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Your search keyword '"Bijl, M."' showing total 18 results
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18 results on '"Bijl, M."'

2. Azathioprine/methylprednisolone versus cyclophosphamide in proliferative lupus nephritis. A randomized controlled trial

Author

Grootscholten, C., Ligtenberg, G., Hagen, E.C., van den Wall Bake, A.W.L., de Glas-Vos, J.W., Bijl, M., Assmann, K.J., Bruijn, J.A., Weening, J.J., van Houwelingen, H.C., Derksen, R.H.W.M., Berden, J.H.M., for the Dutch Working Party on Systemic Lupus Erythematosus, and Pathology

Subjects
Male, Lupus nephritis, Anti-Inflammatory Agents, Administration, Oral, OVARIAN FAILURE, Azathioprine, PULSE CYCLOPHOSPHAMIDE, Gastroenterology, chemistry.chemical_compound, Prednisone, MYCOPHENOLATE-MOFETIL, Renal disorder [IGMD 9], Proteinuria, immunosuppression, Remission Induction, clinical trial, Middle Aged, Treatment Outcome, Methylprednisolone, Nephrology, Creatinine, Injections, Intravenous, Corticosteroid, Drug Therapy, Combination, Female, medicine.symptom, Infection and autoimmunity [NCMLS 1], Immunosuppressive Agents, medicine.drug, Adult, medicine.medical_specialty, Cyclophosphamide, Adolescent, medicine.drug_class, LONG-TERM, Prednisolone, Auto-immunity, transplantation and immunotherapy [N4i 4], HERPES-ZOSTER, SUSTAINED AMENORRHEA, INTRAVENOUS CYCLOPHOSPHAMIDE, Internal medicine, medicine, Humans, IMMUNOSUPPRESSIVE THERAPY, TERM-FOLLOW-UP, lupus nephritis, business.industry, RENAL FLARES, Mycophenolic Acid, medicine.disease, clinical nephrology, Surgery, Renal disorders [UMCN 5.4], chemistry, randomized controlled trial, business
Abstract

Contains fulltext : 50854.pdf (Publisher’s version ) (Closed access) Until recently, intravenous cyclophosphamide pulses with oral corticosteroids were regarded standard therapy for proliferative lupus nephritis (LN). Azathioprine, a less toxic alternative, was never proven to be inferior. In the first Dutch lupus nephritis study (enrollment between 1995 and 2001), we randomized 87 proliferative LN patients to either cyclophosphamide pulses (750 mg/m(2), 13 pulses in 2 years) combined with oral prednisone (CY) or to azathioprine (2 mg/kg/day in 2 years) combined with intravenous pulses of methylprednisolone (3 x 3 pulses of 1000 mg) and oral prednisone (AZA). After a median follow-up of 5.7 years (interquartile range 4.1-7.2 years), doubling of serum creatinine was more frequent in the AZA group, although not statistically significant (relative risk (RR): 4.1, with 95% confidence interval (95% CI): 0.8-20.4). Relapses occurred more often in the AZA group (RR: 8.8, 95% CI: 1.5-31.8). Creatinine and proteinuria at last visit did not differ between the two treatment arms. Moreover, 88.4% of the patients in the AZA arm were still free of cyclophosphamide treatment. During the first 2 years, the frequency of remission was not different, but infections, especially herpes zoster virus infections (HZV) were more frequent in the AZA group. Parameters for ovarian function did not differ between the two groups. In conclusion, in this open-label randomized controlled trial, cyclophosphamide was superior to azathioprine with regard to renal relapses and HZV. At last follow-up, there were no differences in serum creatinine or proteinuria between the two groups. However, since our study lacked sufficient power, longer follow-up is needed to reveal putative differences.

Published
2006
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8. Vaccination in paediatric patients with auto-immune rheumatic diseases: A systemic literature review for the European League against Rheumatism evidence-based recommendations

Author

Heijstek, M.W., primary, Ott de Bruin, L.M., additional, Borrow, R., additional, van der Klis, F., additional, Koné-Paut, I., additional, Fasth, A., additional, Minden, K., additional, Ravelli, A., additional, Abinun, M., additional, Pileggi, G., additional, Borte, M., additional, Bijl, M., additional, and Wulffraat, N.M., additional

Published
2011
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9. Vaccination in adult patients with auto-immune inflammatory rheumatic diseases: A systematic literature review for the European League Against Rheumatism evidence-based recommendations for vaccination in adult patients with auto-immune inflammatory rheumatic diseases

Author

van Assen, S., primary, Elkayam, O., additional, Agmon-Levin, N., additional, Cervera, R., additional, Doran, M.F., additional, Dougados, M., additional, Emery, P., additional, Geborek, P., additional, Ioannidis, J.P.A., additional, Jayne, D.R.W., additional, Kallenberg, C.G.M., additional, Müller-Ladner, U., additional, Shoenfeld, Y., additional, Stojanovich, L., additional, Valesini, G., additional, Wulffraat, N.M., additional, and Bijl, M., additional

Published
2011
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