased at FU1 and FU2. Patients with higher UCT scores had better sleep and HRQoL. The presence of angioedema without wheals, episodic disease, omalizumab treatment, and male sex were associated with CC (P
- Published
- 2023
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