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Your search keyword '"Christ, D."' showing total 19 results
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19 results on '"Christ, D."'

1. Systematic Implementation of Effective Quality Assurance Processes for the Assessment of Radiation Target Volumes in Head and Neck Cancer

Author

Gogineni, E., primary, Schaefer, D., additional, Ewing, A., additional, Andraos, T., additional, DiCostanzo, D., additional, Weldon, M., additional, Christ, D., additional, Baliga, S., additional, Jhawar, S., additional, Mitchell, D., additional, Grecula, J., additional, Konieczkowski, D.J., additional, Palmer, J., additional, Jahraus, T., additional, Dibs, K., additional, Chakravarti, A., additional, Martin, D., additional, Gamez, M.E., additional, and Blakaj, D., additional

Published
2024
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3. Vertebral Compression Fracture Post Spine Stereotactic Body Radiotherapy: The Role of Vertebral Endplate

Author

Dibs, K., primary, Facer, B.D., additional, Palmer, J.D., additional, Pan, J., additional, Raval, R., additional, Thomas, E.M., additional, Cochran, E.R., additional, Beyer, S., additional, Grecula, J.C., additional, Ayan, A.S., additional, Zoller, W., additional, Christ, D., additional, Scharschmidt, T., additional, Elder, J.B., additional, Bourekas, E., additional, Xu, D., additional, Chakravarthy, V., additional, Elguindy, A.N., additional, Chakravarti, A., additional, and Blakaj, D.M., additional

Published
2023
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5. Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability.

Author

Burnett, DL, Jackson, KJL, Langley, DB, Aggrawal, A, Stella, AO, Johansen, MD, Balachandran, H, Lenthall, H, Rouet, R, Walker, G, Saunders, BM, Singh, M, Li, H, Henry, JY, Jackson, J, Stewart, AG, Witthauer, F, Spence, MA, Hansbro, NG, Jackson, C, Schofield, P, Milthorpe, C, Martinello, M, Schulz, SR, Roth, E, Kelleher, A, Emery, S, Britton, WJ, Rawlinson, WD, Karl, R, Schäfer, S, Winkler, TH, Brink, R, Bull, RA, Hansbro, PM, Jäck, H-M, Turville, S, Christ, D, Goodnow, CC, Burnett, DL, Jackson, KJL, Langley, DB, Aggrawal, A, Stella, AO, Johansen, MD, Balachandran, H, Lenthall, H, Rouet, R, Walker, G, Saunders, BM, Singh, M, Li, H, Henry, JY, Jackson, J, Stewart, AG, Witthauer, F, Spence, MA, Hansbro, NG, Jackson, C, Schofield, P, Milthorpe, C, Martinello, M, Schulz, SR, Roth, E, Kelleher, A, Emery, S, Britton, WJ, Rawlinson, WD, Karl, R, Schäfer, S, Winkler, TH, Brink, R, Bull, RA, Hansbro, PM, Jäck, H-M, Turville, S, Christ, D, and Goodnow, CC

Abstract

Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy. Second-generation vaccines will need to elicit neutralizing antibodies against sites that are evolutionarily conserved across the sarbecovirus subgenus. Here, we immunized mice containing a human antibody repertoire with diverse sarbecovirus receptor-binding domains (RBDs) to identify antibodies targeting conserved sites of vulnerability. Antibodies with broad reactivity against diverse clade B RBDs targeting the conserved class 4 epitope, with recurring IGHV/IGKV pairs, were readily elicited but were non-neutralizing. However, rare class 4 antibodies binding this conserved RBD supersite showed potent neutralization of SARS-CoV-2 and all variants of concern. Structural analysis revealed that the neutralizing ability of cross-reactive antibodies was reserved only for those with an elongated CDRH3 that extends the antiparallel beta-sheet RBD core and orients the antibody light chain to obstruct ACE2-RBD interactions. These results identify a structurally defined pathway for vaccine strategies eliciting escape-resistant SARS-CoV-2 neutralizing antibodies.

Published
2021

7. Capon–Bartlett cross-spectrum and a perspective on robust adaptive filtering

Author

Christ D. Richmond

Subjects
Beamforming, Computer science, Estimator, 020206 networking & telecommunications, 02 engineering and technology, Filter (signal processing), Capon, Covariance, Sample mean and sample covariance, Adaptive filter, Minimum-variance unbiased estimator, Control and Systems Engineering, Signal Processing, 0202 electrical engineering, electronic engineering, information engineering, Probability distribution, Coherence (signal processing), Periodogram, 020201 artificial intelligence & image processing, Computer Vision and Pattern Recognition, Electrical and Electronic Engineering, Algorithm, Cross-spectrum, Software, Coherence (physics)
Abstract

Adaptive filtering / beamforming (ABF) optimized for maximum signal-to-interference-plus-noise ratio (SINR) results in filter weights that depend on the data covariance and the signal array response vector. The effectiveness of practical application of such solutions, however, is limited by (i) extent of data stationarity and (ii) imperfect knowledge of the true signal array response vector. Robust ABF methods attempt to address these two critical issues via a slight reformulation of the ABF problem statement. Many robust ABF solutions result in some form of diagonal loading of the data covariance, and can be interpreted as a hybrid beamformer that engages the tradespace between data adaptive beamforming and conventional beamforming (CBF). In view of this interpretation, an exact joint probability distribution is derived for 1) the data adaptive Capon minimum variance distortionless response (MVDR) spectral estimator, and 2) the conventional Bartlett spectral estimator (a.k.a. the smoothed periodogram) when based on the same data covariance estimate. The resulting joint distribution motivates (i) proposal of a robust adaptive filtering design that constrains filter weight cross coherence (a metric quantifying the statistical coupling between the Capon and Bartlett spectral statistics), and (ii) introduction of a coherence estimate called the Capon–Bartlett cross spectrum.

Published
2020

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