1. pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems
- Author
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Herman J. Woerdenbag, Duong N Nguyen, Annemarie Broesder, Grietje H. Prins, Henderik W. Frijlink, and Wouter L. J. Hinrichs
- Subjects
0301 basic medicine ,RESPONSIVE POLYMERS ,Colon ,Ph dependent ,Pharmacology ,5-AMINOSALICYLIC ACID ,PHARMACEUTICAL DOSAGE FORMS ,03 medical and health sciences ,Drug Delivery Systems ,0302 clinical medicine ,Gamma scintigraphy ,Ileum ,Drug Discovery ,Humans ,Medicine ,business.industry ,Gastrointestinal transit ,Hydrogen-Ion Concentration ,medicine.disease ,Ulcerative colitis ,In vitro ,INTRAGASTRIC ACIDITY ,030104 developmental biology ,GASTROINTESTINAL TRANSIT ,ULCERATIVE-COLITIS ,SULFAPYRIDINE APPEARANCE ,030220 oncology & carcinogenesis ,Drug delivery ,SMALL-INTESTINAL TRANSIT ,Ph dependency ,business ,INTRALUMINAL PH ,Clinical evaluation ,GAMMA-SCINTIGRAPHY - Abstract
After the pH dependency of novel pH-dependent ileocolonic drug delivery systems is confirmed in vitro, their performance should be evaluated in human volunteers.
- Published
- 2020
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