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5. Liver disease alters high-density lipoprotein composition, metabolism and function

Author

Walter Spindelboeck, Ulrike Taschler, Ruth Birner-Gruenberger, Markus Trieb, Lisa Pasterk, Vanessa Stadlbauer, Michael Holzer, Rudolf E. Stauber, Sanja Curcic, Gunther Marsche, Angela Horvath, and Akos Heinemann

Subjects
Liver Cirrhosis, Male, 0301 basic medicine, Apolipoprotein E, Cirrhosis, Apolipoprotein B, 030204 cardiovascular system & hematology, Monocytes, chemistry.chemical_compound, Liver disease, 0302 clinical medicine, High-density lipoprotein, biology, Middle Aged, Liver, Creatinine, Cytokines, Female, lipids (amino acids, peptides, and proteins), medicine.medical_specialty, Article, 03 medical and health sciences, Apolipoproteins E, Internal medicine, medicine, Humans, Serum amyloid A, Molecular Biology, Serum Albumin, Triglycerides, Aged, Apolipoproteins B, Apolipoprotein C-III, Serum Amyloid A Protein, Apolipoprotein A-I, Aryldialkylphosphatase, Cholesterol, Cholesterol, HDL, Paraoxonase, nutritional and metabolic diseases, Bilirubin, Cholesterol, LDL, Cell Biology, medicine.disease, Survival Analysis, Cross-Sectional Studies, 030104 developmental biology, Endocrinology, chemistry, biology.protein
Abstract

High-density lipoproteins (HDL) are important endogenous inhibitors of inflammatory responses. Functional impairment of HDL might contribute to the excess mortality experienced by patients with liver disease, but the effect of cirrhosis on HDL metabolism and function remain elusive. To get an integrated measure of HDL quantity and quality, we assessed several metrics of HDL function using apolipoprotein (apo) B-depleted sera from patients with compensated cirrhosis, patients with acutely decompensated cirrhosis and healthy controls. We observed that sera of cirrhotic patients showed reduced levels of HDL-cholesterol and profoundly suppressed activities of several enzymes involved in HDL maturation and metabolism. Native gel electrophoresis analyses revealed that cirrhotic serum HDL shifts towards the larger HDL2 subclass. Proteomic assessment of isolated HDL identified several proteins, including apoA-I, apoC-III, apoE, paraoxonase 1 and acute phase serum amyloid A to be significantly altered in cirrhotic patients. With regard to function, these alterations in levels, composition and structure of HDL were strongly associated with metrics of function of apoB-depleted sera, including cholesterol efflux capability, paraoxonase activity, the ability to inhibit monocyte production of cytokines and endothelial regenerative activities. Of particular interest, cholesterol efflux capacity appeared to be strongly associated with liver disease mortality. Our findings may be clinically relevant and improve our ability to monitor cirrhotic patients at high risk.

Published
2016
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7. Direct acting anti-viral therapy rescues neutrophil dysfunction in hepatitis C infection by reduction of heamolysis

Author

A Streit, Angela Horvath, W Spindelböck, Rudolf E. Stauber, A Posch, Philipp Stiegler, B. Schmerboeck, Bettina Leber, and Vanessa Stadlbauer

Subjects
Hepatology, business.industry, medicine.medical_treatment, Immunology, medicine, Viral therapy, Neutrophil dysfunction, Hepatitis C, medicine.disease, business, Reduction (orthopedic surgery), Direct acting
Published
2018
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8. THU-147-Improvement of neutrophil function in hepatitis C patients under direct acting anti-viral treatment is associated with hemolysis parameters

Author

A Streit, Irina Komarova, Rudolf E. Stauber, Bettina Leber, Walter Spindelböck, Philipp Stiegler, Vanessa Stadlbauer, A Posch, and Angela Horvath

Subjects
Hepatology, business.industry, Immunology, medicine, Hepatitis C, Antiviral treatment, medicine.disease, business, Direct acting, Function (biology), Hemolysis
Published
2019
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9. SAT-048-Changes in the intestinal microbiome during probiotic intervention in cirrhosis

Author

Angela Horvath, Florian Rainer, Philipp Stiegler, F Durchschein, Gernot Zollner, Vanessa Stadlbauer, Peter Fickert, Marija Durdevic, Rudolf E. Stauber, Elisabeth Krones, Katharina di Vora, Bettina Leber, Walter Spindelboeck, and Philipp Douschan

Subjects
medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, medicine.disease, Gastroenterology, law.invention, Probiotic, law, Internal medicine, Intervention (counseling), Intestinal Microbiome, medicine, business
Published
2019
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10. The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol

