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Your search keyword '"Anastasiya Hurieva"' showing total 3 results
Start Over Author "Anastasiya Hurieva" Publisher elsevier bv
3 results on '"Anastasiya Hurieva"'

1. Convenient method for the synthesis of C-phosphorylated N-arylformamidines

Author

Aleksandr A. Yurchenko, Aleksandr N. Kostyuk, Aleksandr M. Pinchuk, Anatoliy Marchenko, Georgyi Koidan, Anastasiya Hurieva, and A. S. Merkulov

Subjects
Steric effects, medicine.drug_class, Stereochemistry, Phosphorus, Organic Chemistry, chemistry.chemical_element, Carboxamide, Biochemistry, Chemical synthesis, Amidine, chemistry.chemical_compound, chemistry, Drug Discovery, Electronic effect, Chemical reduction, medicine, Phosphorylation
Abstract

C -Phosphorylated (P V ) arylformamidines have been prepared by the reaction of N -arylamidotrichloromethyl derivatives of phosphorus, thiophosphorus, and selenophosphorus acids with secondary amines. Dependence of the reaction on the nature of chalcogene, electronic and steric factors has been studied. By reduction of N -arylformamidinophosphonoselenides the corresponding C -phosphorylated (P III ) arylformamidines have been synthesized.

Published
2010
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2. Facile synthesis of C-phosphanylformamidines via a carbene pathway

Author

Aleksandr Savateev, Anastasiya Hurieva, Anatoliy Marchenko, Georgyi Koidan, and Aleksandr N. Kostyuk

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, Deprotonation, chemistry, Nitrogen atom, Organic Chemistry, Drug Discovery, Phosphorylation, Biochemistry, Medicinal chemistry, Carbene, Alkyl
Abstract

A direct synthetic approach to C-phosphanyl-N,N-dialkyl-N′-aryl(alkyl)-formamidines was developed. It was shown that phosphorylation of the formamidines proceeds at the nitrogen atom affording N-phosphanylformamidinium salts. Upon deprotonation, these salts gave C-phosphanylformamidines via formation of carbenes followed by a 1,2-phosphorus shift.

Published
2013
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3. Cyclization of C-phosphorylated (P(III)) arylformamidines to 3H-1,3-benzazaphospholes

Author

Anatolyi Merkulov, Alexander B. Rozhenko, Peter G. Jones, Heorgii N. Koidan, Holger Thönnessen, A. P. Marchenko, Aleksandr N. Kostyuk, Anastasiya Hurieva, Aleksandr A. Yurchenko, and Aleksandr M. Pinchuk

Subjects
Activation barrier, Stereochemistry, Chemistry, Organic Chemistry, Reaction energy, 3H-1, Biochemistry, DFT, C-Phosphorylated arylformamidines, Meta, Computational chemistry, Cyclization, Drug Discovery, 3-Benzazaphosphole, Phosphorylation
Abstract

A synthesis of 3H-1,3-benzazaphospholes starting from C-phosphorylated P(III) arylformamidines has been developed. Electron-donating substituents were found to enhance markedly the rate of the cyclization, with substituents at the meta position having the greatest effect. A plausible mechanism of the cyclization was proposed based on DFT calculations. (C) 2011 Elsevier Ltd. All rights reserved.

Published
2011

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