1. A Controlled Safety Study of Elevated Dosages of Trimethoprim Plus Sulfadiazine in Mature Horses
- Author
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Robbin Koenig, Peggy Anne Hawkins, and Craig Reinemeyer
- Subjects
medicine.medical_specialty ,Dose ,Equine ,business.industry ,Horse ,bacterial infections and mycoses ,Gastroenterology ,Trimethoprim ,Surgery ,Loose feces ,Sulfadiazine ,Internal medicine ,medicine ,Adverse effect ,business ,medicine.drug - Abstract
A novel, proprietary, oral suspension of trimethoprim plus sulfadiazine (TMP/SDZ) had no serious adverse effects on clinical, laboratory, or pathologic parameters of mature horses when administered at up to five times the intended combined dosage of 24 mg/kg twice daily for 30 consecutive days. Loose feces was the most common observation that was likely related to TMP/SDZ treatment, and the incidence of loose feces was greater in groups treated with higher dosages of TMP/SDZ. However, all episodes were self-limiting, and no horses were treated for loose feces.
- Published
- 2014
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