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Your search keyword '"Chen, Danqing"' showing total 21 results
Start Over Author "Chen, Danqing" Publisher elsevier bv
21 results on '"Chen, Danqing"'

6. P07-035-23 AWeight-Gain-for-Gestational-Age Z-Score Chart for the Assessment of Gestational Weight Gain in Twin Pregnancies in China and Its Association With Preterm Birth

Author

Liang, Zhaoxia, primary, Hu, Ying, additional, Zhu, Shuqi, additional, Liu, Jia, additional, Hong, Die, additional, Wen, Hong, additional, Chen, Lu, additional, Chen, Xixi, additional, Zou, Yuqing, additional, Liu, Jingjing, additional, Chen, Danqing, additional, and Ma, Hao, additional

Published
2023
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11. The FG Loop of PD-1 Serves as a 'Hotspot' for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy

Author

Shuguang Tan, Jianhua Zhu, Yan Chai, Rui Shi, Zhou Tong, He Weiwu, George F. Gao, Jianxun Qi, Shan Gao, Chen Danqing, Jinghua Yan, Minghui Xiao, Hao Zhang, Hao Cheng, and Haiyuan Wang

Subjects
0301 basic medicine, Glycosylation, medicine.drug_class, 02 engineering and technology, Monoclonal antibody, Article, 03 medical and health sciences, chemistry.chemical_compound, Immune system, Structural Biology, Programmed cell death 1, medicine, lcsh:Science, Biological sciences, Multidisciplinary, biology, Immunobiological Therapy Center, Biological Sciences, 021001 nanoscience & nanotechnology, Immune checkpoint, 030104 developmental biology, chemistry, Structural biology, Cancer research, biology.protein, lcsh:Q, 0210 nano-technology
Abstract

Summary Programmed cell death 1 (PD-1)/PD-1 ligand-1 (PD-L1)-blocking monoclonal antibodies (mAbs) have taken center stage for tumor immune checkpoint therapy. Identification of the “hotspots” on PD-1 for mAbs will help to develop next-generation oral deliverable agents with long-lasting efficacy. Here, we identified two PD-1-targeting mAbs, GY-5 and GY-14, with PD-1/PD-L1-blocking efficacy. Complex structural information revealed that both mAbs mainly bind to the FG loop of PD-1, which also contributes multiple interactions with PD-L1. The FG loop adopts substantially varied conformations upon binding to different mAbs, providing a novel targetable region for the development of PD-1-specific biologics and small chemical molecules. Glycosylation modifications of PD-1 could be observed in three of the four potential N-linked glycosylation sites. However, the binding of GY-5 and GY-14 to PD-1 was not affected by glycosylation. These findings broaden our understanding of the mechanism of anti-PD-1 mAbs and provide insight into the development of agents targeting PD-1., Graphical Abstract, Highlights • GY-5 and GY-14 show efficient anti-tumor efficacy in NCG mouse model • Both GY-5 and GY-14 bind to the FG loop of PD-1 • Glycosylation is observed in PD-1, but not involved in binding to GY-5 and GY-14 • The loops of PD-1 may serve as “hotspot” for development of PD-1-targeting biologics, Biological Sciences; Immunobiological Therapy Center; Structural Biology

Published
2019

15. The FG Loop of PD-1 Serves as a “Hotspot” for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy

Author

Chen, Danqing, primary, Tan, Shuguang, additional, Zhang, Hao, additional, Wang, Haiyuan, additional, He, Weiwu, additional, Shi, Rui, additional, Tong, Zhou, additional, Zhu, Jianhua, additional, Cheng, Hao, additional, Gao, Shan, additional, Chai, Yan, additional, Qi, Jianxun, additional, Xiao, Minghui, additional, Yan, Jinghua, additional, and Gao, George F., additional

Published
2019
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16. Changes in visfatin levels after oral glucose tolerance test in women with gestational diabetes mellitus

Author

Wu Ying, Chen Danqing, and Liang Zhaoxia

Subjects
Adult, Blood Glucose, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Blood lipids, Body Mass Index, Endocrinology, Insulin resistance, Pregnancy, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Insulin, Nicotinamide Phosphoribosyltransferase, Glucose tolerance test, medicine.diagnostic_test, business.industry, nutritional and metabolic diseases, General Medicine, Glucose Tolerance Test, medicine.disease, Gestational diabetes, Diabetes, Gestational, Female, Insulin Resistance, business, Body mass index
Abstract

Visfatin levels increased following an oral glucose tolerance test (OGTT) in normal pregnancy, and this increase correlated with metabolic indexes such as blood glucose, blood fat, and insulin resistance. Conversely, visfatin levels in women with gestational diabetes mellitus (GDM) increased to lesser extent than in normal pregnancy, which suggests a disorder in the relationship between visfatin, blood glucose and insulin.

Published
2012

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