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171 results on '"Andersson, S."'

13. PO-1642: CBCT Padding for Full Field of View Daily Dose Accumulation and Head and Neck Adaptive Radiotherapy

Author

Brock, K., primary, Ohrt, A., additional, Cazoulat, G., additional, McCulloch, M., additional, Balter, P., additional, Ohrt, J., additional, Svensson, S., additional, Nilsson, R., additional, Andersson, S., additional, Mohamed, A., additional, Bahig, H., additional, Ding, Y., additional, Wang, J., additional, McDonald, B., additional, Yang, J., additional, Vedam, S., additional, Elgohari, B., additional, Sen, A., additional, and Fuller, C., additional

Published
2020
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21. Red Carotenoid Coloration in the Zebra Finch Is Controlled by a Cytochrome P450 Gene Cluster

Author

Mundy, N.I., Stapley, J., Bennison, C., Tucker, R., Twyman, H., Kim, K.W., Burke, T., Birkhead, T.R., Andersson, S., Slate, J., Mundy, Nicholas [0000-0002-5545-1517], and Apollo - University of Cambridge Repository

Subjects
Male, animal structures, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Pigmentation, Beak, Pigments, Biological, Tarsus, Animal, Retina, Avian Proteins, Cytochrome P-450 Enzyme System, Animals, Female, Finches
Abstract

Bright-red colors in vertebrates are commonly involved in sexual, social, and interspecific signaling [1-8] and are largely produced by ketocarotenoid pigments. In land birds, ketocarotenoids such as astaxanthin are usually metabolically derived via ketolation of dietary yellow carotenoids [9, 10]. However, the molecular basis of this gene-environment mechanism has remained obscure. Here we use the yellowbeak mutation in the zebra finch (Taeniopygia guttata) to investigate the genetic basis of red coloration. Wild-type ketocarotenoids were absent in the beak and tarsus of yellowbeak birds. The yellowbeak mutation mapped to chromosome 8, close to a cluster of cytochrome P450 loci (CYP2J2-like) that are candidates for carotenoid ketolases. The wild-type zebra finch genome was found to have three intact genes in this cluster: CYP2J19A, CYP2J19B, and CYP2J40. In yellowbeak, there are multiple mutations: loss of a complete CYP2J19 gene, a modified remaining CYP2J19 gene (CYP2J19(yb)), and a non-synonymous SNP in CYP2J40. In wild-type birds, CYP2J19 loci are expressed in ketocarotenoid-containing tissues: CYP2J19A only in the retina and CYP2J19B in the beak and tarsus and to a variable extent in the retina. In contrast, expression of CYP2J19(yb) is barely detectable in the beak of yellowbeak birds. CYP2J40 has broad tissue expression and shows no differences between wild-type and yellowbeak. Our results indicate that CYP2J19 genes are strong candidates for the carotenoid ketolase and imply that ketolation occurs in the integument in zebra finches. Since cytochrome P450 enzymes include key detoxification enzymes, our results raise the intriguing possibility that red coloration may be an honest signal of detoxification ability., Current Biology, 26 (11), ISSN:0960-9822, ISSN:1879-0445

Published
2016

22. A study of mechanisms behind extreme aggression: the possible existence of functional signaling mechanisms modulated by ACTH IgG

Author

Værøy, H., primary, Adori, C., additional, Legrand, R., additional, Lucas, N., additional, Breton, J., additional, Cottard, C., additional, Do Rego, J.C., additional, Duparc, C., additional, Louiset, E., additional, Lefebvre, H., additional, Western, E., additional, Andersson, S., additional, Dechelotte, P., additional, Hökfelt, T., additional, and Fetissov, S., additional

Published
2017
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25. Mass spectrometric detection of biomarkers for early assessment of intraamniotic fluid infection

Author

Cháfer-Pericás C, Stefanovic V, Sánchez-Illana Á, Escobar J, Cernada M, Cubells E, Núñez-Ramiro A, Andersson S, Vento M, and Kuligowski J

Subjects
Intraamniotic fluid infection, Time-of-flight mass spectrometry (TOF-MS), Biomarker detection, High performance liquid chromatography (HPLC), Liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS), Glutathione sulfonamide (GSA)
Abstract

This data article contains information on glutathione sulfonamide (GSA) structural confirmation and purity after synthesis, as well as mass spectrometry acquisition parameters for the determination of GSA and other biomarkers for the early assessment of intraamniotic fluid infection in amniotic fluid samples (Chafer-Pericas et al., 2015) [1]. GSA standards were synthesized and structural confirmation was carried out employing time-of-flight mass spectrometry (TOF-MS); purity was assessed by high performance liquid chromatography (HPLC) with UV detection. For optimization of the acquisition parameters of GSA and other biomarkers, individual analytical standard solution at a concentration of 1 micromol L(-) (1) was injected into an Acquity - Xevo TQ liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS) system from Waters (Milford, MA, USA) operating in the positive electrospray (ESI(+)) mode. Mass spectrometric detection of 3-nitro-tyrosine (3NO2-Tyr), 3-chloro-tyrosine (3Cl-Tyr), 8-hydroxy-2'-deoxyguanosine (8OHdG), GSA and oxidized glutathione (GSSG) was carried out by multiple reaction monitoring (MRM). Linear response curves were calculated for each analyte normalizing the signal with peak areas of internal standards.

Published
2015

27. Ultra high performance liquid chromatography coupled to tandem mass spectrometry determination of lipid peroxidation biomarkers in newborn serum samples

Author

Cháfer-Pericás, C., primary, Rahkonen, L., additional, Sánchez-Illana, A., additional, Kuligowski, J., additional, Torres-Cuevas, I., additional, Cernada, M., additional, Cubells, E., additional, Nuñez-Ramiro, A., additional, Andersson, S., additional, Vento, M., additional, and Escobar, J., additional

Published
2015
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