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Chondroid syringoma - also known as mixed tumor of the skin - is a benign skin tumor often occurring in the head and neck region, that usually presents as a slow growing well-defined swelling in adults, with occasional commitment of the lips. The aim of this study was to report an illustrative case of chondroid syringoma in the lower lip of a 43-year-old male patient from Brazil. Physical examination revealed an asymptomatic hardened swelling of normal coloration, measuring 3.0 cm, located at the transition between the skin and semi-mucosa of the lower lip. Under the clinical hypothesis of a salivary gland tumor, an excisional biopsy was performed under local anesthesia. After histopathologic examination the final diagnosis was of chondroid syringoma of the lower lip. There is no evidence of recurrence one year after surgical procedure. Clinicians should consider chondroid syringoma when evaluating well-defined swellings of the lower lip.

Chondroid syringoma (CS) is an uncommon, benign mixed tumor of the skin, composed of mesenchymal and sweat gland elements. In this report, we present a rare case of CS in the middle finger of a 53-year-old male patient. Excisional biopsy and skin grafting were performed. At 2 years of follow-up, the patient had no recurrence. Timely diagnosis and wide excision with a broad margin should be the preferred treatment. Pathologists and clinicians should be aware of the malignant component of CS.

Background and Objective Chondroid syringoma is a rare skin adnexal tumor, mostly involving the head and neck region. It is usually present as a skin painless nodule. We present a rare case of chondroid syringoma with extensive mature bone and cartilage formation. Methods Chondroid syringoma usually presents as a skin painless nodule. The histopathology is usually composed of a variable mixture of epithelial and myoepithelial structures on a background of chondromyxoid and fibrous stroma. It rarely shows mature bone or cartilage formation. Results To the best of our knowledge, only several cases of chondroid syringoma with bone formation and few cases of chondroid syringoma with cartilage formation have been reported in published studies to date. We report a case of chondroid syringoma with extensive mature bone and cartilage formation that is probably the first reported case showing this mixture of appearances. Conclusions Histopathologically, the presence of tumor with extensive mature bone and cartilage formation may cause diagnostic difficulties and wide differential diagnosis. Therefore, awareness of this rare entity can be helpful to avoid future diagnostic pitfalls, particularly when the appearances are unusual.

Resume Introduction Le syringome chondroide est une tumeur cutanee rare caracterisee par une double composante epitheliale et mesenchymateuse. Le diagnostic histologique morphologique peut etre oriente par l’immuno-histochimie. Nous presentons 10 cas et leurs caracteristiques clinico-pathologiques. Materiel et methode Dix cas de syringomes chondroides ont ete inclus, entre janvier 2000 et aout 2013, sur les CHU Louis-Mourier et de Fort-de-France. Ils ont tous ete relus par un expert en pathologie cutanee et des complements d’immuno-histochimie ont ete realises. Les donnees cliniques et histologiques ont ete colligees. Resultats Les lesions etaient surtout localisees au visage (3/10) et aux extremites (3/10). La taille variait de 1,2 a 5,2 cm. Tous les cas ont ete traites chirurgicalement, aucun cas de malignite n’a ete diagnostique. L’histologie montrait un aspect de tumeur dermique limitee, avec une double differenciation syringo-chondroide, et des cavites revetues d’une a deux assises cellulaires evoquant une tumeur annexielle de type apocrine (5/10) ou eccrine (4/10). L’etude immuno-histochimique montrait une positivite de l’EMA, l’ACE et de la CK7 sur les cellules bordant les lumieres, et une positivite de la PS100 et de la vimentine sur les cellules de la bordure externe. Discussion Le syringome chondroide est caracterise par une double composante epitheliale et mesenchymateuse au sein d’un stroma myxoide ou chondroide. Notre serie a des particularites cliniques et histologiques (localisation aux extremites, raccordement epidermique…). Les principaux diagnostics differentiels sont les autres lesions annexielles, dont l’immuno-histochimie ne serait pas caracteristique de celle des syringomes chondroides : les cellules bordant les lumieres expriment les marqueurs epitheliaux (EMA, cytokeratines et ACE), les cellules de la bordure externe les marqueurs mesenchymateux (PS100, vimentine). Le traitement est chirurgical. Conclusion L’aspect histologique du syringome chondroide est evocateur mais en cas de doute la realisation d’une etude immuno-histochimique montrant une double composante cellulaire peut en faciliter le diagnostic.

Chondroid syringoma or mixed skin tumour is a rare, benign skin adnexal tumour which typically occurs in the head and neck region of middle-aged patients. Due to their rarity, they are often clinically misdiagnosed and with the diagnosis only confirmed on histological examination. They typically comprise sweat gland elements within a prominent ‘cartilage-like' stroma. Treatment involves total excision with clear surgical margins. Where excision is incomplete, routine follow up is required due to risk of recurrence or malignant transformation, though the latter is extremely rare. Herein we describe a classical case with review of the current literature.

Chondroid syringoma, or mixed tumour of the skin, is an uncommon benign sweat gland tumour. It is the cutaneous counterpart of pleomorphic adenoma of the salivary glands. The clinical presentation of chondroid syringoma is non-specific and its histological diagnosis can prove difficult. Characteristically, it is composed of a proliferation of epithelial cells set in a chondromyxoid matrix. We report a case of chondroid syringoma arising from a polyp in the external auditory canal in a 25 year old male who presented with a sensation of blockage of the ear and impaired hearing. The aim of this report is to help both the clinician and the pathologist recognize this uncommon benign neoplasm. © 2010 SEAP y SEC. Published by Elsevier Espana, S.L. All rights reserved.

