25 results on '"Andres Cardenas"'
Search Results
2. Household Air Pollution and Epigenetic Aging
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Batel Blechter, Andres Cardenas, Junming Shi, Jason Y.Y. Wong, Hu Wei, Mohammad L. Rahman, Charles Breeze, George S. Downward, Lützen Portengen, Yongliang Zhang, Bofu Ning, Bu-Tian Ji, Richard Cawthon, Jihua Li, Kaiyun Yang, Anne K. Bozack, H. Dean Hosgood, Debra T. Silverman, Yunchao Huang, Nathaniel Rothman, Roel C.H. Vermeulen, and Qing Lan
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- 2023
3. Epigenome-Wide Association Study of Lung Cancer Among Never Smokers in Two Prospective Cohorts in Shanghai
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Mohammad L. Rahman, Charles Breeze, Xiao-Ou Shu, Jason Y.Y. Wong, Andres Cardenas, Xuting Wang, Bu-Tian Ji, Hu Wei, Batel Blechter, Qiuyin Cai, H. Dean Hosgood, Gong Yang, Jianxin Shi, Jirong Long, Yu-Tang Gao, Douglas A. Bell, Wei Zheng, Nathaniel Rothman, and Qing Lan
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- 2023
4. Associations between prenatal phthalate exposure and childhood epigenetic age acceleration
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Dennis Khodasevich, Nina Holland, Alan Hubbard, Kim Harley, Julianna Deardorff, Brenda Eskenazi, and Andres Cardenas
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Biochemistry ,General Environmental Science - Published
- 2023
5. Diet and erythrocyte metal concentrations in early pregnancy—cross-sectional analysis in Project Viva
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Chitra Amarasiriwardena, Mohammad L. Rahman, Marie-France Hivert, Robert O. Wright, Andres Cardenas, Pi-I D. Lin, Sheryl L. Rifas-Shiman, Emily Oken, and Tamarra James-Todd
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0301 basic medicine ,Pregnancy ,Nutrition and Dietetics ,biology ,Cross-sectional study ,business.industry ,Maximum likelihood ,Medicine (miscellaneous) ,Early pregnancy factor ,Environmental exposure ,010501 environmental sciences ,medicine.disease ,01 natural sciences ,03 medical and health sciences ,First trimester ,030104 developmental biology ,Animal science ,biology.protein ,White rice ,medicine ,Gestation ,business ,0105 earth and related environmental sciences - Abstract
Background Dietary sources of metals are not well established among pregnant women in the United States. Objective We aimed to perform a diet-wide association study (DWAS) of metals during the first trimester of pregnancy. Methods In early pregnancy (11.3 ± 2.8 weeks of gestation), 1196 women from Project Viva (recruited 1999-2002 in eastern Massachusetts) completed a validated FFQ (135 food items) and underwent measurements of erythrocyte metals [arsenic (As), barium, cadmium, cesium (Cs), copper, mercury (Hg), magnesium, manganese, lead (Pb), selenium (Se), zinc]. The DWAS involved a systematic evaluation and visualization of all bivariate relations for each food-metal combination. For dietary items with strong associations with erythrocyte metals, we applied targeted maximum likelihood estimations and substitution models to evaluate how hypothetical dietary interventions would influence metals' concentrations. Results Participants' mean ± SD age was 32.5 ± 4.5 y and prepregnancy BMI was 24.8 ± 5.4 kg/m2; they were mostly white (75.9%), college graduates (72.4%), married or cohabitating (94.6%), had a household income >$70,000/y (63.5%), and had never smoked (67.1%). Compared with other US-based cohorts, the overall diet quality of participants was above average, and concentrations of erythrocyte metals were lower. The DWAS identified significant associations of several food items with As, Hg, Pb, Cs, and Se; for example, As was higher for each SD increment in fresh fruit (11.5%; 95% CI: 4.9%, 18.4%), white rice (17.9%; 95% CI: 9.4%, 26.9%), and seafood (50.9%; 95% CI: 42.8%, 59.3%). Following the guidelines for pregnant women to consume ≤3 servings/wk of seafood was associated with lower As (-0.55 ng/g; 95% CI: -0.82, -0.28 ng/g) and lower Hg (-2.67 ng/g; 95% CI: -3.55, -1.80 ng/g). Substituting white rice with bread, pasta, tortilla, and potato was also associated with lower As (35%-50%) and Hg (35%-70%). Conclusions Our DWAS provides a systematic evaluation of diet-metals relations. Prenatal diet may be an important source of exposures to metals.
