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Start Over Author "Anum, Shahzadi" Publisher elsevier bv
8 results on '"Anum, Shahzadi"'

2. Formation of biocompatible MgO/cellulose grafted hydrogel for efficient bactericidal and controlled release of doxorubicin

Author

Iram Shahzadi, Muhammad Islam, Hamid Saeed, Ali Haider, Anum Shahzadi, Junaid Haider, Nadeem Ahmed, Anwar Ul-Hamid, Walid Nabgan, Muhammad Ikram, and Hassaan Anwer Rathore

Subjects
Nanogels, Antineoplastic Agents, Hydrogels, General Medicine, Biochemistry, Anti-Bacterial Agents, Nanocomposites, Molecular Docking Simulation, Doxorubicin, Structural Biology, Delayed-Action Preparations, Nanoparticles, Prospective Studies, Cellulose, Magnesium Oxide, Reactive Oxygen Species, Molecular Biology
Abstract

In this study, MgO-doped CNC-g-PAA hydrogel was synthesized by grafting poly (acrylic acid) (PAA) onto cellulose nanocrystals (CNC) and then doped Magnesium oxide (MgO) using pH 7.0 and 12.0 to obtain an efficient nanocomposite hydrogel for antibacterial and anti-cancer activities. The synthesized nanocomposite hydrogels were evaluated by detailed characterization and confirmed the formation of a well-interconnected porous structure. MgO/CNC-g-PAA (pH = 12.0) exhibited improved bactericidal tendencies towards gram-negative and gram-positive bacteria, which was further investigated by in-silico molecular docking analyses and also examined the reactive oxygen species production by photocatalysis and free radical-scavenging assay. After this, Doxorubicin (DOX), a model anticancer drug, was successfully loaded into nanocomposites (∼79 %) by electrostatic interaction and confirmed pH-triggered based release, which was over 53.7 % in 24 h. Finally, in vitro cytotoxicity-based analysis confirmed the improved antitumor efficacy of nanocomposite hydrogels. These findings revealed that MgO/CNC-g-PAA hydrogels might be prospective carriers for controlled drug delivery.

Published
2022
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6. Facile synthesis of copolymerized cellulose grafted hydrogel doped calcium oxide nanocomposites with improved antioxidant activity for anti-arthritic and controlled release of doxorubicin for anti-cancer evaluation

Author

Iram Shahzadi, Muhammad Islam, Hamid Saeed, Anum Shahzadi, Junaid Haider, Ali Haider, Muhammad Imran, Hassaan Anwer Rathore, Anwar Ul-Hamid, Walid Nabgan, and Muhammad Ikram

Subjects
Structural Biology, General Medicine, Molecular Biology, Biochemistry
Published
2023
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7. Cellulose grafted poly acrylic acid doped manganese oxide nanorods as novel platform for catalytic, antibacterial activity and molecular docking analysis

Author

Muhammad Ikram, Ali Haider, Muhammad Imran, Junaid Haider, Sadia Naz, Anwar Ul-Hamid, Anum Shahzadi, Sawaira Moeen, Ghazanfar Nazir, Walid Nabgan, Ayesha Bashir, and Salamat Ali

Subjects
General Physics and Astronomy, Surfaces and Interfaces, General Chemistry, Condensed Matter Physics, Surfaces, Coatings and Films
Published
2023
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