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Scholars have identified many determinants of regulatory outcomes in unconventional oil and gas development, but few have focused on industry structure. We examine the effects of company size and ownership on revenue sharing outcomes in North Dakota (ND), drawing on political economy bargaining models. We examine firm-level characteristics of ND’s oil producers from 2005 to 2015, matching these data against revenue sharing outcomes and estimating effects using graphical and statistical methods. Along with this core analysis, we conduct key informant interviews with four elite actors in the unconventional oil and gas sector in ND, to provide supplementary details on industry structure and voluntary contributions to local communities. Our findings suggest that when industry is dominated by larger, publicly-traded firms, there is more revenue sharing between firms and the state government. However, we find anecdotal evidence that smaller, local firms may better target resources towards local needs. Our work contributes to a better understanding of the varied outcomes at the sub-national and sub-state level and expands the “resource curse” literature that suggests that industry characteristics shape local outcomes. more...

Objective: We report a new, life-threatening adverse effect of zoledronic acid. One of the adverse effects of zoledronic acid is acute phase reaction (APR). Mild APR is characterized by arthralgia, myalgia, headache, and fever, which are usually self-limiting. Here, we present a case of severe systemic inflammatory response syndrome (SIRS) following zoledronic acid infusion, leading to multi-organ failure.Methods: A 63-year-old female presented to the emergency department with fever, headache, and myalgia within hours after zoledronic acid infusion. Approximately 24 hours later, she developed progressive weakness and confusion. She was febrile, tachycardic, and tachypneic on presentation. Subsequently, she developed acute respiratory distress syndrome, stress or Takotsubo cardiomyopathy, shock with hypotension, and acute tubular necrosis with acute kidney failure.Results: All infectious work-up was unrevealing. She was diagnosed with severe SIRS leading to multi-organ failure. She needed aggressive supportive therapies, including mechanical ventilation, multiple vasopressors, and renal replacement therapy. She was treated with systemic steroids. She gradually improved over the next 4 weeks.Conclusion: Mild APRs are common with administration of nitrogen-based bisphosphonates. However, to date, severe life-threatening APR as seen in the above-mentioned case has not been reported. It is important for clinicians to be aware of the possibility of such adverse effects. This case highlights the need for further investigation related to underlying mechanisms of APR by bisphosphonates and identification of patients at risk so that alternative treatments may be considered.Abbreviations: APR acute phase reaction; FPPS farnesyl pyrophosphate synthase; IPP isopentenyl pyrophosphate; IV intravenous; UTI urinary tract infection more...

Two theories exist on the relationship between bicuspid aortic valve (BAV) and aortapathy: Hemodynamic - aortic dilation results from shear stress of diseased BAV; Genetic - aorta is genetically abnormal and dilates independently of BAV disease progression. We explored these theories in patients more...