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- 2021
6. The prenatal environment and its influence on maternal and child mitochondrial DNA copy number and methylation: A review of the literature
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Anna R. Smith, Alejandra Hinojosa Briseño, Martin Picard, and Andres Cardenas
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Biochemistry ,General Environmental Science - Published
- 2023
7. Long-term exposure to ambient fine particulate matter and carotid intima media thickness at bilateral, left and right in adults from Mexico City: Results from GEA study
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Rocio Torrico- Lavayen, Gilberto Vargas-Alarcón, Horacio Riojas-Rodriguez, Marco A. Sánchez Guerra, José-Luis Texcalac-Sangrador, Eduardo Ortiz-Panozo, Iván Gutiérrez-Avila, Andrea De Vizcaya-Ruiz, Andres Cardenas, Rosalinda Posadas-Sánchez, and Citlalli Osorio-Yáñez C
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Environmental Engineering ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Environmental Chemistry ,General Medicine ,General Chemistry ,Pollution - Published
- 2023
8. Non-essential and essential trace element mixtures and kidney function in early pregnancy – A cross-sectional analysis in project viva
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Pi-I.D. Lin, Andres Cardenas, Sheryl L. Rifas-Shiman, Ami R. Zota, Marie-France Hivert, Izzuddin M. Aris, and Alison P. Sanders
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Selenium ,Cross-Sectional Studies ,Lead ,Pregnancy ,Humans ,Female ,Mercury ,Renal Insufficiency, Chronic ,Kidney ,Biochemistry ,Trace Elements ,General Environmental Science - Abstract
Some trace elements are established nephrotoxicants, yet their associations with kidney function remain understudied in the context of pregnancy, a time of substantial change in kidney physiology and function. We aimed to estimate the individual and joint associations of trace element mixtures with maternal kidney function during the 1st trimester of pregnancy (mean 9.7 gestational weeks). 1040 women from Project Viva contributed blood samples which were assessed for erythrocyte non-essential [arsenic (As), cadmium (Cd), cesium (Cs), mercury (Hg), lead (Pb)] and essential [barium (Ba), magnesium (Mg), manganese (Mn), selenium (Se), and Zinc (Zn)] trace elements, and plasma creatinine for kidney function. We estimated glomerular filtration rate using the Chronic Kidney Disease Epidemiology Collaboration (eGFR
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- 2023
9. Nephrotoxic and Non-Nephrotoxic Metal Mixtures and Kidney Function in Early Pregnancy – a Cross-Sectional Analysis in Project Viva
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Pi-I Debby Lin, Andres Cardenas, Sheryl Rifas-Shiman, Ami Zota, Marie-France Hivert, Izzuddin M. Aris, and Alison Sanders
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
10. Serum dioxin levels and sperm DNA methylation age: Findings in Vietnam war veterans exposed to Agent Orange
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Edward W. Boyer, Andres Cardenas, Elena Colicino, Andrea A. Baccarelli, Jamaji C. Nwanaji-Enwerem, and Timothy G. Jenkins
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Male ,Population ,Gene Expression ,Physiology ,010501 environmental sciences ,Biology ,Dioxins ,Toxicology ,01 natural sciences ,Vietnam Conflict ,03 medical and health sciences ,chemistry.chemical_compound ,Humans ,education ,Aged ,Veterans ,030304 developmental biology ,0105 earth and related environmental sciences ,Aged, 80 and over ,0303 health sciences ,education.field_of_study ,Agent Orange ,Forkhead Transcription Factors ,Environmental Exposure ,Methylation ,DNA Methylation ,Spermatozoa ,Sperm ,CpG site ,chemistry ,Endocrine disruptor ,DNA methylation ,Environmental Pollutants ,Cell Adhesion Molecules ,Body mass index - Abstract
Exposure to dioxin, a known endocrine disruptor and carcinogen, is associated with poor reproductive outcomes. Yet, few studies have explored the role of DNA methylation in these relationships. Utilizing a publicly available dataset from 37 male Air Force Health Study participants exposed to dioxin-contaminated Agent Orange during the Vietnam war, we cross-sectionally examined the relationship of serum dioxin levels with a novel DNA methylation-based measure of sperm age (DNAm-agesperm). DNAm-agesperm was calculated using CpG sites on the Illumina HumanMethylation450 BeadChip. We estimated associations of dioxin levels with DNAm-agesperm using linear regression models adjusted for chronological age, body mass index, and smoking status. Chronological age was highly correlated with DNAmagesperm (r = 0.80). In fully-adjusted linear models, a one percent increase in serum dioxin levels was significantly associated with a 0.0126-year (i.e. 4.6-day) increase in DNAm-agesperm (95%CI: 0.003, 0.022, p = 0.01). Further analyses demonstrated significant negative associations of dioxin levels (β = −0.0005, 95%CI: −0.0010, 0.00004, P = 0.03) and DNAm-agesperm (β = −0.02, 95%CI: −0.04, −0.001, P = 0.03) with methylation levels of FOXK2 – a gene previously reported to be hypomethylated in infertile men. In sum, we demonstrate associations of dioxin with increased methylation aging of sperm. DNAm-agesperm may provide utility for understanding how dioxin levels impact sperm health and potentially male reproductive capacity in human population studies. Moreover, our pilot study contributes further evidence that some environmental toxicants are associated with methylation aging. Additional studies are necessary to confirm these findings, and better characterize dioxin and sperm methylation relationships with male reproductive health.
