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Your search keyword '"Bencivelli W"' showing total 10 results
Start Over Author "Bencivelli W" Publisher elsevier bv
10 results on '"Bencivelli W"'

1. The role of compact PSPMTs for image quality enhancement in nuclear medicine

Author

Cinti, M.N., primary, Pani, R., additional, Pellegrini, R., additional, Garibaldi, F., additional, Cusanno, F., additional, Campanini, R., additional, Lanconelli, N., additional, Riccardi, A., additional, Zavattini, G., additional, Di Domenico, G., additional, Belcari, N., additional, Bencivelli, W., additional, Motta, Alfonso, additional, Vaiano, Angela, additional, and Del Guerra, A., additional

Published
2003
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10. Preparation and evaluation of [99mTc]DEPE as a cardiac perfusion agent

Author

Alberto Margonato, R. Colombo, Paolo Gerundini, F. Fregoso, G. Taddei, Mathew L. Thakur, F. Fazio, R. Bencivelli, M. C. Gilardi, Fabio Colombo, Gabriele Vicedomini, C.H. Park, Thakur, M, Park, C, Fazio, F, Gerundini, P, Margonato, A, Vicedomini, G, Colombo, R, Colombo, F, Gilardi, M, Fregoso, F, Bencivelli, W, and Taddei, G

Subjects
cardiac perfusion agent, [99mTc]DEPE, medicine.medical_specialty, Phosphines, Myocardial Infarction, Perfusion scanning, Scintigraphy, Mice, Dogs, Organophosphorus Compounds, In vivo, Internal medicine, medicine, Animals, Humans, Distribution (pharmacology), Tissue Distribution, Radiology, Nuclear Medicine and imaging, Myocardial infarction, Radionuclide Imaging, Radiation, medicine.diagnostic_test, business.industry, Technetium, Heart, Organotechnetium Compounds, Blood flow, medicine.disease, Nuclear Energy and Engineering, Cardiology, business, Perfusion, Preclinical imaging
Abstract

Technetium-99m labeled bis(1,2-diethylphosphino)ethane was evaluated as a cardiac perfusion agent in mice, dogs and normal human volunteers. The agent produced as a single cationic compound was prepared by a simple kit type method and had a rapid myocardial uptake in animals. The cardiac uptake of the agent in dogs averaged 4.6% of administered dose and delineated left and right ventricles by in vivo imaging. In dogs with experimental myocardial infarction, the agent was distributed according to the regional myocardial blood flow, had excellent correlation with myocardial distribution of 85Sr microspheres (r = 0.96, 0.93)] and 201 Tl (r = 0.91 and 0.83) , and enabled us to detect perfusion defects by in vivo scintigraphy. The agent, however, failed to have a useful degree of cardiac uptake in humans.

Published
1984
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