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Your search keyword '"Carisey, A. F."' showing total 8 results
Start Over Author "Carisey, A. F." Publisher elsevier bv
8 results on '"Carisey, A. F."'

1. Cytoneme signaling provides essential contributions to mammalian tissue patterning

Author

Hall, Eric T., primary, Dillard, Miriam E., additional, Cleverdon, Elizabeth R., additional, Zhang, Yan, additional, Daly, Christina A., additional, Ansari, Shariq S., additional, Wakefield, Randall, additional, Stewart, Daniel P., additional, Pruett-Miller, Shondra M., additional, Lavado, Alfonso, additional, Carisey, Alex F., additional, Johnson, Amanda, additional, Wang, Yong-Dong, additional, Selner, Emma, additional, Tanes, Michael, additional, Ryu, Young Sang, additional, Robinson, Camenzind G., additional, Steinberg, Jeffrey, additional, and Ogden, Stacey K., additional

Published
2024
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2. Human signal transducer and activator of transcription 5b (STAT5b) mutation causes dysregulated human natural killer cell maturation and impaired lytic function

Author

Vargas-Hernández, Alexander, primary, Witalisz-Siepracka, Agnieszka, additional, Prchal-Murphy, Michaela, additional, Klein, Klara, additional, Mahapatra, Sanjana, additional, Al-Herz, Waleed, additional, Mace, Emily M., additional, Carisey, Alexandre F., additional, Orange, Jordan S., additional, Sexl, Veronika, additional, and Forbes, Lisa R., additional

Published
2020
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3. Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells

Author

Carisey, Alexandre F, Mace, Emily M, Saeed, Mezida, Davis, Daniel M, Orange, Jordan S, Carisey, Alexandre F, Mace, Emily M, Saeed, Mezida, Davis, Daniel M, and Orange, Jordan S

Abstract

Natural killer (NK) cells are innate immune effectors that lyse virally infected and tumorigenic cells through the formation of an immunological synapse. Actin remodeling at the lytic immunological synapse is a critical requirement for multiple facets of cytotoxic function. Activating receptor and integrin signaling leads to the regulated turnover and remodeling of actin, which is required for adhesion, sustained receptor signaling, and ultimately exocytosis. NK cells undergo lytic granule exocytosis in hypodense regions of a pervasive actin network. Although these requirements have been well demonstrated, neither the dynamic regulation of synaptic actin nor its specific function, however, has been determined at a nanoscale level. Here, live-cell super-resolution microscopy demonstrates nanoscale filamentous actin dynamism in NK cell lytic granule secretion. Following cell spreading, the overall content of the branched actin network at an immune synapse is stable over time and contains branched actin fibers and discrete actin foci. Similar actin architecture is generated in cytolytic T cells, although the timescale differs from that of NK cells. Individual filament displacement leads to stochastic clearance formation and disappearance, which are independent of lytic granule positioning. Actin dynamism is dependent upon branched network formation mediated by Arp2/3 and contractility generated by myosin IIA. Importantly, the use of small-molecule inhibitors demonstrates that actin dynamism is ultimately needed for granule secretion. Thus, we describe a requirement for nanoscale actin fiber rearrangement in generating the complex actin architecture that enables lytic granule secretion., QC 20240906

Published
2018
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4. Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations

Author

Vargas-Hernández, Alexander, primary, Mace, Emily M., additional, Zimmerman, Ofer, additional, Zerbe, Christa S., additional, Freeman, Alexandra F., additional, Rosenzweig, Sergio, additional, Leiding, Jennifer W., additional, Torgerson, Troy, additional, Altman, Matthew C., additional, Schussler, Edith, additional, Cunningham-Rundles, Charlotte, additional, Chinn, Ivan K., additional, Carisey, Alexandre F., additional, Hanson, Imelda C., additional, Rider, Nicholas L., additional, Holland, Steven M., additional, Orange, Jordan S., additional, and Forbes, Lisa R., additional

Published
2018
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5. Heterozygous Truncating Variants in POMP Escape Nonsense-Mediated Decay and Cause a Unique Immune Dysregulatory Syndrome

Author

Poli, M. Cecilia, primary, Ebstein, Frédéric, additional, Nicholas, Sarah K., additional, de Guzman, Marietta M., additional, Forbes, Lisa R., additional, Chinn, Ivan K., additional, Mace, Emily M., additional, Vogel, Tiphanie P., additional, Carisey, Alexandre F., additional, Benavides, Felipe, additional, Coban-Akdemir, Zeynep H., additional, Gibbs, Richard A., additional, Jhangiani, Shalini N., additional, Muzny, Donna M., additional, Carvalho, Claudia M.B., additional, Schady, Deborah A., additional, Jain, Mahim, additional, Rosenfeld, Jill A., additional, Emrick, Lisa, additional, Lewis, Richard A., additional, Lee, Brendan, additional, Zieba, Barbara A., additional, Küry, Sébastien, additional, Krüger, Elke, additional, Lupski, James R., additional, Bostwick, Bret L., additional, and Orange, Jordan S., additional

Published
2018
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