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- 2020
11. Prenatal lead exposure and childhood executive function and behavioral difficulties in project viva
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Lauren A. Wise, David C. Bellinger, Andres Cardenas, Emily Oken, Chitra Amarasiriwardena, Sheryl L. Rifas-Shiman, Birgit Claus Henn, Roberta F. White, Robert O. Wright, and Victoria Fruh
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Adult ,Male ,Population ,Child Behavior ,Toxicology ,Article ,Executive Function ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Interquartile range ,Humans ,Medicine ,Child ,education ,Association (psychology) ,030304 developmental biology ,0303 health sciences ,education.field_of_study ,business.industry ,General Neuroscience ,Strengths and Difficulties Questionnaire ,Lead Poisoning ,Pregnancy Complications ,Behavior Rating Inventory of Executive Function ,Lead ,Prenatal Exposure Delayed Effects ,Cohort ,Lead exposure ,Female ,business ,030217 neurology & neurosurgery ,Clinical psychology ,Environmental epidemiology - Abstract
Background Lead is an established neurotoxicant and early life exposure to lead is associated with detrimental impacts on IQ and several neurobehavioral domains. Less is known, however, about effects of prenatal lead exposure below 5 μg/dL on executive function and on social, emotional and self-regulatory behaviors in childhood. Objectives To examine the association between prenatal lead exposure and childhood executive function and social, emotional and self-regulatory behaviors. Methods We included 1006 mother-child pairs from the Project Viva prospective pre-birth cohort. We measured prenatal maternal lead in second-trimester erythrocytes. In mid-childhood (median 7.7 years), parents and teachers rated executive function related behaviors using the Behavior Rating Inventory of Executive Function (BRIEF) and behavioral difficulties using the Strengths and Difficulties Questionnaire (SDQ). We used multivariable linear regression models adjusted for maternal, paternal, and child characteristics and metal co-exposures. Results Mean maternal erythrocyte lead concentration was 1.2 μg/dL (interquartile range [IQR] 0.8–1.5 μg /dL), equivalent to approximately 0.4 μg/dL in whole blood. In adjusted models, associations with parent and teacher-rated scales were largely null, although effect estimates were consistently positive, suggesting worse scores with increasing lead levels. For an IQR increase in lead, BRIEF Global Executive Composite (GEC) was 0.73 (95% CI: -0.06, 1.52) points higher for parent-rated scores and 0.42 (95% CI: -0.39, 1.23) points higher for teacher-rated scores. Associations were strongest for parent-rated BRIEF plan/organize (β = 0.85; 95% CI: 0.12, 1.59) and shift (β = 0.88; 95% CI: 0.01, 1.75) subscales, as well as the SDQ emotional problems subscale (β = 0.18; 95% CI: 0.03, 0.33). Discussion In this cohort with lead levels commonly experienced by U.S. women, there were few statistically significant associations with childhood executive function and behavior. However, there was a trend of worse neurobehavioral scores with increasing prenatal lead concentrations, in particular for childhood emotional problems and capacity to plan/organize and shift. Our results highlight the importance of continuing efforts to eliminate lead exposure in the general population.
