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ObjectiveTo explore the effect of traditional Chinese comprehensive therapy (TCCT) on promoting gestation in patients with previously failed in vitro fertilization and embryo transfer (IVF-ET) because of kidney deficiency, liver stagnation, and blood stasis (KLB).MethodsSixty-seven patients were enrolled in this study and divided into two groups: a trial group with 35 patients and a control group with 32 patients. The trial group was given TCCT for 3 months, then administered IVF-ET or awaited natural pregnancy. The control group was administered IVF-ET without TCCT 3 months after the previous IVF-ET or natural pregnancy attempt. The patterns of KLB were observed both before and after treatment. The natural pregnancy rate of the two groups was calculated after treatment. Differences between the two groups were compared after using IVF-ET treatment again in fertilized egg number and fertilization rate were evaluated.ResultsAfter treatment with TCM comprehensive therapy, seven patients in the treatment group became pregnant, while there were no successful conceptions in the control group. The difference in clinical pregnancy rate in the initial cycle and transfer cycle of IVF were significantly different (P < 0.05). The trial group had a significantly higher conception rate than that of the control group (P < 0.05).ConclusionTCCT can promote the natural pregnancy rate in patients with previously failed IVF-ET. TCCT could increase patients' fertilized egg number, fertilization rate, pregnancy rate, and clinical pregnancy rate after another IVF-ET treatment. TCCT can also relieve the symptoms of KLB.