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Your search keyword '"C. De Filippo"' showing total 6 results
Start Over Author "C. De Filippo" Publisher elsevier bv
6 results on '"C. De Filippo"'

1. Comparison of meat-based versus pesco-vegetarian diets harmful metabolite content in faeces: preliminary results from the MeaTIc Study

Author

Francesco Sofi, Monica Dinu, Giuditta Pagliai, Giovanna Caderni, S. Ristori, Vincenzo Longo, C. De Filippo, C.M. Della Croce, Lisa Giovannelli, and Francesco Vitali

Subjects
chemistry.chemical_compound, Nutrition and Dietetics, chemistry, Endocrinology, Diabetes and Metabolism, Metabolite, Medicine (miscellaneous), Food science, Biology, Cardiology and Cardiovascular Medicine, Feces, Vegetarian diets
Published
2021

3. Inhibition of 1,2-dimethylhydrazine-induced oxidative DNA damage in rat colon mucosa by black tea complex polyphenols

Author

Michael N. Clifford, Maura Lodovici, X Xu, Piero Dolara, C. Casalini, C. De Filippo, and Edward M. Copeland

Subjects
Male, Alkylating Agents, endocrine system, medicine.medical_specialty, Antioxidant, Polymers, medicine.medical_treatment, Thearubigin, Toxicology, Antioxidants, Catechin, chemistry.chemical_compound, Phenols, Internal medicine, medicine, Animals, Intestinal Mucosa, Saline, Anticarcinogen, Chromatography, High Pressure Liquid, Flavonoids, Tea, Deoxyguanosine, Polyphenols, 8-Hydroxy-2'-deoxyguanosine, Biological activity, General Medicine, Rats, Inbred F344, 1,2-Dimethylhydrazine, Rats, Endocrinology, Biochemistry, chemistry, Mechanism of action, 8-Hydroxy-2'-Deoxyguanosine, Colonic Neoplasms, Carcinogens, medicine.symptom, DNA Damage, Phytotherapy, Food Science
Abstract

The effect of black tea polyphenols on 1,2-dimethylhydrazine (DMH)-induced oxidative DNA damage in rat colon mucosa has been investigated. Fischer 344 rats were treated orally with thearubigin (TR) or theafulvin (TFu) for 10 days (40 mg/kg), injected ip with DMH (20 mg/kg) or saline and sacrificed 24 hr after DMH administration. The levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured in colonic mucosa DNA and expressed as a ratio relative to 2'-deoxyguanosine (2dG). Control rat mucosa had 8-OHdG values of 1.12 +/- 0.14/10(5) dG (mean +/- SEM, n=11), whereas DMH-treated rats significantly higher values (1.52 +/- 0.14/10(5) dG, n=26, P0.05). Pretreatment of rats with TR had significantly inhibited DMH-induced oxidative DNA damage 0.99 +/- 0.09/10(5) dG, n=10, P0.05) and a similar, although less marked, effect was observed with TFu (1.15 +/- 0.19/10(5), n=9, P=0.06). These findings confirm that DMH causes oxidative DNA damage in the colon mucosa of rats and demonstrate that this effect is prevented by the consumption of complex polyphenols from black tea.

Published
2000

5. Further observations on cell adhesion molecules in circulating and CSF lymphocytes in MS

Author

C. De Filippo, M. Zaffaroni, G. Crovetti, S. Baldini, A. Zibetti, and Angelo Ghezzi

Subjects
Neurology, Cell adhesion molecule, Chemistry, Immunology, Soluble cell adhesion molecules, Immunology and Allergy, Neurology (clinical), Intercellular adhesion molecule, Cell adhesion, Lymphocyte homing receptor, Csf lymphocytes, Cell biology
Published
1995

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