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Your search keyword '"Boopathi, Seenivasan"' showing total 16 results
Start Over Author "Boopathi, Seenivasan" Publisher elsevier bv
16 results on '"Boopathi, Seenivasan"'

7. Combined effects of a high-fat diet and polyethylene microplastic exposure induce impaired lipid metabolism and locomotor behavior in larvae and adult zebrafish

Author

Boopathi, Seenivasan, primary, Haridevamuthu, B., additional, Mendonca, Edrea, additional, Gandhi, Akash, additional, Priya, P. Snega, additional, Alkahtani, Saad, additional, AL-Johani, Norah S., additional, Arokiyaraj, Selvaraj, additional, Guru, Ajay, additional, Arockiaraj, Jesu, additional, and Malafaia, Guilherme, additional

Published
2023
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11. Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae

Author

Haridevamuthu, B., primary, Manjunathan, Tamilvelan, additional, Guru, Ajay, additional, Ranjith Wilson Alphonse, Carlton, additional, Boopathi, Seenivasan, additional, Murugan, Raghul, additional, Gatasheh, Mansour K., additional, Atef Hatamleh, Ashraf, additional, Juliet, Annie, additional, Gopinath, Pushparathinam, additional, and Arockiaraj, Jesu, additional

Published
2022
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15. Withaferin A targets the membrane of Pseudomonas aeruginosa and mitigates the inflammation in zebrafish larvae; an in vitro and in vivo approach

Author

Raghul Murugan, Ravi Rajesh, Boopathi Seenivasan, B. Haridevamuthu, Gokul Sudhakaran, Ajay Guru, Rajakrishnan Rajagopal, Palaniselvam Kuppusamy, Annie Juliet, Pushparathinam Gopinath, and Jesu Arockiaraj

Subjects
Inflammation, Biological Products, Superoxide Dismutase, Withania, Catalase, Microbiology, Antioxidants, Anti-Bacterial Agents, Infectious Diseases, Larva, Pseudomonas aeruginosa, Animals, Reactive Oxygen Species, Zebrafish
Abstract

Infections due to multidrug-resistant Pseudomonas aeruginosa are prevalent among patients with cystic fibrosis. The emergence of antibiotic-resistant pathogens necessitated the development of novel low-risk natural antibacterial compounds. Herbal medicines are used from dates of the origin of mankind and still serve their purpose as therapeutic agents. We demonstrated the antibacterial activity of Withaferin A extracted from the traditional herb, ashwagandha or winter cherry (Withania somnifera). Withaferin A exhibits strong antibacterial activity against P. aeruginosa with a minimum inhibitory concentration of 60 μM and minimum bactericidal concentration of 80 μM. Results obtained from membrane stabilization assay and electron microscopic analysis showed that Withaferin A acts by damaging the cell membrane of P. aeruginosa. Additionally, we investigated oxidative stress and inflammatory response after Withaferin A treatment in P. aeruginosa infected zebrafish larvae model. The results indicate that the level of ROS, and its related lipid peroxidation and apoptosis were significantly reduced after treated with Withaferin A. Consequently, an increment in antioxidant enzymes level such as superoxide dismutase (SOD) and catalase (CAT) was observed. Macrophage localization experiment showed a smaller number of localized macrophages in zebrafish, which indicates the reduction in inflammatory response. In conclusion, Withaferin A could serve as an alternative natural product in the treatment of infections caused by P. aeruginosa.

Published
2022

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