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- 2019
12. Corrigendum to 'Association of DNA methylation in circulating CD4+ T cells with short-term PM2.5 pollution waves: A quasi-experimental study of healthy young adults' [Ecotoxicol. Environ. Saf. 239 (2022) 1–8/113634]
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Meijie Jiang, Xinmei Wang, Xu Gao, Andres Cardenas, Andrea A. Baccarelli, Xinbiao Guo, Jing Huang, and Shaowei Wu
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Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,General Medicine ,Pollution - Published
- 2022
13. Association of DNA methylation in circulating CD4+T cells with short-term PM2.5 pollution waves: A quasi-experimental study of healthy young adults
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Meijie Jiang, Xinmei Wang, Xu Gao, Andres Cardenas, Andrea A. Baccarelli, Xinbiao Guo, Jing Huang, and Shaowei Wu
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Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,General Medicine ,Pollution - Published
- 2022
14. Corrigendum to ‘Baveno VII – Renewing consensus in portal hypertension’ [J Hepatol (2022) 959-974]
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Roberto de Franchis, Jaime Bosch, Guadalupe Garcia-Tsao, Thomas Reiberger, Cristina Ripoll, Juan G. Abraldes, Agustin Albillos, Anna Baiges, Jasmohan Bajaj, Rafael Bañares, Marta Barrufet, Lina Benajiba, Annalisa Berzigotti, Christophe Bureau, Vincenza Calvaruso, Andres Cardenas, Gennaro D’Amico, Andrea De Gottardi, Alessandra Dell’Era, Angels Escorsell, Jonathan Fallowfield, Hector Ferral, Sven Francque, Ron Gaba, Juan Carlos Garcia-Pagàn, Joan Genescà, Susana Gomes Rodrigues, Jordi Gracia-Sanscho, Guohong Han, Virginia Hernandez-Gea, Jidong Jia, Jean Jacques Kiladjian, Aleksander Krag, Wim Laleman, Vincenzo La Mura, Sabela Lens, Xuefeng Luo, Mattias Mandorfer, Sarwa Darwish Murad, Valerie Paradis, David Patch, Salvatore Piano, Massimo Pinzani, Aurelie Plessier, Massimo Primignani, Bogdan Procopet, Pierre Emmanuel Rautou, Marika Rudler, Shiv K. Sarin, Filippo Schepis, Marco Senzolo, Vijay Shah, Akash Shukla, Puneeta Tandon, Luis Tellez, Dominique Thabut, Maja Thiele, Jonel Trebicka, Dhiraj Tripathi, Emmanouil Tsochatzis, Laura Turco, Fanny Turon, Dominique Valla, Candid Villanueva, Ian Wanless, Hitoshi Yoshiji, de Franchis, Roberto, Bosch, Jaime, Garcia-Tsao, Guadalupe, Reiberger, Thoma, Ripoll, Cristina, and Calvaruso, Vincenza
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Porta hypertension ,Hepatology - Published
- 2022
15. PER ORAL CHOLANGIOSCOPY (POCS) IN LIVER TRANSPLANT PATIENTS: A PROSPECTIVE, INTERNATIONAL SERIES
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Tomazo Franzini, Eduardo G. De Moura, Andres Cardenas, Adam Slivka, Jan Werner-Poley, Georgios Papachristou, Mordechai Rabinovitz, Marco J. Bruno, Joyce A. Peetermans, Matthew Rousseau, Srey Yin, Wellington Andraus, Jean Emond, and Amrita Sethi
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Gastroenterology ,Radiology, Nuclear Medicine and imaging - Published
- 2022
16. Cross sectional association of arsenic and seroprevalence of hepatitis B infection in the United States (NHANES 2003–2014)
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Barrett M. Welch, Molly L. Kile, Andres Cardenas, Ellen Smit, and Jeffrey W. Bethel
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0301 basic medicine ,medicine.medical_specialty ,National Health and Nutrition Examination Survey ,010501 environmental sciences ,medicine.disease_cause ,01 natural sciences ,Biochemistry ,Article ,Arsenic ,03 medical and health sciences ,Seroepidemiologic Studies ,Internal medicine ,medicine ,Humans ,Seroprevalence ,0105 earth and related environmental sciences ,General Environmental Science ,Hepatitis ,Hepatitis B virus ,business.industry ,Odds ratio ,Hepatitis B ,Nutrition Surveys ,medicine.disease ,United States ,Vaccination ,Cross-Sectional Studies ,030104 developmental biology ,business ,Viral hepatitis - Abstract
Background Arsenic alters immunological parameters including antibody formation and antigen-driven T-cell proliferation. Objective We evaluated the cross-sectional relationship between urinary arsenic and the seroprevalence of hepatitis B (HBV) infection in the United States using data from six pooled cycles of the National Health and Nutrition Examination Survey (2003–2014, N = 12,447). Methods Using serological data, participants were classified as susceptible, immune due to vaccination, or immune due to past natural infection. We used multinomial logistic regression to evaluate the association between urinary DMA and HBV classification. A sensitivity analysis using total urinary arsenic (TUA) was also conducted. Both DMA and TUA were adjusted for arsenobetaine using a residual regression method Results A 1-unit increase in the natural logarithm (ln) of DMA was associated with 40% greater adjusted odds of having immunity due to natural infection compared to being susceptible (Odds Ratio [aOR]: 1.40, 95% Confidence Intervals [CI] 1.15, 1.69), 65% greater odds of having immunity due to a natural infection (aOR: 1.65, 95% CI: 1.34, 2.04) and 18% greater odds of being susceptible (aOR: 1.18, 95% CI: 1.05, 1.33) compared to being immune due to vaccination after adjusting for creatinine, age, sex, race, income, country of birth, BMI, survey cycle, serum cotinine, recent seafood intake, and self-reported HBV immunization status. Conclusion In the U.S. general public, higher urinary arsenic levels were associated with a greater odds of having a serological classification consistent with a past natural hepatitis B infection after adjusting for other risk factors. Additionally, higher urinary arsenic levels were linked to a greater odds of not receiving hepatitis B vaccinations. Given the cross-sectional nature of this analysis, more research is needed to test the hypothesis that environmentally relevant exposure to arsenic modulates host susceptibility to hepatitis B virus.