Author

Steven A. Kliewer, Parkyong Song, Ming Chang Hu, Yang Xie, José Cánovas, Vanessa Stadlbauer, Christoph Peter Gerhard Zechner, Martin Wagner, Bettina Leber, Orson W. Moe, Angela Horvath, David J. Mangelsdorf, Genaro Hernandez, and Varun Sondhi

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, FGF21, Alcohol Drinking, Physiology, medicine.medical_treatment, Adrenergic beta-Antagonists, Drinking, Hypothalamus, Alcohol, Mice, 03 medical and health sciences, chemistry.chemical_compound, Nutrient, Internal medicine, Basic Helix-Loop-Helix Transcription Factors, medicine, Animals, Humans, Receptor, Molecular Biology, Mice, Knockout, Water drinking, business.industry, Cell Biology, Healthy Volunteers, Fibroblast Growth Factors, Mice, Inbred C57BL, Repressor Proteins, 030104 developmental biology, Endocrinology, chemistry, Female, Diet, Ketogenic, business, Signal Transduction, Hormone, Ketogenic diet
Abstract

Summary Alcohol and ketogenic diets increase water consumption. Here, we show that the hormone FGF21 is required for this drinking response in mice. Circulating levels of FGF21 are increased by alcohol consumption in humans and by both alcohol and ketogenic diets in mice. Pharmacologic administration of FGF21 stimulates water drinking behavior in mice within 2 hr. Concordantly, mice lacking FGF21 fail to increase water intake in response to either alcohol or a ketogenic diet. The effect of FGF21 on drinking is mediated in part by SIM1-positive neurons of the hypothalamus and is inhibited by β-adrenergic receptor antagonists. Given that FGF21 also is known to suppress alcohol intake in favor of pure water, this work identifies FGF21 as a fundamental neurotropic hormone that governs water balance in response to specific nutrient stresses that can cause dehydration.

Published
2018
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11. Acellular growth retardation ability (AGRA), a novel biomarker for humoral immune function, predicts the occurrence of severe bacterial infections in cirrhosis

Author

Bettina Leber, Vanessa Stadlbauer, Florian Rainer, Angela Horvath, B. Schmerboeck, and Philipp Stiegler

Subjects
Immune system, Cirrhosis, Hepatology, Growth retardation, biology, business.industry, Immunology, medicine, Biomarker (medicine), Agra, medicine.disease, biology.organism_classification, business
Published
2018
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12. Changes of bile acids profile in different etiologies of liver cirrhosis and its association with neutrophil response

Author

Tatjana Stojakovic, W Spindelböck, Rudolf E. Stauber, Bettina Leber, Elisabeth Krones, Irina Komarova, Günter Fauler, F Durchschein, Angela Horvath, B. Schmerboeck, Philipp Stiegler, Vanessa Stadlbauer, G. Zollner, Daniela Kniepeiss, and Philipp Douschan

Subjects
medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Internal medicine, medicine, Etiology, medicine.disease, business, Gastroenterology
Published
2018
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13. Loss of colonization resistance in cirrhosis facilitates proton pump inhibitor-associated oralization of the colonic microbiome

Author

Rudolf E. Stauber, Bettina Leber, B. Schmerboeck, Andrea Groselj-Strele, J.A. Abrams, Holger Jon Møller, Florian Rainer, Mina Bashir, Marija Durdevic, Vanessa Stadlbauer, D.E. Freedber, Ingeborg Klymiuk, Philipp Stiegler, Henning Grønbæk, Angela Horvath, A Blesl, Tobias Madl, and Peter Fickert

Subjects
Cirrhosis, Hepatology, medicine.drug_class, Chemistry, medicine, Proton-pump inhibitor, Colonisation resistance, Microbiome, medicine.disease, Microbiology
Published
2018
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14. Dysbiosis of the gut microbiota and increased gut permeability characterize secondary sclerosing cholangitis in critically ill patients (SSC-CIP)

Author

Peter Fickert, Frank Lammert, M Tawdrous, Bettina Leber, Angela Horvath, C Jüngst, Philipp Stiegler, Vanessa Stadlbauer, Florian Rainer, B. Schmerboeck, A Blesl, Walter Spindelboeck, and Matthias C. Reichert

Subjects
medicine.medical_specialty, Hepatology, biology, Critically ill, business.industry, Gut flora, medicine.disease, biology.organism_classification, Gastroenterology, Internal medicine, Gut permeability, medicine, Secondary sclerosing cholangitis, business, Dysbiosis
Published
2017
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15. Macrophage activation markers sCD163 and mannose receptor predict survival and correlate with markers of gut permeability in patients with liver cirrhosis