Chondroid syringoma of skin is a rare type of soft tissue tumor originating from the sweat glands. We report a documented case of giant chondroid syringoma occurring in the upper arm, which developed over the course of one year. The radiographic, sonographic, MR imaging, gross pathologic, and histologic findings of the tumor are described. Because the clinical suggestion of such a tumor was low, we present the imaging appearances of chondroid syringoma that could be used to make a presumptive diagnosis, and discuss the many entertained differential diagnostic possibilities.

Resumen Introduccion El siringoma condroide es un tumor cutaneo raro que se presenta como una lesion de lento crecimiento, indolente, mas frecuente en varones adultos y habitualmente benigna. Se trata quirurgicamente y su diagnostico es histologico. Se puede clasificar en ecrino y apocrino segun sus caracteristicas anatomopatologicas. Material y metodos Se reevaluan clinica e histologicamente 8 casos diagnosticados de siringoma condroide en nuestro Servicio en los ultimos 8 anos, asi como la microscopia de epiluminiscencia de uno de ellos. Resultados La mayoria de los casos se presentaron como lesions nodulares, bien delimitadas, cuyo diagnostico clinico de presuncion fue de patologia anexial o quistica. Todas fueron tratadas quirurgicamente. La microscopia de epiluminiscencia mostro un patron de coloracion blanquecino-azulado homogeneo. Todos los casos presentaban una matriz mixoide, y la mayoria tambien condroide. Cinco de los 8 casos fueron del tipo apocrino, uno de ellos con diferenciacion follicular y sebacea. Discusion El siringoma condroide habitualmente es un tumor cutaneo de pequeno tamano, con localizacion, frecuentemente, en cabeza y cuello. La dermatoscopia no parece aportar ningun rasgo especifico a esta lesion. El examen microscopico de estas lesiones revela estructuras tubuloalveolares y de tipo glandular dispuestas a modo de islas en el seno de un estroma fibroadiposo, condroide, mixoide o hialino. El tratamiento definitivo de estos tumores es quirurgico. Como regla general, se trata de un tumor benigno. Algunos autores han propuesto el termino de tumor mixto cutaneo atipico para aquellos siringomas condroides con rasgos histologicos de malignidad, pero sin evidencia de metastasis.

Chondroid syringoma is a rare eccrine tumor that is often benign but has the potential for malignant transformation and distant metastasis. Histopathological analysis may not be definitive, and any patient with atypical features, an accelerated clinical course, or high suspicion for malignant transformation is a candidate for immediate surgical intervention and close follow-up. The purpose of this article is to review the clinical features of this rare tumor with a special emphasis on its atypical presentation.

Chondroid syringoma or mixed tumour of the skin is a relatively uncommon neoplasm thought to originate in sweat glands.1 They are usually found in the head and neck or trunk and have rarely been reported arising on the foot. 4 cases are presented which occurred on the plantar aspect of the foot. There was a history of trauma in 3 of the cases, and 1 recurred following excision. The number of specialities involved in the care of this group of patients is also highlighted. We can find only 6 previous cases of chondroid syringoma arising on the foot described in the world literature. We report on the clinicopathological features of a further 4 cases diagnosed in Edinburgh over a 9-year period.

Chondroid syringoma of the external auditory canal is an extremely rare neoplasm, representing the cutaneous counterpart of pleomorphic adenoma of salivary glands. This tumour is thought to derive from the apocrine duct of the follicular-sebaceous-apocrine unit. We report the case of a 68-year-old male in whom the clinical and radiological examinations showed a well-circumscribed tumour limited to the external auditory canal. The diagnosis was confirmed by histologic examination. We also reviewed the literature.

Chondroid syringoma, or Pleomorphic adenoma of the skin, is a rare, benign skin adnexal tumour. It is usually exhibited as a slowly growing intradermal or subcutaneous nodule, typically located in the head and neck region. Because of the unremarkable clinical symptomatology of this rare tumour, the diagnosis is exclusively made retrospectively based on histological confirmation of the surgically excised tumour. We present a rare case of a Chondroid Syringoma located in the left medial canthal of a 58-year-old man. The patient had no symptoms and decided to excise it for cosmetic reasons only. Local excision with a macroscopic wide cuff of normal tissue was done, without destroying the aesthetic and functional structures, since the defect was restored by a finger flap. One year postoperatively, the patient has remained disease-free. Chondroid syringoma usually appears in the face but the location in the medial canthal is not mentioned in the literature the last twenty years.

Chondroid syringoma is a rare benign skin tumor of the head and neck. Only 15 cases presenting on the eyelid have been described in the literature. An 84-year-old patient presented with an 8-mm nodule on the right inferior eyelid that had grown over 5 years. The lesion was surgically removed, and the histopathological examination showed a chondroid syringoma. Knowledge of this disease is important because malignant transformations do occur.

Sweat gland tumors are uncommon, and yet the chondroid syringoma (mixed tumor of the skin) appears most frequently on the faces of adults. Clinicians diagnosing and treating diseases of the head and neck should be aware of these tumors. A case of the chondroid syringoma in the upper lip is reported; the clinical features, histology, treatment, and follow-up are discussed.

The case of a 38-year-old white man with a chondroid syringoma in the left side of the upper lip is reported. Histochemical study of the lesion showed that the morphologic distributions of the neutral mucosubstances, sulfated acid mucopolysaccharides, and elastic fibers in the reported case were similar to those of mixed salivary gland tumor. The recently reported ultrastructural and immunohistochemical features of chondroid syringoma are also discussed in an effort to clarify its histogenesis.