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- 2018
17. Early pregnancy exposure to metal mixture and birth outcomes – A prospective study in Project Viva
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Robert O. Wright, Brent A. Coull, Marie-France Hivert, Elena Colicino, Diane R. Gold, Birgit Claus Henn, Sheryl L. Rifas-Shiman, Andres Cardenas, Emily Oken, Mohammad L. Rahman, Pi-I D. Lin, and Chitra Amarasiriwardena
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Male ,medicine.medical_specialty ,Percentile ,010504 meteorology & atmospheric sciences ,Birth weight ,chemistry.chemical_element ,Gestational Age ,010501 environmental sciences ,01 natural sciences ,Article ,Arsenic ,Pregnancy ,Interquartile range ,Birth Weight ,Humans ,Medicine ,GE1-350 ,Prospective Studies ,Prospective cohort study ,0105 earth and related environmental sciences ,General Environmental Science ,Manganese ,business.industry ,Obstetrics ,Birth outcome ,Infant ,Gestational age ,Bayes Theorem ,Environmental exposure ,medicine.disease ,Environmental sciences ,Lead ,chemistry ,Metals ,Maternal Exposure ,Female ,business - Abstract
Background Prenatal exposure to metals has been individually associated with birth outcomes. However, little is known about the effect of metal mixture, particularly at low exposure levels. Objectives To estimate individual and joint effects of metal mixture components on birth outcomes. Methods We used data from 1,391 mother-infant pairs in Project Viva (1999–2002). We measured 11 metals in maternal 1st trimester erythrocyte; abstracted birth weight from medical records; calculated gestational age from last menstrual period or ultrasound; and obtained birth length (n = 729) and head circumference (n = 791) from research measurements. We estimated individual and joint effects of metals using multivariable linear and Bayesian kernel machine regressions. Results In both single metal and metal mixture analyses, exposure to higher concentrations of arsenic was associated with lower birth weight in males, zinc with higher head circumference in females, and manganese with higher birth length in sex-combined analysis. We also observed sex-specific metal interactions with birth outcomes. Arsenic and manganese showed a synergistic association with birth weight in males, in whom an interquartile range (IQR) increase in arsenic was associated with 25.3 g (95% CI: −79.9, 29.3), 47.9 g (95% CI: −98.0, 2.1), and 72.2 g (95% CI: −129.8, −14.7) lower birth weight when manganese concentrations were at 25th, 50th, and 75th percentiles, respectively. Lead and zinc showed an antagonistic association with head circumference in males, where an IQR increase in lead was associated with 0.18 cm (95% CI: −0.35, −0.02), 0.10 cm (95% CI: −0.25, 0.04), 0.03 cm (95% CI: −0.2, 0.14) smaller head circumference when zinc concentrations were at 25th, 50th, and 75th percentiles, respectively. Exposure to higher concentrations of arsenic was also associated with lower gestational age in males when concentrations of manganese and lead were higher. Discussion Maternal erythrocyte concentrations of arsenic, manganese, lead, and zinc were individually and interactively associated with birth outcomes. The associations varied by infant sex and exposure level of other mixture components.