Author

Walter Spindelboeck, B. Schmerboeck, Thomas Damgaard Sandahl, Holger Jon Møller, Elisabeth Krones, A Blesl, Vanessa Stadlbauer, Philipp Stiegler, Bettina Leber, Florian Rainer, Rudolf E. Stauber, Philipp Douschan, Angela Horvath, F Baumann-Durchschein, G. Zollner, Peter Fickert, and Henning Grønbæk

Subjects
Cirrhosis, Hepatology, business.industry, Activation markers, Immunology, Gut permeability, Macrophage, Medicine, In patient, business, medicine.disease, Mannose receptor
Published
2017
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17. Intestinal colonisation by Veillonella spp. is predictive for mortality in stable cirrhosis and could be partially reduced by a multispecies probiotic in a randomized placebo controlled trial

Author

F Baumann-Durchschein, Elisabeth Krones, Walter Spindelboeck, Philipp Stiegler, G. Zollner, Vanessa Stadlbauer, Rudolf E. Stauber, Mina Bashir, Peter Fickert, Philipp Douschan, Bettina Leber, Florian Rainer, B. Schmerboeck, and Angela Horvath

Subjects
0301 basic medicine, medicine.medical_specialty, Cirrhosis, Hepatology, biology, Veillonella, Placebo-controlled study, biology.organism_classification, medicine.disease, Gastroenterology, Microbiology, law.invention, 03 medical and health sciences, Probiotic, 030104 developmental biology, 0302 clinical medicine, law, Internal medicine, medicine, Intestinal colonisation, 030211 gastroenterology & hepatology
Published
2017
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18. Multispecies Probiotic Maintains Health Related Quality of Life in Cirrhosis Better than Placebo

Author

O. Yueksel, M Tawdrous, Bettina Leber, F Durchschein, Angela Horvath, B. Schmerboeck, Dietmar Fuchs, Philipp Stiegler, S Lemesch, Walter Spindelboeck, Gernot Zollner, Peter Fickert, Vanessa Stadlbauer, K. Sherzay, Rudolf E. Stauber, Elisabeth Krones, Philipp Douschan, and A. Hartl

Subjects
Health related quality of life, Probiotic, medicine.medical_specialty, Cirrhosis, Hepatology, law, Internal medicine, Immunology, medicine, Biology, medicine.disease, Placebo, law.invention
Published
2016
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19. P0115 : Serum bile acids in cirrhosis depend on aetiology

Author

Walter Spindelboeck, Günter Fauler, Rudolf E. Stauber, Elisabeth Krones, Philipp Stiegler, Vanessa Stadlbauer, Philipp Douschan, Gernot Zollner, Bettina Leber, Peter Fickert, Angela Horvath, F Durchschein, S Lemesch, and Tatjana Stojakovic

Subjects
medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Internal medicine, Etiology, Medicine, Chemical laboratory, business, medicine.disease, Gastroenterology
Abstract

P0115 SERUM BILE ACIDS IN CIRRHOSIS DEPEND ON AETIOLOGY A. Horvath, B. Leber, E. Krones, G. Zollner, F. Durchschein, W. Spindelboeck, S. Lemesch, P. Douschan, G. Fauler, T. Stojakovic, P. Fickert, R. Stauber, P. Stiegler, V. Stadlbauer. Division for Gastroenterology and Hepatology, Department for Tranplantation Surgery, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria E-mail: angela.horvath@medunigraz.at

Published
2015
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20. 244 INCREASED GUT PERMEABILITY, ELEVATED ENDOTOXIN RELATED PROTEINS AND NEUTROPHIL DYSFUNCTION IN LIVER CIRRHOSIS

Author

Vanessa Stadlbauer, Elisabeth Krones, Rudolf E. Stauber, Philipp Douschan, Walter Spindelboeck, Philipp Stiegler, Bettina Leber, G. Zollner, F Durchschein, Angela Horvath, Peter Fickert, and S Lemesch

Subjects
Cirrhosis, Hepatology, business.industry, Immunology, Gut permeability, Medicine, Neutrophil dysfunction, business, medicine.disease
Published
2013
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21. 1367 INCREASED GUT PERMEABILITY IN METABOLIC SYNDROME IS NOT ASSOCIATED WITH CHANGES IN BILE ACID PROFILE

Author

Tatjana Stojakovic, Rudolf E. Stauber, H. Sourji, Vanessa Stadlbauer, Bettina Leber, S Lemesch, Peter Fickert, Günter Fauler, N. Tripolt, and Angela Horvath

Subjects
medicine.medical_specialty, Endocrinology, Hepatology, Bile acid, Biochemistry, medicine.drug_class, Chemistry, Internal medicine, medicine, Gut permeability, Metabolic syndrome, medicine.disease
Published
2013
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