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Start Over Author "B. Benatti" Publisher elsevier bv
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10. PLLA Synthesis and Nanofibers Production: Viability by Human Mesenchymal Stem Cell from Adipose Tissue

Author

Carlos Salles Lambert, A. C. B. Benatti, Maria Filomena Macedo, André Luiz Jardini, Ana Amélia Rodrigues, Rubens Maciel Filho, M.S. Lopes, Paulo Kharmandayan, and Mariana Vitelo Xavier

Subjects
cell culture, Materials science, biofabrication, 0206 medical engineering, Mesenchymal stem cell, MTT test, material synthesis, 02 engineering and technology, 021001 nanoscience & nanotechnology, PLLA, 020601 biomedical engineering, tissue-engineering, Electrospinning, Tissue engineering, Cell culture, Nanofiber, General Earth and Planetary Sciences, MTT assay, 0210 nano-technology, Cytotoxicity, biomaterials, General Environmental Science, Biomedical engineering, Biofabrication
Abstract

The absorbable polyacid is one of the most used and studied materials in tissue engineering. This work synthesized a poly (L-lactic acid) (PLLA) through ring-opening polymerization and produced with it nanofibers by the electrospinning process. The PLLA was analyzed by FTIR and its cytotoxicity was evaluated by the MTT assay and Live/Dead® (Molecular Probes). The tests were performed in contact with human mesenchymal cells at varying times. The high rates of viability and proliferation of cells in contact with the PLLA shown by MTT and Live/Dead® tests demonstrate that this PLLA is a biocompatible material. There was also the successful production of electrospinning nanofibers, which can be converted for specific biomedical applications in the future.

Published
2016
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