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- 2021
18. Early pregnancy essential and non-essential metal mixtures and gestational glucose concentrations in the 2nd trimester: Results from project viva
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Chitra Amarasiriwardena, Robert O. Wright, Yinnan Zheng, Birgit Claus Henn, Sheryl L. Rifas-Shiman, Emily Oken, Marie-France Hivert, Marc G. Weisskopf, Tamarra James-Todd, Pi-I D. Lin, Paige L. Williams, and Andres Cardenas
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medicine.medical_specialty ,010504 meteorology & atmospheric sciences ,Bayesian Kernel Machine Regression ,Blood glucose concentrations ,chemistry.chemical_element ,010501 environmental sciences ,Carbohydrate metabolism ,01 natural sciences ,Article ,Metal mixtures ,Pregnancy ,Internal medicine ,medicine ,Humans ,GE1-350 ,Gestational diabetes ,0105 earth and related environmental sciences ,General Environmental Science ,Glycemic ,Cadmium ,Reproducibility of Results ,Bayes Theorem ,Barium ,medicine.disease ,Confidence interval ,Environmental sciences ,Diabetes, Gestational ,Glucose ,Endocrinology ,chemistry ,Pregnancy Trimester, Second ,Gestation ,Female - Abstract
Metals are involved in glucose metabolism, and some may alter glycemic regulation. However, joint effects of essential and non-essential metals on glucose concentrations during pregnancy are unclear. This study explored the joint associations of pregnancy exposures to essential (copper, magnesium, manganese, selenium, zinc) and non-essential (arsenic, barium, cadmium, cesium, lead, mercury) metals with gestational glucose concentrations using 1,311 women enrolled 1999–2002 in Project Viva, a Boston, MA-area pregnancy cohort. The study measured erythrocyte metal concentrations from 1st trimester blood samples and used glucose concentrations measured 1 h after non-fasting 50-gram glucose challenge tests (GCT) from clinical gestational diabetes screening at 26–28 weeks gestation. Bayesian Kernel Machine Regression (BKMR) and quantile-based g-computation were applied to model the associations of metal mixtures—including their interactions—with glucose concentrations post-GCT. We tested for reproducibility of BKMR results using generalized additive models. The BKMR model showed an inverse U-shaped association for barium and a linear inverse association for mercury. Specifically, estimated mean glucose concentrations were highest around 75th percentile of barium concentrations [2.1 (95% confidence interval: −0.2, 4.4) mg/dL higher comparing to the 25th percentile], and each interquartile range increase of erythrocyte mercury was associated with 1.9 mg/dL lower mean glucose concentrations (95% credible interval: −4.2, 0.4). Quantile g-computation showed joint associations of all metals, essential-metals, and non-essential metals on gestational glucose concentrations were all null, however, we observed evidences of interaction for barium and lead. Overall, we found early pregnancy barium and mercury erythrocytic concentrations were associated with altered post-load glucose concentrations in later pregnancy, with potential interactions between barium and lead.
- Published
- 2021
19. Paleoclimatic and paleoecological reconstruction of a middle to late Eocene South American tropical dry forest
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Andrés Pardo-Trujillo, William L. Crepet, Federico Moreno, Jaime Escobar, Carlos Jaramillo, Camila Martínez, Jhonatan Martínez-Murcia, Dayenari Caballero-Rodríguez, and Andres Cardenas
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Palynology ,Tropical and subtropical dry broadleaf forests ,Global and Planetary Change ,biology ,Range (biology) ,Macrofossil ,Climate change ,Oceanography ,biology.organism_classification ,Paleontology ,Paleobotany ,Bombacoideae ,Climate state ,Geology - Abstract
Movement toward our current climate state began in the middle Eocene to early Oligocene interval when the global temperature cooled and the first Antarctic ice sheet appeared. This dramatic climate change caused a significant global turnover in both marine and terrestrial biotas. The biotic response to this event at low latitudes remains mostly unexplored. Here, we studied a recently discovered Eocene fossil macro- and palynoflora from Esmeraldas Formation (Colombia). The Esmeraldas Flora consists of more than seven hundred macrofossil specimens found in two localities, including 45 morphotypes of leaves, seeds, cuticles, fruits, and flowers and > 5000 palynomorphs, that include 210 morphospecies. The Esmeraldas Formation is dominated by meandering river floodplain deposition, and was dated, using palynology and isotopic stratigraphy, as middle to late Eocene (~47.3 to ~33.9 Ma). Quantitative paleoclimatic calculations based on leaf physiognomy and coexistence analyses indicate a warm temperature and a seasonal precipitation within the range of modern tropical dry forests. Furthermore, the floristic composition that includes the presence of macrofossils of the Pterocarpus clade (Fabaceae), and pollen records of the subfamily Bombacoideae (Malvaceae), and Euphorbiaceae, could be indicative of a tropical dry forest. The overall paleobotanical record suggests that the Esmeraldas flora represents one of the earliest records of a tropical dry forest from low latitudes.
