1. Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors
- Author
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Dirk B. Mendel, Matthew A. Williams, Paul A. Escarpe, W. Graeme Laver, Raymond C. Stevens, Choung U. Kim, Willard Lew, and Chun Y. Tai
- Subjects
chemistry.chemical_classification ,biology ,Chemistry ,Stereochemistry ,Influenzavirus B ,fungi ,Organic Chemistry ,Clinical Biochemistry ,Orthomyxoviridae ,Pharmaceutical Science ,Influenza a ,biology.organism_classification ,Biochemistry ,Virus ,body regions ,Enzyme ,Enzyme inhibitor ,Drug Discovery ,biology.protein ,Molecular Medicine ,skin and connective tissue diseases ,Molecular Biology ,Neuraminidase - Abstract
The structure-activity relationships (SAR) for a new class of potent inhibitors (1) of influenza neuraminidase are described. Systematic modifications of substituents at the C-3, C-4, and C-5 positions of the carbocyclic ring were performed to establish fundamental SAR to assist in the design of potent inhibitors with activity against both of influenza A and B viruses.
- Published
- 1997
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