- Published
- 2021
20. A Longitudinal Epigenetic Aging and Leukocyte Analysis of Simulated Space Travel: The Mars-500 Mission
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Nancy S. Redeker, Jamaji C. Nwanaji-Enwerem, Uzoji Nwanaji-Enwerem, Andres Cardenas, Jonathan M. Galazka, and Lars van der Laan
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Adult ,Epigenomics ,Male ,0301 basic medicine ,Aging ,Time Factors ,Biology ,Article ,General Biochemistry, Genetics and Molecular Biology ,Epigenesis, Genetic ,Leukocyte Count ,03 medical and health sciences ,0302 clinical medicine ,Biomarkers of aging ,Leukocytes ,Humans ,Longitudinal Studies ,Epigenetics ,health care economics and organizations ,Weightlessness ,Mars Exploration Program ,DNA Methylation ,Space Flight ,030104 developmental biology ,Astronauts ,030217 neurology & neurosurgery ,Demography - Abstract
SUMMARY Astronauts undertaking long-duration space missions may be vulnerable to unique stressors that can impact human aging. Nevertheless, few studies have examined the relationship of mission duration with DNA-methylation-based biomarkers of aging in astronauts. Using data from the six participants of the Mars-500 mission, a high-fidelity 520-day ground simulation experiment, we tested relationships of mission duration with five longitudinally measured blood DNA-methylation-based metrics: DNAmGrimAge, DNAmPhenoAge, DNA-methylation-based estimator of telomere length (DNAmTL), mitotic divisions (epigenetic mitotic clock [epiTOC2]), and pace of aging (PoA). We provide evidence that, relative to baseline, mission duration was associated with significant decreases in epigenetic aging. However, only decreases in DNAmPhenoAge remained significant 7 days post-mission. We also observed significant changes in estimated proportions of plasmablasts, CD4T, CD8 naive, and natural killer (NK) cells. Only decreases in NK cells remained significant post-mission. If confirmed more broadly, these findings contribute insights to improve the understanding of the biological aging implications for individuals experiencing long-duration space travel., Graphical Abstract, In Brief Long-duration space travel is marked by a unique combination of stressors known to impact human aging. Using data from six participants of the Mars-500 mission, a high-fidelity 520-day ground simulation experiment, Nwanaji-Enwerem et al. report significant associations of mission duration with decreased biological aging measured via blood DNA methylation.
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- 2020
21. The presence and outcome of biliary sphincter disorders in liver transplant recipients according to the Rome IV classification
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Alejandro Fernandez Simon, Oriol Sendino, Karina Chavez Rivera, Jordi Colmenero, Gonzalo Crespo, Yilliam Fundora, Pablo Ruiz, Constantino Fondevila, Miguel Navasa, and Andres Cardenas
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Hepatology - Published
- 2020
22. Dietary characteristics associated with plasma concentrations of per- and polyfluoroalkyl substances among adults with pre-diabetes: Cross-sectional results from the Diabetes Prevention Program Trial
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Ken Kleinman, Marco Sanchez-Guerra, Abby F. Fleisch, Edward S. Horton, Citlalli Osorio-Yáñez, Diane R. Gold, Antonia M. Calafat, Emily Oken, Marie-France Hivert, Andres Cardenas, Russ Hauser, Pi-I D. Lin, and Thomas F. Webster
- Subjects
Male ,010504 meteorology & atmospheric sciences ,Cross-sectional study ,Population ,High-protein diet ,010501 environmental sciences ,medicine.disease_cause ,01 natural sciences ,Article ,Prediabetic State ,Food group ,Perfluorononanoic acid ,chemistry.chemical_compound ,Diabetes mellitus ,medicine ,Animals ,Food science ,education ,lcsh:Environmental sciences ,Shellfish ,0105 earth and related environmental sciences ,General Environmental Science ,lcsh:GE1-350 ,Fluorocarbons ,education.field_of_study ,business.industry ,food and beverages ,medicine.disease ,United States ,Diet ,Cross-Sectional Studies ,Alkanesulfonic Acids ,Diabetes Mellitus, Type 2 ,Seafood ,chemistry ,Perfluorooctanoic acid ,Environmental Pollutants ,Female ,business - Abstract
Diet is assumed to be the main source of exposure to per- and polyfluoroalkyl substances (PFAS) in non-occupationally exposed populations, but studies on the diet-PFAS relationship in the United States are scarce. We extracted multiple dietary variables, including daily intakes of food group, diet scores, and dietary patterns, from self-reported dietary data collected at baseline (1996–1999) from adults with pre-diabetes enrolled in the Diabetes Prevention Program, and used linear regression models to evaluate relationships of each dietary variable with plasma concentrations of six PFAS (perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), 2-(N-ethyl-perfluorooctane sulfonamido) acetic acid (EtFOSAA), 2-(N-methyl-perfluorooctane sulfonamido) acetic acid (MeFOSAA), perfluorononanoic acid (PFNA) adjusting for covariates. Participants (N = 941, 65% female, 58% Caucasian, 68% married, 75% with higher education, 95% nonsmoker) had similar PFAS concentrations compared to the general U.S. population during 1999–2000. Using a single food group approach, fried fish, other fish/shellfish, meat and poultry had positive associations with most PFAS plasma concentrations. The strongest effect estimate detected was between fried fish and PFNA [13.6% (95% CI: 7.7, 19.9) increase in median concentration per SD increase]. Low-carbohydrate and high protein diet score had positive association with plasma PFHxS. Some food groups, mostly vegetables and fruits, and the Dietary Approaches to Stop Hypertension diet score had inverse associations with PFOS and MeFOSAA. A vegetable diet pattern was associated with lower plasma concentrations of MeFOSAA, while high-fat meat and low-fiber and high-fat grains diet patterns were associated with higher plasma concentrations of PFOS, PFHxS, MeFOSAA and PFNA. We summarized four major dietary characteristics associated with variations in PFAS plasma concentrations in this population. Specifically, consuming more meat/fish/shellfish (especially fried fish, and excluding Omega3-rich fish), low-fiber and high-fat bread/cereal/rice/pasta, and coffee/tea was associated with higher plasma concentrations while dietary patterns of vegetables, fruits and Omega-3 rich fish were associated with lower plasma concentrations of some PFAS. Keywords: Diet, Food intake, Dietary pattern, Diet score, Per- and polyfluoroalkyl substances, Prediabetic adults
- Published
- 2020
23. Epigenetic age acceleration is associated with allergy and asthma in children in Project Viva
- Author
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Juan C. Celedón, Lydiana Avila, Diane R. Gold, Emily Oken, Xihong Lin, Marie-France Hivert, Dawn L. DeMeo, Thomas A.E. Platts-Mills, Andres Cardenas, Augusto A. Litonjua, Cheng Peng, Andrea A. Baccarelli, Sheryl L. Rifas-Shiman, and Scott T. Weiss
- Subjects
Adult ,Hypersensitivity, Immediate ,Male ,0301 basic medicine ,Allergy ,Immunology ,Mothers ,Logistic regression ,Article ,Epigenesis, Genetic ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Immunology and Allergy ,Medicine ,Epigenetics ,Early childhood ,Child ,Sensitization ,Asthma ,business.industry ,Smoking ,Epigenome ,DNA Methylation ,Immunoglobulin E ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,DNA methylation ,Female ,business - Abstract
Background Epigenetic clocks have been suggested to capture one feature of the complexity between aging and the epigenome. However, little is known about the epigenetic clock in childhood allergy and asthma. Objective We sought to examine associations of DNA methylation age (DNAmAge) and epigenetic age acceleration with childhood allergy and asthma. Methods We calculated DNAmAge and age acceleration at birth, early childhood, and midchildhood based on the IlluminaHumanMethylation450BeadChip in Project Viva. We evaluated epigenetic clock associations with allergy and asthma using covariate-adjusted linear and logistic regressions. We attempted to replicate our findings in the Genetics of Asthma in Costa Rica Study. Results At midchildhood (mean age, 7.8 years) in Project Viva, DNAmAge and age acceleration were cross-sectionally associated with greater total serum IgE levels and greater odds of atopic sensitization. Every 1-year increase in intrinsic epigenetic age acceleration was associated with a 1.22 (95% CI, 1.07-1.39), 1.17 (95% CI, 1.03-1.34), and 1.29 (95% CI, 1.12-1.49) greater odds of atopic sensitization and environmental and food allergen sensitization. DNAmAge and extrinsic epigenetic age acceleration were also cross-sectionally associated with current asthma at midchildhood. DNAmAge and age acceleration at birth and early childhood were not associated with midchildhood allergy or asthma. The midchildhood association between age acceleration and atopic sensitization were replicated in an independent data set. Conclusions Because the epigenetic clock might reflect immune and developmental components of biological aging, our study suggests pathways through which molecular epigenetic mechanisms of immunity, development, and maturation can interact along the age axis and associate with childhood allergy and asthma by midchildhood.
- Published
- 2019
24. Hepatorenal Syndrome
- Author
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Pere Ginès and Andres Cardenas
- Subjects
Hepatorenal Syndrome ,Hepatology ,Renal Dialysis ,Humans ,Portasystemic Shunt, Surgical ,Vasoconstrictor Agents ,Liver Transplantation - Abstract
Among the many causes of renal failure in patients who have advanced liver disease, functional renal failure occurring in the absence of parenchymal kidney disease, better known as hepatorenal syndrome (HRS), is the most frequent cause of renal dysfunction in patients who have cirrhosis. This article focuses on the pathogenesis, clinical features, diagnostic approach, and current treatment of HRS in cirrhosis.
- Published
- 2006
25. Hepatology Highlights
- Author
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Gonzalo Crespo and Andres Cardenas
- Subjects
RC581-951 ,Hepatology ,Specialties of internal medicine ,General Medicine - Published
- 2012
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